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Predictive Modeling
in Biomedical Data Mining
and Analysis
This page intentionally left blank
Predictive Modeling
in Biomedical Data Mining
and Analysis
Edited by
Sudipta Roy
Department of Artificial Intelligence and Data Science, Jio Institute,
Navi Mumbai, Maharashtra, India
Valentina E. Balas
Professor of Automation and Applied Informatics, Aurel Vlaicu University
of Arad, Arad, Romania
Basant Agarwal
Department of Computer Science and Engineering, Indian Institute
of Information Technology Kota, Jaipur, Rajasthan, India
Mamta Mittal
Delhi Skill and Entrepreneurship University, New Delhi, India
Academic Press is an imprint of Elsevier
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This book and the individual contributions contained in it are protected under copyright by the Publisher
(other than as may be noted herein).
Notices
Knowledge and best practice in this field are constantly changing. As new research and experience broaden our
understanding, changes in research methods, professional practices, or medical treatment may become
necessary.
Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using
any information, methods, compounds, or experiments described herein. In using such information or methods
they should be mindful of their own safety and the safety of others, including parties for whom they have a
professional responsibility.
To the fullest extent of the law, neither the Publisher nor the authors, contributors, or editors, assume any liability
for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or
from any use or operation of any methods, products, instructions, or ideas contained in the material herein.
ISBN: 978-0-323-99864-2
Contributors xi
About the Editors xv
Preface xix
1. Introduction 1
2. Role of deep learning techniques in epileptic seizure
detection 3
3. Proposed method of seizure detection 5
4. Results and discussion 12
5. Conclusions 16
References 16
1. Introduction 21
2. A brief literature survey 23
3. Dataset and modus operandi 24
4. Data visualization 30
5. Feature selection and dimensionality reduction 33
6. Experimental results and discussions 39
7. Conclusions 45
References 46
v
vi Contents
1. Introduction 49
2. Medical decision support system: A review 50
3. Ontological representation of MDSS 53
4. Integrated medical decision support system 57
5. Conclusion and future enhancement 62
References 63
1. Introduction 65
2. Modalities 66
3. Fusion process 67
4. AI based fusion 70
5. Evaluation 73
6. Experimental results 75
7. Conclusion and future scope 79
Acknowledgment 79
References 79
1. Introduction 83
2. Methods: Related work and dataset 86
3. Backpropagation neural network and training optimizers 88
4. BPNN implementation 92
Contents vii
1. Introduction 105
2. Related works 108
3. Methodology 109
4. Results 115
5. Conclusion 119
References 120
1. Introduction 123
2. Research background 125
3. Methods 126
4. Results and discussions 132
5. Conclusions 135
Conflicts of interest 135
References 135
1. Introduction 137
viii Contents
1. Introduction 157
2. Related work 158
3. Methodology 160
4. Results 163
5. Conclusion 167
References 167
1. Introduction 171
2. Related work 174
3. Methodology 175
4. Experimental results 178
5. Conclusion 184
References 184
Contents ix
1. Introduction 187
2. Architectural design and circuit modeling 189
3. Implementation and experimental verification 193
4. Results and discussions 201
5. Conclusion and future directions 202
References 204
1. Introduction 207
2. Dataset collection 209
3. LSTM neural network model 209
4. Implementation of LSTM neural network 215
5. Results and discussions 217
6. Conclusions 221
References 221
1. Introduction 295
2. Machine learning in healthcare 296
3. Proposed framework 302
4. Results and discussion 303
5. Conclusion and future scope 306
References 309
Index 313
Contributors
xi
xii Contributors
Dr. Sudipta Roy is working as an assistant professor in the Artificial Intelligence and Data
Science Department at JIO Institute, Navi Mumbai, Maharashtra, India. Prior to that, he
was a postdoctoral research associate at Washington University in St. Louis, MO, United
States. He has received his PhD in Computer Science and Engineering from the Depart-
ment of Computer Science and Engineering, University of Calcutta, Kolkata, West Bengal,
India. He is the author of more than 50 publications in refereed international journals and
conference proceedings published by IEEE, Springer, Elsevier, and many other publishers.
He has authored/edited four books and many book chapters. He holds a US patent in
medical image processing and has filed an Indian patent in the field of smart agricultural
systems. He has served as a regular reviewer for many international journals including
those published by IEEE, Springer, Elsevier, IET, and many other publishers, and interna-
tional conferences. He has served as an international advisory committee member and
program committee member of INDIAcom-2020, AICAE-2019, INDIACom-2019, CAAI
2018, ICAITA-2018, ICSESS-2018, INDIACom-2018, ISICO-2017, AICE-2017, and many
other conferences. Currently, he is serving as associate editor of IEEE Access (IEEE) and
International Journal of Computer Vision and Image Processing (IJCVIP; IGI Global) and
topic editor of Journal of Imaging (MDPI). In recognition of his exceptional contributions
to the IEEE Access journal as associate editor, the IEEE Access Editorial Board and Editorial
Office honored him as an Outstanding Associate Editor of 2020. He has more than 5 years
of experience in teaching and research. His fields of research interests are biomedical
image analysis, image processing, steganography, artificial intelligence, big data analysis,
machine learning, and big data technologies.
Dr. Lalit Mohan Goyal has completed PhD in Computer Engineering from Jamia Millia
Islamia, New Delhi, India, MTech (Honors) in Information Technology from Guru Gobind
Singh Indraprastha University, New Delhi, India, and BTech (Honors) in Computer Engi-
neering from Kurukshetra University, Kurukshetra, India. He has 17 years of teaching
experience in the areas of theory of computation, parallel and random algorithms, distrib-
uted data mining, and cloud computing. He has completed a project sponsored by the
Indian Council of Medical Research, Delhi. He has published and communicated more
than 40 research papers in SCI, SCIE, and Scopus-indexed journals and attended many
workshops, Faculty Development Programs, and seminars. He has filed nine patents in
the area of artificial intelligence and deep learning, out of which four have been granted
and others are published online. He is a reviewer of many reputed journals and confer-
ences. He is a series editor for CRC Press, Taylor & Francis, and has edited many books
xv
xvi About the Editors
for Elsevier and Springer. Presently, he is working in the Department of Computer Engi-
neering, J.C. Bose University of Science and Technology, YMCA, Faridabad, India.
