Science Notes
Science Notes
•Cerebellum: Responsible for balance, posture, muscle tone, and learning using
muscles.
•Cerebrum (Telencephalon): The largest part of the brain; each hemisphere controls
•sensory and motor functions of the opposite side of the body.
•Central Nervous System (CNS): The brain and spinal cord are the main control system.
• Peripheral Nervous System (PNS): Contains nerves outside the CNS.
2. Neuron Functionality:
Information is received through sensory neurons, and processed in the brain, and
responses are sent via motor neurons to effectors (muscles or glands).
Damage to the nervous system disrupts signal transmission, affecting overall body
function.
4. Homeostasis Maintenance:
Achieved by the nervous and endocrine systems regulating variables like body
temperature, water levels, metabolic waste, blood calcium, and hormone levels.
Failure of these systems disrupts normal body function, leading to imbalance and health
issues.
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5. Examples of Homeostasis:
Maintain a balanced diet, exercise regularly, stay hydrated, get enough rest, and avoid
stress.
The endocrine system consists of glands that secrete chemicals called hormones to
control various body processes. This control system usually brings about how slow
changes in the body because chemical messengers move more slowly than nerve
impulses. The major glands in the body are the pituitary, thyroid, parathyroid, thymus,
adrenal, pancreas, ovaries, and testes.
Endocrine glands are specialized organs that release hormones directlyinto the
bloodstream to regulate various bodily functions. Unlike exocrine glands, which release
their secretions through ducts (e.g., sweat or salivary glands), endocrine glands are
ductless. The hormones produced by these glands serve as chemical messengers,
traveling through the blood to target specific organs or tissues and influencing
processes such as growth, metabolism, reproduction, and homeostasis.
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Characteristics of Endocrine Glands:
•Pituitary gland: Often referred to as the "master gland," it regulates other endocrine
glands.
•Thyroid gland: Controls metabolism and energy use.
•Adrenal glands: Manage stress responses and metabolic processes.
•Pancreas:Regulates blood sugar levels.
The endocrine system plays a vital role in maintaining the body's internal balance, or
homeostasis, by regulating various physiological processes through hormones. Below
are the key functions of the endocrine system:
1. Regulation of Metabolism
•Controls the body's energy production, storage, and usage.
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•Influences physical growth and organ development from infancy to adulthood.
4. Stress Response
•Helps the body respond to stress by releasing hormones that increase alertness and
energy availability.
•Glands involved: Adrenal (adrenaline, cortisol).
5. Maintenance of Homeostasis
•Regulates critical processes like body temperature, fluid balance, blood pressure, and
electrolyte levels.
•Glands involved: Hypothalamus, Pituitary, Adrenal (aldosterone).
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The endocrine system works in close coordination with the nervous system, forming the
neuroendocrine system, to ensure the body responds appropriately to internal and
external changes.
Endocrine glands work together in a network called the endocrine system, ensuring that
the body functions efficiently and maintains homeostasis.
Gland
Pituitary
(Location of the glands)
Base of the brain, below the hypothalamus
(Hormones Released)
Growth hormone (GH), Prolactin, Adrenocorticotropic hormone (ACTH), Thyroid-
stimulating hormone (TSH), Follicle-stimulating hormone (FSH), Luteinizing hormone
(LH), Antidiuretic hormone (ADH), Oxytocin
(Function)
Regulates growth, metabolism, reproduction, water balance, and stress responses.
Thyroid
(Location of the glands)
Front of the neck, below the voice box
( Hormones Released)
Thyroxine (T4), Triiodothyronine (T3), Calcitonin
(Function)
Controls metabolism, growth, development, and lowers blood calcium levels.
Parathyroid
(Location of the glands)
Behind the thyroid gland, in the neck
(Hormones Released)
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Parathyroid hormone (PTH)
(Function)
Increases blood calcium levels by stimulating bone resorption and calcium absorption.
Thymus
(Location of the glands)
In front of the heart or Upper chest, behind the sternum
(Hormones released)
Thymosin
(Function)
Stimulates T-cell development and immune response.
