PMID- 34119573

OWN - NLM
STAT- MEDLINE
DCOM- 20220217
LR - 20220217
IS - 1878-4216 (Electronic)
IS - 0278-5846 (Linking)
VI - 111
DP - 2021 Dec 20
TI - Brain structural alterations in MDD patients with gastrointestinal symptoms:
Evidence from the REST-meta-MDD project.
PG - 110386
LID - S0278-5846(21)00145-7 [pii]
LID - 10.1016/j.pnpbp.2021.110386 [doi]
AB - OBJECTIVE: While gastrointestinal (GI) symptoms are very common in patients
with
major depressive disorder (MDD), few studies have investigated the neural
basis
behind these symptoms. In this study, we sought to elucidate the neural basis
of
GI symptoms in MDD patients by analyzing the changes in regional gray matter
volume (GMV) and gray matter density (GMD) in brain structure. METHOD:
Subjects
were recruited from 13 clinical centers and categorized into three groups,
each
of which is based on the presence or absence of GI symptoms: the GI symptoms
group (MDD patients with at least one GI symptom), the non-GI symptoms group
(MDD
patients without any GI symptoms), and the healthy control group (HCs).
Structural magnetic resonance images (MRI) were collected of 335 patients in
the
GI symptoms group, 149 patients in the non-GI symptoms group, and 446
patients in
the healthy control group. The 17-item Hamilton Depression Rating Scale
(HAMD-17)
was administered to all patients. Correlation analysis and logistic
regression
analysis were used to determine if there was a correlation between the
altered
brain regions and the clinical symptoms. RESULTS: There were significantly
higher
HAMD-17 scores in the GI symptoms group than that of the non-GI symptoms
group
(P < 0.001). Both GMV and GMD were significant different among the three
groups
for the bilateral superior temporal gyrus, bilateral middle temporal gyrus,
left
lingual gyrus, bilateral caudate nucleus, right Fusiform gyrus and bilateral
Thalamus (GRF correction, cluster-P < 0.01, voxel-P < 0.001). Compared to the
HC
group, the GI symptoms group demonstrated increased GMV and GMD in the
bilateral
superior temporal gyrus, and the non-GI symptoms group demonstrated an
increased
GMV and GMD in the right superior temporal gyrus, right fusiform gyrus and
decreased GMV in the right Caudate nucleus (GRF correction, cluster-P < 0.01,
voxel-P < 0.001). Compared to the non-GI symptoms group, the GI symptoms
group
 demonstrated significantly increased GMV and GMD in the bilateral thalamus,
as
well as decreased GMV in the bilateral superior temporal gyrus and bilateral
insula lobe (GRF correction, cluster-P < 0.01, voxel-P < 0.001). While these
changed brain areas had significantly association with GI symptoms
(P < 0.001),
they were not correlated with depressive symptoms (P > 0.05). Risk factors
for
gastrointestinal symptoms in MDD patients (p < 0.05) included age, increased
GMD
in the right thalamus, and decreased GMV in the bilateral superior temporal
gyrus
and left Insula lobe. CONCLUSION: MDD patients with GI symptoms have more
severe
depressive symptoms. MDD patients with GI symptoms exhibited larger GMV and
GMD
in the bilateral thalamus, and smaller GMV in the bilateral superior temporal
gyrus and bilateral insula lobe that were correlated with GI symptoms, and
some
of them and age may contribute to the presence of GI symptoms in MDD
patients.
CI - Copyright © 2021. Published by Elsevier Inc.
FAU - Liu, Peng-Hong
AU - Liu PH
AD - Department of Psychiatry, First Hospital of Shanxi Medical University,
Taiyuan
030001, China; Department of First Clinical Medicine, Shanxi Medical
University,
Taiyuan 030001, China.
FAU - Li, Yan
AU - Li Y
AD - Department of Clinical Medicine, Fenyang College of Shanxi Medical
University,
032200, China.
FAU - Zhang, Ai-Xia
AU - Zhang AX
AD - Department of Psychiatry, First Hospital of Shanxi Medical University,
Taiyuan
030001, China.
FAU - Sun, Ning
AU - Sun N
AD - Department of Psychiatry, First Hospital of Shanxi Medical University,
Taiyuan
030001, China; Department of First Clinical Medicine, Shanxi Medical
University,
Taiyuan 030001, China.