Prof. Valentina E. Balas is currently full professor in the Department of Automatics and
Applied Software at the Faculty of Engineering, Aurel Vlaicu University of Arad, Romania.
She holds a PhD cum laude in Applied Electronics and Telecommunications from Poly-
technic University of Timisoara. Dr. Balas is the author of more than 400 research papers
in refereed journals and international conferences. Her research interests are in intelligent
systems, fuzzy control, soft computing, smart sensors, information fusion, and modeling
and simulation. She is the editor-in-chief of the International Journal of Advanced Intel-
ligence Paradigms (IJAIP) and International Journal of Computational Systems Engineer-
ing (IJCSysE), editorial board member of several national and international journals, and
expert evaluator for national/international projects and PhD theses. Dr. Balas is the direc-
tor of Intelligent Systems Research Centre in Aurel Vlaicu University of Arad and director
of the Department of International Relations, Programs and Projects in the same univer-
sity. She served as the general chair for nine editions of the International Workshop on Soft
Computing and Applications (SOFA) organized during the period 2005–2020 and held in
Romania and Hungary. Dr. Balas participated in many international conferences as orga-
nizer; honorary chair; session chair; member of the steering, advisory, or international
program committees; and keynote speaker. Recently, she was working on a national pro-
ject with EU funding support “BioCell-NanoART ¼ Novel Bio-inspired Cellular Nano-
Architectures—For Digital Integrated Circuits,” 3M Euro from the National Authority
for Scientific Research and Innovation. She is a member of the European Society for Fuzzy
Logic and Technology (EUSFLAT), member of the Society for Industrial and Applied
Mathematics (SIAM), a senior member of IEEE, member of Technical Committee—Fuzzy
Systems (IEEE Computational Intelligence Society), chair of the Task Force 14 in Technical
Committee—Emergent Technologies (IEEE CIS), and member of Technical Committee—
Soft Computing (IEEE SMCS). Dr. Balas was past vice president of the International Fuzzy
Systems Association (IFSA) Council (2013–2015), is a joint secretary of the governing
council of the Forum for Interdisciplinary Mathematics (FIM, a multidisciplinary aca-
demic body based in India), and is a recipient of the “Tudor Tanasescu” Prize from the
Romanian Academy for contributions in the field of soft computing methods (2019).
Dr. Basant Agarwal is working as an assistant professor at the Indian Institute of Informa-
tion Technology Kota (IIIT-Kota), India, which is an institute of national importance. He
holds a PhD and MTech from the Department of Computer Science and Engineering,
Malaviya National Institute of Technology Jaipur, India. He has more than nine years of
experience in research and teaching. He has worked as a postdoc research fellow at the
Norwegian University of Science and Technology (NTNU), Norway, under the prestigious
European Research Consortium for Informatics and Mathematics (ERCIM) fellowship in
2016. He has also worked as a research scientist at Temasek Laboratories, National
About the Editors xvii
University of Singapore (NUS), Singapore. His research interests are in artificial intelli-
gence, cyber-physical systems, text mining, natural language processing, machine learn-
ing, deep learning, intelligent systems, expert systems, and related areas.
Dr. Mamta Mittal is working as program head and associate professor (Data Analytics and
Data Science) in Delhi Skill and Entrepreneurship University (under the Government of
NCT Delhi), New Delhi, India. She received her PhD in Computer Science and Engineering
from Thapar University, Patiala; MTech (Honors) in Computer Science and Engineering
from YMCA, Faridabad; and BTech in Computer Science and Engineering from Kurukshe-
tra University, Kurukshetra, in 2001. She has been teaching for the last 18 years and spe-
cializes in data mining, machine learning, DBMS, and data structure. Dr. Mittal is a
lifetime member of CSI and has published more than 80 research papers in SCI, SCIE,
and Scopus-indexed journals. She holds five patents, two copyrights granted, and three
more published patents in the areas of artificial intelligence, IoT, and deep learning. Dr.
Mittal has edited/authored many books with reputed publishers like Springer, IOS Press,
Elsevier, and CRC Press and is working on a DST-approved project “Development of
IoT-Based Hybrid Navigation Module for Mid-sized Autonomous Vehicles” with a research
grant of 25 lakhs. Currently, she is guiding PhD scholars in the areas of machine learning,
computer vision, and deep learning. Dr. Mittal is an editorial board member for publishers
like Inderscience, Bentham Science, Springer, and Elsevier, and has handled special issues
and chaired a number of conferences. She is book series editor of Innovations in Health
Informatics and Healthcare: Using Artificial Intelligence and Smart Computing and
another series Edge AI in Future Computing for CRC Press, Taylor & Francis, United States.
She is associate editor, advisory member, and editor for Springer journals, Dyna (Spain),
and Elsevier journals, respectively.
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Preface
Machine learning (ML) techniques are used as predictive models for many applications
including those in the field of biomedicine. These techniques have shown impressive
results across a variety of domains in biomedical engineering research. Biology and med-
icine are data-rich disciplines, but the data are complex and often not properly under-
stood. Most biomedical data are categorized into structured, semi-structured, and
unstructured types with very high volume. The volume and complexity of these data pre-
sent new opportunities, but also pose new challenges. Automated algorithms that extract
meaningful patterns could lead to actionable knowledge and change how we develop
treatments, categorize patients, or study diseases, all within privacy-critical environ-
ments. This book addresses the issues described to predict and model biomedical data
mining and analysis. The book has been organized into 15 chapters.
Chapter 1 titled “Data Mining with Deep Learning in Biomedical Data” presents a time-
domain study of EEG signals to detect various neurological disorders with a specific focus
on epilepsy. The presented convolutional neural network (CNN), long short-term memory
network (LSTM), and CNN-LSTM hybrid models were used to detect seizure activities in
precisely filtered EEG segments. The experimental results reveal the suitability of the
CNN-LSTM hybrid model for accurate and prompt detection of epileptic seizures with
an accuracy of 98%, sensitivity of 98.48%, and specificity of 99.19%, so that patients could
be saved from major injuries or sudden expected deaths. These models can be useful in
the detection of various diseases or disorders such as schizophrenia, Parkinson’s disease,
and the identification of breast cancer and bone- or skin-related diseases.
