Biomedical Engineering (BME) 1

BIOMEDICAL ENGINEERING (BME)

BME 100 BME 315
Introduction to the Profession Instrumentation and Measurement Laboratory
Introduces the student to the scope of the biomedical engineering Laboratory exercises stress instrumentation usage and data
profession and its role in society, and develops a sense of analysis used to determine physiological functions and variables
professionalism in the student. Provides an overview of biomedical and the relations to the physiological variability.
engineering through lectures, presentations by outside speakers, Prerequisite(s): ECE 211*, An asterisk (*) designates a course which
hands-on exercises, and scientific literature analyses. Develops may be taken concurrently.
professional communication and teamwork skills. Lecture: 0 Lab: 3 Credits: 2
Lecture: 1 Lab: 2 Credits: 2
Satisfies: Communications (C) BME 320
Fluids Laboratory
BME 200 Laboratory experiments in thermodynamics, biological fluid
Biomedical Engineering Computer Applications flow, and heat transfer. Emphasis is placed on current methods,
In this course, students will apply programming to solve quantitative instrumentation, and equipment used in biomedical engineering; oral
biomedical engineering problems across cell/tissue engineering, presentation of results; and on the writing of comprehensive reports.
neural engineering, and medical imaging. Students will also be Open only to Biomedical Engineering majors.
exposed to additional engineering and product development Corequisite(s): BME 301
programming tools and environments. Prerequisite(s): BIOL 117 and BME 315
Prerequisite(s): MATH 252* and CS 104, An asterisk (*) designates a Lecture: 0 Lab: 3 Credits: 1
course which may be taken concurrently. Satisfies: Communications (C)
Lecture: 1 Lab: 2 Credits: 2
BME 325
BME 301 Bioelectronics Laboratory
Bio-Fluid Mechanics Practical hands on design, construction and testing of electric and
Basic properties of fluids in motion. Lagrangian and Eulerian electronic circuitry for biomedical applications. Basic concepts
viewpoints, material derivative, streamlines. Continuity, energy, will be presented with emphasis on their relevance to the design of
angular and linear momentum equations in integral and differential systems that can be used for clinical and basic scientific research.
forms. Applications in biofluids and biomedical devices; rheology of Prerequisite(s): ECE 213* and BME 315, An asterisk (*) designates a
biological fluids. course which may be taken concurrently.
Corequisite(s): BME 320 Lecture: 0 Lab: 3 Credits: 1
Prerequisite(s): BIOL 115 and MATH 251 and MMAE 202
Lecture: 3 Lab: 0 Credits: 3 BME 330
Analysis of Biosignals and Systems
BME 309 This course is a junior level introduction to the theoretical and
Biomedical Imaging practical aspects of signal processing and dynamic systems
An introduction to biomedical imaging concepts and modalities. behavior as they relate to physiological, biological, and biomedical
Topics covered include general principles of image science (image systems. The topics covered will include sampling theory,
quality, sampling, etc.), X-ray-based imaging [conventional x-ray continuous and discrete Fourier transforms and series, Laplace
imaging, mammography, computed tomography (CT), and digital transforms, Linear systems theory, signal filtering, models of
subtraction angiography (DSA)], and nuclear medicine [gamma biological and physiological systems, and analysis of dynamic and
camera, single photon emission computed tomography (SPECT), feedback systems.
and positron emission tomography (PET)]. Prerequisite(s): ECE 211 and MATH 252
Prerequisite(s): (BME 330* or ECE 308*) and PHYS 221, An asterisk Lecture: 3 Lab: 0 Credits: 3
(*) designates a course which may be taken concurrently.
Lecture: 3 Lab: 0 Credits: 3 BME 331
Modeling and Control of Biological Systems
BME 310 The course expands upon the systems and signal processing
Biomaterials concepts introduced in BME 330 to develop the tools to model
Applications of biomaterials in different tissue and organ systems. physiological processes and the feedback control of these
Relationship between physical and chemical structure of materials processes.
and biological system response. Choosing, fabricating, and Prerequisite(s): (BME 330 or ECE 308) and BME 422
modifying materials for specific biomedical applications. Lecture: 3 Lab: 0 Credits: 3
Prerequisite(s): CHEM 125 and PHYS 123
Lecture: 3 Lab: 0 Credits: 3
Satisfies: Communications (C)
2 Biomedical Engineering (BME)

