21BTB102T Jan 2023

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Reg. No.

B.Tech. /M.Tech (Integrated) DEGREE EXAMINATION, JANUARY 2023


First Semester

21BTB102T--INTRODUCTION TO COMPUTATIONAL BIOLOGY


T'or the candidates admitted from the acadenic year 2022-2023)
Note:
(i) Part - A should be answercd in OMR shcet within first 40 minutes and OMR sheet should be handed
over to hall invigilator at the end of 40th minulc.
(ii) Part-B and Part-C should be answered in answer booklet.

Time: 3 Hours Max. Marks: 75


Marks BL CO PO
PART-A (20 x 1 =20Marks)
Answer ALL Qucstions
4
1. In cell division, is for growth and maintenance.
(A) Cytokinesis (B) Meiosis
(C) Interphase (D) Mitosis
1 1
2. The genetic material of a prokaryotic is present in the
{A) Nucleus (B) Cytoplasm
(C) Nucleoid (D) Plasmid
1 1 1 4
3. The term "Cell" was given by
A) Robert Hooke (B) Jatum
(C) Schwann (D) Debary
4
4. Ribosomes are also known as
(A) Power house (B) Store house
(C) Protein factory (D) Suicide bag
1 2
5. Genetic information is stored in the formed of
(A) tRNA (B) mRNA
(C) DNA (D) RNA
1 1 2 1
6. Blastocyst is
(A) Totipotent cell (B) Embryo
(C) Zygote D) Early stage of embryo
1 2
7. DNA is made of hydrogen bands they are
(A) lonic bond (B) Covalent bond
(C) Vander walls interaction (D) Non bonded interaction
1 2
8. A program compares amino acid query sequence against a protein
sequence database
(A)_BLASTn (B) BLASTp
(e) BLASTx (D) TBLASTX

Page I of 3 10JF1-21BTB102T
1 3 2
1

encountering stop codon


synthesis stops when (B) GGA
9. Protein (D) CGA
Reg.No. (A) AUG 1 3 2

(C) UGA
polypeptide in
ch./M.Tech.
(Ir
assembled into a (B) Ribosome
acids are
10. The amino (D) RNA
(A) mRNA 1 3 2
(For
thecand
(C) DNA activity is called
enzyme
answered
i nO!
molecule needed for
40th, Non-proteinaceous (B) Enzymes
of
end b ea
11. (A) Cofactors (D) Inhibitors
theshould 3 2
C
(C Hormones
{B) Statistic tool
Pymol is a
12. (A) analysis tool
Visualization tool (D) Sequence 4
(C) Python tool
shaped structure?
e s tl'un
LeRollandC
following cells have star(B) Digodendrocytes
C) LHexagone 13. Which ofthe (D) Schwann cells
(A) Microglia
4
Choisissezl eno (C Astrocytes 1
Septcent

signaling involves
Septcent
(B) Paracrine signals
(A)
(C)
14. Synaptic
(A) Autocrine signals (D) Neurochannel signals
TGVest
Train
à (C) Neurotransmitters 4
Train of neurOn.
to
in a ANN is equivalent
(A)
(C) connecting weights
15. The (B) Axon
Tu
(A) Soma D) Synapse
4
(A) Nou (C) Dendrite ? 4
(C)
by
16. Parkinson's is caused
5. Comnmer
.Jo
(B) Neurofibrillary tangles
(A) A) Amyloid plaques (D) Spongiform
(C) Dopamine related neurons
(C) 1 1 5

by lymphatic circulation.
6
17. is a plasma-like liquid carriedB) Blood
(A) Lymph (D) Gastric juices
7 Ch (C) Saliva 1
1 1 5
(A'
at infant stage because
(C
18. Polio drops are administrated better digestion of
(A) It increases RBCcount (B) Helps
8. !
antigens
(D Produces antibodies
(C) Corrects bone marrow stem
cells
9
1 1
19. Tc cells are
(B) Cellular T cells
(A) Cytotoxic T cells
(C) Ciliated T cells (D} Cell mediatedT cells
1 1
20. Epitope prediction of B cell is based on
(A) Linear (B) Conformational
(C) Long D) Core of antigen

Page 2 of 3
10JF1-21BTB102T
PART -B (4 × 10 = 40 Marks) Marks BL Co PO

Answer ANY FOUR Questions


21. Give the different organelles of cells. Briefly its structure and function. 10 2 1 4

22. Describe what is DNA and RNA? 10 2 2 1

23. Write the types of secondary structure prediction tools. 10 2 3 2

24. Describe machine learning and its uses in


biology. 10 2 4

25. Ilustrate with neat diagrams cell


mediated immune response. 10 2 5

26. Detailed overview of stem cell


technology. 10 2 1 4

PART-C(1x15 =15 Marks) Marks BL CO PO


Answer ANY ONE Questions
27. Give the algorithm to
a database. predict similar sequences to a protein
sequence using 15 4 2

28. What are the immune processes that happen when we got
COVID? vaccinated for 15 4 5

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