Developmental Biology

BIOL 3090-001 - Fall 2024

TR from 8:00 - 9:20 AM in WO1205
3 Credit Hours; CRN 42462
Instructor
Dr. Robert Steven (he/him/his)
Office: BO1100 (across the hall from BO1099, which is easier to find)
Phone: 419-530-7890
Email: [email protected]
Threads: @BiologyWithDrSteven
Office Hours: Drop in to meet with me at any of these times: Mondays 11:30 AM-12:30 PM,
Tuesdays 3-4 PM, or Wednesdays 2-3 PM. Just come by my office or use the Blackboard
“Office Hours” link to join online. One-on-one appointments can be scheduled for select times
on Thursdays through Starfish. Appointments can be made for other times as well; just send
me an email and we will try to arrange a time that works for you. Contact me to ask
questions, review your exams, express your concerns, or just talk. I want you to succeed and
I am here to help you!

Course Description
This course is offered by the Department of Biological Sciences in the College of Natural
Sciences and Mathematics. It introduces students to the molecular and cellular mechanisms
that underlie the early development of organisms. This course is good preparation for
students in the medical field who are required to take an embryology course for their
professional degree. The focus is on the genes and proteins involved in controlling the
behavior of cells in the processes of differentiation, morphogenesis and growth.
Developmental mechanisms and processes will be examined in genetic model organisms
such as the fruit fly (D. melanogaster) and the worm (C. elegans) as well as in vertebrates
such as the frog (X. laevis), chicken, mouse and humans.

Main Learning Outcomes

Students who successfully complete the course will be able to:
• Name, describe and order the main stages of development common to most animals.
• Describe the main anatomical changes that occur during the development of humans and
model organisms.
• Identify the cellular behaviors that lead to morphological change during development.
• Describe the hierarchy of gene activation that occurs in early Drosophila development.
• Understand how gene activation plays a role in differentiation and development.
• Describe the unique characteristics of the Hox genes and explain how they act as master
regulators of development in multicellular organisms.
• Describe the main signaling pathways that play important roles in development.
• Explain how embryonic stem cells and their alternatives can be used in medical
treatments.

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• Demonstrate how errors in development lead to congenital defects and spontaneous

abortion (miscarriage).

Teaching Strategies
Course topics are presented in a lecture format supplemented with “clicker question” based
learning activities. Students are encouraged to read the relevant textbook chapter(s) before
class so they can fully participate in class discussions to maximize learning and retention.
Lecture slides are available in PDF form on Blackboard in advance of class, however, these
slides are not complete so students must remain engaged and annotate the slides with their
own notes in class. Weekly discussion board posts facilitate student engagement with the
course material.

Prerequisite
BIOL 3030 (Cell Biology) with a minimum grade of C.

Required/Recommended Materials

• Textbook (Highly Recommended): Principles of Development (6th edition, ISBN

9780198800569, but the 5th edition is also acceptable), Lewis Wolpert editor. Oxford
University Press.

• Technology: 1) A smartphone, tablet or laptop is required to use the iClicker system in

class and 2) either a laptop or iPad is required to take the in-class exams.

• iClicker Student Response System: Students will use the iClicker system to respond to
“clicker questions” during lectures. You will need to purchase an iClicker subscription
long enough to last at least one semester. The system requires 1) the “iClicker Student”
app (free) on your phone or tablet, or 2) an internet browser to run iClicker on a laptop.
Pick the device you prefer. We will not be using iClicker remotes so do not purchase one.
Instructions for how to get set up with iClicker are provided on the course Blackboard
website under the “iClicker Info” link. Make sure you are set up before the start of the third
lecture, which will be the first to include graded clicker questions. If you have technical
issues please contact https://macmillan.force.com/iclicker/s/contactsupport for assistance.

General Information
• Lecture slides are posted under the “Lecture Slides” course menu link on Blackboard the
day before class at the latest.
• Lectures will be recorded so you may view them after class if necessary. Click on the
Blackboard “Lecture Recordings” course menu link to view the recordings. The recordings
are not intended as a replacement for in-person attendance; graded clicker questions will
be asked during the lectures, so you must attend the lectures to receive credit for your
clicker question responses.