BME 335 BME 418

Thermodynamics of Living Systems Reaction Kinetics for BME
Principles of thermodynamics and conservation of mass applied This course focuses on analysis of rate data and single and
to living systems and biomedical devices. The first and second multiple reaction schemes. Biomedical topics include biological
laws of thermodynamics, pHs and chemical equilibrium, metabolic systems, enzymatic pathways, enzyme and receptor-ligand kinetics,
stoichiometry and energetics. pharmacokinetics, heterogeneous reactions, microbial cell growth
Prerequisite(s): MATH 251 and CHE 202 and product formation, and the design and analysis of biological
Lecture: 3 Lab: 0 Credits: 3 reactors.
Prerequisite(s): BME 335 and MATH 252
BME 402 Lecture: 3 Lab: 0 Credits: 3
Introduction to Regulatory Science for Engineers
Engineers must be equipped to answer the growing demands for BME 419
new medical technologies. Introduction to Regulatory Science Introduction to Design Concepts in Biomedical Engineering
teaches engineers how the regulated environment impacts the Introduction to Design Concepts in Biomedical Engineering. This
design, testing. and delivery of medical devices. It will equip course aims to educate students on project definition, and on the
students with the essential skills and tools critical to the practice design, development and technology transfer of potential biomedical
of engineering in the medical device industry. In this course, products in the context of the student's major capstone project.
students will be exposed to the core concepts, processes, and tools Students will learn best practices for designing a marketable
surrounding the global medical device regulatory framework, and medical device, including the design process from the clinical
will gain foundational knowledge for the practical application of problem definition through prototype and clinical testing to market
regulations throughout the product development lifecycle. From readiness.
knowledge gained in the class, students will be expected to work Prerequisite(s): BME 320 or BME 325
in teams and use critical thinking, data analysis and interpretation Lecture: 2 Lab: 0 Credits: 2
skills to research, evaluate, and present a scientific, technical, and Satisfies: Communications (C)
legally justifiable approach for the global introduction of a new
medical device. BME 420
Lecture: 3 Lab: 0 Credits: 3 Design Concepts in Biomedical Engineering
An introduction to the strategies and fundamental bioengineering
BME 405 design criteria behind the development of biomedical engineering
Physiology Laboratory systems and implantable devices that use either synthetic materials
A laboratory course which demonstrates basic concepts of or hybrid (biological-synthetic)systems. Analysis and design of
bioengineering design through experimental procedures involving replacements for the heart, kidneys, and lungs. Specification and
humans and experimental animals. Statistical principles of realization of structures for artificial organ systems. Students will be
experimental design. Study of possible errors. Experiments required to complete a team-oriented design project in their chosen
include nerve action, electrocardiography, mechanics of muscle, track.
membranes, and noninvasive diagnostics in humans. Open only to Prerequisite(s): BME 419
Biomedical Engineering majors. Lecture: 3 Lab: 0 Credits: 3
Corequisite(s): BME 453 Satisfies: Communications (C)
Prerequisite(s): BME 315
Lecture: 0 Lab: 3 Credits: 2 BME 422
Mathematical Methods for Biomedical Engineers
BME 417 This course integrates mathematical and computational tools that
Technologies for Treatment of Diabetes address directly the needs of biomedical engineers. The topics
Study of physiological control systems and engineering of external covered include the mathematics of diffusion, pharmacokinetic
control of biological systems by focusing on an endocrine system models, biological fluid mechanics, and biosignal representations
disorder -- diabetes. The effects of type 1 diabetes on glucose and analysis. The use of MATLAB will be emphasized for
homeostasis and various treatment technologies for regulation numerically solving problems of practical relevance.
of glucose concentration. Development of mathematical models Prerequisite(s): ((MATH 252 and CS 104) or Graduate standing) and
describing the dynamics of glucose and insulin concentration (BME 330* or ECE 308*), An asterisk (*) designates a course which
variations, blood glucose concentration measurement and inference may be taken concurrently.
techniques, insulin pumps, and artificial pancreas systems. Lecture: 3 Lab: 0 Credits: 3
Lecture: 3 Lab: 0 Credits: 3
 Biomedical Engineering (BME) 3

BME 423 BME 427

Cell Biomechanics: Principles and Biological Processes Extracellular Matrix Biology
This course will provide students an opportunity to learn about The Extra Cellular Matrix (ECM) is that which connects cells in
mechanical forces that develop in the human body and how they tissues and provides much of the organization and support in
can influence cell functions in a range of biological processes almost every tissue and or organ system of the body. Thus the aim
from embryogenesis, wound healing, and regenerative medicine of this course is to give students insights into ECM biology and its
to pathological conditions such as cancer invasion. Examples of relevance to modern medicine and biomedical (tissue) engineering.
research methods for investigating cell biomechanics in various A significant portion of working population is suffering from ECM-
biological systems will be discussed. related maladies, and the focus of research has shifted into creating
Prerequisite(s): BME 301 ECM implants. The ECM implant market is growing rapidly. For
Lecture: 3 Lab: 0 Credits: 3 instance, the collagen meniscus implant market was reported to be
at $308.6 million in 20181. Understanding the implications of the
BME 424 molecular biology of ECM to feed into this research is highly relevant
Quantitative Aspects of Cell and Tissue Engineering for students considering careers (academic and industry) in life
This course is designed to cover fundamentals of cell and sciences in industry, academia and healthcare. Extracellular Matrix
tissue engineering from a quantitative perspective. Topics (ECM) is a highly complex system in mammalian biology responsible
addressed include elements of tissue development, cell growth for structural support and functional (biochemical) signals for
and differentiation, cell adhesion, migration, molecular and cellular physiology. Specific amino acid sequences on the various ECM
transport in tissues and polymeric hydrogels for tissue engineering elements are responsible to trigger intra- and extracellular cascades
and drug delivery applications. leading to cell division, proliferation, tissue regeneration, wound
Prerequisite(s): BME 482 and BME 418 healing and inflammation. This course will focus on the following
Lecture: 3 Lab: 0 Credits: 3 key concepts: a) Gene expression, structure and function of various
ECM proteins and complexes and the physiological processes.
BME 425 b) Etiology and the molecular progression of diseases caused by
Introduction to Medical Devices, BioMEMS and Microfluidics abnormalities to ECM proteins. c) Mechanobiology of various ECM
This course will present fundamentals and applications of medical proteins. d) Structure function and mechanical function of ECM
devices, BioMEMS, and microfluidic technologies for applications interfaces with other tissues (muscle, bone, skin etc.) e) Implications
in the broad health and biomedical engineering. It will provide for tissue engineering and development of novel biomimetic and
a broad view of the general field and a knowledge of relevant biological ECM implants.
fabrication methods and analysis techniques. Fabrication and Lecture: 750 Lab: 0 Credits: 3
analytical techniques, interfacing with biological materials, and
techniques for analyte detection will be emphasized. The course will BME 428
include individual projects and critical paper reviews in which each Engineering World Health
student will be encouraged to master basic concepts in design and This course covers the major types of medical equipment,
fabrication for devices for specific applications. including the principles of operation, the physiology underlying
Lecture: 3 Lab: 0 Credits: 3 the measurement, the major functional (system) pieces for each
instrument, and typical problems/applications of each instrument.
Special focus is placed on making reliable and safe repairs in a
low resource setting: Troubleshooting, creative problem solving,
calibration and testing. Laboratory sessions will focus on learning
hands on and technical knowledge required for completing basic
electronic and mechanical repairs. Basic electronics through
simple power supply design will be covered. Over the course of the
semester, the class will travel to a hospital or training laboratory to
troubleshoot and repair medical equipment as a group.
Prerequisite(s): MATH 152 and PHYS 221
Lecture: 3 Lab: 0 Credits: 3

