Cellular-Respiration

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CELLULAR RESPIRATION

CELLULAR RESPIRATION
- It is the respiration process in which organisms
combine oxygen with food molecules to produce
energy in the form of ATP which takes place in the
mitochondria of cells.
-This process occurs in presence of oxygen and
releases carbon dioxide and water as waste
products.
Three Stages of Cellular Respiration
GLYCOLYSIS
GLYCOLYSIS
- the first step in the breakdown
of glucose to extract energy
for cell metabolism.
- takes place in the cytoplasm
of most prokaryotic and all
eukaryotic cells.
GLYCOLYSIS

High energy molecule

Substrate-level phosphorylation
GLYCOLYSIS
A summary of the process of
glycolysis can be written as follows:
KREBS CYCLE
KREBS CYCLE
-is also known as Citric Acid Cycle or
the tricarboxylic acid cycle
- occurs in the mitochondrial matrix
and generates a pool of chemical
energy (ATP, NADH, and FADH2)
from the oxidation of pyruvate, the
end product of glycolysis.
KREBS CYCLE
Results of the KREBS CYCLE

- The original glucose


molecule has been broken
down completely.
- All six of its carbon atoms
have combined with
oxygen to form carbon
dioxide.
- The energy from its
chemical bonds has been 410ATP (including 2 from glycolysis)
NADH(including 2 from glycolysis)
stored in a total of 16 2FADH2
energy-carrier molecules .
GROUP ACTIVITY

Modelling Glycolysis and Krebs Cycle

Arrange the beads on the string according


to the sequence of reactions in each
pathway and create index cards with short
descriptions of each step and attach them to
the corresponding beads.
Assessment Questions

1) What are the major molecules


involved in glycolysis?

2) Describe the sequence of


reactions in Krebs cycle.

3) Explain the significance of ATP


production in glycolysis and
Krebs cycle.
ELECTRON TRANSPORT CHAIN
ELECTRON TRANSPORT CHAIN
- the final stage of cellular respiration.
- In this stage, energy from NADH and
FADH2, which result
from glycolysis and the Krebs cycle, is
transferred to ATP.
TRANSPORTING ELECTRONS

High-energy electrons are released from NADH and FADH2, and they move along electron transport
chains, like those used in photosynthesis. The electron transport chains are on the inner membrane
of the mitochondrion. As the high-energy electrons are transported along the chains, some of their
energy is captured. This energy is used to pump hydrogen ions (from NADH and FADH2) across the
inner membrane, from the matrix into the intermembrane space.
The pumping of hydrogen ions across the inner membrane creates a greater concentration of the
ions in the intermembrane space than in the matrix. This chemiosmotic gradient causes the ions to
flow back across the membrane into the matrix, where their concentration is lower. ATP synthase acts
as a channel protein, helping the hydrogen ions to cross the membrane. It also acts as an enzyme,
forming ATP from ADP and inorganic phosphate. After passing through the electron transport chain,
the “spent” electrons combine with oxygen to form water. This is why oxygen is needed; in the
absence of oxygen, this process cannot occur.
How much ATP is produced? The two NADH produced in the cytoplasm produces 2 to 3 ATP each
(4 to 6 total) by the electron transport system, the 8 NADH produced in the mitochondria produces
three ATP each (24 total), and the 2 FADH2 adds its electrons to the electron transport system at a
lower level than NADH, so they produce two ATP each (4 total). This results in the formation of 34
ATP during the electron transport stage.

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