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• Please ask questions during the lectures! If you are unsure of something, it is almost
guaranteed that other students will have the same issue and it is best to get clarification
immediately.
• Exam, clicker, and discussion post grades will be posted on Blackboard. Note, however,
that your iClicker grades will only be synced to the Blackboard grade book at the end of
every week.
• Contact me immediately if you notice any issues regarding the accuracy of your grades on
Blackboard. The grades posted on Blackboard are the grades ultimately used for the
calculation of your final grade.
• Let me know if you are concerned about your grades at any time during the course. The
course material can become overwhelming, but I can help you rein it in! You are absolutely
capable of meeting my expectations for the course.
• When using a cellphone, laptop or tablet in class please restrict their use to responding to
“clicker” questions or taking notes.
• Please do not bring food into the lecture hall; drinks are acceptable.
• If you need help using Blackboard go to http://www.utoledo.edu/dl/helpdesk/index.html, call
419-530-8835 or email utdl@utoledo.
• You are encouraged to follow me on Threads, @BiologyWithDrSteven, where interesting
news, stories and images related to the course, and biology in general, will be posted.

Student Evaluation
Your final grade will be calculated using the following weightings:

60% Three “midterm” exams (20% of your final grade for each)
25% Comprehensive final exam
10% “Clicker questions” (an average of about four per class)
5% Discussion posts
100%

Grading Scale: 90-100% A 67-70% C

87-89% A- 63-66% C-
83-86% B+ 59-62% D+
79-82% B 55-58% D
75-78% B- 50-54% D-
71-74% C+ <50% F

• An overall midterm grade will be posted on Blackboard to give you an indication of how
well you are doing in the course near the midpoint. It will be calculated using the available
exam, clicker and discussion post grades, weighted 85%, 10% and 5% respectively.
Students who stop attending class will be reported at this time to meet state and federal
laws regarding financial aid disbursement.
• Any extra credit given, or any exam adjustments made, will not be used to boost grades
beyond a maximum of 100% overall in any individual weighted category (above) or for any
individual exam.

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• Extra credit opportunities and exam adjustments (other than for grading errors) will not be
available for students on an individual basis. If available, all students will receive the extra
credit opportunity or exam adjustment in a fair and equitable manner.

Exam Information

• All exams will take place in the usual lecture room. “Midterm” exams will take place
during the regularly scheduled class time. You will have the whole class time to
complete the exam. The final exam will be at a different time (see below).
• Be ready to take the exams at the scheduled times. Additional time will not be given to
students who come late, and latecomers will not be permitted to start an exam if someone
has already finished and left the room.
• All exams will be accessed online while you are in the classroom, therefore, you must
bring a laptop or iPad capable of running the Respondus lockdown browser to all exams.
• Make sure your device is connected to the EduRoam Wi-Fi network for the exams.
• Detailed instructions for taking exams are available on Blackboard under the Blackboard
“Exams” link. You will use a lockdown browser, which will not allow you to access
anything other than your exam while you use your computer.
• Take the “Practice Test,” under “Exams” on Blackboard, to test your device before you
come to the first exam.
• Connect your device to the EduRoam Wi-Fi network for the in-class exams as it is the most
reliable network.
• Please consult the exam schedule before making any travel or vacation plans during the
semester. To be fair, everyone must take the exams at the scheduled times.
• There will be three “midterm” exams (see the course schedule on the last page).
• Each “midterm” exam will consist of multiple-choice, multiple answer, fill-in-the-blank,
matching, numerical, and/or ordering types of questions, (~75% of the grade) and short-
answer questions (~25% of the grade).
• Exam questions will test your knowledge of the material discussed in class and will
address the main learning outcomes for the course.
• The “midterm” exams will cover mainly new material (since the last exam), although some
concepts from earlier in the course will be revisited on the later exams.
• Prepared notes, textbooks, calculators, phones, smart watches or any other electronic
devices including headphones, are not permitted while you are taking exams.
• Bring a picture ID and writing utensils to the exams. A sheet of blank paper will be
provided for you to write notes and make calculations during the exams.
• If for any reason the university is closed on the day of a scheduled exam, for bad weather
for example, the exam will be given during the next scheduled class.
• The exam schedule will not be changed for individuals who have more than one exam on
an exam day. This also applies for the final exam. The best way to prepare for this
situation is to be aware of the exam schedules for all your courses, and review course
materials regularly in advance of the exams.
• Your most recent exam can be reviewed during office hours, but only up until the day of
the next scheduled exam. You have this same time period to respond with any exam
grading concerns. It is highly recommended that you review your exam results.