BME 431
Modern Optics and Lasers
This is an undergraduate course covering the basics of optics and
modern aspects of the field such as lasers and nonlinear optics.
Connections to other fields such as acoustics, microwaves, electron-
beam optics, quantum mechanics will be pointed out. The theory
will be supplemented with demonstration experiments of optical
phenomena. Practical problems will be discussed such as the
design of an optical imaging system or precision interferometry.
Prerequisite(s): PHYS 221 or Graduate standing
Lecture: 3 Lab: 0 Credits: 3
4 Biomedical Engineering (BME)

BME 433 BME 445

Biomedical Engineering Applications of Statistics Quantitative Neural Function
Application of modern computing methods to the statistical analysis Computational approach to basic neural modeling and function,
of biomedical data. Sampling, estimation, analysis of variance, including cable theory, ion channels, presynaptic potentials,
and the principles of experimental design and clinical trials are stimulation thresholds, and nerve blocking techniques. Synaptic
emphasized. function is examined at the fundamental level.
Prerequisite(s): MATH 251 Prerequisite(s): BME 453
Lecture: 3 Lab: 0 Credits: 3 Lecture: 3 Lab: 0 Credits: 3

BME 437 BME 450

Introduction to Molecular Imaging Animal Physiology
This course provides an overview of molecular imaging, a Respiration; circulation; energy metabolism; temperature regulation;
subcategory of medical imaging that focuses on noninvasively water and osmotic regulation; digestion and excretion; muscle and
imaging molecular pathways in living organisms. Topics include movement; nerve excitation; information control and integration;
imaging systems, contrast agents, reporter genes and proteins, chemical messengers. Emphasis on general principles with
tracer kinetic modeling. Preclinical and clinical applications will also examples drawn from various animal phyla. Same as BIOL 430.
be discussed with an emphasis on cancer and the central nervous Prerequisite(s): BIOL 107 or BIOL 115 or Graduate standing
system. Lecture: 3 Lab: 0 Credits: 3
Prerequisite(s): BME 422
Lecture: 3 Lab: 0 Credits: 3 BME 452
Control Systems for Biomedical Engineers
BME 438 Control systems design and analysis in biomedical engineering.
Neuroimaging Time and frequency domain analysis, impulse vs. step response,
This course describes the use of different imaging modalities open vs. closed loop response, stability, adaptive control, system
to study brain function and connectivity. The first part of the modeling. Emphasis is on understanding physiological control
course deals with brain function. It includes an introduction to systems and the engineering of external control of biological
energy metabolism in the brain, cerebral blood flow, and brain systems.
activation. It continues with an introduction to magnetic resonance Prerequisite(s): BME 330
imaging (MRI), perfusion-based fMRI, BOLD fMRI, fMRI paradigm Lecture: 3 Lab: 0 Credits: 3
design and statistical analysis, introduction to positron emission
tomography (PET) and studying brain function with PET, introduction BME 453
to magneto encephalography and studying brain function with Quantitative Physiology
(MEG). The second part of the course deals with brain connectivity. This course provides a quantitative approach to fundamental
It includes an introduction to diffusion tensor MRI, explanation to physiological principles and systems. The course covers basic cell
the relationship between the diffusion properties of tissue and its physiology, membrane transport, action potentials and excitable
structural characteristics, white matter fiber tractography. tissue, and skeletomuscular, nervous, cardiovascular, respiratory,
Prerequisite(s): PHYS 221 renal, and endocrine systems.
Lecture: 3 Lab: 0 Credits: 3 Corequisite(s): BME 405
Prerequisite(s): BIOL 115
BME 439 Lecture: 3 Lab: 0 Credits: 3
Advanced Medical Imaging
This course introduces advanced clinical imaging modalities, BME 455
research imaging techniques, and concepts from image science Cardiovascular Fluid Mechanics
and image perception. The first part of the course introduces the Anatomy of the cardiovascular system. Scaling principles. Lumped
perception of image data by human observers and the visualization parameter, one-dimensional linear and nonlinear wave propagation,
of brain structure and function. It includes an introduction to and three-dimensional modeling techniques applied to simulate
magnetic resonance imaging (MRI) and a survey of neurological blood flow in the cardiovascular system. Steady and pulsatile
imaging via functional MRI (fMRI). The second part of the course flow in rigid and elastic tubes. Form and function of blood, blood
covers image science, clinical imaging applications, and novel vessels, and the heart from an engineering perspective. Sensing,
research imaging techniques. It includes an introduction to radiation feedback, and control of the circulation. Possible project using
detection and image quality evaluation, a survey of clinical cases, custom software to run blood flow simulations. Same as MMAE 455.
and an overview of new imaging methods. Prerequisite(s): BME 301 or MMAE 310 or MMAE 313 or Graduate
Prerequisite(s): BME 309 standing
Lecture: 3 Lab: 0 Credits: 3 Lecture: 3 Lab: 0 Credits: 3