Adrenal
(Location of the glands)
On top of each kidney
(Hormones released)
Adrenaline (Epinephrine), Cortisol, Aldosterone
(Function)
Regulates stress responses, blood pressure, electrolyte balance, and metabolism.
Pancreas
(Location of the glands)
Between the kidneys, Behind the stomach
( Hormones Released)
Insulin, Glucagon
(Function)
Regulates blood glucose levels by lowering (insulin) or raising (glucagon) them.
Testes (Males)
(Location of the glands)
Lower abdomen, Within the scrotum
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( Hormones Released)
Testosterone
(Function)
Promotes development of male reproductive organs, secondary sexual characteristics,
and sperm production.
Ovaries (Females)
(Location of the glands)
Lower abdomen, near the uterus
( Hormones Released)
Estrogen, Progesterone
(Function)
Regulates menstrual cycle, supports pregnancy, and develops secondary sexual
characteristics.
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3. Goiter: This is an enlargement of the thyroid gland, often caused by iodine deficiency
or irregular secretion of thyroid hormones. When the thyroid gland struggles to produce
enough thyroid hormones (hypothyroidism), it enlarges to compensate. Conversely, it
may also swell in cases of excessive hormone production (hyperthyroidism).
1. Diabetes Mellitus:
Cause: Insufficient production of insulin (Type 1) or the body's inability to use insulin
effectively (Type 2), both regulated by the pancreas.
3. Hypothyroidism:
Effects: High blood sugar levels, leading to complications like nerve damage, kidney
failure, and cardiovascular issues.
2. Hyperthyroidism:
4. Cushing's Syndrome:
Cause: Excess production of cortisol by the adrenal glands, often due to prolonged use
of corticosteroid medications or adrenal tumors.
Effects: Weight gain, high blood pressure, muscle weakness, and a "moon face"
appearance.
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5. Addison's Disease:
Cause: Insufficient production of cortisol and aldosterone by the adrenal glands.
Effects: Fatigue, weight loss, low blood pressure, and hyperpigmentation of the skin.
7. Acromegaly:
Cause: Excess growth hormone secretion in adulthood, after the growth plates have
closed.
Effects: Enlargement of facial features, hands, feet, and thickening of the skin.
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or obesity can interfere with hormonal balance.
Proper diagnosis and treatment are essential to manage these conditions effectively
and maintain overall health.
(Parts)
Testis
(Function)
Produces sperm cells and the hormone testosterone.
(Parts)
Scrotum
(Function)
Holds and protects the testes; regulates temperature for optimal sperm production.
(Parts)
Penis
(Function)
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Delivers sperm into the female reproductive tract; also used for urination.
(Parts)
Vas Deferens (Tube)
(Function)
Transports sperm from the testes to the urethra.
(Parts)
Seminal Vesicles
(Function)
Produce seminal fluid that nourishes and supports sperm motility.
(Parts)
Prostate Gland
(Function)
Produces a milky fluid that protects and enhances sperm survival in the acidic
environment of the vagina.
(Parts)
BulbourethralGland
(Function)
Secretes a lubricating fluid that neutralizes acidity in the urethra before ejaculation.
(Parts)
Ovary
(Function)
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Produces eggs (ova) and the hormones estrogen and progesterone.
(Parts)
Oviduct (Fallopian Tube)
(Function)
Transports the egg from the ovary to the uterus; where fertilization usually occurs.
(Parts)
Uterus
(Function)
Houses and nourishes the developing fetus during pregnancy.
(Parts)
Vagina
(Function)
Receives sperm during intercourse; serves as the birth canal during childbirth.
This comparison highlights the complementary roles of male and female reproductive
systems in the reproductive process.
2. Hormone Production:
•The testes produce testosterone, which is responsible for the development of male
secondary sexual characteristics (e.g., deeper voice, facial hair) and sperm production.
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3. Protection and Nourishment of Sperm:
•Accessory glands (seminal vesicles, prostate gland, and bulbourethral gland) produce
fluids that nourish, protect, and transport sperm during ejaculation.