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Final Exam
• Please consult the final exam schedule before making your end of semester travel plans.
In fairness to all students, everyone must take the final exam at the same scheduled time.
• The final exam will take place in the usual classroom, but at a new time during final exam
week (see the course schedule on the last page for scheduling details).
• The final exam will be comprehensive and two hours in length.
• The final exam will consist of multiple-choice, multiple answer, fill-in-the-blank, matching,
numerical, ordering, and short-answer questions, like the midterm exams.
• Approximately half of the final exam will cover the last section of the course, from the last
midterm to the end, while the remaining half of the exam will cover the earlier sections of
the course.

“Clicker” Questions
• You will be asked several “clicker” questions about the topic material in each class. Your
responses will be recorded using your choice of 1) the “iClicker Student” app on your
phone or tablet, or 2) an internet browser running iClicker Student on your laptop. Both
options require the purchase of an iClicker subscription. See “Required Materials” above.
• Make sure your device is connected to the EduRoam Wi-Fi network during lectures.
• Although the iClicker system works over Wi-Fi, students must be in class to receive
credit for their clicker question responses; do not respond to clicker questions
unless you are in the classroom.
• Detailed instructions for how to set up and use your device during lectures are available
under the “iClicker Info” link on Blackboard. Please read these instructions.
• Students are responsible for maintaining their devices in working order and keeping the
app up to date with the latest version.
• If the iClicker app happens to freeze during use or is somehow not working properly,
please just quit the app and restart it. This will solve most problems. Let me know if you
continue to have problems even after restarting and checking that the app is up to date.
• Do not panic if you miss a question in a lecture because your device/app was not working
temporarily. The grading mechanism (see below) is very generous and considers that
students may occasionally miss a question, therefore, credit will not be given for individual
clicker questions missed in class due to technical issues.
• Confirm that your clicker question grades are being transferred from your iClicker account
to Blackboard by checking your clicker grades on Blackboard. Clicker grades will be
transferred from the iClicker gradebook to Blackboard towards the end of each week.
• If you do not see your clicker grades showing up on Blackboard please follow the
troubleshooting instructions under “iClicker Info” on Blackboard. The most common issue
is an incorrect email address associated with your iClicker account.
• Your overall clicker grade on Blackboard will be different from the grade you see on
iClicker since not all clicker questions asked in class will contribute to your clicker grade.
• One point is given for a correct answer to a clicker question, half a point is given for an
incorrect answer.
• Graded clicker questions will begin in the third lecture.
• Clicker questions are a version of formative assessment: Students can immediately view
the results of their clicker responses and gauge their understanding. Repeated questioning

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(graded and non-graded) through the class period will allow me to quickly assess student
understanding and adjust the discussion accordingly as the class progresses.
• Final Overall Clicker Grade (%) = Clicker Points Earned / Total Clicker Points Available x
100 (with the three lowest clicker grades, by lecture, dropped for the calculation). This
grade contributes 10% towards your final grade.
• Please contact tech support at https://macmillan.force.com/iclicker/s/contactsupport if you
have technical difficulties using iClicker. Additional resources are available under “iClicker
Info” on Blackboard.

