2004 Long
2004 Long
Channing Laboratory
181 Longwood Avenue
Boston, MA 02115-5804
(617) 525-2279 Fax (617) 525-2008
www.NursesHealthStudy.org
This is your ID
Dear Colleague:
In the summer of 1976 you and 121,700 other registered nurses embarked on a remarkable journey
to expand our understanding of the health of women. Twenty-eight years later, the fruits of our
collaboration are bountiful. Hundreds of scientific papers have been published and, as a result,
many of the facts that people take for granted about health and diet have come from the Nurses'
Health Study. We humbly thank you for making this possible through your dedication,
enthusiasm and loyal participation.
3/8” spine
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The attached questionnaire updates your health status and continues our work. As always, your
answers will be kept strictly confidential and used for medical statistical purposes only. Your
prompt reply is helpful and greatly appreciated.
We value each member of the Nurses' Health Study as a colleague in our research, regardless of
your employment (or retirement) status. Also, whether your health has been excellent or if you
have been ill, your response is equally important. In short, no matter what your circumstances,
we need to hear from you!
Your continued participation by documenting your lifestyle is fundamental to the validity of the
study. It is with our deepest gratitude that we thank you again for the time and care that you have
continued to offer to help us all learn more about women’s health.
Best Regards,
EXAMPLE 2: Mark “Yes” bubble and Year of Diagnosis bubble for each illness you
have had diagnosed.
16.
3/8” spine
Since June 2002, have you had YEAR OF 16
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any of these clinician-diagnosed DIAGNOSIS
illnesses? BEFORE JUNE ’02 AFTER
LEAVE BLANK FOR “NO”. MARK HERE FOR “YES” JUNE 1 TO JUNE 1
2002 MAY 2004 2004
Breast cancer Y 2
• Please tear off the cover letter (to preserve confidentiality) and return the
questionnaire in the enclosed postage-paid envelope.
• If your name and address as printed on this questionnaire are no longer
correct or are incomplete, or if you are providing your e-mail address,
please make any necessary changes on the letter and return it to us.
• Thank you for completing the 2004 Nurses’ Health Study Questionnaire.
1. What is your 2. What is the difference between your highest and lowest weight during the last 2 years? 04 05 06 11 12
current weight? No change 2–4 lbs. 5–9 lbs. 10–14 lbs. 15–29 lbs. 30–49 lbs. 50+ lbs. 2
Never Less than once/month Once/month 2–3 times/month About once/week Almost every day
i) When you lose your urine, how much usually leaks? i
A few drops Enough to wet your underwear Enough to wet your outerclothing Enough to wet the floor
ii) When you lose urine, what is the usual cause? ii
a Coughing, sneezing, laughing, or doing physical activity b A sudden and urgent need to go to the bathroom
c Both a) and b) equally d In other circumstances
10. Since June 2002, have you used Evista (raloxifene) or Nolvadex (tamoxifen)? 10
Yes a) How many months have you used each drug during the 24 month period between June 2002 and June 2004? a
No Evista Not Used 1–4 months 5–9 10–14 15–19 20–24 months Used only after 6/04 E
Nolvadex Not Used 1–4 months 5–9 10–14 15–19 20–24 months Used only after 6/04 N
3/8” spine
b) Are you currently using Evista or Nolvadex? No, not currently Yes, Evista Yes, Nolvadex b
