BioSpec®

High Field MRI/MRS Research

MRI/ MRS
Innovation with Integrity
Unlimited Research Possibilities

With the power to conduct limitless imaging applications, BioSpec®

opens up a whole new world of applications. Customers across the
world undertake daily investigations into:

Angiography
„„ - flow contrast and flow analysis of the velocity of
each voxel for glioblastoma and aneurysm studies
„„Cardiology - investigation of cardiac strain, ejection fraction, and
septum defects, using triggered sequences or Bruker’s patented
IntraGate for navigator based retrospective gating
„„Diffusion - visualization of disturbed pathology, such as in multiple
sclerosis, epilepsy, and stroke tumors
„„fMRI - insight into the brain‘s function
„„Molecular MRI - imaging at the cellular level
„„Perfusion - with and without CA for tumor- detection, -neoangio-
Cortical Layers of Mouse
genesis, and -vascularization, and disruption of the blood brain
Cerebellum in vivo
barrier MRI CyroProbeTM at 7 Tesla, Magnitude and phase
„„Spectroscopy – quantification of metabolic disorders and long images depict cortical layers of mouse cerebellum –
term changes in metabolic processes ml (molecular layer), gl (granular layer),
WM (white matter), PI (Purkinje cells)
Acquisition details: SWI FLASH, resolution
(30 × 30 × 200) µm³, scan time: 12 min 50 s.
Courtesy: N. Baxan, D. von Elverfeldt, University
Medical Center Freiburg, Freiburg, Germany

DTI Fibers
Brain connectivity studies in small animals are
challenging but can be achieved using state-of-
the-art MRI technologies for acquisition, such as
the 7 T BioSpec® with MRI CryoProbe. High-
resolution DTI MRI and fiber tracking of the living
Angiography
mouse brain delineate the organization of the
Time-Of-Flight angiography with no contrast agent fiber tracts.
at high spatial resolution, showing the excellent Acquisition details: MRI CyroProbeTM at 7 Tesla,
contrast that enables the identification of fine vas- DTI-EPI, diffusion directions: 30, resolution:
cular structures. (12.5 × 15.5 × 50) µm³, scan time: 25 min.
Acquisition details: Mouse brain in vivo: MRI Courtesy: L. A. Harsan, D. von Elverfeldt et al.,
CryoProbe™ at 9.4 Tesla, GEFC, TR: 30 ms, University Medical Center Freiburg,
TE: 5.9 ms, resolution: (59 × 59 × 59) µm3 Freiburg, Germany
Courtesy: H. Waiczies, Berlin Ultra-High Field
Facility (BUFF), MDC, Berlin, Germany
 The Benefits You Want
Leading scientists worldwide are taking their
research closer to the molecular and cellular level
thanks to BioSpec®. Designed for the emerging
market of preclinical imaging and molecular MRI,
its innovative modular concept enables virtually any
small animal MR imaging application in life science,
biomedical, and preclinical research.
BioSpec® already brings proven performance,
safety, convenience, and future-proof cost-effective
operation to over 600 labs worldwide. With our new
multimodal animal platforms and accessories and
our latest generation ParaVision® software more
Cellular Imaging users than ever can access a new level of research
– Mesenchymal stem cells were labeled and quicker than they think.
used as markers for stroke regions. They
are readily visible in T2- and T2*-weighted Key Benefits
images both in vivo and ex vivo. Full 3D Cost
„„ effective - Helium zero boil off and Nitrogen-free for
brain coverage enables quantification and reduced maintenance costs and longer service intervals
volume rendering. Scalable – upgradeable electronics, options, and accessories
„„
Courtesy: P. Walczak, J. W. Bulte, et al. to keep your system at the cutting edge
Johns Hopkins University School of Compatible – multimodal animal handling solutions for use
„„
Medicine, Baltimore, Maryland, USA with all Bruker preclinical modalities
Intuitive – with Bruker’s gold standard preclinical imaging
„„
software, ParaVision®, users can start scanning immediately
Proven – more than 30 methods with various contrast
„„
modules and hundreds of measurement protocols designed
and tested on mice and rats to guarantee the highest image
quality

