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Bioactive Restorative Materials Assignment

The document discusses bioactive restorative materials in dentistry, emphasizing their mechanical, physical, and bonding properties that enhance dental restoration while minimizing tooth structure removal. It highlights the antibacterial activity of materials like MDPB and the effectiveness of calcium silicate-based materials such as MTA and Biodentine in pulp capping and dentin regeneration. The conclusion advocates for the use of bioactive materials in modern restorative dentistry for their ability to interact positively with biological tissues.

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9 views6 pages

Bioactive Restorative Materials Assignment

The document discusses bioactive restorative materials in dentistry, emphasizing their mechanical, physical, and bonding properties that enhance dental restoration while minimizing tooth structure removal. It highlights the antibacterial activity of materials like MDPB and the effectiveness of calcium silicate-based materials such as MTA and Biodentine in pulp capping and dentin regeneration. The conclusion advocates for the use of bioactive materials in modern restorative dentistry for their ability to interact positively with biological tissues.

Uploaded by

mohameddafify159
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Operative Assignment

Topic: Bioactive Restorative materials in dentistry

Made by:
Mohammed intsar 5191126 (Leader)

Ahmed Youssef Elhattab (5191239) Mohamed Mohamed badwy(5191129)

Mohamed Ashraf Afify (5191084) Mahmoud Abdelaziz (5191031)

Moataz Mohamed (5191123) Ahmed yaser Mohamed (5191116)

Ahmed Osama Ali (5191072) Muhammad abdellatief (5191024)

Ahmed Eltemamy (5191028 ) Ahmed abdelnaser (5191051)

Essam Abdullah (5191131) Ahmed sobh (5191028)

Ahmed Ayman Elhussiny (5191041) Nour eldeen anas (5191239)


Bioactive restorative materials

Introduction
• Improving dental material’s basic properties as mechanical, physical,
and bonding properties has contributed to the restoration of ideal
anatomical form and function with less removal of the tooth structure
facilitating the combination of both aesthetic restorative treatment
and minimal intervention dentistry.
• Innovation of restorative materials could be directed toward a new
dimension which is the development of materials with bioactive
functions to provide therapeutic effects.
• Differentiation between the following terms is extremely helpful in
understanding the concept of bioactive restorative materials:
• Bioinductive property: the ability of a bioactive material to induce a
response in a biological system.
• Bioactive material: It is a material that can stimulate living tissues,
organisms, or cells to produce a response such as the induction of
hydroxyapatite formation.
• Biomaterial: any material, surface, or construct that can interact with
biological systems such as dental implants and heart prosthetic
valves.
• Biomimetics: it is the synthesis of materials that mimic natural
structures through artificial mechanisms. (This requires the study of
the formation, structure, and function of natural products in addition
to the biological mechanisms such as protein synthesis).

Discussion:

1-Anti-bacterial activity of bioactive restorative materials


• Anti-bacterial activity is one of the most important bioactive functions
that needs to be provided in restorative materials that are used in the
restorative treatment of dental caries.
- Antibacterial monomer (MDPB):
• MDPB is an antibacterial monomer that is used in resin-based
restorative materials with antibacterial effects.
• MDPB monomer is composed of quaternary ammonium dodecyl
pyridinium bromide that is responsible for the antibacterial effect
and methacryloyl group.
• MDPB is not only effective against facultative and obligate anaerobe
detected in coronal lesions, but it is also effective against bacterial
species predominantly detected in root caries such as actinomyces,
and candida albicans.
• MDPB is proven to be a strong bactericidal agent when used at MBC
(minimal bactericidal concentration)
• When the concentration of MDPB exceeds MBC (minimal
bactericidal concentration), It can provide more rapid killing of
bacteria.
• The antibacterial component of MDPB is immobilized after the curing
of MDPB and this will retain the antibacterial component within the
resin matrix as they are connected with a covalent bond maintaining
the physical properties of the restorative material at a stable
condition under wet circumstances.
• MDPB is incorporated into dental primers to produce a primer with
an antibacterial effect.
- Clearfil protect bond system:
• It is a dental adhesive in which MDPB is incorporated into the primer
of this adhesive system.
• It is a two-step self-etching adhesive system.
• Incorporation of MDPB into the primer of clearfil protect bond system
produces a cavity disinfecting effects therefore, this adhesive
contributes to a reduction in the risk of secondary caries and
protects the pulp in caries treatment.
• The primer of this adhesive system is effective against S. mutans, L.
casei and A. viscosus and, it is also effective against acid-tolerant
species such as lactobacilli due to the intrinsic antibacterial activity
of MDPB.
2-Effectiveness of Direct Pulp Capping Bioactive Materials in
Dentin Regeneration

It has been demonstrated that the use of calcium silicate–based


materials as pulp capping agents can effectively treat dental pulp.