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11. Are you currently using any over-the-counter (e.g., “herbal,” “natural,” or soy-based) preparations for hormone 11
replacement or to treat post-menopausal symptoms? (Do NOT include food sources like tofu, soy milk, etc.) a
No Yes What type(s)? Soy estrogen products Natural progesterone cream or wild yam cream
Dong quai (e.g., Rejuvex) Black cohosh (e.g., Remifemin) Other
12. Since June 2002, have you used prescription female hormones? 0 0 0 12
Yes a) How many months did you use hormones since June 2002? 1 1 1 a
No 1–4 months 5–9 10–14 15–19 20–25 26–30 31–35 36+ months 2 2 2
b) Are you currently using them (within the last month)? Yes No If No, skip to Part e. 3 3 3 b
Combined: Prempro (cream) Prempro (gold) Prempro (peach) Prempro (light blue) 5 5 5
d) Since June 2002, how many months have you used the preparation(s) you marked in Part c? 3 3 3 d
1–4 months 5–9 10–14 15–19 20–25 26–30 31–35 36+ months 4 4 4
e) If you used oral conjugated estrogen (e.g., Premarin) what dose did you usually take? 5 5 5 e
1.25 mg/day or higher Unsure Did not take oral conjugated estrogen 7 7 7
f) If you used oral medroxyprogesterone (e.g., Provera, Cycrin), what dose did you usually take? 8 8 8 f
Oral or Patch Estrogen: Days per Month Not used <1 day/mo. 1–8 days 9–18 19–26 27+ days/mo. 1
Progesterone: Days per Month Not used <1 day/mo. 1–8 days 9–18 19–26 27+ days/mo. 2
15. Number of times you have fallen to the ground in the past year: 15
None 1 2 3 4 5 6 7 8 9 or more
a) Did you lose consciousness when you fell? No Yes, each time Yes, some times a
Melanoma Y 8 Osteoarthritis Y
Other cancer Y 12 18. In the past two years have you had: Yes, for Yes, for
18
Specify site of other cancer (If yes, mark all that apply) No screening symptoms
A physical exam? N Y Y
Coronary bypass, angioplasty, or stent Y 18 Visible blood Occult fecal blood Abdominal pain
Congestive heart failure Y 19 Diarrhea/constipation Family history of colon cancer
3/8” spine
Stroke (CVA) Y 20 Barium enema Follow-up of (virtual) CT colonoscopy
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TIA (Transient ischemic attack) Y 21 Prior polyps Asymptomatic or routine screening
Peripheral artery disease or Y 22
19. Indicate each year in which you have had the following 19
Pernicious Anemia/B12 deficiency Y 40 for financial reasons? (Mark all that apply)
Multiple sclerosis Y 41 Medical care Medical screening Dental care
SLE (systemic lupus) Y 42 Eye care Mental health care None of these
Rheumatoid arthritis, clinician Dx Y 43 23. Is this your correct date of birth? 23
June 2002 1 2 4 8 P
Please specify: Date:
0 1 2 3 4 5 6 7 8 9 0 1 2 1 2 4 8 P 1 2 4 8 P A
0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 1 2 4 8 P 1 2 4 8 P B
0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6 7 8 9 1 2 4 8 P 1 2 4 8 P C
HARVARD MEDICAL SCHOOL Page 3 NURSES’ HEALTH STUDY
24. Regular Medication (Mark if used regularly in past 2 years) 24 27. Have any of the following Relative’s Age at First Diagnosis
(Do not count half siblings.)
27
(e.g., Aleve, Naprosyn, Relafen, Ketoprofen, Anaprox) 28. Have your parents or any siblings had dementia? 28
Thiazide diuretic Lasix Potassium Mother: No Yes < age 55 age 55–64 65+
Calcium blocker (e.g., Calan, Procardia, Cardizem) Father: No Yes < age 55 age 55–64 65+
Beta-blocker (e.g., Inderal, Lopressor, Tenormin, Corgard) Sibling: No Yes < age 55 age 55–64 65+
ACE Inhibitors (e.g., Capoten, Vasotec, Zestril) 29. Do you consider yourself to be 29
“Statin” cholesterol-lowering drug: (Mark one or more to indicate what your consider yourself to be.)
