DAIE

Notes
NqBELPRIZES FoR MMDNOoLpGaY
LAR YAmE 0E SC1tNTIST
uNTA LoNTR18UT1ONS
90S Robead Koch | alludas. huni
ELe Mecmmtrn
1930 Kg Landsemeo sAPhogoctosis
USA Humon d
DSA|Mai Histoc.ompal-
R cople.
yPES E MMUNI T
IMMUNIT
NNATE ImmoNIT7 ADAPT JVE JMMONIT
NATORAAL ARTIAciAL
ACTLyE
PAssl QLTIUE
Cnkec1oN) MATE RNAL) ANTLOD /ne
tamnye umizaioo

FFeronte l
nmatulnon- Specltic) ama
SpecigieLADAPTIvE)
INNATE DAPTIVE
NonShecisio Janmunity SpecipL Lminiy
Besponse etigen-lndependent kespone i ntigh
epencteii:
hee mealk mmakfon heke is a Lag-
time b|u) ezposR
pose
md..mMaximal D.
 DAIE
TITLE
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Notes
Non-amdhen-Speciio
ExposuRd Ausults n Extosuwe
n Immumdletc mbk

NNATE IMMUNTTY
Hrnansb0Rngs QAL eoiecled byo m df Q
JuO
mmunftfos - We matd mnumi
Aapive mmnmumIAHp Msu
notenade Immum s mbte ?k tve
s &4si a Pkaverting- he enttz o haRn
Thkauah Voious boktet machauisim u d
h e Rdhoaen bkeach Ahis bagk te U
toaaes kil omd. elKonincde em uck
L míctabes stfu Pssfs,A actioalns Jhe
moto e teciua md hiak SReciiu cdophue
momumi to ensue aL md cOmplslo
lmfolbn k he MILobes amd Omte
ARACTERSTLE TATEmoNytF
the dikamdfakfnq aka dhe adabtiue
Specidicity amd Divbksly
DiieYentiaion betweem Selymd mon- Sely
DeveloPmentamd Immdnological Memty.
SPecEICL7 AND DIVERSLut:
e AcankEO IMuNiY develad SPeeipcally do
Lachamtigen LB liminahon.These_deel z
diAneLan antiboctiesdeveloped do hterd
aligeb 0 MiCehes So Ahat each B "Bpesiji
QM.aELiLAAdaiRAL.L.aAhe.
 DATE TLE

Notes
thus, these Cold he_a vetu Vasl Voreid1
mtbodies keset_ fo dhe bdy agafns
agalnal
Lqually Lalge \h&lchy 0, anliges0
am
ohis teht oz lpanitude e heeifici "
kesekkod do Divesity
o4
ne the caULed Ummune kosponseg
INNATEISTEM;- broad baaed md
pnal
Aatuke2a
t t is Same amd ack in lhe Same
Jhe omttaens Oma mífckahes hor O al
jot all
thud, M s mon-Sheeint Immunity
DELF Ho Non- ELFGEUS
blhthe mat and ldapive mmnity
Ssen
hauehe ebiLty lo dkceimináll -Kewern
he sety m d n Selp
_hey stond onl l e e iqm hhich ale
m D6 bodys pwi 0agn Ye Tmon-
On Ahe eth homd, sely cel
Qwm Cetls antigene, bedy-s
md melcculs ate eAod lo a
Howewe Ahe laaphie mmune Sysum
AAeamLlne d In 1hé aiscaiminahon hoces
Jathe than the lmau mmune
sslem as u
i med Omd SpecitHL In lecOme
Patnogend)p
 DATE
TTIE
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Notes

VEvetoPMENT AND MMUNoLola1t MemOR

MemoR
he lammume Syslen o
The tbod has The Humam
Dnaueabitti A develeping aenbej
he anhigen n e rthoge 2ncointei3,
o Mawim~ been cttacued ice b Cm mhaen
t develops md keeps hmaintoA U
am
he
hpm o Memott Cells tp allL utuke
aenes
Whenevet he Same amugen is encoLnlereol
gam The exislimg memeny Cells hetp n
éeognitiom Cmd levelcnent Of aSkong nd
ona La2ting lmme Ponke
Ahis
his Llnique chasaclershc seime ossesseds
b AdaPtive lmmun Systerm
o mnat mmume
Syslemhee
mechaMSm o daeloptng- MOMBy
mo Suc
aS1h
hee mo mfadion î dhe mhune Reaponse
eNen he aihegen
bcoly Ps he
opeadecdl atlocks Ihe
&ame
IEFERENT
1hise
TACOES Up NNATE IMMUNE SIEM.
ase Scvesal mecthanisms cg lnnal
Tarmunuil l
dtheaent stages op_hpechon
BARRIERS the2 04e mdpmftal md hsfol02ital
PoPet_ties oh U o d y which acts a y boitiess
me 3hcemH adhogens nto
C w bod -om he
he PoJenB Pal
 DATE

