Senester-|| Paper-I

Course T'itle: Bioorpanic and Materials Chemistry

Semester: II
Programme: Certiticate in
Bioorgaic and Meclicinal Year: I
Chemistry
Paper-| Elective Subject: Chemistry
Course Code: B020201T Course Title: Bioorganic and Medicinal Chemistry
Course outeomes: Biomolecules are important for the functioning of livingorganisms. These molecules perlorn
gge important biochemical reactions in living organisms. When studying biomolecules, onecan understand
e pnysiological function that regulates the proper growth and development of a human body. This course aims
lo introduce the students with basic experimental understanding of carbohydrates, amino acids, proteins, nucleie aids
and medicinal chemistry. Upon completion of this course students may get job opportunities in food, beverage and
pharmaceutical industries.
Credits: 4 Elective

Max. Marks: 25+75 Min. Passing Marks:.

Total No. of Lectures = 60
No. of
Unit Topics Lectures
Chemistry of Carbohydrates :Classification of carbohydrates, reducing and non-reducing
sugars, General Properties of Glucose and Fructose, their open chain structure. Epimers,
mutarotation and anomers. Mechanism of mnutarotation Determination of configuration of
Glucose (Fischer's proof). Cyclic structure of glucose. Haworth projections. Cyclic structure
of fructose. Inter conversions of sugars (ascending and descending of sugar series, conversion 10
of aldoses to ketoses). Lobry de Bruyn-van Ekenstein rearrangement; stepping-up (Kiliani
Fischer method) and stepping-down (Ruff's &Wohl's methods) of aldoses; end-group
interchange of aldoses Linkage between monosachharides, structure ofdisacharrides (sucrose,
maltose, actose.)
Chemistry of Proteins: Classification of aminoacids, zwitter ion structure and Isoelectrid
point. Overview of primary, secondary, tertiary and quaternary structure of proteins.
Determinaion of primary structure of peptides, determination of N-terminal amino acid (by
DNFB and Edman method) and C-terminal amino acid (by thiohydantoin and with)
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carboxypeptidase enzyme). Synthesis of simple peptides (upto dipeptides) by N-protection &
C-activating groups and Merrifield solid phase synthesis. Protein denaturation/ renaturation
Mcchanism of cnzynmc action, factors affccting cnzymcaction, Cocnzymcs and cofactors and
their role in biological reactions).
Chemistry of Nucleic Acids: Constituents of Nucleic acids: Adenine, guanine, thymine and
III 05
Cytosine (Structure only), Nucleosides and nucleotides (nomenclature), Synthesis of nucleic
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 ps, Sinucture of polynuclcotides: Structue of DNA (Watson-Crick modcl) and RNA (ypes
KNA), GiencticCodc, Biological rolcs of DNA and RNA: Replication, Transcription and
T'ranslation
development; BastC
roductory Medicinal Chemistry : Drug discovery, design and
relationships of drug
eirosynthctic approach. Drug action-receptor thcory. Structure -activity
aromatic ring
olecules, binding role of -OH group,-NH, group, double bond and
Mcchanism of action of the representative drugs of the following classes: analgesics agents, 10
IV
paracetamol); antibiotics
antipyretic agents, anti-inflammatory agents (Aspirin,
Chloramphenicol); antibacterial and antifungal agents (Sulphonamides; Sulphanethoxazol
(Phenobarb1tal.
Sulphacetamide); antiviralagents (Acyclovir), Central Nervous System agents
Zidovudine
Diazepam),Cardiovascular (Glyceryl trinitrate), HIV-AIDSrelated drugs (AZT-
Solid State
constancy of
Definition of space lattice, unit cell. Laws of crystallography - (i) Law of
crystals and
interfacial angles,(ii) Law of rationality of indices and ii) Symmetry clements in
05
V
equation. Determination
law of symmetry .X-ray diffraction by crystals. Derivation of Bragg
of crystal structure of NaC1, KCl and CsCI (powder method).
Introduction to Polymer
Monomers, Oligomers, Polymers and their characteristics, Classification of polymers
fibres,
Natural synthetic, linear, cross linked and network; plastics, elastomers,
Homopolymers and Co-polymers, Bonding in polymers : Primary and secondary bond forces
Molecular
in polymers ; cohesive energy, and decomposition of polymers. Determination of 10
mass of polymers: Number Average molecular mass (Mn) and Weight average molecular mass
VI

(Mw) of polymers and determination by (i) Viscosity (ii) Light scattering method (ii) Gell
permeation chromatography (iv) Osmometry and Ultracentrifuging.
Silicones and Phosphazenes -Silicones and phosphazenes as examples of inorganic
polymers, nature of bonding in triphosphazenes.
Kinetics and Mechanism of Polymerization
Polymerization techniques, Mechanism and kinetics of copolymerization, Adition or chain
growth polymerization, Free radical vinyl polymerization, ionic vinyl polymerization, Ziegler
VII 05
Natta polymerization and vinyl polymers, Condensation or step growth-polymerization.
Polyesters, polyamides,phenol formaldehyde resins, urea formaldehyde resins, epoxy resins
and polyurcthanes.
Synthetic Dyes: Colour and constitution (clectronic Concepl), Classification of dyes,
VIII Chemistry and synthesis of Mcthyl orange, Congo red, Malachite grecn, crystal violet, 05

phenolphthalein, fluorescein, Alizarin and Indigo.

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