Mevacor (Iovastatin) Zocor (simvastatin) Crestor White Black or African American Asian
Pravachol (pravastatin) Lipitor (atorvastatin) Lescol American Indian/Alaska native
Other cholesterol-lowering drug [e.g., niacin, Lopid (gemfibrozil), Native Hawaiian or Pacific Islander Other
Tricor (fenofibrate), Questran (cholestyramine), Colestin, Zetia] 31. Do you currently take a multi-vitamin? 31
3/8” spine
Steroids taken orally (e.g., Prednisone, Decadron, Medrol) (Please report other individual vitamins in question 31)
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Insulin Oral hypoglycemic medication Yes a) How many do you take per week? a
SSRI’s (e.g., Prozac, Zoloft, Paxil, Celexa) No 2 or less 3–5 6–9 10 or more
Other antidepressants (e.g., Elavil, Tofranil, Pamelor) 32. Do you take any of the following separate preparations 32
Minor tranquilizers (e.g., Valium, Xanax, Ativan, Librium) on a regular basis? DO NOT REPORT CONTENTS OF
Prilosec, Nexium, Prevacid (Iansoprazole), Protonix, Aciphex MULTI-VITAMINS MENTIONED ABOVE.
Years used: 0–2 yrs 3–5 yrs 6–9 yrs 10+ yrs Vitamin C Vitamin E Calcium
H2 blocker (e.g., Pepcid, Tagamet, Zantac, Axid) Vitamin A Beta Carotene Folic Acid
Aricept Namenda Vitamin D B-Complex Iron
Fosamax, Actonel, or other bisphosphonate Zinc Selenium Niacin
No regular medication 33. Since June 2000, did you receive an influenza vaccination? 33
Other regular medications (no need to specify) Yes In what years? (Mark all that apply)
25. For each of the following periods of your life, please 25 No 2000 2001 2002 2003 2004
add up the TOTAL amount of time you used antibiotics. 34. In a typical week during the past year, on how many days 34
(Exclude skin creams, mouthwash or Isoniazid.) did you consume an alcoholic beverage of any type?
Total Time Using Antibiotics No days 1 day 2 days 3 days 4 days
Less 15 days 5 days 6 days 7 days
than to 2–4 4 Mos– 2–3 3–5 5+
None 15 days 2 Months Months 2 Years Years Years Years 35. In a typical month during the past year, what was the 35
a) What was the most common reason that you used an antibiotic? a lesions have you ever had removed by surgery,
cryotherapy or other means? (Include only new
Respiratory infection UTI Acne/Rosacea
primary cancers. Exclude melanoma and benign
Chronic bronchitis Dental Other lesions like moles or actinic keratoses.)
26. Have you ever had gastrointestinal bleeding that 26 Never had squamous or basal cell carcinoma
required hospitalization or a transfusion? a 1 2–4 5–10 11+
Yes a) What was the site of the bleeding? (Mark all that apply) 37. What is your usual walking pace outdoors? 37
b) What year(s) did this happen? (Mark all that apply) b Brisk pace (3–3.9 mph) 4 4 4 4 4 4 4
For each age range below, please estimate the average amount of time that you spent in these activities. We
recognize that this is a difficult task, but we ask that you average your activity over seasons and years during the
given age categories.
a) Walking to and from Average hours per WEEK b) TV Watching Average hours per WEEK a b
School or Work None 0.5 1–2 3–4 5–6 7–10 11+ None 1 2–5 6–10 11–20 21–40 41–60 61–90 91+
Grades 7–8 Grades 7–8
Grades 9–12 Grades 9–12
Ages 18–22 Ages 18–22
Ages 23–29 Ages 23–29
Ages 30–34 Ages 30–34
c) Strenuous Recreational Activity d) Moderate Recreational Activity
c d
Causing increased breathing, heart-rate, or sweating e.g., hiking, walking for exercise, casual cycling, yard work
(e.g., running, aerobics, lap swimming) (do not count activities already reported)
Average hours per WEEK Average hours per WEEK
None 0.5 1–2 3–4 5–6 7–10 11+ None 0.5 1–2 3–4 5–6 7–10 11+
Grades 7–8 Grades 7–8
Grades 9–12 Grades 9–12
Ages 18–22 Ages 18–22
Ages 23–29 Ages 23–29
Ages 30–34 Ages 30–34
3/8” spine
Tennis, squash, racquetball
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Lap swimming
Other aerobic exercise (aerobic, dance, ski or stair machine, etc.)