Chapter 2 titled “Applications of Supervised Machine Learning Techniques with the
Goal of Medical Analysis and Prediction: A Case Study of Breast Cancer” analyzes the Wis-
consin Breast Cancer Diagnosis dataset for identifying essential features and assessing the
performance of some popular machine learning (ML) classifiers in breast cancer predic-
tion. The dataset is first cleaned by eliminating non-numerical values and normalizing the
data. The processed data are then visualized to grasp the hidden patterns and non-
essential attributes are trimmed. Eight different ML models are trained and tested over
the refined data for prediction of the two tumor classes. The presented study identified
vital features that were must-haves for the analysis, and the empirical results investigated
the superiority of particular ML classifiers over the others.
Chapter 3 titled “Medical Decision Support System Using Data Mining” describes how
a medical decision support system can support the medical decision-making processes at
both clinical and diagnostic levels. To provide an error-free and accurate service, clinicians
xix
xx Preface
must apply relevant computer-based information and decision support systems. Decision
support systems can be designed as a system based on knowledge or a system based on
learning. Human-engineered mappings to suggestions based on best medical treatments
and patient data are known as knowledge-based systems. Learning-based systems utilize
data mining, statistics, and ML approaches to map the system. Integrated decision sup-
port incorporates both the systems of knowledge and learning to solve the problem of
presence of partial information in a realistic situation. This effort aims to assist physicians
medically and to apply the medicine prescription specifically. The approach may be
utilized for query-based applications, online web browser applications, or mobile appli-
cations on numerous terminal interfaces.
Chapter 4 titled “Role of AI Techniques in Enhancing Multi-Modality Medical Image
Fusion Results” outlines the benefits of using AI methods for medical image fusion of dif-
ferent modalities. The modality can be computed tomography, magnetic resonance-T1,
magnetic resonance-T2, and Positron emission tomography depending on the suspected
malignant region. The aim of fusion is to collaborate each modality’s best information into
a single image called a fused image. This chapter addresses the multi-modality medical
image fusion using AI techniques like Fuzzy Logic and Adaptive Neuro-Fuzzy Inference
System (ANFIS). The study reveals that the AI techniques not only give better results
but their learning capabilities will likely make the future work self-driven.
Chapter 5 titled “A Comparative Performance Analysis of Backpropagation Training
Optimizers to Estimate Clinical Gait Mechanics” indicates that the clinical gait analysis
of healthy people of different age groups plays a significant role in the early estimation
of different physiological and neurological disorders. However, due to complicated data
acquisition setups and in-person requirements, the estimation of the gait analysis has
been quite tough to follow. To avoid such issues, a ML-based approach has been proposed
in this work to estimate the biomechanical gait parameters. Three backpropagation neural
network models with Levenberg-Marquardt method, resilient backpropagation method,
and gradient descent method optimizers have been designed to estimate the joint angles,
joint moments, and ground reaction forces in the sagittal plane. The dataset used in the
neural network models has been taken from an open-source repository. The anthropo-
metric, biological, and spatiotemporal parameters of 50 different subjects have been
exploited as input dataset.
Chapter 6 titled “High-Performance Medicine in Cognitive Impairment: Brain–Computer
Interfacing for Prodromal Alzheimer’s Disease” suggests that Alzheimer’s disease is fre-
quently misdiagnosed as normal aging because it has always been difficult to detect early
on. Mild cognitive impairment (MCI) can be identified, but there is little that can be
done at that time because no medicine can reverse the effect of MCI; instead, it can only
slow down the progression. Alzheimer’s disease is difficult to diagnose medically, espe-
cially in its early stages. As a response, a method for early diagnosis of Alzheimer’s dis-
ease is urgently needed even now. In this chapter, the authors have proposed a strategy
for detecting Alzheimer’s disease in its early stage using noninvasive brain-computer
interface technology. Electroencephalography (EEG) brain wave patterns were used for
Preface xxi
aspects of the stimulator device. The feasibility of this device is successfully tested in
in vivo and in vitro stages for a period of more than a month. This embedded design
has been developed taking into account cost-effectiveness, user-friendliness, and preci-
sion, which are the main focus of this chapter. The brain-computer interface can be useful
in taking effective clinical decision-making at an early stage. However, there is limited
research in this area so far. Therefore, all the efforts in this direction are extremely impor-
tant for numerous young flourishing specialists, and aspirations toward the brain-
computer interface.
Chapter 12 titled “LSTM Neural Network-Based Classification of Sensory Signals for
Healthy and Unhealthy Gait Assessment” describes the modeling of the long short-term
memory (LSTM) deep neural network model and its implementation to classify healthy
and unhealthy gait based on a sensory dataset. The reference sensory dataset of 22 subject
samples (11 healthy and 11 with knee pathology) is taken from the UCI Irvine Machine
Learning Repository. Two different optimizers, namely Stochastic Gradient Descent and
Adam, have been exploited in the designed LSTM model with different sets of learning
hyperparameters. The classification results of the proposed deep learning model with
both optimizers have been compared with each other using several performance mea-
sures like precision, recall, and F1 score.
Chapter 13 titled “Data-Driven Machine Learning: A New Approach to Process and
Utilize Biomedical Data” includes a study of precise and accurate diagnostic tools to ease
the pressure on medical personnel, simultaneously enhancing efficiency. This chapter
explores the development of artificial neural network based diagnostic tools that focus
on the challenges described previously. A brief overview of the current scenarios and
future prospects of ML in biomedicine is also presented.
Chapter 14 titled “Multiobjective Evolutionary Algorithm Based on Decomposition for
Feature Selection in Medical Diagnosis” presents a mathematical model of a multi-
objective evolutionary algorithm based on decomposition (MOEA/D) and its application
in feature selection in medical diagnosis. Most of the medical datasets are high dimen-
sional in nature and so there is a need for optimal feature selection, which is a difficult
problem. The negative influence may be due to the possibility of irrelevant or many redun-
dant features. Intelligent models including classification, clustering, regression, and
boosting techniques are helpful in extracting useful knowledge. The performance of
the MOEA/D method is compared with that of state-of-the-art multi-objective optimiza-
tion methods when applied to most of the datasets.