4. Regulation of Temperature:
•The scrotum ensures the testes remain at an optimal temperature for sperm
production, slightly lower than body temperature.
1. Egg Production:
•The ovaries produce eggs (ova) through oogenesis and release them during ovulation.
2. Fertilization:
•The fallopian tubes provide the site where sperm can meet the egg, resulting in
fertilization.
3. Support of Pregnancy:
•The uterus supports and nourishes the fertilized egg, allowing it to develop into a fetus
during pregnancy.
4. Hormone Production:
•The ovaries secrete hormones (estrogen and progesterone) that regulate the menstrual
cycle, prepare the body for pregnancy, and influence secondary sexual characteristics.
Both systems work together to enable reproduction, ensuring the species' survival.
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Heredity
Definition: The process through which traits and characteristics are passed from parents
to their offspring through genetic material (DNA)
Key Features:
•Traits such as eye color, hair type, and height are inherited from parents.
•The genetic information is stored in genes, which are segments of DNA located on
chromosomes.
Inheritance
Definition: The mechanism by which genetic traits are transmitted from one generation
to the next.
Key Aspects:
•Mendelian Inheritance: Follows the laws of Gregor Mendel, involving dominant and
recessive traits.
•Non-Mendelian Inheritance:
•Includes incomplete dominance,
•codominance, and polygenic traits
•Types of Traits Inherited: Physical traits (eg., skin color), physiological traits (eg, blood
type), and predisposition to certain diseases.
•Inheritance occurs through the transmission of alleles from parents to offspring during
reproduction.
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Variation
Definition: The differences in traits or characteristics among individuals within a
population or species,
Sources of Variation:
1. Genetic Variation:
•Caused by differences in the DNA sequence, mutations, recombination during meiosis,
and random fertilization.
2. Environmental Variation:
•Differences arising due to environmental factors like climate, diet, and lifestyle.
3. Phenotypic Variation:
•The observable differences in appearance or function among individuals due to genetic
and environmental factors.
Importance of Variation:
•Drives evolution and natural selection.
•Ensures species adaptability and survival in changing environments.
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Key Processes in the Central Dogma
1. Replication
•Definition: The process of copying DINA to produce identical DNA molecules.
•Purpose: Ensures genetic information is accurately passed to new cells during cell
division.
Key Steps:
•DNA strands unwind.
•Enzymes (e.g., DNA polymerase) synthesize a •complementary strand for each original
strand.
•Results in two identical DNA molecules.
•Location: Nucleus (in eukaryotes)
2. Transcription
•Definition: The process of synthesizing RNA from a DNA template.
•Purpose: Converts genetic information stored in DNA into a form (messenger RNA, or
mRNA) that can be read by ribosomes to make proteins
Key Steps:
•DNA unwinds, exposing a template strand.
•RNA polymerase binds to the DNA and synthesizes a complementary mRNA strand.
•The mRNA is processed (e.g., splicing) and exported from the nucleus to the
cytoplasm.
•Location: Nucleus (in eukaryotes).
3. Translation
•Definition: The process by which ribosomes use the mRNA sequence to synthesize a
specific protein.
•Purpose: Converts the nucleotide sequence in mRNA into an amino acid sequence of a
protein.
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Key Steps:
•Ribosomes bind to the mRNA.
•Transfer RNA (RNA) molecules bring amino acids corresponding to the codons in the
mRNA.
•Amino acids are linked together to form a polypeptide chain, which folds into a
functional protein.
•Location: Cytoplasm (at ribosomes).
1. Reverse Transcription
•Some organisms, like retroviruses (e.g., HIV), use reverse transcriptase to synthesize
DNA from an RNA template.
•RNA-DNA is the reverse of transcription and is key in viral replication.
3. Epigenetics
Modifications to DNA (eg, methylation) and histones can affect gene expression without
altering the DNA sequence.
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•Defines Life's Molecular Framework: Explains how genetic information controls cellular
functions.
•Medical Applications: Helps understand genetic diseases and develop therapies (e.g.,
CRISPR, RNA-based vaccines).
•Biotechnology: Underpins techniques like recombinant DNA technology and gene
editing.
