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Bioscan Flow Count Brochure

The Flow-Count Radio-HPLC Detector System is designed for the remote detection of various isotopes in radiopharmaceutical purity and HPLC analysis. It features compatibility with all HPLC systems, adjustable flow cells, and multiple detector options to enhance flexibility and reduce background interference. The system supports a range of applications including monoclonal antibody labeling and PET tracer analysis, and is integrated with Bio-Chrom software for data collection and analysis.

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17 views2 pages

Bioscan Flow Count Brochure

The Flow-Count Radio-HPLC Detector System is designed for the remote detection of various isotopes in radiopharmaceutical purity and HPLC analysis. It features compatibility with all HPLC systems, adjustable flow cells, and multiple detector options to enhance flexibility and reduce background interference. The system supports a range of applications including monoclonal antibody labeling and PET tracer analysis, and is integrated with Bio-Chrom software for data collection and analysis.

Uploaded by

Diogo Freitas
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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Bioscan Analytical Instrument

Flow-Count
Radio-HPLC Detector System

Quality Control

Applications:
Radiopharmaceutical Purity (99mTc, 111In, 125I, 123I, 131I, 90Y)
HPLC Analysis of I-125 and P-32 labeled compounds
Monoclonal antibody labeling and analysis (125I, 131I, 90Y)
Protein and DNA labeling and analysis (32P, 125I)
PET tracer analysis (18F, 11C)

Flow-Count is a radioisotope HPLC detection system, which is


Features and benefits compatible with all HPLC systems. It is designed for the remote
detection of a wide range of isotopes and has a variety of shielding,
Easy-to-use system with maximum detector, and flow cell options. It uses specially configured
flexibility photomultipliers and/or PIN diode detectors to detect gamma,
positron, and high energy beta emitters at both high and low levels
Disposable and easily adjustable flow of activity. Flow-Count eliminates the need for fraction collection
cells and scintillation counting.

Compatible with all chromatography data


systems and Bio-Chrom software Flow-Count is a flexible and easy-to-use system. Background
interference is reduced with variable energy window settings and
Various flow cells and holders for most sensitivity is optimized with adjustable flow cell volumes. Miniature
types of applications detectors can fit into small locations and can operate up to 12 feet
away from the base unit, making shielding easier. Several detector
Capable of monitoring two detectors holders and flow cells are available to suit your particular application
simultaneously requirements.

Lead shielded detector and flow cell


holders A standard 0-1 volt analog signal or optional extended range module
is used to connect Flow-Count to your existing chromatography data
Optional extended range module for 6 system. Or interface the digital TTL pulse signal with Bio-Chrom
decade analog output range radio-chromatography software for maximum sensitivity, dynamic
range, and optional cGMP and 21 CFR Part 11 compliance.

www.bioscan.com
Models:

FLOW 1.

2.
FC-1000: Radiochromatography base unit with inputs for both PMT/NaI and PIN
Diode detectors. Analog and digital output for one detector at a time.
FC-2000: Radiochromatography base unit with inputs for both PMT/NaI and
PIN Diode detectors. Analog and digital outputs for both detectors available

COUNT
simultaneously.
3. FC-2000D: Radiochromatography base unit with inputs for two PIN Diode
detectors. Analog and digital outputs for both detectors available simultaneously.
4. FC-2000P: Radiochromatography base unit with inputs for two PMT/NaI
detectors. Analog and digital outputs for both detectors available simultaneously.

Detectors: Holders and flow cells:


Two types of detectors are available A variety of detector holders and flow cells are easily adapted to a wide range of
for the Flow-Count system, a standard applications. Since the flow cells are made of inexpensive standard Teflon tubing,
photomultiplier tube (PMT) combined with the flow cells are disposable should they become contaminated. All of our flow cells
a scintillation crystal, and a solid state PIN have variable volumes, which can be set by the user.
Diode detector. These interchangeable
detectors provide the system with the
flexibility to measure a wide range of
isotopes and activities.

1. The FC-3100 Na/I PMT based detector


is a low energy gamma (10-60keV)  
FC-5200: Lead shielded (0.5’’) FC-5250: Heavily Shielded FC-5260: Heavily Shielded (2.0’’) lead
detector used primarily for I-125. holder and flow cell for FC- (2.0’’) lead holder and flow- holder and flow-cell assembly for FC-
2. The FC-3200 Na/I PMT based detector 3100/3200 - (FC-3600) detectors. cell for FC-3200 detectors. 3400 and FC-3500 detectors. For use
is a high energy gamma (>60keV) For use with high activity gammas. For use with PET isotopes. with high activity PET isotopes
detector used in most nuclear medicine
applications. Extended Range Module:
3. The FC-3600 Plastic Scintillator/PMT The extended Range module, FC-6106, is designed to
based detector is ideal for the detection work with radio-HPLC Flow-Count system.
of 32P, 90Y and other high energy beta It converts TTL pulses from the radio-HPLC detectors to an analog voltage output
emitters. which is readily interfaced to most chromatography data systems.
4. The FC-3300 NaI/PMT based detector The accuracy of the analog signal is 18-bit which provides a six-decade dynamic
is a wide range gamma detector range. It has both high and low ranges for maximum flexibility, and also provides
with built-in lead shielding to reduce both 1 sec and 6 sec filtering of the analog output signal.
background. It uses a well configuration

5.
which gives 4 pi counting geometry.
The FC-3400 PIN Diode detector is Bio-Chrom Software:
compact and easy to shield. It has a high Bio-Chrom is a comprehensive chromatography data collection and analysis package
count rate capability and low sensitivity specifically configured for Bioscan instruments and working with radioisotopes.
to provide a linear range from 10 µCi to Bio-Chrom is the perfect complement to your Flow-Count HPLC detector, Mini-Scan
1 Ci for most gamma emitters. TLC system, AR-2000 TLC Scanner and PET Metabolite detector.
6. The FC-3500 PIN Diode detector is
compact and easy to shield. It uses a
CsI crystal to provide greater sensitivity Upgrade your Flow-Count to a TLC Scanner:
for gammas. With the sheilding FC-
5260, the FC-3500 is recommended Mini-Scan:
for quality control of high activity F-18 Reference MS-1000: Mini-Scan TLC mechanical scanning unit with scan speed
labeled compounds. control and collimated detector holder.

Bioscan’s representative: Bioscan, Inc. 4590 MacArthur Blvd, NW, Bioscan Europe, Ltd.
RevFC-29/04/10

Washington, DC 20007, USA. 58, Av. de Wagram, Paris 75017, France.


Tel: 1-202-338-0974 Fax: 1-202-333-8514 Tel: 33-383-636-267 Fax: 33-383-636-267
Toll free: 1-800-255-7226 - [email protected] [email protected]

www.bioscan.com www.spect-ct.com

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