Chapter 15 titled “Machine Learning Techniques in Healthcare Informatics: Showcas-
ing Prediction of Type 2 Diabetes Mellitus Disease using Lifestyle Data” focuses on the role
of the ML paradigms in healthcare analytics and presents the implementation of the
framework for developing ML models for type 2 diabetes mellitus (T2DM) disease. In this
chapter, lifestyle indicators rather than clinical/pathological parameters have been used
for the prediction of T2DM. The study involves different experts like diabetologists, endo-
crinologists, dieticians, and nutritionists for selecting the contributing lifestyle parame-
ters to promote health and manage diabetes. The study aims to develop an intelligent
Preface xxiii
knowledge-based system for the prediction of T2DM without conducting clinical tests. It
can save the patient undue delays caused by unnecessary readmissions and pathological
tests in hospitals. The proposed work emphasizes the use of ML techniques, namely K-
nearest neighbor (KNN), logistic regression (LR), naı̈ve Bayes (NB), support vector
machine (SVM), decision tree (DT), random forest (RF), and artificial neural network
(ANN), for the prediction of T2DM disease. The RF technique attained the highest accu-
racy of 93.56% followed by DT, LR, SVM, NB, ANN, and KNN with accuracies of 92.70%,
91.41%, 90.98%, 89.27%, 87.98%, and 84.54%, respectively.
We are grateful to Elsevier, especially Chris Katsaropoulos, Senior Acquisitions Editor,
for providing us the opportunity to edit this book.
Sudipta Roy
Maharashtra, India
Lalit Mohan Goyal
Faridabad, India
Valentina E. Balas
Romania
Basant Agarwal
Jaipur, India
Mamta Mittal
New Delhi, India
This page intentionally left blank
1
Data mining with deep learning
in biomedical data
Kuldeep Singha and Jyoteesh Malhotrab
a
DEPARTMENT OF ELECTRONICS TECHNOLOGY, G U R U NAN A K DE V UN I V E R S I T Y AM R I T S AR ,
P U NJAB, I NDI A b DEPARTMENT OF ENGI NEERING AND TECHNO LOGY , GURU NANAK DEV
U N I V E R S I T Y RE GI ON A L C AM P U S JALANDHAR, PUNJAB, INDIA
1. Introduction
In the era of Internet of things (IoT) technologies, smart health care is an emerging sector
that is attracting the attention of medical personnel, the research community, and
patients [1, 2]. These technological advances in association with machine learning and
cloud-fog computing capabilities have started revolutionizing the health-care sector by
shifting the traditional patient monitoring approach to remote patient monitoring [3].
In this sector, biomedical data analysis is crucial in the detection and diagnosis of a variety
of health-related issues such as bacterial and viral infectious diseases; neurological and
mental disorders, particularly, epilepsy, schizophrenia, Alzheimer’s disease, etc.; cardio-
vascular diseases; autoimmune diseases; cancer; and skin- or bone-related diseases [2,
4–10]. The biomedical data may include electroencephalogram (EEG) or electrocardio-
gram (ECG) signals, X-ray, CT scan, MR-based images or microscopic images, etc., which
could be analyzed using machine learning or deep learning-based signal analysis tech-
niques [10–13].
Among the aforementioned diseases, neurological and mental disorders are one of the
most serious hazards to public health [4]. These disorders have become one of the main
causes of disabilities and deaths globally. The social and economic burden of these disor-
ders is more severe in underdeveloped or impoverished countries due to a scarcity of
health-care infrastructure. This burden is likely to grow rapidly in forthcoming years as
a result of an intensive increase in population and aging [14]. Modern IoT-enabled
health-care technologies may be useful in detecting and predicting these neurological
and mental problems to save patients’ lives.
In this regard, epilepsy is considered to be a prevalent fatal neurological illness, which
usually affects the human brain by causing spontaneous and repeated seizures [15]. This
disorder distresses the lives of different age groups from infants to old people. According
to the World Health Organization (WHO) data, around 50 million individuals suffer from
epilepsy around the world [16], and 80% of them are living in the developing and under-
developed countries. According to the Indian Epilepsy Centre in New Delhi, around
10 million Indians are the victims of this illness and this number is growing by the day with
the annual addition of 0.5–1 million new epileptic patients [17]. All these facts make it one
of the most common global neurological diseases and a major threat to mankind.
The usual rhythm of neuronal functions in the human brain is disrupted during
epileptic seizures, resulting in crucial clinical symptoms such as erratic behavior, weird
stimuli, emotions, cramps, and reduced or lost consciousness, among others [15, 18].
These factors may result in serious injuries or unexpected deaths of patients as a result
of brain injury or suffocation in traffic accidents or while working in dangerous work envi-
ronments [15]. Epileptic seizures can be managed and controlled by practicing regular
meditation activities and taking antiepileptic drugs [19, 20]. In some cases, when these
therapies fail to control the onset of seizures and the patients become drug resistant, then
the brain surgeries could be performed to remove seizure-causing neurons from their
brain for reducing the occurrence of seizures [21]. But all these remedies are not able
to provide any everlasting cure to this disorder. Therefore, there is a pressing need for
an automated system of epileptic seizure detection that can detect seizure onsets, and
can transfer alert messages to the family, doctors/neurologists, or ambulance services
to save the lives of epileptic patients [22].
The efficient detection of epileptic seizures could be achieved by brain monitoring of
the patients using EEG technique [23–26]. It is because of the capability of EEG to monitor
brain functions directly from the brain and generate signals with high temporal and
spatial resolutions [10, 27]. Furthermore, the use of machine learning and deep learning
techniques has been currently being investigated by the research community for timely
identification of seizure initiation using EEG signal processing [22, 28]. Deep learning
techniques, instead, have grown in popularity for accurate seizure detection due to their
independence from feature extraction techniques and ability to efficiently handle issues
such as big data and the nonstationary existence of EEG signals [7, 11, 29].