Notes
PHAGOcATOSIS: 1f lhe baleieAs ata beeached
the uthogen iS
Cells eaUed
tcenfsed mc kfled b Speepeeil
Phagoyter Jo Limit CGre lPmnlnat he
eioon
NDUCED RESPoNSES Recogmilion ok
rathene Pothogen0
b osous ailks mc Owd mele udes hugh
PRRs 4iaRA he siqolL San&ducdion
which ctuc Jhe
which adhdnys
the P<odud c ëxbiuion Seseual 2eros
hese qenes t h e enrhtee
fnmote lesponse. Jhese hcude O

mfcuobo
molecules ike Otr-nmicuoroL Veptdes,
teAeSLONS hemokines md Coknes which
Keiuul othesCells, emzymes Gke NO
(NoSS Cmcl
oMACeLmmaloty mechicdoL2
BaRAIE MeMANISM
natomlcal
phy siol zial Gerikrs
ntiniczobal Bonrlers
1. ANATOMEcAL BARRLERS;
SKfa Skin is he MatuhalL outeimmost
Kolechive
COeaiaxDAhe
fhe Lahia autd
aod
od th ocis 0A h e Sehum,
al he Skin cPH acilic 3-5) which 15 Wowiable
he
thePamogeas Jo suive.
h e kekadin PAsemt Inhe pTthe'um pAuile
ep
aHah ouoh wnte fhoo Coueimg.
inakp.Phacduts.amtinihplan2Ad..SsSo
 DATE
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Notes
SaARain which eNedM colovizahidn o E-LoLi
Li N G
Mco MeMBRANE AD CTLART

os Mecmmfcal bakres owd Rovoal Aatay

atheNs om ma hlegnal Stte Such a dhe
NOSoPha zynt aastdhntestimau, e m t a m d
ma AACASS
1hick NcowA mucus m d aciue Clfa
movewmea thoge ano malk i _ Na
cAieh o hem dbael t hold v YmutogaL
mdlsome
MiC2oDfal PlorAtagoni sm n onsine
hsiooicnl braRL EAS
AST RICPH:
oghl acidc ma umEaVoLaabl
he Btomach kiLl he Palh enen md a h asa baun
SorPhe
Su2vivsl
Poene ob Lerlic_Qid In leams amd
Vaainau
be cieHons, abo Q y in mahanisvM
ENzyMES
Lsmes and
her hydkolytil en24nmes esei
in Body Secyeblons k e Heass, masal
a Lal va d0 seéseions
l allow h entty e4 Dalhose
Ahneg hesc Ad zeene
ubseqtuer 6 u i tt
 DATE TITLE
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Notes
ANTLMICADBIAL PEPTIDES:
thd epfhilial Lin1ng o he gastzoinlinal, Tspizalor
And miteutinas
active peptides wth
aeck Pzocluca Ssmall,phyioLegrialy
aimieroofa ativi g
hese pepideS
ph gti
Okealso-poeduudby-
omd elblgti adh
CalS shoud
Sudh
MeuthephfLs, oloxAL T UAmmnoAes Omdu matu0a
KfLLe cel $o

fhesePplieles cotains Less 1han loo amimo Quds

md ezhipit aimaa SAauduie Phoheins
they ezisi amphipaht moluues
hese
DCtensins:
Cysteine mcw mplecelis wih Cirula Shabe8.
ddetemsins ake aoducod b maephiis, GT
utesime, lezvi, alopf am ube
-dehemsîs e Secaeled by kdmous,umas _amd
JRMade nftul Aoacds
HRStns
Hstrdme t h pelfdes
sent n numwom Sala
Gatamulsin
oducad b* atoloteT-ymbhouies Od álusal
e cels
c at alang Rerjtins do kf miedooiganisms