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169 Genetic Algorithm Based Script For A

The document discusses the optimization of VMAT plans for head and neck treatments using a genetic algorithm-based script, demonstrating good agreement with commercial treatment planning systems. It also evaluates a machine QA software tool for monitoring MLC parameters, showing that the genetic algorithm outperformed existing systems in terms of target coverage and organ-at-risk sparing. The findings suggest that these tools can enhance treatment planning and quality assurance in clinical settings.

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0% found this document useful (0 votes)
5 views1 page

169 Genetic Algorithm Based Script For A

The document discusses the optimization of VMAT plans for head and neck treatments using a genetic algorithm-based script, demonstrating good agreement with commercial treatment planning systems. It also evaluates a machine QA software tool for monitoring MLC parameters, showing that the genetic algorithm outperformed existing systems in terms of target coverage and organ-at-risk sparing. The findings suggest that these tools can enhance treatment planning and quality assurance in clinical settings.

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lxlalg
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© © All Rights Reserved
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168 Abstracts / Physica Medica 56 (2018) 133–278

metastases. For all patients VMAT plans with 10 MV FFF beam were 169. Genetic algorithm based script for automation of head and
optimized in Eclipse and calculated with Acuros. The DICOM files neck VMAT treatment planning
(plan, structure and images) were imported in PRIMO. DPM was C. Fiandra a, G. Loi b, M Fusella c, A. Scaggion c, A. Alparone d,
used to calculate the dose distribution in the patients. The plans F.R. Giglioli e, M. Paiusco c
were compared in terms of DVHs through Homogeneity (HI) and a
Gradient (GI) Indexes. Department of Oncology, Radiation Oncology, University of Turin, via
Results. The agreement between simulated and real beam was Genova 3, 10126 Turin, Italy
b
good with differences 6 1:5% for all parameters considered. Some University Hospital ‘‘Maggiore della Carità”, Department of Medical
differences were observed in the MLC modeling. PRIMO showed a Physics, Novara, Italy
c
larger DLG with values 2 mm greater than both Acuros and the Medical Physics Department, Veneto Institute of Oncology IOV IRCCS,
related experimental measurements (Fig. 1). Padua, Italy
d
The analysis of PDDs in the slab-phantom materials showed dis- Tecnologie Avanzate Srl, Turin, Italy
e
crepancies of 1.2% between Acuros and PRIMO in cartilage and lung Medical Physics Unit, A.O.U. Città della Salute e della Scienza, corso
(Fig. 2). The MC dose distributions of the VMAT plans always had Bramante 88/90, 10126 Turin, Italy
mean uncertainties within the PTV < 1.5%. Comparing the VMAT Purpose. To use a specific Phyton script for automatic optimization
plans an overall good agreement was observed. process in RayStation treatment planning system (TPS) in the head
Conclusions. PRIMO is an interesting tool for the clinical environ- and neck treatments. Comparison with different commercial auto-
ment, useful to verify and support the commercially available TPS. matic planning is reported.
The agreement with Acuros is good though further analysis should Methods. Genetic algorithm (GA) was implemented for head and
be done. neck VMAT treatments. The chromosomes of the algorithm were
max equivalent uniform dose functions (maxEUD) for: larynx, oral
cavity and both parotid glands. Ten initial couples were randomly
https://doi.org/10.1016/j.ejmp.2018.04.178
generated and a maximum of five reproductions were permitted.
The script was tested for fifteen patients in three different centres:
some patients had three dose levels (70 Gy, 63 Gy and 54 Gy) in 35
fractions, others had two levels (69.96 Gy, 60 Gy) in 32 fractions. A
