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sistemas biológicos examen práctico

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2 views

Example

sistemas biológicos examen práctico

Uploaded by

laurasanchezgomis
Copyright
© © All Rights Reserved
Available Formats
Download as PDF, TXT or read online on Scribd
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Systems Biology: Practical Exam

October 31, 2024

Exercise 1 Given the following pathway,

1. Write down the differential equations. You can assume mass action
kinetics

2. Simulate the system in COPASI. You can chose whichever values you
see fit for the parameters.

Solution:

1.
dR
= k1 S − k2 X R
dt
dX
= k3 S − k4 X
dt

2. COPASI file.

1
Exercise 2 Protein X is phosphorilated by a kinase activated by signal (Z)
and dephosphorylated by a certain phosphatase. The equation describing
the process is:

dXP
= k1 X Z − k2 XP
dt
XT = X + XP
1. Calculate the steady state value of XP as a function of Z.
2. Draw the stimulus-response curve XP (Z)

Solution:
1.
Z
|XP |0 = XT k2
Z+ k1

2. Curve

Exercise 3 Given The following system


dX
= x (x − a)
dt
,
1. Find the steady states.
2. Analyze the stability for all steady states where x ̸= 0.

2
Solution:

1. Steady states: x = 0, x = a

2.
df
= 2x − a
dx
So the linearized system for x = a
d
δx = aδx
dt
The steady state is unstable

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