Discussion Board
• Every week you will be required to: 1) post a question or a comment to the discussion
board about the past week’s lecture material, and 2) reply to someone’s post on the
discussion board. This encourages students to think critically about the course material on
a weekly basis and identifies topics that may require additional discussion in class.
• Thinking critically about the material does not mean copy and pasting information from
ChatGPT for your reply posts. Sure, use ChatGPT as a guide if you need to, just as you
would with Wikipedia or any other source on the internet, but make sure you cite primary
references in your replies if you discuss information that is not coming from the textbook.
• Ask original questions and do not copy or paraphrase any replies already in the discussion.
Post your own thoughts.
• Example questions: I saw Jack Hana with a two-headed turtle in a video post online. Did
that turtle have a mutation in the cerberus gene? I don’t understand topic X; can someone
explain topic X? If you don’t have a question, a comment related to the lecture material is
also acceptable.
• Post your question/comment about the week’s lecture topics to the discussion board by
11:59 PM on the Sunday following the lectures of the previous week. Then post a reply by
8:00 AM, the start of class on the Tuesday. Note that you do not have to wait until the
Sunday to post; the discussion board forums open after the first lecture each week.
• The first discussion board post is due on the Sunday after the second week of class.
• Note that for the most part, I will only comment or reply to posts to correct inaccuracies, not
to answer the questions. The point is to have students address the material and answer
the questions. If you want an answer to a question that does not get answered on the
discussion board, please email the question to me directly.
• Grading: The focus is on participation and just thinking about some aspect of the material
so don’t stress too much about your post. One point will be given for a “reasonable”
question or comment related to the material. Another point will be given for a thoughtful
reply to someone else’s post. Very brief replies will not receive credit.
• Discussion grade (%) = Total Points Received / Total Points Available x 100 (with the
lowest grade, by class, dropped from the calculation). This grade contributes 5% towards
your final overall grade in the course.

Inclusive Classroom Statement

In this class, we will work together to develop a learning community that is inclusive and
respectful. Our diversity is reflected by differences in race, culture, age, religion, sexual

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orientation, gender identity/expression, socioeconomic background, and other social

identities and life experiences. Expressions of different ideas, opinions, and beliefs are
encouraged and appreciated so that conversations and interactions that could potentially be
divisive turn, instead, into opportunities for intellectual and personal development. Please let
me know ways to improve the effectiveness of the course for you personally or for other
students or student groups. Diversity fuels innovation and excellence!

Religious Accommodations

The Testing Your Faith Act requires Ohio universities to provide reasonable accommodations
for students who miss up to three days each academic semester to take holidays for reasons
of faith, or religious or spiritual belief system, or to participate in organized activities
conducted under the auspices of a religious denomination church, or other religious or
spiritual organization. Accommodations will be provided under the following circumstances:

i. The student’s sincerely held religious belief or practice severely affects the student’s
ability to take an exam or meet an academic requirement; and
ii. the student submits a form through https://forms.office.com/r/gBBCQkQj3H (which
includes a link to the non-exhaustive list of religious holidays/holy days) within 14 days
after the first day of instruction; and
iii. the Office of the Provost will send notification to each instructor indicating the specific
dates for which the student will be absent; and
iv. the student and faculty member agree on how and when the missed coursework and/or
exam will be completed, which may be prior to or after the missed class, but must be
completed before the end of the term.

A student may notify the institution of any grievance regarding the policy’s implementation
using the 3364-71-05.1 Academic Grievance procedure.

Absences
• I trust that you will take the absences you need to take, and on the other hand, I hope you
will try to miss as few classes as possible. I understand that there may be a time that you
are just going to miss class even though you do not have an “acceptable” excuse. The
clicker grading takes this into account (see above) and I am available to help you with any
questions you have about the material you miss. Additional information on absences,
including what constitutes an excusable absence, follows.
• Make-up exams, clicker question exemptions and discussion board deadline adjustments
will be provided for serious medical or personal reasons. Accommodations will be made if I
am notified by email or phone call as soon as possible after the absence.
• Make-up exams usually have a larger proportion of free response questions and will be
scheduled as soon as possible after the original exam date. If multiple students need a
make-up exam, they will take it at the same time.
• Student athletes who need to reschedule an exam because it will interfere with a university
sanctioned athletic competition must meet with me, as soon as the competition schedule is
available, to reschedule the exam. The student should be prepared to take the exam in
advance of the regularly scheduled exam date. Go Rockets!