BME 443
Biomedical Instrumentation and Electronics
Principles of circuit analysis are applied to typical transducer and
signal recording situations found in biomedical engineering.
Prerequisite(s): (BME 315 and ECE 211) or Graduate standing
Lecture: 3 Lab: 0 Credits: 3
 Biomedical Engineering (BME) 5

BME 475 BME 497

Neuromechanics of Human Movement Special Problems
Concepts from mechanics and neurophysiology will be introduced Design, development, analysis or research on special topics defined
and employed to analyze and model human movement, especially of by a faculty member or the department. **Instructor permission
the extremities. Topics will include forward and inverse kinematics required.**
and dynamics, muscle modeling, and feedback control. Lecture: 0 Lab: 3 Credits: 3
Prerequisite(s): BME 330 or ECE 308 or MMAE 305 or Graduate
standing BME 500
Lecture: 3 Lab: 0 Credits: 3 Introduction to Biomedical Engineering
Introduction to the concepts and research in biomedical
BME 482 engineering. Provides an overview of current biomedical engineering
Mass Transport for Biomedical Engineers research areas, emphasis on application of an engineering approach
This course seeks to provide students with an introduction to to medicine and physiology signals. The focus is on connecting
advanced concepts of mass transport with an emphasis on theory with practice: students are expected to critically analyze
biological systems. Students will be exposed to derivation of the research manuscripts and perform corresponding analysis on
conservation equations for heat, mass, and momentum. Following relevant biomedical data.
derivation of these laws, focus will be placed on mass transport Lecture: 2 Lab: 0 Credits: 2
applications, including diffusion, convection-diffusion, diffusion with
reactions, and facilitated diffusion. Students will be able to apply BME 501
mass transport equations to solve problems in biological systems. Communication Skills in BME
Prerequisite(s): BME 301 and CHE 202 Students will be taught to communicate biomedical engineering
Lecture: 3 Lab: 0 Credits: 3 research findings through written, poster, and oral presentation
formats. Masters of Science with Thesis and PhD program students
BME 490 will be required to present their own research annually at the BME
Senior Seminar Seminar while enrolled in their thesis program.
Professional issues in bioengineering. Role of bioengineers in Lecture: 1 Lab: 0 Credits: 1
industry. Professional identity. Structure of bioengineering industries
and product development process. Job market analysis. Current BME 502
employment opportunities. Recruiting process and interview. Introduction to Regulatory Science for Engineers
Analysis of employer. Marketing versus engineering. Management Engineers must be equipped to answer the growing demands for
by objective. Role of higher degrees. new medical technologies. Introduction to Regulatory Science
Lecture: 1 Lab: 0 Credits: 1 teaches engineers how the regulated environment impacts the
Satisfies: Communications (C) design, testing. and delivery of medical devices. It will equip
students with the essential skills and tools critical to the practice
BME 491 of engineering in the medical device industry. In this course,
Independent Study students will be exposed to the core concepts, processes, and tools
Focused reading and study under the supervision of a BME surrounding the global medical device regulatory framework, and
faculty member. A final written report is required to receive credit. will gain foundational knowledge for the practical application of
**Instructor permission required.** regulations throughout the product development lifecycle. From
Credit: Variable knowledge gained in the class, students will be expected to work
Satisfies: Communications (C) in teams and use critical thinking, data analysis and interpretation
skills to research, evaluate, and present a scientific, technical, and
BME 492 legally justifiable approach for the global introduction of a new
Undergraduate Research medical device.
Independent research (experimental or theoretical/computational) Lecture: 3 Lab: 0 Credits: 3
under the supervision of a BME faculty member. A final written
report is required to receive credit. **Instructor permission BME 503
required.** Mathematical and Statistical Methods for Neuroscience I
Credit: Variable This quarter introduces mathematical ideas and techniques in
Satisfies: Communications (C) a neuroscience context. Topics will include some coverage of
matrices and complex variables; eigen value problems, spectral
BME 493 methods and Greens functions for differential equations; and some
BME Undergraduate Project discussion of both deterministic and probabilistic modeling in the
Research or design projecting involving 2 or more students under neurosciences. Instructor permission required.
supervision of a BME faculty member. A final written report from Lecture: 2 Lab: 0 Credits: 2
each student is required to receive credit. **Instructor permission
required.**
Lecture: 3 Lab: 0 Credits: 3
6 Biomedical Engineering (BME)

