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Heart Failure Drugs Table

The document outlines various classes of medications including diuretics, positive inotropes, afterload reducers, hypertension medications, and sympathetic nervous system drugs, along with their mechanisms of action and potential adverse effects. Key drugs mentioned include Furosemide, Spironolactone, Pimobendan, Dobutamine, and Enalapril, each with specific effects on fluid balance, cardiac function, and blood pressure regulation. Adverse effects range from dehydration and electrolyte abnormalities to GI upset and risk of toxicity.

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15 views2 pages

Heart Failure Drugs Table

The document outlines various classes of medications including diuretics, positive inotropes, afterload reducers, hypertension medications, and sympathetic nervous system drugs, along with their mechanisms of action and potential adverse effects. Key drugs mentioned include Furosemide, Spironolactone, Pimobendan, Dobutamine, and Enalapril, each with specific effects on fluid balance, cardiac function, and blood pressure regulation. Adverse effects range from dehydration and electrolyte abnormalities to GI upset and risk of toxicity.

Uploaded by

dctr.george
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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Diuretics

Drug Mechanism of Action Adverse Effects


Furosemide, Torsemide Inhibits Na/K/Cl cotransporter in ascending loop of Henle Dehydration
K wasting Electrolyte abnormalities
Spironolactone Aldosterone receptor antagonist Hyperkalemia – rare
Na excretion
K sparing
Hydrochlorothiazide Inhibits Na and Cl reabsorption in distal tubule Dehydration
Electrolyte abnormalities
Positive Inotropes
Drug Mechanism of Action Adverse Effects
Pimobendan Increases sensitivity to Ca, DOES NOT INCREASE Ca
PDE-III inhibitor
Arterial and venous vasodilation
Dobutamine/Dopamine Beta adrenergic stimulation GI upset
Increased cytoplasmic Ca Proarrhythmic (increased Ca)
Peripheral vasodilation
Digoxin Inotrope and antiarrhythmic GI upset
Inhibits Na/K ATPase Proarrhythmic (Increased Ca)
Increases cytoplasmic Ca Risk of toxicity (azotemia, hypokalemia)
Slows HR (AV and SA conduction) Monitor levels
Sympatholytic
Afterload Reducers
Drug Mechanism of Action Adverse Effects
Prazosin, Phenoxybenzamine, Carvedilol Alpha adrenergic blockade
Amlodipine Calcium channel blocker
Hydralazine Direct acting vascular smooth muscle blocker Reflex tachycardia
Stimulation of RAAS
Reflex vasoconstriction
Enalapril, Benazepril ACE inhibitors Azotemia
Pimobendan PDE-III inhibitor
Hypertension Medications
Drug Mechanism of Action Adverse Effects
Oxygen Vasodilation
Sildenafil PDE-5 inhibitor
Increased NO production
L-arginine NO precursor
Pimobendan PDE-III inhibitor
Sympathetic Nervous System Drugs
Drug Mechanism of Action Adverse Effects
Atenolol, Carvedilol Negative chronotropes
Negative inotropes
Beta blockers

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