FAU - Li, Gai-Zhi
AU - Li GZ
AD - Department of Psychiatry, First Hospital of Shanxi Medical University,
Taiyuan
030001, China; Department of First Clinical Medicine, Shanxi Medical
University,
Taiyuan 030001, China.
FAU - Chen, Xiao
AU - Chen X
AD - CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing
100054, China; Department of Psychology, University of Chinese Academy of
Sciences, Beijing 100054, China.
FAU - Bai, Tong-Jian
AU - Bai TJ
AD - Anhui Medical University, Hefei, Anhui 230022, China.
FAU - Bo, Qi-Jing
AU - Bo QJ
AD - Beijing Anding Hospital, Capital Medical University, Beijing 100054, China.
FAU - Chen, Guan-Mao
AU - Chen GM
AD - The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong
510630,
China.
FAU - Chen, Ning-Xuan
AU - Chen NX
AD - CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing
100054, China; Department of Psychology, University of Chinese Academy of
Sciences, Beijing 100054, China.
FAU - Chen, Tao-Lin
AU - Chen TL
AD - Mental Health Center, West China Hospital, Sichuan University Chengdu,
Sichuan
610041, China.
FAU - Chen, Wei
AU - Chen W
AD - Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou,
Zhejiang 310012, China.
FAU - Cheng, Chang
AU - Cheng C
AD - The Institute of Mental Health, Second Xiangya Hospital of Central South
University, Changsha, Hunan 410008, China.
FAU - Cheng, Yu-Qi
AU - Cheng YQ
AD - First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan
650221,
China.
FAU - Cui, Xi-Long
AU - Cui XL
AD - The Institute of Mental Health, Second Xiangya Hospital of Central South
University, Changsha, Hunan 410008, China.
FAU - Duan, Jia
AU - Duan J
AD - Department of Psychiatry, First Affiliated Hospital, China Medical
University,
Shenyang, Liaoning 110001, China.
FAU - Fang, Yi-Ru
AU - Fang YR
AD - Department of Psychiatry, Shanghai Jiao Tong University School of Medicine,
Shanghai 200240, China.
FAU - Gong, Qi-Yong
AU - Gong QY
AD - Department of Radiology, Huaxi MR Research Center,West China Hospital of
Sichuan
University, Chengdu, Sichuan 610041, China; Psychoradiology Research Unit of
Chinese Academy of Medical Sciences, West China Hospital of Sichuan
University,
Chengdu, Sichuan 610041, China.
FAU - Guo, Wen-Bin
AU - Guo WB
AD - The Institute of Mental Health, Second Xiangya Hospital of Central South
University, Changsha, Hunan 410008, China.
FAU - Hou, Zheng-Hua
AU - Hou ZH
AD - Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical
University, Chongqing 400016, China.
FAU - Hu, Lan
AU - Hu L
AD - Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical
University, Chongqing 400016, China.
FAU - Kuang, Li
AU - Kuang L
AD - Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical
University, Chongqing 400016, China.
FAU - Li, Feng
AU - Li F
AD - Anhui Medical University, Hefei, Anhui 230022, China.
FAU - Li, Kai-Ming
AU - Li KM
AD - Department of Radiology, Huaxi MR Research Center,West China Hospital of
Sichuan
University, Chengdu, Sichuan 610041, China.
FAU - Li, Tao
AU - Li T
AD - Mental Health Center, West China Hospital, Sichuan University Chengdu,
Sichuan
610041, China.
FAU - Liu, Yan-Song
AU - Liu YS
AD - Department of Clinical Psychology, Suzhou Psychiatric Hospital, The
Affiliated
Guangji Hospital of Soochow University, Suzhou, Jiangsu 215137, China.
FAU - Liu, Zhe-Ning
AU - Liu ZN
AD - The Institute of Mental Health, Second Xiangya Hospital of Central South
University, Changsha, Hunan 410008, China.
FAU - Long, Yi-Cheng
AU - Long YC
AD - The Institute of Mental Health, Second Xiangya Hospital of Central South
University, Changsha, Hunan 410008, China.
FAU - Luo, Qing-Hua
AU - Luo QH
AD - Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical
University, Chongqing 400016, China.