BME 504 BME 509

Neurobiology Vertebrate Neural Systems
This course is concerned with the structure and function of systems This lab-centered course teaches students the fundamental
of neurons, and how these are related to behavior. Common patterns principles of mammation neuroanatomy. Students learn the major
of organization are described from the anatomical, physiological, structures and the basic circuitry of the CNS and PNS. Students
and behavioral perspectives of analysis. The comparative approach become practiced at recognizing the nuclear organization and
is emphasized throughout. Laboratories include exposure to cellular architecture of many regions in animal brain models. This
instrumentation and electronics, and involve work with live course is taught at the University of Chicago. Instructor permission
animals. A central goal of the laboratory is to expose students to required.
in vivo extracellular electrophysiology in vertebrate preparations. Lecture: 3 Lab: 0 Credits: 3
Laboratories will be attended only on one day a week but may run
well beyond the canonical period. Instructor permission required. BME 510
Lecture: 2 Lab: 0 Credits: 2 Neurobiology of Disease I
This seminar course is devoted to basic clinical and pathological
BME 505 features and pathogenic mechanisms of neurological diseases. The
Mathematical and Statistical Methods for Neuroscience II first semester is devoted to a broad set of disorders ranging from
This quarter treats statistical methods important in understanding developmental to acquired disorders of the central and peripheral
nervous system function. It includes basic concepts of nervous system. Weekly seminars are given by experts in the
mathematical probability; information theory, discrete Markov clinical and scientific aspects of the disease under discussion.
processes, and time series. Instructor permission required. For each lecture, students are given a brief description of clinical
Prerequisite(s): BME 503 with min. grade of C and pathological features of a given set of neurological diseases
Lecture: 2 Lab: 0 Credits: 2 followed by a more detailed description of the current status of
knowledge of several of the prototypic pathogenic mechanisms.
BME 506 Lecture: 2 Lab: 0 Credits: 2
Computational Neuroscience II: Vision
This course considers computational approaches to vision. It BME 511
discusses the basic anatomy and physiology of the retina and Extracellular Matrices: Chemistry and Biology
central visual pathways, and then examines computational Advanced topics dealing with the biology and chemistry of
approaches to vision based on linear and non-linear systems theory, the extracellular matrix, cell-matrix interactions, and current
and algorithms derived from computer vision. methodologies for engineering these interfaces.
Lecture: 3 Lab: 0 Credits: 3 Lecture: 2 Lab: 0 Credits: 2

BME 507 BME 512

Cognitive Neuroscience Behavioral Neurosciences
This course is concerned with the relationship of the nervous This course is concerned with the structure and function of systems
system to higher order behaviors such as perception and encoding, of neurons and how these are related to behavior. Common patterns
action, attention and learning and memory. Modern methods of of organization are described from the anatomical, physiological,
imaging neural activity are introduced, and information theoretic and behavioral perspectives of analysis. The comparative approach
methods for studying neural coding in individual neurons and is emphasized throughout. Laboratories include exposure to
populations of neurons are discussed. Instructor permission instrumentation and electronics and work involvement with live
required. animals.
Lecture: 2 Lab: 0 Credits: 2 Lecture: 2 Lab: 0 Credits: 2

BME 508 BME 513

Mathematics and Statistics for Neuroscience III Methods of Computational Neuroscience: Single Neurons
This course covers more advanced topics including perturbation Topics include, but are not limited to, Hodgkin-Huxley equations,
and bifurcation methods for the study of dynamical systems, cable theory, single neuron models, information theory, signal
symmetry methods, and some group theory. A variety of applications detection theory, reverse correlation, relating neural responses to
to neuroscience with be described. Instructor permission required. behavior, and rate versus temporal codes. Instructor permission is
Prerequisite(s): BME 505 with min. grade of C and BME 503 with required.
min. grade of C Lecture: 3 Lab: 0 Credits: 3
Lecture: 2 Lab: 0 Credits: 2
 Biomedical Engineering (BME) 7

