DDX For Diarrhea & Weight Loss

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Congenital, Developmental Disorders:

0 Agammaglobulinemia, congenital/autosomal 0 Tufting Enteropathy/Epithelial Dysplasia

Hereditary, Familial, Genetic Disorders:


0 Cystic fibrosis

(mucoviscidosis) 0 Acrodermatitis enteropathica 0 Gardner syndrome 0 Shwachman (Shwachman0 Iga deficiency, selective Diamond) syndrome 0 Johanson Blizzard genetic 0 Microvillous familial syndrome (unco) diarrhea/Davidson's syndrome 0 Familial pheochromocytoma

0 Turcot syndrome

Infectious Disorders (Specific Agent) :


Severity Active diarrhea, any CD4 count Differential Diagnosis Viruses (especially Norwalk virus) Viral hepatitis Herpes enteritis C. difficile (suspect in patients who have recently undergone treatment with antibiotics, or hospitalization) Salmonella Shigella Campylobacter E. coli O157:H7 C. difficile (suspect in patients who have been treated with antibiotics Giardia lamblia E. histolytica Microsporidia Cryptosporidium parvum MAC (CD4 count <50 cells/L) Isospora belli CMV (CD4 count <50 cells/L)

Chronic diarrhea, any CD4 count

Chronic diarrhea, CD4 count <300 cells/L

Allergic, Collagen, AutoImmune Disorders:


0 Crohn's disease 0 Celiac disease

0 Inflammatory bowel disease


0 Diffuse intestinal

0 Scleroderma bowel
0 Behcet's Disease

ulceration (sprue) 0 Sprue (gluten enteropathy) 0 Ulcerative colitis

Metabolic, Storage Disorders:


0 Diabetic diarrhea syndrome

0 Pancreatic lipase deficiency


0 Fructose intolerance, hereditary 0 Congenital Sodium Diarrhea

Neoplastic Disorders:
0 Carcinoid syndrome/Carcinoid metastatic

0 Neuroblastoma
0 Pheochromocytoma 0 Zollinger-Ellison syndrome/gastrinoma

0 Intestinal/gut lymphoma
0 Neural crest tumor

Deficiency Disorders:
0 Malnutrition, fetal

0 Folate depletion
0 Folic acid deficiency anemia 0 Malnutrition/Starvation

0 Pellagra/niacin deficiency
0 Zinc deficiency

Vegetative, Autonomic, Endocrine Disorders:


0 Hyperthyroidism (Graves disease)

0 Postural hypotension
0 Addison's disease (chronic adrenal ins) 0 Adrenocorticoid (Isolated) Deficiency

0 Hypergastrinemia

Reference to Organ System:


0 Chloride-wasting diarrhea

0 Immune deficiency/suppressed status


0 Malabsorption syndrome 0 Steatorrhea

0 Hypogammaglobulinemia/Agammaglobuline mia
0 Pancreatic insufficiency

0 Mastocytosis, systemic

Drugs:
0 Laxative abuse

0 Lactulose (Cephulac) Administration/Toxicity


0 Sorbitol Administration/Toxicity/intake 0 Thyrotoxicosis/exogenous

Poisoning (Specific Agent):


0 Alcoholism, chronic

Surgical, Procedure Complication:


0 Ileum/jejunocolic bypass

0 Small intestinal bypass


0 Pancreatectomy 0 Short-bowel syndrome

Radiation Causes:
0 Radiation enteritis

0 Radiation proctitis
0 Radiation Colitis

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