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The document outlines a laboratory demonstration for synthesizing iron oxide nanoparticles, which have significant potential in biomedical applications due to their non-toxic nature and multifunctional properties. The synthesis is performed using a co-precipitation method, which is cost-effective and allows for easy industrialization. The procedure involves mixing specific chemical solutions and adding ammonia to produce iron oxide nanoparticles, which can be used in cancer treatment and diagnosis.

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7 views1 page

Adobe Scan Feb 13, 2023

The document outlines a laboratory demonstration for synthesizing iron oxide nanoparticles, which have significant potential in biomedical applications due to their non-toxic nature and multifunctional properties. The synthesis is performed using a co-precipitation method, which is cost-effective and allows for easy industrialization. The procedure involves mixing specific chemical solutions and adding ammonia to produce iron oxide nanoparticles, which can be used in cancer treatment and diagnosis.

Uploaded by

LAG FF
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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KSSEM/ APPLIED CHEMISTRY LAB MANUAL

DEMONSTRATIONEXPERIMENT. A
sYNTIESISOFIRON-OXIDE NANOPARTICLES
In recent years. inon oxide nanoparticles have demonstrated great potential in biomedical

applications due to their non-toxic role in biological systems. Also, the magnctic and semiconductor
properties of iron oxide nanoparticles can lecad to multifunctional applications in medicine. These
nanoparticles have been developed as antibacterial, antifungal, and anticancer. For cancer treatment
and diagnosis, iron oxide nanoparticles have been functionalized with drugs. However, many ofthose

drugs have been related to adverse effects on health. On the other hand, phytochemicals from extracts
of plants have been used as an alternative for the functionalization of these nanoparticles preventing

negative effects. The main advantage ofthese nanoparticles is the high biodistribution in the organism
compared with other drug delivery systems. The magnetism of iron oxide nanoparticles has been used
in cancer treatment and diagnosis, for example, thermoablation, hyperthermia, and contrast media in

magnetic resonance imag1ng.


Iron oxide nanoparticles are synthesized by precipitation method, which is a simple technique

among chemical route. This method is given more priority due to its low cost and easy
industrialization with improved reproducibility. This method offers low temperature growth and
scale-up fabrication which yields colloidal solutions with wide range of particle distributions.
Principle: Co-precipitation is a very facile and convenient way to synthesize iron oxide
nanoparticles (Fe:O4) from aqueous Fe / Fe*" salt solutions by the addition of a base at room
temperature or at elevated temperature.
Chemicals required- FesO.2H:0 (0.2M), FeCls.6H,0 (0.1M)
Ammonia solution (3M) and deionized water
Procedure: 0.2M ferrous sulphate solution and 0.1 M ferric chloride solutions are mixed with 100ml
deionized water in a beaker. Ammonia solution (3M) is added dropwise with constant stirring at 1000
rpm using a magnetic stirrer ill pH 10. The black precipitate of iron oxide obtained is filtered and

dried in hot-air over at 150- 200°C.

Reaction:
2 FeSO4+ FeCl t+
5 NHs Fes0; +
(NH4):SO4 +
3 NHCI

Report: Weight of Iron Oxide nanoparticles= ---

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