FAU - Meng, Hua-Qing
AU - Meng HQ
AD - Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical
University, Chongqing 400016, China.
FAU - Peng, Dai-Hui
AU - Peng DH
AD - Department of Psychiatry, Shanghai Jiao Tong University School of Medicine,
Shanghai 200240, China.
FAU - Qiu, Hai-Tang
AU - Qiu HT
AD - Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical
University, Chongqing 400016, China.
FAU - Qiu, Jiang
AU - Qiu J
AD - Faculty of Psychology, Southwest University, Chongqing 400716, China.
FAU - Shen, Yue-Di
AU - Shen YD
AD - Department of Diagnostics, Affiliated Hospital, Hangzhou Normal University
 Medical School, Hangzhou, Zhejiang 311121, China.
FAU - Shi, Yu-Shu
AU - Shi YS
AD - Mental Health Center, West China Hospital, Sichuan University Chengdu,
Sichuan
610041, China.
FAU - Wang, Fei
AU - Wang F
AD - Department of Psychiatry, First Affiliated Hospital, China Medical
University,
Shenyang, Liaoning 110001, China.
FAU - Wang, Kai
AU - Wang K
AD - Anhui Medical University, Hefei, Anhui 230022, China.
FAU - Wang, Li
AU - Wang L
AD - National Clinical Research Center for Mental Disorders, Peking University
Sixth
Hospital, Beijing 100191, China; Key Laboratory of Mental Health, Ministry of
Health, Peking University, Beijing 100191, China.
FAU - Wang, Xiang
AU - Wang X
AD - The Institute of Mental Health, Second Xiangya Hospital of Central South
University, Changsha, Hunan 410008, China.
FAU - Wang, Ying
AU - Wang Y
AD - The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong
510630,
China.
FAU - Wu, Xiao-Ping
AU - Wu XP
AD - Xi'an Central Hospital, Xi'an, Shannxi 710003, China.
FAU - Wu, Xin-Ran
AU - Wu XR
AD - Faculty of Psychology, Southwest University, Chongqing 400716, China.
FAU - Xie, Chun-Ming
AU - Xie CM
AD - Department of Neurology, Affiliated ZhongDa Hospital of Southeast University,
Nanjing, Jiangsu 210009, China.
FAU - Xie, Guang-Rong
AU - Xie GR
AD - The Institute of Mental Health, Second Xiangya Hospital of Central South
University, Changsha, Hunan 410008, China.
FAU - Xie, Hai-Yan
AU - Xie HY
AD - Department of Psychiatry, The Fourth Affiliated Hospital, College of
Medicine,
Zhejiang University, Hangzhou, Zhejiang 310058, China.
FAU - Xie, Peng
AU - Xie P
AD - Institute of Neuroscience, Chongqing Medical University, Chongqing 400016,
China;
Chongqing Key Laboratory of Neurobiology, Chongqing, 400016, China;
Department of
Neurology, The First Affiliated Hospital of Chongqing Medical University,
Chongqing, 400016, China.
FAU - Xu, Xiu-Feng
AU - Xu XF
AD - Beijing Anding Hospital, Capital Medical University, Beijing 100054, China.
FAU - Yang, Hong
AU - Yang H
AD - Department of Radiology, The First Affiliated Hospital, College of Medicine,
Zhejiang University, Hangzhou, Zhejiang 310058, China.
FAU - Yang, Jian
AU - Yang J
AD - The First Affiliated Hospital of Xi'an Jiaotong University, Shaanxi 710061,
China.
FAU - Yao, Jia-Shu
AU - Yao JS
AD - Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou,
Zhejiang 310012, China.
FAU - Yao, Shu-Qiao
AU - Yao SQ
AD - The Institute of Mental Health, Second Xiangya Hospital of Central South
University, Changsha, Hunan 410008, China.
FAU - Yin, Ying-Ying
AU - Yin YY
AD - Department of Psychosomatics and Psychiatry, Zhongda Hospital, School of
Medicine, Southeast University, Nanjing, Jiangsu 210096, China.
FAU - Yuan, Yong-Gui
AU - Yuan YG
AD - Department of Psychosomatics and Psychiatry, Zhongda Hospital, School of
Medicine, Southeast University, Nanjing, Jiangsu 210096, China.