The central dogma remains a cornerstone of biology, providing a foundation for studying
lide at the molecular level.
Protein synthesis is a vital biological process in which cells create proteins using the
genetic information stored in DNA. This process occurs in two main stages: transcription
and translation
1. The enzyme RNA polymerase binds to a specific region of the DNA called the
promoter.
2. The DNA strand unwinds, and RNA polymerase reads the template strand of the
DNA.
3. RNA polymerase synthesizes a complementary strand of messenger RNA (mRNA)
by pairing RNA nucleotides with their complementary DNA bases:
•Adenine (A) pairs with Uracil (U) (in RNA), and Thymine (1) pairs with Adenine (A).
•Cytosine (C) pairs with Guanine (G), and Guanine (G) pairs with Cytosine (C).
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4. Once the mRNA is complete, it detaches, and the DNA re-forms its double hellx
The mRNA strand carries the genetic code out of the nucleus to the cytoplasm
Proteins are then folded into specific three-dimensional shapes to perform their
biological functions.
Mutations are changes in the DNA sequence of a gene, and they can significantly
impact the structure and function of the protein produced from that gene. These effects
depend on the type and location of the mutation.
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DNA contains the instructions for assembling amino acids into proteins. Mutations alter
these instructions, potentially leading to changes in the resulting protein.
•Silent Mutation: The altered codon still codes for the same amino acid (no change in
protein structure or function).
•Example: GAA (glutamate)+GAG (glutamate).
•Missense Mutation: The altered codon codes for a different amino acid, potentially
affecting the protein's structure and function.
Example: Sickle cell anemia results from a single amino acid substitution in hemoglobin.
•Nonsense Mutation: The altemd codon becomes a stop codon, leading to premature
termination of the protein, often rendering it nonfunctional
Example: Cystic fibrosis (some cases).
2. Frameshift Mutations
•Insertion or deletion of nucleotides (not in multiples of three) shifts the reading frame,
changing all downstream codons.
3. Large-Scale Mutations
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1. Primary Structure (Amino Acid Sequence): Mutations may change the order of amino
acids, which can alter how the protein folds.
2. Secondary and Tertiary Structures (Folding and Shape): Changes in amino acids
may disrupt hydrogen bonds, ionic bonds, or hydrophobic interactions, affecting the 3D
shape.
•No Effect: Some mutations have no impact due to redundancy in the genetic code of
non-critical regions of the protein being affected
Mutations can have diverse affects, from no noticeable impact to severe structural and
functional changes. These effects depend on the mutation type, location, and the role of
the protein in the organism
Explain how fossil records, comparative anatomy, and genetic information provide
evidence for evolution. Fossil records, comparative anatomy, and genetic information
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collectively provide evidence for evolution, illustrating how life on Earth has changed
over time and how different species share common ancestors.
1. Fossil Records: Fossils are preserved remains or traces of organisms from the past,
often found in sedimentary rocks. They reveal a chronological life history on Earth,
showing how species have changed over millions of years. Transitional fossils, like
Archaeopteryx (linking dinosaurs and birds) or Tiktaalik (bridging fish and amphibians),
demonstrate intermediate forms that support evolutionary relationships. Patterns in the
fossil record also show the emergence of more complex organisms over time,
consistent with evolutionary theory.
3. Genetic Information: DNA and molecular evidence provide the most compelling
support for evolution. Similarities in genetic sequences among species point to shared
ancestry. For instance, humans and chimpanzees share about 98-99% of their DNA.
Molecular clocks, based on the rate of genetic mutations, also help estimate the
divergent times of species, aligning with fossil evidence. Furthermore, the universality of
the genetic code across all living organisms supports the idea of a single common origin
for life.
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Evolution occurs as a result of changes in the genetic composition of populations over
generations, driven by several mechanisms that shape how species adapt and diversify.
Here's an overview of how evolution occurs:
1. Genetic Variation
•Evolution begins with variation within a population. Genetic differences arise through:
•Mutations: Random changes in DNA that can create new traits.
•Gene flow: The exchange of genes between populations through migration.
