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ESCRO Changes

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7 views2 pages

ESCRO Changes

Uploaded by

gamtamara
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© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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UNIVERSITY OF WASHINGTON

OFFICE OF RESEARCH

ESCRO Changes
(plus a little background)

What is UW’s Embryo and Embryonic Stem Cell Research Oversight?


 Why does ESCRO exist – what makes it unique?
o ESCRO addresses unique ethical issues specific to stem cell research, such as the use
of human embryonic stem cell lines created from the destruction of a human embryo.
 In late 2007, GIM 36 was born: UW’s policy and guidelines on human embryonic stem cell
research.
o Then-President Bush allowed very limited federal funding for research on a set of
established hESC lines.
o UW responded by creating GIM 36 in anticipation of further regulation and
protection of UW interests:
 Use of equipment, supplies, buildings for research involving hESCs ineligible
for federal funding;
 Types of research that could occur at the UW;
 ESCRO Committee composition and review;
 Establishment of registry of hESC lines at UW.
o President Obama allowed more federal funding for research using established hESCs
and the creation of an NIH human embryonic stem cell registry still in effect today.
 GIM 36 is based on the below federal regulations, national and international guidance:
o NIH Guidelines on Human Stem Cell Research
o Executive Order, March 9, 2009
o National Academies of Science (NAS) Stem Cell Information Guidelines and
Amendments
o International Society for Stem Cell Research, known as the ISSCR Guidelines for
Stem Cell Research and Clinical Translation

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3/2/2023
GIM 36 updates
UW’s policy GIM 36 has been revised. Some of the major additions to the policy (in place since
2007) include oversight of research involving human induced pluripotential stem cells (hiPSC).
These stem cells in many ways function like human Embryonic Stem Cells (hESCs) although
they are not derived from embryos. Other oversight now includes organoids that have the
potential to form neural networks or gametes and in vitro-developed embryos using hESCs or
hiPSCs. Scientific advances in these fields were informed by the guidelines at ISSCR and are
reflected in the updated GIM 36 in 2022.
Detailed changes include:
o Significantly shortened GIM 36 to take out procedural/process information – much of
which will be placed on the ESCRO webpage.
o Oversight still includes:
 Studies involving in vitro passage or differentiation of hESC lines.
 Studies involving destruction of human embryos for research.
 Generation of embryos for research. Transplantation of hESCs, hiPSCs, or cells
derived from either; into non-human research animals.

o New oversight added (based on ISSCR guidelines):


 Development of complex embryo models (e.g., blastoids, gastruloids, assembloids),
brain organoids, or gametes from either hESCs or hiPSCs;
 In vitro culture of human embryos for research from 12 to 14 days after
fertilization, or until the formation of the primitive streak, whichever occurs first.
View ESCRO webpage for ESCRO policy and procedures. The webpage includes step-by-step
instructions on when and how to submit applications. We invite you to contact us if you’d like
us to provide a brief presentation.
Contact us at [email protected] with questions or for more guidance.

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3/2/2023

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