FAU - Zhang, Hong
AU - Zhang H
AD - Xi'an Central Hospital, Xi'an, Shannxi 710003, China.
FAU - Zhang, Lei
AU - Zhang L
AD - CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing
100054, China; Department of Psychology, University of Chinese Academy of
Sciences, Beijing 100054, China.
FAU - Zhang, Zhi-Jun
AU - Zhang ZJ
AD - Department of Neurology, Affiliated ZhongDa Hospital of Southeast University,
Nanjing, Jiangsu 210009, China.
FAU - Zhou, Ru-Bai
AU - Zhou RB
AD - Department of Psychiatry, Shanghai Jiao Tong University School of Medicine,
Shanghai 200240, China.
FAU - Zhou, Yi-Ting
AU - Zhou YT
AD - Mental Health Center, West China Hospital, Sichuan University Chengdu,
Sichuan
610041, China.
FAU - Zhu, Jun-Juan
AU - Zhu JJ
AD - Department of Psychiatry, Shanghai Jiao Tong University School of Medicine,
Shanghai 200240, China.
FAU - Zou, Chao-Jie
AU - Zou CJ
AD - First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan
650221,
China.
FAU - Si, Tian-Mei
AU - Si TM
AD - National Clinical Research Center for Mental Disorders, Peking University
Sixth
Hospital, Beijing 100191, China; Key Laboratory of Mental Health, Ministry of
 Health, Peking University, Beijing 100191, China.
FAU - Zuo, Xi-Nian
AU - Zuo XN
AD - CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing
100054, China; Department of Psychology, University of Chinese Academy of
Sciences, Beijing 100054, China; Magnetic Resonance Imaging Research Center
and
Research Center for Lifespan Development of Mind and Brain (CLIMB), Institute
of
Psychology, Chinese Academy of Sciences, Beijing 100054, China.
FAU - Yan, Chao-Gan
AU - Yan CG
AD - CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing
100054, China; Department of Psychology, University of Chinese Academy of
Sciences, Beijing 100054, China; Magnetic Resonance Imaging Research Center
and
Research Center for Lifespan Development of Mind and Brain (CLIMB), Institute
of
Psychology, Chinese Academy of Sciences, Beijing 100054, China; Department of
Child and Adolescent Psychiatry, NYU Langone Medical Center School of
Medicine,
New York, NY 10016, USA.
FAU - Zhang, Ke-Rang
AU - Zhang KR
AD - Department of Psychiatry, First Hospital of Shanxi Medical University,
Taiyuan
030001, China. Electronic address: [email protected].
LA - eng
PT - Journal Article
PT - Research Support, Non-U.S. Gov't
DEP - 20210611
PL - England
TA - Prog Neuropsychopharmacol Biol Psychiatry
JT - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
SB - IM
MH - Abdominal Pain/etiology/psychology
MH - Adult
MH - Brain/pathology
MH - Brief Psychiatric Rating Scale
MH - Caudate Nucleus/pathology
MH - Depressive Disorder, Major/*pathology
MH - Female
MH - Gray Matter/*pathology
MH - Humans
MH - Image Processing, Computer-Assisted
MH - Magnetic Resonance Imaging
MH - Male
MH - Temporal Lobe/pathology
MH - Thalamus/pathology
OTO - NOTNLM
OT - Gastrointestinal symptoms
OT - Gray matter density
OT - Gray matter volume
OT - Major depressive disorder
EDAT- 2021/06/14 06:00
MHDA- 2022/02/19 06:00
CRDT- 2021/06/13 20:39
PHST- 2020/10/29 00:00 [received]
PHST- 2021/06/07 00:00 [revised]
PHST- 2021/06/08 00:00 [accepted]
PHST- 2021/06/14 06:00 [pubmed]
PHST- 2022/02/19 06:00 [medline]
PHST- 2021/06/13 20:39 [entrez]
AID - S0278-5846(21)00145-7 [pii]
AID - 10.1016/j.pnpbp.2021.110386 [doi]
PST - ppublish
SO - Prog Neuropsychopharmacol Biol Psychiatry. 2021 Dec 20;111:110386. doi:
10.1016/j.pnpbp.2021.110386. Epub 2021 Jun 11.