comparison with corresponding plans created with Monaco TPS
168. Evaluation of a machine QA software tool for MLC perfor-
(M, Elekta), MCO option of RayStation (MCO, RaySearch) and Rapid-
mance checks
Plan (RP, Varian) was carried out. All the plans were evaluated with a
S. Strolin a, P. Grimaldi a, R. Nigro b, S. Riccardi b, N. Franza c
score of PlanIQ (Sun Nuclear) in terms of target coverage, conformity
a
INI Divisione Città Bianca, Radiotherapy Department, Veroli, Italy index of PTVs and constraints of OARs.
b
S.Camillo De Lellis, Radiotherapy Department, Rieti, Italy Results. In figure are reported the totals scores (TS) obtained.
c
Dosimetrica, Italy Script plans scores were always higher than RP and M (mean TS:
80.0 ± 9.1 for GA and 72.2 ± 9.1 for RP, 77.3 ± 13.9 for GA and 74.2
Purpose. One of the main requirement for a correct intensity mod- ± 14.2 for M). PTVs coverage, Maximum doses of spinal cord and
ulated treatment (IMRT) delivery, is a periodic check of Multileaf brainstem were always below the requested value for all tested sys-
Collimator (MLC) parameters. In some Treatment Planning System tems. For parallel OARs, GA spared parotid glands more than RP
(TPS), the Dosimetric Leaf Gap (DLG) is one of the most important (average score of one parotid gland: 81.0 ± 15.0 for GA and 45.0 ±
parameter for the correct calculation of dose distribution when using 10.0 for RP); GA spared also Larynx more than MCO (average score
dynamic MLC. The purpose of this work is to evaluate the feasibility 78.0 ± 9.0 for GA and 29.0 ± 12.0 for MCO). For other OARs, the
and time saving in using a dedicated machine quality assurance (QA) results obtained with GA, RP and MCO were similar.
software tool to monitor over time the DLG parameter and leaves Conclusions. GA gives results clinically comparable with automatic
positions. commercial systems. These preliminary results must be confirmed
Methods. Two 6 MV Linac equipped with a 120 leaf MLC were with a larger Head and Neck plans dataset [1].
compared to check the measured constancy of the DLG and leaves
positions through use of a 3D diode array equipped with a dedicated Reference
machine QA software tool. The MLC checks were performed at 50°
and 320° gantry angles due to phantom’s plate geometry. In this
1. Wu B, Kusters M, Kunze-Busch M. Cross-institutional knowledge-
way it was possible also to verify gravity effects on leaves banks.
based planning (KBP) implementation and its performance
The analysis was carried out with a version of picket fence test comparison to Auto-Planning Engine (APE). Radiother Oncol
implemented in the software. 2017;123(1):57–62.
Results. The Veroli mean DLG values was 2,0 ± 0.4 mm for 50° gan-
try angle and 2.1 ± 0.5 mm for 320° gantry angle. The Rieti mean DLG https://doi.org/10.1016/j.ejmp.2018.04.180
values was 1.9 ± 0.1 for 50° gantry angle and 2.0 ± 0.1 mm for 320°
gantry angle. The check on the leaves movement has shown gravity
effect on two different angles. In particular the Rieti DLG value car-
ried out at gantry 50° was 1.6 ± 0.1 mm when there was a problem to 170. Implementing single-isocenter volumetric modulated arc
leaf motor. therapy radiosurgery treatment for multiple intracranial metastases
Conclusion. The picket fence test, originally used with radiographic B. Nardiello, F.M. Aquilanti, B. Tolu, G.H. Raza, R. El Gawhary,
film to check the reproducibility of leaf gap, is extended in this C. D’ambrosio, F. Bianciardi, F. Rea, C. Scaringi, L. Capone, L. Nicolini,
machine QA software tool, including checks for gap width and leaf F. Lusini, G. Minniti, P. Gentile
positions. This tool can be used as a routine MLC QA check for mean UPMC San Pietro FBF, Roma, Italy
leaf deviation, DLG, and absolute positions of the leaves.
Purpose. Recently an increase in radiosurgery treatments for mul-
https://doi.org/10.1016/j.ejmp.2018.04.179 tiple metastases has been observed. Traditionally these lesions were
treated using one isocenter for each target and the patient had to be

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