Lower intensity exercise (yoga, stretching, toning)
Other vigorous activities (e.g., lawn mowing)
Weight training or resistance exercises Arm weights
(Include free weights or machines such as Nautilus) Leg weights
41. How many flights of stairs (not individual steps) do you climb daily? 41
Does your health now limit you in these activities? Yes, limited Yes, limited No, not
If so, how much? (Mark one response on each line.) a lot a little limited at all
Vigorous activities, such as running, lifting heavy objects,
participating in strenuous sports
Moderate activities, such as moving a table, pushing a
vacuum cleaner, bowling, or playing golf
Lifting or carrying groceries
Climbing several flights of stairs
Climbing one flight of stairs
Bending, kneeling, or stooping
Walking more than a mile
Walking several blocks
Walking one block
Bathing or dressing yourself
HARVARD MEDICAL SCHOOL Page 5 NURSES’ HEALTH STUDY
43. What is your current status? 43
Alone With spouse or partner With other family Nursing home Assisted living facility Other
45. What is your current work status: (Mark all that apply) 45
More than once a week Once a week 1 to 3 times per month Less than once per month Never or almost never
48. Apart from your children, how many relatives do you have with whom you feel close? 48
None 1 to 2 3 to 5 6 to 9 10 or more
49. How many close friends do you have? 49
None 1 to 2 3 to 5 6 to 9 10 or more
50. Is there any one special person you know that you feel very close to; someone you feel you can share 50
confidences and feelings with?
Yes a) How often do you see or talk to this person?
No Daily Weekly Monthly Several times/year Once/year or less a
51. Can you count on anyone to provide you with emotional support (talking over problems or helping you make a 51
difficult decision)?
None of the time A little of the time Some of the time Most of the time All of the time
52. How many people can you count on to provide you with emotional support? 52
Your grandchildren
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every day you felt sad, blue, or depressed for most of the day? No Yes
55. Below is a list of some of the ways you may have felt or behaved during
55
the past month. Please indicate how often you have felt this way. Occasionally or
Rarely or none Some or a little of a moderate All of
During the past month... (Mark one answer per line) of the time the time amount of time the time
I was bothered by things that usually don’t bother me
I had trouble keeping my mind on what I was doing
I felt depressed
I felt that everything I did was an effort
I felt hopeful about the future
I felt fearful
My sleep was restless
I was happy
I felt lonely
I could not “get going”
56. Below is a list of statements which people have used to describe themselves.
Please mark the response that indicates how you generally feel. 56
Almost
Almost never Sometimes Often always
I feel nervous and restless
I feel satisfied with myself
I wish I could be as happy as others seem to be
I feel like a failure
I worry too much over something that really doesn’t matter
I lack self-confidence
I feel secure
I feel inadequate
I am a steady person
I get in a state of tension or turmoil as I think over my
recent concerns and interests
Page 6 NURSES’ HEALTH STUDY
57. Please indicate the extent to which you agree or disagree with the following statements. 57
66. Do you feel more uneasy traveling on buses or trains, even if they are not crowded? 66
3/8” spine
Very A little Not at all
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67. How tall was YOUR MOTHER, without shoes on, at her maximum adult height? 67
Under 5 feet 5' to 5'3" 5'4 to 5'6" 5'7" to 5'10" 5'11"+ Don’t know
68. How tall was YOUR FATHER, without shoes on, at his maximum adult height? 68
Under 5 feet 5' to 5'8" 5'9" to 5'10" 5'11" to 6' 6'1" to 6'3" 6'4"+ Don’t know
69. What was your birth order, relative to your siblings? 69
Only child 1st born 2nd 3rd 4th 5th 6th 7th 8th 9th or later
70. Did your parents own a home at the time of your birth or infancy? 70
Yes No
71. Did your mother smoke cigarettes during her pregnancy with you? 71
74. Would a weight fluctuation of 5 lbs. affect the way you live your life? 74
Address:
1 1 1 1 1 1 1
2 2 2 2 2 2 2
4 4 4 4 4 4 4
Phone or E-mail:
8 8 8 8 8 8 8
Thank you! Please return form to: Dr. Graham Colditz, 181 Longwood Avenue, Boston, MA 02115. P P P P P P P