Key Technologies
Field
„„ strengths – 4.7 to 15.2 Tesla ultra-shielded supercon-
ducting magnets with reduced stray field
Bore sizes – 11 to 40 cm for optimal working space
„„
Gradient diameters – 6, 9, 12, 20, 26 cm, with 6 and 12 cm
„„
gradients available as inserts (dual gradients)
Gradient strength – up to 1000 mT/m for highest duty cycles
„„
Shim sets – Full 3rd order (6 cm) and 2nd order (9-26 cm) for
„„
best homogeneity
Gradients, Coils, and Electronics
The World’s Leading Hardware

Gradients
The high performance BGA-S HP gradient series delivers
unsurpassed slew rates, up to 9000 T/m/s, and gradient
strengths up to 1000 mT/m. Integrated shim coils enable
optimal field homogeneity even at the highest magnetic
fields. The dedicated cooling design results in unique
duty cycle specifications for high end fMRI applications.
Gradients can be used as inserts and thanks to automat-
ic hardware recognition they are easily exchangeable.

RF-coils
RF-coils are the interface to the sample and have a major
impact on quality, acquisition time, and workflow. Bruker
delivers application-optimized RF-coils for head, brain,
cardio, abdomen, spine, and arterial spin labeling, as
well as RF-coils for non-proton applications for mice and
rats. The closed-loop helium-cooled MRI CryoProbeTM
series RF-coils are available for mice and rats and offer
uncompromised performance for highest signal-to-noise Localized Spectroscopy
requirements. STEAM spectrum of the mouse brain acquired
using the MRI CryoProbeTM at 15.2 Tesla.
AVANCE™ Electronics Acquisition details: STEAM, voxel size:
The AVANCE system architecture delivers an (2 x 2 x 2) mm³, TR: 8 s, 128 averages, resolu-
unprecedented level of digital control for high quality and tion enhancement with shifted Gauss filtering,
high speed MR imaging and spectroscopy applications, TE: 1.1 ms, shift: 7%, broadening: 7 Hz
while offering great flexibility and highly scalable
transmitter and receiver channel architecture.
MRI scanner operation has never been easier, with sin-
gle push-button scanner operation and complete hard-
ware detection for RF-coils, gradients, shims, and signal
routing.

Ischemia and Reperfusion

Ischemia was induced in mouse kidneys. Ischemia was induced severely (30 min., top) or mildly (17.5 min.,
bottom). Recovery can be seen after 48 hours in T2-weighted images & T2-maps in case of mild ischemia.
Acquisition details: 9.4 Tesla, MSME, TE: 10 - 70 ms, resolution: (124 × 124 × 650) µm³
Courtesy: T. Niendorf, Berlin Ultra-High Field Facility (BUFF), MDC, Berlin, Germany
MRI CryoProbeTM
A Quantum Leap in Neuro Imaging

Unique Technology for Outstanding Results

Based on very low temperature, helium-cooled, closed-
cycle RF coils and preamplifiers, the unique MRI Cryo-
Probe delivers a significant increase in SNR over equiva-
lent room-temperature RF-coils in routine in vivo MRI
applications. Animal handling and supervision of the MRI
CryoProbe is very similar to standard room temperature
RF-coils. MRI CryoProbe cooling can be accomplished
outside the magnet ensuring optimum usage of scanner
time.

MRI CryoProbes provide tremendous benefits com-

pared to standard room-temperature RF-coils:

„„Increased signal-to-noise ratio of up to factor 5

„„Higher resolution in vivo down to 20 µm
„„Shorter measurements times directly enable lower
costs per sample and higher productivity
„„Access to new applications not possible with room
temperature RF-coils (high resolution, fMRI)
„„Shorter durations of anesthesia

1
H four channel phased array re- The latest innovation for leading image quality in rat brain Available as a commercial pro-
ceive-only MRI CryoProbe for rat imaging with an enormous signal-to-noise gain of up to duct for 9.4 T
brain applications 2.4 in vivo.
1
H four channel phased array recei- Thanks to the remarkable signal-to-noise gain, a dramatic The four channel phased array
ve-only MRI CryoProbe for mouse scan time reduction is possible while keeping the coils are available at 7 T, 9.4 T,
applications resolution very high. In comparison with a room tempera- and 11.7 T.
ture coil, a four channel phased array coil typically provides
a signal-to-noise-gain of 2.5 in vivo.
1
H Quadrature transmit/receive The quadrature transmit/receive MRI CryoProbe provides Available as a commercial pro-
MRI CryoProbe for mouse an immense signal-to-noise gain of 2.5 to 3.0 in vivo. This duct for 4.7 T, 7 T, 9.4 T, 11.7 T, and
applications MRI CryoProbe is also available in a smaller diameter 15.2 T and for 9.4 T and 11.7 T for
version for 6 cm gradients. use with the 6 cm gradient
X-nuclei MRI CryoProbe with com- Gains in signal-to-noise benefit from lower NMR Available for 13C as a commercial
bined 1H room temperature RF-coil frequencies: The lower the frequencies of the nu- product at 7 T and 9.4 T, other
for mouse applications clei, the higher the SNR gain. Therefore signal- frequencies and nuclei upon
to-noise gains of a factor of 5 are possible in 13C request.
measurements.
ParaVision®
Software for Performance, Flexibility, and Routine Optimization