In this direction, this chapter also focuses on exploring the utilization of deep learning
techniques for data mining on biomedical signals like EEG, to find effective solutions in
the health-care domain. This chapter primarily focuses on the use of deep learning tech-
niques, namely convolutional neural network (CNN), long short-term memory network
(LSTM), and CNN + LSTM hybrid model to detect seizure activities through EEG signal
analysis in the time domain. In the proposed approach of seizure detection, EEG signals
are undergone through filtering to avoid the effect of noise and segmentation to make
them stationary. Afterwards, these segments are fed to the proposed architectures of deep
learning algorithms for classification. The analysis of simulation results in terms of various
performance measures ensures the suitability of CNN-LSTM model to accurately detect
seizure activities of the patients with epilepsy in real time.
This chapter has been organized into various sections. Section 1 debates on the
emergence of the health-care sector and various disorders along with their detection
and management with a special focus on epilepsy. The role of deep learning approaches
for the detection of epileptic seizures has been elaborated in Section 2. Furthermore,
Section 3 presents the proposed method of seizure detection using deep learning models
Chapter 1 • Data mining with deep learning in biomedical data 3
using EEG signal analysis in time domain. The simulation results of this approach are
demonstrated and debated in Section 4. Finally, Section 5 delivers the conclusions made
after analyzing the outcomes of the proposed approach.
decomposed EEG signals using discrete wavelet transform (DWT) and fed them to mul-
tilayer perceptron (MLP)-based deep learning algorithm, which provided accuracy value
of 100% for binary classification of seizure and nonseizure classes.
Furthermore, a model based on a stacked bidirectional LSTM network (Bi-LSTM) [56]
performed well at detecting seizures, with the accuracy value of 99.08%, precision value
of 98%, and recall value of 99.5%. Another LSTM-based method for detecting seizure activity
used short-duration temporal segments of EEG signals [57]. To keep this approach compu-
tationally efficient, these EEG segments only contained two data points. It conducted aver-
age pooling of hidden layer outputs from various LSTM devices, which were then fed to
SoftMax activation-based classification layer for classification. For three-class classification,
this model achieved 100% classification accuracy, sensitivity, and specificity. A new CNN
approach presented by Tu €
€rk and Ozerdem [58] made use of continuous wavelet transform
(CWT) to obtain two-dimensional (2D) frequency-time scalograms of EEG signals and
attained an accuracy of 99% for three-class classification. Similarly, a CNN-based model
for classification of seizure states used segmented EEG signals with a fixed size overlapping
window and had an average accuracy of 99.1% for detecting seizure behaviors [59].
Akut [60] suggested a DWT-based technique for detecting epileptic seizures using CNN
in the same context. This method used DWT to decompose EEG signals into five levels,
which were provided to the proposed CNN model for classification. For a three-class prob-
lem, it produced classification with accuracy value of 99.4%, sensitivity value of 98.5%, and
specificity value of 98.45%. Moreover, for seizure state classification, another CNN model
used raw EEG signals and presented classification results with a 99% accuracy [61]. Daoud
and Bayoumi [62] also presented a deep convolutional autoencoder with MLP combined
model for seizure classification using EEG signals, which had a 96% accuracy, 93% sensi-
tivity, and 99% specificity.
Similarly, several recently published papers describe methods for detecting seizures
effectively. Ilakiyaselvan et al. [63] proposed a seizure detection technique that used
the reconstructed phase space (RPS) approach to transform EEG signals into images. Alex-
Net, a pretrained CNN model, was considered to classify the RPS images into different sei-
zure states. For three-class classification, this technique had a 95% accuracy rate. Another
deep learning technique for three-class seizure classification made use of CNN-LSTM
series model with EEG segments and got a classification accuracy of 95.9%. In this context,
Glory et al. [64] had discussed the idea of adaptive Haar wavelet-based binary grasshopper
optimization algorithm for processing of EEG signals and classification using deep neural
network (DNN). They obtained accuracy value of 93.61%, sensitivity value of 90.24%, and
specificity value of 93.63% for seizure detection in the case of Bonn dataset. Furthermore,
Zhao et al. [65] explored another CNN-based method for seizure classification that used
raw time-domain EEG segments. In a three-class problem, this approach achieved 96.97%
classification accuracy for the detection of seizures.
Moreover, Woodbright et al. [66] had proposed a novel technique for seizure detection
using CNN-based feature extraction, which provided classification accuracy value of
98.65%, sensitivity value of 96.29%, and specificity value of 99.25%. Similarly,
Chapter 1 • Data mining with deep learning in biomedical data 5
Ramakrishnan et al. [67] had presented one-dimensional adaptive average local binary
pattern (1D AaLBP) and one-dimensional adaptive difference local binary pattern (1D
AdLBP) for extracting features and CNN for classification. This method obtained maxi-
mum classification accuracy of 98.88% for three-class seizure classification.
The literature review of deep learning techniques for seizure detection is summarized
in Table 1. These techniques provide higher accuracies for the desired task and are well
suited for real-time use due to their ability to manage the nonstationary character of EEG.
Having returned to his army on July 12, Wellesley gave orders for
the whole force to get ready for a general advance on the morning
of the eighteenth, the day which had been chosen for the
commencement of operations at the conference of Almaraz. It would
have been in every way desirable to have moved out at once, and
not to have waited for these six days. If the march against Victor
had been fixed for the thirteenth or fourteenth, the French would
have been caught unprepared, for as late as the seventeenth King
Joseph and his adviser Jourdan were under the impression that the
force at Plasencia consisted of nothing more than a Portuguese
division of 10,000 men, and it was only on the twenty-second that
they received the definite information that the whole British army
was upon the Tietar[607]. It is clear that, by advancing five days
earlier than he actually did, Wellesley might have caught the enemy
in a state of complete dispersion—the 4th Corps being on July 20
still at Madridejos in La Mancha, and the King with his reserves at
Madrid. If attacked on the seventeenth or the eighteenth, as he
might well have been, Victor would have found it impossible to call
up Sebastiani in time, and must have fallen back in haste to the
capital. The allies could then have cut him off from the 4th Corps,
which must have retreated by a circuitous route, and could not have
rejoined the main body of the French army in time for a battle in
front of Madrid.