BME 516 BME 522

Biotechnology for Engineers Mathematical Methods in Biomedical Engineering
This course will provide students opportunity to learn about the Graduate standing in BME or consent of instructor This course is
field of biotechnology and how to apply engineering principles to an introductory graduate level course that integrates mathematical
biological systems and living organisms for betterment of medicines and computational tools that address directly the needs of
as well as agricultural products. The course covers the introduction biomedical engineers. The topics covered include the mathematics
to biotechnology with information about cell and molecular biology, of diffusion, pharmacokinetic models, biological fluid mechanics,
the role of enzyme and growth kinetics, media preparations for cell and biosignal representations and analysis. The use of MATLAB
culture and various chromatographic techniques, and antibiotics will be emphasized for numerically solving problems of practical
and its role in secondary metabolic production. Biological effluent relevance.
treatment and regulatory issues to obtain FDA will be taught. Lecture: 3 Lab: 0 Credits: 3
Instructor permission is required.
Lecture: 3 Lab: 0 Credits: 3 BME 523
Cell Biomechanics: Principles and Biological Processes
BME 517 This course will provide students an opportunity to learn about
Technologies for Treatment of Diabetes mechanical forces that develop in the human body and how they
Study of physiological control systems and engineering of external can influence cell functions in a range of biological processes
control of biological systems by focusing on an endocrine system from embryogenesis, wound healing, and regenerative medicine
disorder -- diabetes. The effects of type 1 diabetes on glucose to pathological conditions such as cancer invasion. Examples of
homeostasis and various treatment technologies for regulation research methods for investigating cell biomechanics in various
of glucose concentration. Development of mathematical models biological systems will be discussed. Permission of instructor is
describing the dynamics of glucose and insulin concentration required.
variations, blood glucose concentration measurement and inference Lecture: 3 Lab: 0 Credits: 3
techniques, insulin pumps, and artificial pancreas systems.
Lecture: 3 Lab: 0 Credits: 3 BME 524
Quantitative Aspects of Cell andTissue Engineering
BME 518 This course is designed to cover fundamentals of cell and
Reaction Kinetics for Biomedical Engineering tissue engineering from a quantitative perspective. Topics
This course is an introduction to the fundamentals of chemical addressed include elements of tissue development, cell growth
kinetics. Analysis of rate data; single and multiple reaction and differentiation, cell adhesion, migration, molecular and cellular
schemes. Biomedical topics include biological systems, enzymatic transport in tissues and polymeric hydrogels for tissue engineering
pathways, enzyme and receptor-ligand kinetics, pharmacokinetics, and drug delivery applications.
heterogeneous reactions, microbial cell growth and product Lecture: 3 Lab: 0 Credits: 3
formation, and the design and analysis of biological reactors.
Corequisite(s): BME 482 BME 525
Prerequisite(s): BME 301 and MATH 252 and BME 335 Introduction to Medical Devices, BioMEMS and Microfluidics
Lecture: 3 Lab: 0 Credits: 3 This course will present fundamentals and applications of medical
devices, BioMEMS, and microfluidic technologies for applications
BME 519 in the broad health and biomedical engineering. It will provide
Cardiovascular Fluid Mechanics a broad view of the general field and a knowledge of relevant
Anatomy of the cardiovascular system. Scaling principles. Lumped fabrication methods and analysis techniques. Fabrication and
parameter, one-dimensional linear and nonlinear wave propagation, analytical techniques, interfacing with biological materials, and
and three-dimensional modeling techniques applied to simulate techniques for analyte detection will be emphasized. The course will
blood flow in the cardiovascular system. Steady and pulsatile flow include individual projects and critical paper reviews in which each
in rigid and elastic tubes. Form and function of blood, blood vessels, student will be encouraged to master basic concepts in design and
and the heart from an engineering perspective. Sensing, feedback, fabrication for devices for specific applications.
and control of the circulation. Includes a student project. Lecture: 3 Lab: 0 Credits: 3
Lecture: 3 Lab: 0 Credits: 3
BME 526
BME 521 Advanced Biomedical Engineering Design
Medical Imaging This course aims to educate students on project definition, and
Study of modern technology for medical imaging. Theory and on the design, development, and technology transfer of potential
operation of CAT, SPECT, PET, MRI, X-ray and echo imaging biomedical products in the context of the student's major capstone
modalities. project. Students will learn best practices for designing a marketable
Lecture: 3 Lab: 0 Credits: 3 medical device, including the design process from the clinical
problem definition through prototype and clinical testing to market
readiness. Permission from instructor is required.
Lecture: 3 Lab: 0 Credits: 3
8 Biomedical Engineering (BME)