Enhanced Productivity Setting New Standards in Preclinical MRI

A redefined and intuitive workflow introduces optimized, Delivering a quantum leap in ease of use, the redesigned
application-oriented and in vivo validated experimental ParaVision workflow is designed with preclinical imaging
protocols, an interactive 3D scan planning viewport, in mind, featuring a workflow optimized user interface
advanced image analysis tools, and automatic report- and easy parameter handling. A guided imaging work-
ing. The scan queue enables the use of scan programs flow produces consistent results and lowers the learning
with automatic copy references in order to minimize user curve for biomedical researchers new to MRI. A context-
interaction. Thanks to its DICOM-based data exchange sensitive view reduces complexity by visualizing only
module, ParaVision seamlessly integrates with data from parameters relevant to the operations at hand, ensuring
multimodal imaging studies employed in many preclini- intuitive and focused operation.
cal research labs.

High Performance
With true 64-bit architecture and parallel multi-core ac-
quisition and reconstruction, ParaVision delivers high-
resolution 3D images up to virtually unlimited size. It
includes an extensive set of routine and advanced im-
aging sequences, offers seamless integration of paral-
lel transmission techniques and navigator handling, and
incorporates a unique, integrated field map-based shim-
ming procedure.

Integrated real-time optimization features

enable dynamic adjustment of parameters
during scanning, provide integration of navi-
gator scans, and provide on-the-fly pulse
generation for optimum slice profiles.

Advanced users will welcome the fully

integrated method development environ-
ment that enables them to redefine their
own boundaries in imaging research.
Options and Accessories
Keep Your System at the Cutting-Edge

Animal Cradles AutoPac

Bruker’s cradles accomodate mice and rats and enable AutoPac, the automatic positioning system simplifies ani-
a great variety of applications. They feature a bite bar for mal handling via laser positioning and electronic table driv-
head fixation and have provisions for the use of fudicial ing. A touch pad allows positioning adjustment with an
markers, temperature stabilization, anesthesia imple- accuracy of 100 µm. Additionally, the AutoPac RF cover
mentation and exhaust, and monitoring of physiologi- eliminates the necessity for a Faraday cage.
cal signals (ECG, respiration, temperature), which can
be used for triggering. The one-snap system of all con-
trol and monitoring lines allow the cradle to be quickly
transferred from one imaging system to the next while
keeping the animal’s position stable and reproducible.
Automatic cut-off of anesthesia when the cradle is not
connected to the base assures user safety within the
laboratory.
Service & Support
Bruker‘s commitment to providing the highest qual-
ity of service and support means maximum reliability,
productivity, and performance from your MRI system.
From the initial site evaluation, through system instal-
lation, and throughout the lifetime of your instrument,
Bruker’s service program is dedicated to providing per-
sonalized support.

Site Planning - Customized Services

Proper site planning for your MRI scanner is the first
step in ensuring optimum system performance. Beyond
the site-planning guide, Bruker’s technical departments
can provide space-planning and site preparation services
tailored to your individual needs. Bruker‘s site-specific
plans, based on your equipment specifications and local
architectural drawings, can be used to develop bidding
documentation and help estimate construction costs.

Responsive Technical and Software Support

Should you ever have questions or require assistance
with your MRI system, Bruker‘s free service & support
hotlines are your first point of call. Support center engi-
neers and scientists will quickly and efficiently gather key
information, suggest relevant diagnostics, and provide a
swift solution. Worldwide support centers will liaise with
your local service team, enabling on-site diagnosis, part
replacement, repair, or preventative maintenance.

© Bruker BioSpin 11/20 T12215

Bruker BioSpin
www.bruker.com/mri
[email protected]