It would appear that Wellesley had fixed the date of his advance
so late as the eighteenth mainly because of the difficulty as to the
collection of provisions, which was now looming before him in larger
proportions than ever. But it is possible that the necessity for
allowing some days for the transmission of the plan of campaign to
Venegas also counted for something in the drawing up of the time-
table. It would have been rash to start before the army of La
Mancha was prepared to take its part in the joint plan of operations.
So much depended upon the diversion which Venegas was to
execute, that it would have been a mistake to move before he could
break up from his distant cantonments at Santa Cruz de Mudela. No
word, however, concerning this appears in Wellesley’s
correspondence. From July 13 to July 18 his dispatches show anxiety
about nothing save his food and his transport. Every day that he
stayed at Plasencia made him feel more uncomfortable concerning
the all-important question of supplies. The corn which the Alcaldes
of the Vera had promised to secure for him had begun to come in,
though in driblets and small consignments, but there was no means
of getting it forward: transport was absolutely unprocurable[608].
Wellesley sent officers to scour the country-side as far as Bejar and
Ciudad Rodrigo, but they could procure him neither mules nor carts.
He also pressed the Spanish commissary-general, Lozano de Torres,
to hunt up every animal that could be procured, but to small effect.
The fact was that Estremadura was not at any time rich in beasts or
vehicles, and that the peasantry had sent away most of those they
owned while the French lay at Almaraz, lest they should be carried
off by the enemy. Wellesley, who did not understand the limited
resources of this part of Spain, was inclined to believe that the
authorities were hostile or even treacherous. The Central Junta had
promised him transport in order to make sure of his starting on the
campaign along the Tagus, and when transport failed to appear, he
attributed it to ill-will rather than to poverty. No doubt he was fully
justified in his view that an army operating in a friendly country may
rationally expect to draw both food and the means to carry it from
the regions through which it is passing. But sometimes the
provisions or the transport are not forthcoming merely because the
one or the other is not to be found. It is certain that both
Estremadura and the valley of the central Tagus were at this
moment harried absolutely bare: Victor’s despairing letters from
Caceres in May and from La Calzada in June are sufficient proof of
the fact. In a district where the Marshal said that ‘he could not
collect five days’ provisions by any manner of exertion,’ and that ‘his
men were dropping down dead from actual starvation, so that he
must retire or see his whole corps crumble away[609],’ it is clear that
the Central Junta could not have created food for the British army.
Cuesta’s troops were living from hand to mouth on supplies sent
forward from Andalusia, or they could not have continued to exist in
the land. The only district which was intact was that between Coria
and Plasencia, and this was actually at the moment feeding the
British army, and had done so now for ten days or more. But
unfortunately the Vera could give corn but no draught animals. If
Wellesley had known this, he must either have exerted himself to
procure more transport before leaving Abrantes—a difficult task, for
he had already drained Portugal of carts and mules—or have refused
to march till the Spaniards sent him wagon trains from Andalusia. It
would have taken months for the Junta to collect and send forward
such trains: they had dispatched all that they could procure to
Cuesta. The campaign on the Tagus, in short, would never have
been fought if Wellesley had understood the state of affairs that he
was to encounter.
The causes, therefore, of the deadlock that was about to occur
were partly the light-hearted incompetence of the Central Junta in
promising the British army the use of resources which did not exist,
partly Wellesley’s natural ignorance of the miserable state of Central
Spain. He had never entered the country before, and could not know
of its poverty. He had trusted to the usual military theory that the
country-side ought to provide for a friendly army on the march: but
in Spain all military theories failed to act. Napoleon committed
precisely similar errors, when he directed his army corps to move
about in Castile as if they were in Germany or Lombardy, and found
exactly the same hindrances as did the British general. In later years
Wellesley never moved without a heavy train, and a vast provision of
sumpter-beasts and camp-followers. In July 1809 he had still to
learn the art of conducting a Spanish campaign.
Meanwhile he was beginning to feel most uncomfortable about
the question of provisions. His anxiety is shown by his letters to
Frere and Beresford; ‘it is impossible,’ he wrote, ‘to express the
inconvenience and risk that we incur from the want of means of
conveyance, which I cannot believe the country could not furnish, if
there existed any inclination to furnish them. The officers complain,
and I believe not without reason, that the country gives unwillingly
the supplies of provisions that we have required ... and we have not
procured a cart or a mule for the service of the army[610].’ But to
O’Donoju, the chief of the staff of the Estremaduran army, he wrote
in even more drastic terms, employing phrases that were certain to
provoke resentment. He had, he said, scoured the whole region as
far as Ciudad Rodrigo for transport, and to no effect. ‘If the people
of Spain are unable or unwilling to supply what the army requires, I
am afraid that they must do without its services.’ He had been forced
to come to a painful decision, and ‘in order to be fair and candid to
General Cuesta’ he must proceed to inform him that he would
execute the plan for falling upon Victor behind the Alberche, but that
when this had been done he would stir no step further, and ‘begin
no new operation till he had been supplied with the means of
transport which the army requires[611].’
After dispatching this ultimatum, whose terms and tone leave
something to be desired—for surely Cuesta was the last person to be
saddled with the responsibility for the pledges made by his enemies
of the Central Junta—Wellesley issued orders for the army to march.
He had been joined at Plasencia by the last of the regiments from
Lisbon, which reached him in time for Talavera[612], but had been
forced to leave 400 sick behind him, for the army was still in a bad
condition as regards health. It was therefore with little over 21,000
men that he began his advance to the Alberche. It was executed
with punctual observance of the dates that had been settled at the
interview at Almaraz. On July 18 the army crossed the Tietar on a
flying bridge built at Bazagona, and lay at Miajadas. On the next
night the head quarters were at Centinello; on the twentieth the
British entered Oropesa. Here Cuesta joined them with his whole
army, save the two battalions lent to Wilson, and the two others
under the Marquis Del Reino which had been sent to the Puerto de
Baños. Deducting these 2,600 bayonets and his sick, he brought
over 6,000 horse and 27,000 foot to the rendezvous. The junction
having taken place on the twenty-first, the advance to Talavera was
to begin next morning. Oropesa lies only nineteen miles from that
town, and as Victor’s cavalry vedettes were in sight, it was clear that
contact with the enemy would be established during the course of
the day. Accordingly the allied armies marched with caution, the
Spaniards along the high-road, the British following a parallel path
on the left, across the slopes of the hills which divide the valley of
the Tietar from that of the Tagus.