BME 527 BME 530

Extracellular Matrix Biology Inverse Problems in Biomedical Imaging
This course is a the same as the BME 427 Extracellular Matrix This course will introduce graduate students to the mathematical
Biology course that has been approved for banner listing for theory of inverse problems. Concept from functional analysis will
Summer 2020. BME527 is the same class to extend this course to be applied for understanding and characterizing mathematical
graduate students. The Extra Cellular Matrix (ECM) is that which properties of inverse problems. This will permit for the analysis
connects cells in tissues and provides much of the organization of the stability and resolution of image reconstruction algorithms
and support in almost every tissue and or organ system of the for various existing and novel biomedical imaging systems. The
body. Thus the aim of this course is to give students insights into singular value decomposition (SVD) is introduced and applied for
ECM biology and its relevance to modern medicine and biomedical understanding fundamental properties of imaging systems and
(tissue) engineering. A significant portion of working population reconstruction algorithms. Instructor permission required.
is suffering from ECM-related maladies, and the focus of research Lecture: 3 Lab: 0 Credits: 3
has shifted into creating ECM implants. The ECM implant market
is growing rapidly. For instance, the collagen meniscus implant BME 532
market was reported to be at $308.6 million in 20181. Understanding Medical Imaging Science
the implications of the molecular biology of ECM to feed into This course is an introduction to basic concepts in medical
this research is highly relevant for students considering careers imaging, such as: receiver operating characteristics, the rose model,
(academic and industry) in life sciences in industry, academia point spread function and transfer function, covariance and auto
and healthcare. Extracellular Matrix (ECM) is a highly complex covariance, noise, filters, sampling, aliasing, interpolation, and image
system in mammalian biology responsible for structural support registration. Instructor permission required.
and functional (biochemical) signals for physiology. Specific amino Lecture: 3 Lab: 0 Credits: 3
acid sequences on the various ECM elements are responsible to
trigger intra- and extracellular cascades leading to cell division, BME 533
proliferation, tissue regeneration, wound healing and inflammation. Biostatistics
This course will focus on the following key concepts: a) Gene This course is designed to cover the tools and techniques of
expression, structure and function of various ECM proteins and modern statistics with specific applications to biomedical and
complexes and the physiological processes. b) Etiology and the clinical research. Both parametric and nonparametric analysis will
molecular progression of diseases caused by abnormalities to be presented. Descriptive statistics will be discussed although
ECM proteins. c) Mechanobiology of various ECM proteins. d) emphasis is on inferential statistics and experimental design.
Structure function and mechanical function of ECM interfaces with Lecture: 3 Lab: 0 Credits: 3
other tissues (muscle, bone, skin etc.) e) Implications for tissue
engineering and development of novel biomimetic and biological BME 535
ECM implants. Magnetic Resonance Imaging
Lecture: 3 Lab: 0 Credits: 3 This is an introduction to the Physics and technology of magnetic
resonance imaging (MRI). the topics that are covered include:
BME 528 basic MR physics, source of signal, signal acquisition, pulse
Engineering World Health sequences, hardware, artifacts, spectroscopy, and advanced imaging
This course covers the major types of medical equipment, techniques. Instructor permission required.
including the principles of operation, the physiology underlying Lecture: 3 Lab: 0 Credits: 3
the measurement, the major functional (system) pieces for each
instrument, and typical problems/applications of each instrument. BME 537
Special focus is placed on making reliable and safe repairs in a Introduction to Molecular Imaging
low resource setting: Troubleshooting, creative problem solving, This course provides an overview of molecular imaging, a
calibration and testing. Laboratory sessions will focus on learning subcategory of medical imaging that focuses on noninvasively
hands on and technical knowledge required for completing basic imaging molecular pathways in living organisms. Topics include
electronic and mechanical repairs. Basic electronics through imaging systems, contrast agents, reporter genes and proteins,
simple power supply design will be covered. Over the course of the tracer kinetic modeling. Preclinical and clinical applications will also
semester, the class will travel to a hospital or training laboratory to be discussed with an emphasis on cancer and the central nervous
troubleshoot and repair medical equipment as a group. system.
Prerequisite(s): MATH 152 and PHYS 221 Lecture: 3 Lab: 0 Credits: 3
Lecture: 3 Lab: 0 Credits: 3

BME 529
Design of Pharmaceutical Protein Formulations
This course introduces the discovery and development of
pharmaceutical proteins and vaccines. The course focuses on
understanding protein structure physical and chemical stability
and identifying the cause of degradation processes in protein-
based pharmaceutical products. Additionally, this course deals with
vaccine-based formulations and their manufacturing process.
Lecture: 3 Lab: 0 Credits: 3
 Biomedical Engineering (BME) 9

BME 538 BME 543

Neuroimaging Bioinstrumentation and Electronics
This course describes the use of different imaging modalities to Principles of circuit analysis are applied to typical transducer
study brain function and connectivity. The first part of the course and signal recording situations found in biomedical engineering.
deals with brain function. It includes an introduction to energy Basic electrical and electronic circuit theory is reviewed with an
metabolism in the brain, cerebral blood flow, and brain activation. emphasis on biomedical measurement applications. a special topic
It continues with an introduction to magnetic resonance imaging is individually studied by the student and presented to the class
(MRI), perfusion-based fMRI, Bold fMRI, fMRI paradigm design and electrical physics class or basic circuits.
statistical analysis, introduction to positron emission tomography, Lecture: 3 Lab: 0 Credits: 3
(PET) and studying brain function with PET, introduction to
magneto encephalography (MEG) and studying brain function BME 545
with MEG. The second part of the deals with brain connectivity. It Quantitative Neural Function
includes an introduction to diffusion tensor MRI, explanation of the Computational approach to basic neural modeling and function,
relationship between the diffusion properties of tissue its structural including cable theory, ion channels, presynaptic potentials,
characteristics, and white matter fiber tractography techniques. stimulation thresholds, and nerve blocking techniques. Synaptic
Instructor permission required. function is examined at the fundamental level.
Lecture: 3 Lab: 0 Credits: 3 Prerequisite(s): BME 453 with min. grade of C or BME 553* with min.
grade of C, An asterisk (*) designates a course which may be taken
BME 539 concurrently.
Advanced Medical Imaging Lecture: 3 Lab: 0 Credits: 3
This course introduces advanced clinical imaging modalities,
research imaging techniques, and concepts from image science BME 551
and image perception. The first part of the course introduces the Physiological Signal Processing and Control Theory
perception of image data by human observers and the visualization This is the first of a 2 part course co-taught at IIT and the University
of brain structure and function. It includes an introduction to of Chicago. essential elements of signal processing and control
magnetic resonance imaging (MRI) and a survey of neurological theory as it is applied to physiological systems will be covered.
imaging via functional MRI (fMRI). The second part of the course Part I will cover data acquisition and sampling, Laplace and
covers image science, clinical imaging applications, and novel Fourier transforms, filtering, time and frequency domains, system
research imaging techniques. It includes an introduction to radiation descriptions and lumped vs. distributed parameters. Students will
detection and image quality evaluation, a survey of clinical cases, use Mat lab to test concepts presented in class.
and an overview of new imaging methods. Lecture: 2 Lab: 0 Credits: 2
Lecture: 3 Lab: 0 Credits: 3
BME 552
BME 540 Control Systems for Biomedical Engineers
Wave Physics and Applied Optics for Imaging Scientists Control systems design and analysis in biomedical engineering.
This course will introduce students to fundamental concepts Time and frequency domain analysis, impulse vs. step response,
in wave physics and the analysis of optical wave fields. These open vs. closed loop response, stability, adaptive control, system
principles will be utilized for understanding existing and novel modeling. Emphasis is on understanding physiological control
imaging methods that employ coherent radiation. Solutions to systems and the engineering of external control of biological
inverse scattering and inverse source problems will be derived and systems.
algorithmic realizations of the solutions will be developed. Phase Lecture: 3 Lab: 0 Credits: 3
contrast imaging techniques and X-ray imaging systems that employ
coherent radiation will be studied. Instructor permission required. BME 553
Lecture: 3 Lab: 0 Credits: 3 Advanced Quantitative Physiology
The main systems that control the human body functions will be
BME 542 reviewed to enable the students to understand the individual role of
Advanced Concepts in Image Science each major functional system as well as the need for the integration
This graduate level course introduces students to fundamental or coordination of the activities of the various systems.
concepts in image science that are related to the optimization Lecture: 3 Lab: 0 Credits: 3
and evaluation of biomedical imaging systems. Topics covered
include: deterministic descriptions of imaging systems, stochastic
descriptions of imaging systems, statistical decision theory, and
objective assessment of image quality.
Prerequisite(s): BME 532 with min. grade of C and BME 530 with
min. grade of C
Lecture: 3 Lab: 0 Credits: 3
10 Biomedical Engineering (BME)