•Sexual reproduction: The combination of genetic material from two parents leads to
unique offspring.
These variations provide the raw material for evolution.
2. Natural Selection
•Natural selection is the process by which traits that provide a survival or reproductive
advantage become more common in a population. Key elements include:
•Overproduction of offspring: Organisms produce more offspring than can survive.
•Struggle for existence: Limited resources create competition.
•Differential survival and reproduction: Individuals with favorable traits (e.g.,
camouflage, speed) are more likely to survive and reproduce, passing these traits to the
next generation.
Over time, advantageous traits accumulate, and populations adapt to their
environments.
3. Genetic Drift
In small populations, random events can cause certain traits to become more or less
common, regardless of their advantage. This is known as genetic drift and can lead to
significant evolutionary changes over time.
4. Speciation
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As populations become isolated (geographically or reproductively), they accumulate
genetic differences. Over time, these differences can lead to the emergence of new
species, a process called speciation.
5. Evidence of Evolution
Evolutionary changes are observable in fossil records, anatomical structures, and
genetic information which demonstrate common ancestry and adaptation over time.
Evolution occurs through the interaction of genetic variation, natural selection, genetic
drift, and other factors, shaping life to adapt to changing environments and ensuring
biodiversity.
Explain how species diversity increases the probability of adaptation and survival of
organisms in changing environments
Species diversity plays a crucial role in increasing the probability of adaptation and
survival of organisms in changing environments.
A diverse species pool means that within any given population, there is a wide range of
genetic traits. This diversity provides a greater chance that some individuals will
possess characteristics suited to surviving in a changing environment. For example, if
an environmental change occurs (such as a new predator, a shift in climate, or a
disease outbreak), individuals with traits that confer resistance or better adaptability to
those changes are more likely to survive and reproduce. These traits are then passed
down to future generations, helping the species to adapt to the new conditions.
Higher species diversity creates more opportunities for natural selection to act. With a
greater variety of traits present in a population, the chances increase that one or more
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traits will be beneficial in the face of environmental changes. As those with favorable
traits survive and reproduce, these traits become more common in the population. For
example, in a population of animals, some may have more efficient metabolism that
helps them survive during a drought, while others may be better at resisting a specific
disease. Natural selection will favor those traits, allowing the population to adapt more
rapidly to new challenges.
4. Evolutionary Potential
With more diverse species, there's a larger genetic pool from which new adaptations
can emerge. When environmental pressures change, populations with diverse genetic
traits have a higher likelihood of containing individuals that can adapt to those
pressures. This evolutionary potential increases the chances of survival over the long
term, as diverse species are more flexible in responding to changes.
Diverse populations are less susceptible to being wiped out by environmental changes,
such as disease outbreaks, climate shifts, or habitat destruction. If a population is
genetically homogeneous (lacking diversity), it's more vulnerable to a single factor that
could impact the entire group. A diverse population, however, has a better chance of
survival because different genetic traits provide different ways to cope with or resist
changes in the environment.
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Species diversity ensures a broader range of traits that can improve survival and
adaptation to new conditions. The more genetically diverse a species is, the more likely
it is to have individuals with the necessary traits to survive environmental changes,
contributing to the resilience and long-term success of the population or ecosystem.
Theories of Evolution
Key Ideas:
Use and Disuse: Body parts that are frequently used become stronger, while those that
are not used deteriorate (e.g., giraffes' necks lengthened because they stretched to
reach high leaves).
•Inheritance of Acquired Traits: Traits acquired during an organism's lifetime could be
passed to offspring.
•Criticism: This theory has been largely discredited, as acquired traits (e.g., a muscular
body) are not encoded in DNA and cannot be inherited.
Key Ideas:
•Variation: Individuals in a population show variation in traits.
•Struggle for Existence: More offspring are produced than can survive, leading to
competition for resources.
•Survival of the Fittest: Individuals with favorable traits are more likely to survive and
reproduce.
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•Descent with Modification: Over generations, favorable traits become more common,
leading to the evolution of species.
Supported by evidence from fossil records, comparative anatomy, and genetic studies.
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