About midday the Spaniards fell in with the whole of the cavalry
division of Latour-Maubourg, which Victor had thrown out as a
screen in front of Talavera. He had ascertained on the evening of the
preceding day that Cuesta was about to move forward, and was
anxious to compel him to display his entire force. Above all he
desired to ascertain whether the rumours concerning the presence
of British troops in his front were correct. Accordingly he had left
two battalions of infantry in the town of Talavera, and thrown out
the six regiments of dragoons in front of it, near the village of
Gamonal. The Spaniards were advancing with Albuquerque’s cavalry
division as an advanced guard. But seeing Latour-Maubourg in his
front the Duke refused to attack, and sent back for infantry and
guns. Cuesta pushed forward the division of Zayas to support him,
but even when it arrived the Spaniards made no headway. They
continued skirmishing for four hours[613] till the British light cavalry
began to appear on their left. ‘Though much more numerous than
the enemy,’ wrote an eye-witness, ‘they made no attempt to drive
him in, but contented themselves with deploying into several long
lines, making a very formidable appearance. We had expected to see
them closely and successfully engaged, having heard that they were
peculiarly adapted for petty warfare, but we found them utterly
incapable of coping with the enemy’s tirailleurs, who were driving
them almost into a circle.’
On the appearance, however, of Anson’s cavalry upon their flank
the French went hastily to the rear, skirted the suburbs of Talavera,
and rode off along the great Madrid chaussée to the east, followed
by the British light dragoons. As they passed the town two small
columns of infantry came out of it and followed in their rear.
Albuquerque sent one of his regiments against them, but could not
get his men to charge home. On three separate occasions they came
on, but, after receiving the fire of the French, pulled up and fell into
confusion. The impression made by the Spanish cavalry on the
numerous British observers was very bad. ‘No men could have more
carefully avoided coming to close quarters than did the Spaniards
this day[614],’ wrote one eye-witness. ‘They showed a total lack not
only of discipline but of resolution[615],’ observes another.
After crossing the plain to the north of Talavera the French, both
cavalry and infantry, forded the Alberche and halted on the further
bank. On arriving at the line of underwood which masks the river the
pursuers found the whole of Victor’s corps in position. The thickets
on the further side were swarming with tirailleurs, and two batteries
opened on Anson’s brigade as it drew near to the water, and sent
balls whizzing among Wellesley’s staff when he pushed forward to
reconnoitre the position.
It was soon seen that Victor had selected very favourable
fighting-ground: indeed he had been staying at Talavera long
enough to enable him to get a perfect knowledge of the military
features of the neighbourhood. The 1st Corps was drawn up on a
range of heights, about 800 yards behind the Alberche, with its left
resting on the impassable Tagus, and its right on a wooded hill,
behind which the smaller river makes a sharp turn to the east, so as
to cover that flank. The position was formidable, but rather too long
for the 22,000 men who formed the French army. Having learnt from
the people of Talavera that the enemy had received no
reinforcements up to that morning, from Madrid or any other
quarter, Wellesley was anxious to close with them at once. The
afternoon was too far spent for any attempt to force the passage on
the twenty-second, but on the next day (July 23) the British general
hoped to fight. The Alberche was crossed by a wooden bridge which
the enemy had not destroyed, and was fordable in many places:
there seemed to be no reason why the lines behind it might not be
forced by a resolute attack delivered with numbers which were as
two to one to those of the French.
Accordingly Wellesley left the 3rd division and Anson’s light horse
in front of the right wing of Victor’s position, and encamped the rest
of his army some miles to the rear, in the plain between Talavera
and the Alberche. In the same way Albuquerque and Zayas halted
for the night opposite the bridge on the French left, while the main
body of the Spaniards occupied the town in their rear. In the evening
hours Wellesley endeavoured to urge upon Cuesta the necessity for
delivering an attack at dawn: he undertook to force the northern
fords and to turn the enemy’s right, if his colleague would attack the
southern fords and the bridge. The Captain-General ‘received the
suggestion with dry civility,’ and asked for time to think it over. After
a conference with his subordinates, he at last sent word at midnight
that he would accept the proposed plan of operations.
At 3 o’clock therefore on the morning of the twenty-third,
Wellesley brought down Sherbrooke’s and Mackenzie’s divisions to
the ground opposite the fords, and waited for the arrival of the
Spanish columns on his right. They did not appear, and after long
waiting the British general rode to seek his colleague. He found him
opposite the bridge of the Alberche, ‘seated on the cushions taken
out of his carriage, for he had driven to the outposts in a coach
drawn by nine mules, the picture of mental and physical inability.’
The old man murmured that the enemy’s position had not been
sufficiently reconnoitred, that it would take time to get his army
drawn out opposite the points which it was to attack, that he was
not sure of the fords, that the bridge over which his right-hand
column would have to advance looked too weak to bear artillery, and
many other things to the same effect—finally urging that the forcing
of the Alberche must be put off to the next day. As he had not got
his troops into battle order, it was clear that the morning would be
wasted, but Wellesley tried to bargain for an attack in the afternoon.
The Captain-General asked for more time, and would listen to no
arguments in favour of fighting on that day. After a heated
discussion Wellesley had to yield: he could not venture to assail the
French with his own army alone, and without any assistance from
the Spaniards. Accordingly it was agreed that the advance should
not be made till the dawn of the twenty-fourth.
In the afternoon the pickets sent back information that Victor
seemed to be on the move, and that his line was growing thin.
Cuesta was then persuaded to go forward to the outposts; he was
hoisted on to his horse by two grenadiers, while an aide-de-camp
stood on the other side to conduct his right leg over the croup and
place it in the stirrup. Then, hunched up on his saddle, he rode
down to the river, observed that the greater part of the enemy were
still in position, and refused to attack till next morning.