BME 560 BME 585

Methods in Biomedical Data Science Computational Models of the Human Cardiovascular System
The course provides an overview of predictive and descriptive This course will focus on the use of computational fluid dynamics
statistical modeling methods for large biomedical datasets. for the modeling and analysis of the human cardiovascular system.
Building on undergraduate-level knowledge of statistics, the course The course will cover both computational methods for fluid
introduces Bayes and information theory, develops from these dynamics and biomedical aspects of the human cardiovascular
modeling algorithms and provides a series of biomedical application system. Computer models for the simulation and analysis
areas. Methods include meta-analytic techniques, linear and non- of hemodynamic phenomena will be developed. Requires an
linear dimensionality reduction, traditional “non-deep” predictive Introductory fluid dynamics.
tools (e.g. perceptron, support vector machines, logistic regression, Lecture: 3 Lab: 0 Credits: 3
decision trees, boosting, etc.), and some applications of deep neural
networks. Application areas may include medical imaging (e.g. BME 591
image segmentation), EEG and ECG signal analysis (e.g. anomaly Research and Thesis for Master of Science Degree
detection), genetics (e.g. imputation methods, polygenic risk score Research and thesis for master of science degree students.
computation, cell-free DNA analysis, etc.). Each course module Instructor permission required.
involves analysis of real data using existing modeling libraries Credit: Variable
and students’ own implementation. The predictive results may be
compared to the state-of-the-art for each example dataset to assess BME 594
the usefulness of the models. (3-0-3) Special Projects
Prerequisite(s): (MATH 225 or BME 433 or CHE 426) and (MATH 332 Special projects.
or MATH 333) Credit: Variable
Lecture: 3 Lab: 0 Credits: 3
BME 595
BME 575 Seminar in Biomedical Engineering
Neuromechanics of Human Movement Current research and development topics in biomedical engineering
This course will explore how we control movement of our as presented by outside speakers, faculty and advanced students.
extremities, with concepts drawn from mechanics and Lecture: 0 Lab: 1 Credits: 1
neurophysiology. The progression from neurological signals to
muscle activation and resulting movement of the hand or foot will BME 597
be modeled, starting at the periphery and moving back toward the Special Problems
central nervous system. Biomechanics of the limbs will be modeled Special problems.
using dynamic simulation software (Working Model) which will be Credit: Variable
driven by a neural controller, implemented in MATLAB. Issues related
BME 691
to sensory feedback and redundancy will be addresses.
Research and Thesis PHD
Lecture: 3 Lab: 0 Credits: 3
Research and Thesis for PhD degree. (variable credit)
BME 581 Credit: Variable
Fluid Mechanics for Biomedical Engineers
This course is primarily focused on the development of theoretical
and experimental principles necessary for the delineation of fluid
flow in various in vitro chambers and the cardiovascular system.
Its content will primarily deal with the basic concepts of flow
in various geometries, the heterogeneous nature of blood and
the application of such principles in flow chambers designed to
expose blood elements to defined flow conditions. The relationship
to flow in the normal and diseased vascular system will also be
considered. A basic Fluid Dynamics Course is recommended.
Instructor permission required.
Prerequisite(s): BME 500 with min. grade of C
Lecture: 3 Lab: 0 Credits: 3

BME 582
Advanced Mass Transport for Biomedical Engineers
This course is primarily focused on the development of theoretical
and mathematical principles necessary for the delineation of mass
transport processes in biological & medical systems. The content
includes heterogeneous reactions that occur at or in the vicinity of
cells or vascular structures under applied laminar flow and transport
across cell membranes and within tissues.
Lecture: 3 Lab: 0 Credits: 3