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Bioinformatics

Bioinformatics is the interdisciplinary field that combines biology, computer science, and mathematics to analyze biological data, particularly focusing on genomics and proteomics. Major tasks in bioinformatics include Next Generation Sequencing (NGS), structural bioinformatics, drug designing, phylogenetics, and software development. The field employs programming languages like Python and R, along with advanced mathematical algorithms and statistical models for data analysis.

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4 views2 pages

Bioinformatics

Bioinformatics is the interdisciplinary field that combines biology, computer science, and mathematics to analyze biological data, particularly focusing on genomics and proteomics. Major tasks in bioinformatics include Next Generation Sequencing (NGS), structural bioinformatics, drug designing, phylogenetics, and software development. The field employs programming languages like Python and R, along with advanced mathematical algorithms and statistical models for data analysis.

Uploaded by

Annaya Ch
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Question

Please provide a brief overview of bioinformatics.


what are your thoughts about it? What are the major
tasks we perform here?
Bioinformatics
The only definition of bioinformatics you get to know on the internet
or in your course slide is that bioinformatics is the integration of
computer science and biology or a marriage between biology and
programming. Another definition is sorting biological data using
computer science algorithms and programming.so these are some
basic definitions you get to know until you deep study about the
field and subjects.
this is multi-dimension field which consist of 3 major pillars, The
first one is genomic and proteomics side (About DNA, RNA, and
proteins), The second one is computer science (totally programing)
and the last one is math and statistics. The proteomics side deal
with alignment of sequences, phylogeny finding different conserved
domains etc. The computer side basically deals with algorithms to
solve biological data using different types of programming
language. Now a days popular languages are Python and R
scripting. The third domain math and statistics are essential tools in
bioinformatics now a days involves analyzing complex biological
networks using graph theory and other mathematical tools.
Genomic data requires advanced mathematical algorithms and
statistical models’ methods for data analysis.
Major tasks
The major task going so far in bioinformatics are.
1-NGS (Next Generation Sequencing)
DNA and RNA sequencing by using massively parallel sequencing
also know as High throughput sequencing (HTS).it allows rapid and
cost-effective sequencing. You can sequence the whole genome
and transcriptomes. In this approach the DNA is break down into
fragments, then fragments are amplified, and sequence then
aligned and assembled. 3 generation sequencing is also
introduced in which PCR step is missing direct go for sequencing.
2-Structural Bioinformatics
Analyze 3D structure of protein and other biological molecules to
study their function using different software.
3-Drug Designing
Trying to understand new diseases and designing a drug against
them using a knowledge of genomics and proteomics.
4-Phylogenetics
Phylogenetics is a graphical representation of evolutionary
relationships among different species .by using bioinformatics you
can predict these trees.
5-Software development
By using a knowledge of Programing, algorithms, and biology you
can also design a software of bioinformatics. which can help
biologists to do different tasks like sequencing, 3D modelling etc.
These are only few tasks there are a lot of more development going
on in bioinformatics.

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