At dawn, therefore, on the twenty-fourth the allied army moved
forward to the Alberche in three columns, and found, as might have
been expected, that the French had disappeared. On seeing the
masses of redcoats opposite his right upon the previous day, Victor
had realized at last that he had before him the whole British army.
He had sent his train to the rear in the afternoon, and drawn off his
entire force after dusk. By dawn he was more than ten miles away,
on the road to Santa Ollala and Madrid. It was useless to pursue him
with any hope of forcing him to a battle. The chance of crushing him
before he should receive any further reinforcements had
disappeared. It is not at all to his credit as a general that he had
held his ground so long; if he had been attacked on the twenty-
third, as Wellesley had desired, he must certainly have suffered a
disaster. He had but 22,000 men; and it is clear that, while the
Spaniards were attacking his left and centre, he could not have set
aside men enough to hold back the assault of the solid mass of
20,000 British troops upon his right. He should have vanished on the
twenty-second, the moment that Latour-Maubourg reported that
Wellesley’s army was in the field. By staying for another day on the
Alberche he risked the direst disaster.
The British general would have been more than human if he had
not manifested his anger and disgust at the way in which his
colleague had flinched from the agreement to attack, and sacrificed
the certainty of victory. He showed his resentment by acting up to
the terms of his letter written from Plasencia five days before, i.e. by
announcing to Cuesta that, having carried out his pledge to drive the
French from behind the Alberche, he should now refuse to move
forward, unless he were furnished with transport sufficient to make
it certain that the army could reach Madrid without any privations.
He was able to state with perfect truth that he had already been
forced to place his troops on half-rations that very morning: to the
10,000 men of Sherbrooke’s and Mackenzie’s divisions and of
Anson’s light cavalry, he had only been able to issue 5,000 rations of
bread[616]. Nothing, of course, could be found at Talavera, where the
French had been quartered for many days. Victor had only been
maintaining his troops by the aid of biscuit sent down from Madrid,
and by seizing and threshing for himself the small amount of corn
which had been sown in the neighbourhood that spring. Wellesley
was wrong in supposing that the 1st Corps had been supporting
itself with ease from the country-side[617]. He was equally at fault
when he asserted that the ‘Spanish army has plenty to eat.’ Cuesta
was at this moment complaining to the Junta that he was short of
provisions, and that the food which he had brought forward from the
Guadiana was almost exhausted. Meanwhile every exertion was
being made to collect flour and transport from the rear: Wellesley
wrote to O’Donoju that he had at last hopes of securing some
wagons from the Plasencia district within three days, and that ‘in the
meantime he might get something to eat.’ He had some days before
sent orders back even so far as Abrantes, to order up 200
Portuguese carts which had been collected there, and the Central
Junta had informed him that a train for his use had already started
from Andalusia. But ‘there was no very early prospect of relieving
the present distress[618].’
Cuesta was, as might have been expected, as angry with
Wellesley for refusing to move forward from Talavera, as Wellesley
was with Cuesta for missing the great opportunity of July 23. When
informed that the British army was not about to advance any further,
he announced that he for his part should go on, that Victor was in
full flight, and that he would pursue him to Madrid. ‘In that case’
dryly observed Wellesley, ‘Cuesta will get himself into a scrape; but
any movement by me to his assistance is quite out of the question.
If the enemy discover that we are not with him, he will be beaten, or
must return. The enemy will make this discovery to-day, if he should
risk any attempt upon their rearguard at Santa Ollala[619].’ In reply to
the Captain-General’s declaration that he should press Victor hard,
his colleague only warned him that he would be wiser ‘to secure the
course of the Tagus and open communication with Venegas, while
the measures should be taken to supply the British army with means
of transport[620].’ The Spaniard would not listen to any such advice,
and hurried forward; though he had been for many weeks refusing
to fight the 1st Corps when it lay in Estremadura, he was now
determined to risk a second Medellin. Apparently he was obsessed
by the idea that Victor was in full retreat for Madrid, and would not
make a serious stand. Underlying his sudden energy there was also
some idea that he would disconcert his masters of the Central Junta
by recovering the capital: he had discovered, it would seem, that the
Junta had sent secret orders to Venegas, directing him to take
charge of the city on its reconquest, and giving him authority to
nominate the civil and military officers for its administration. If the
Army of Estremadura seized Madrid, while the Army of La Mancha
was still lingering on the way thither, all these plans would be
frustrated[621].
Accordingly Cuesta pushed on very boldly on the afternoon of the
twenty-fourth, dividing his army into two columns, of which one
marched on Santa Ollala by the high-road to the capital, while the
other moved by Cevolla and Torrijos on the side-road to Toledo. He
was uncertain whether Victor had retired by one or by both of these
routes: if all his corps had taken the former path, the natural
deduction was that he was thinking only of Madrid: if the Toledo
road had also been used, there was reason for concluding that the
Marshal must be intending to join Sebastiani and the 4th Corps, who
might be looked for in that direction. Late in the day the Spanish
general ascertained that the main body of Victor’s army had taken
the latter route: he proceeded to follow it, placing his head quarters
that night at Torrijos, only fifteen miles from Toledo. Next morning
he learnt to his surprise and dismay that he had in front of him not
only the 1st Corps, but also Sebastiani and the King’s reserves from
Madrid: for just at this moment the whole French force in New
Castile had been successfully concentrated, and nearly 50,000 men
were gathered in front of the 33,000 troops of the Army of
Estremadura. Venegas’s diversion had utterly failed to draw off the
4th Corps to the East; the King had come down in haste from
Madrid, and thus the whole plan of campaign which the allied
generals had drawn up had been foiled—partly by the sloth of
Venegas, partly by Cuesta’s inexplicable and perverse refusal to fight
on July 23 upon the line of the Alberche.
SECTION XVI: CHAPTER V
CONCENTRATION OF THE FRENCH ARMIES: THE
KING TAKES THE OFFENSIVE: COMBATS OF
TORRIJOS AND CASA DE SALINAS