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Process Flow Chart

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0% found this document useful (0 votes)
12 views3 pages

Process Flow Chart

Uploaded by

NAGAIAH
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
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PROCESS FLOW CHART

Step –I: Drug coating:


Purified water,
1000 L solution preparation tank
HPMC E5,
Preparation of drug solution
Duloxetine HCl
RPM: 600±20

Sucrose spheres
20#25
FBC: Drug coating
Spray rate: 100-1000
g/min

Dry the drug coated pellets


in FBC for 20 minutes

Cool the pellets

Un Load
Sieving 16#24

Weigh & Pack in HDPE


Part –II: Sub coating of containers
Drug pellets: Purified water, 1000 L Solution
Load Sucrose, preparation tank
HPMC E5 RPM: 500±20

FBC
Coat with sub coating Sub coating solution
solution at the rate of
200 - 1200 g/min

Dry the sub coated pellets in FBC


Inlet air temp. 45 + 10oC
for 20 min
Cool the pellets

Un Load

Weigh & Pack in HDPE


containers

Purified water, Colloidal mill:


Talc, Milling
Load
Part –III: Enteric coating of Purified water,
Sub coated pellets: HPMC Acetate
succinate, 1000 L Solution
Ammonia solution preparation tank
(25-30%), RPM: 600±20
Triethyl citrate,

FBC Enteric coating solution


Sub coated pellets
Coat with enteric coating
solution 400-1200 g/min

Dry the pellets in FBC


for 45 minutes.

Cool the pellets

Un Load

Weigh & Pack in HDPE


containers
Colloidal mill:
Purified water Milling
Part –IV: Sealing coating of Talc, Titanium
Enteric coated pellets Dioxide.
1000 L Solution
Purified water, preparation tank
RPM: 400±20
HPMC E5.

FBC
Enteric coated pellets Sealing coating solution
Coat with Sealing coating
solution 300-1000 g/min

Dry the pellets in FBC


for 20 minutes.

Cool the pellets

Sieving 14 #

Weigh & Pack in HDPE


containers

Finished product analysis

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