- Calcium Hydroxide:
• CH has long been regarded as the gold standard of pulp capping
material because of its: Biocompatibility, high pH, antibacterial effect,
ability to form new dentine bridge at exposure site.

• The use of calcium Hydroxide as a pulp capping material was proven to


have a higher clinical success rate according to studies that followed
patients for more than 10 years.

• however, Calcium Hydroxide has high alkalinity, which leads to necrosis


and inflammation to the pulp. Besides its high solubility and lack of
adhesion with hard tissues, it does not provide an optimal seal, even
though the dentin bridge appears to be fully formed by the time of its
complete dissolution.

- MTA:
• MTA has a higher rate of clinical success and can result in dentin-bridge
formation that is much thicker.

• Based on calcium oxide, Calcium Hydroxide and MTA both react to


carbon dioxide in tissues, which is a similar mechanism of action.

• At the exposure site, calcite granulations are formed, and fibronectin


accumulates, promoting cellular migration, proliferation, adhesion, and
differentiation, resulting in the formation of hard tissue.
Bioactive molecules are released during this process that facilitate
regeneration of dental pulp and are integrated into the dentin matrix
during the process of dentinogenesis.

• Nowadays, MTA has proven to be a suitable choice for pulp capping


material because of its good sealing ability and biocompatibility,
However, MTA has some disadvantages, including high cost, difficulty
in handling, and long setting time.
- Biodentine:
• Biodentine is a newer calcium silicate–based pulp capping material
having properties similar to Calcium Hydroxide and MTA, as well as
favorable effects on the dental-pulp cells that promote the formation of
tertiary reparative dentin by releasing TGF-β1 and stimulating
odontoblasts,

• Biodentine promotes pulpal healing and mineralization.


• Biodentine also releases silicon ions that play a significant role during
the process of mineralizing the dentinal bridge.

• It has been demonstrated that the formation of the dentin bridge by


Biodentine is the same that of MTA with no pulpal inflammatory
response. This is due to the anti-inflammatory effect, which inhibits the
secretion of pro-inflammatory substances and reduces the recruitment
of inflammatory cells.

• Therefore, Biodentine material has great potential as a pulp-capping


agent because of its proper setting time and restorative properties.
However, studies suggested that long-term clinical research is still
required to check the efficacy of Biodentine.

Conclusion:
• Bioactive restorative material is a biomaterial with a Bioinductive
property.

• Instead of Using conventional restorative materials that will restore


both function and esthetic only, we can get the benefit of bioactive
restorative materials that will restore the function, esthetic and will also
interact with the biological tissues stimulating them to produce a
favorable response.

• We support the use of bioactive restorative materials in restorative


dentistry because it is considered a main part in modern dentistry in our
daily basis
Refrences:
1. Sonarkar, S. and Purba, R., 2015. Bioactive materials in conservative
dentistry. Int J Contemp Dent Med Rev, 2015, pp.1-4.

2. Imazato, S., 2009. Bio-active restorative materials with antibacterial


effects: new dimension of innovation in restorative dentistry. Dental
materials journal, 28(1), pp.11-19.

3. Nowicka A., Wilk G., Lipski M., Kołecki J., Buczkowska-Radlińska J.


Tomographic evaluation of reparative dentin formation after direct pulp
capping with Ca (OH) 2, MTA, Biodentine, and dentin bonding system
in human teeth Endod. pp16-20

4. Accorinte M.L.R., Loguercio A.D., Reis A., Carneiro E., Grande R.H.M.,
Murata S.S., Holland R. Response of human dental pulp capped with
MTA and calcium hydroxide powder. pp21-26

5. Kunert M., Lukomska-Szymanska M. Bio-inductive materials in direct


and indirect pulp capping—A review article. Materials.

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