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• Be aware that the university has an attendance policy requiring instructors to verify student
participation at the start of each semester. If you have not participated in class (completed
any clicker questions or homework) within the first 14 days, I am required by federal law to
report you as not attended. Unfortunately, not participating impacts your eligibility to
receive financial aid, so it is essential that you attend class and complete course work in
these first two weeks. Please contact me as soon as possible to discuss your options if you
have any difficulty participating within the first two weeks.
• Additional information regarding absences can be found in the University of Toledo Missed
Class Policy, located at:
http://www.utoledo.edu/policies/academic/undergraduate/pdfs/3364-71-14 Missed class
policy.pdf.
• Congratulations on reading so deep into the syllabus! I’m sure you will be successful in the
course! Just a bit more reading left.

Special Expectations During COVID-19 and Flu Season

Maintaining a safe campus during the ongoing COVID-19 pandemic and flu season remains
a top priority. Please keep me informed of concerns you may have about the class,
completing course work/assignments on time, and/or health concerns related to COVID-19
and the flu. UToledo continues to follow the guidance of the U.S. Centers for Disease Control
and Prevention and Ohio Department of Health to keep our campus safe.

Attendance
• Anyone with a temperature at or above 100.0 degrees Fahrenheit or who is experiencing
symptoms consistent with COVID-19 or the flu should not come to campus until
symptoms abate.
• If you are symptomatic, it is recommended that you do a self-administered COVID test and
contact your primary care physician, the University Health Center at 419-530-3451, or the
Health Science Campus Student Health and Wellness Center to be treated if necessary.
• Absences due to COVID-19 or flu quarantines are considered excused absences.
Students should notify me as soon as possible about their situation. Additional COVID
information is available at https://www.utoledo.edu/coronavirus/.

Face Coverings
• Face coverings are not required while on campus, but students should feel free to wear
them as risk of exposure to individuals with COVID-19, the flu, or other respiratory
illnesses is ongoing.

Vaccination
• All UToledo employees, undergraduate and graduate students are required to receive a
seasonal flu vaccine once it becomes available in the fall. The U.S. Centers for Disease
Control and Prevention recommends everyone age six months and older receive a flu
vaccine every year.
• UToledo provides free influenza immunization clinics for students and employees each
year, typically beginning in October.
• Proof of vaccination must be submitted by Dec. 1 of each year.

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• Note that other immunizations are also required. More information is available at:
https://www.utoledo.edu/health/immunizations.html
• UToledo no longer requires COVID-19 vaccines for students or employees, but strongly
recommends COVID-19 vaccinations and boosters. Proof of COVID-19 vaccination can be
voluntarily shared through the University's secure vaccine registry portal.
• Students can receive a COVID-19 vaccine on Main Campus at the Main Campus
Pharmacy and on Health Science Campus at the outpatient pharmacy in the UTMC
Medical Pavilion. For more information, call the Main Campus pharmacy at 419.530.3471
or the UTMC outpatient pharmacy at 419.383.3750.

University Policies and Support Services

Policy Statement on Non-Discrimination on the Basis of Disability:
• The University is an equal opportunity educational institution. Please read The University’s
Policy Statement on Nondiscrimination on the Basis of Disability - Americans with Disability
Act Compliance. Students can find this policy along with other university policies listed by
audience on the University Policy webpage:
(http://www.utoledo.edu/policies/audience.html/#students)
• The University of Toledo embraces the inclusion of students with disabilities. We are
committed to ensuring equal opportunity and seamless access for full participation in all
courses. For students who have an Accommodations Memo from the Office of Accessibility
and Disability Resources, I invite you to correspond with me as soon as possible so that
we can communicate confidentially about implementing accommodations in this course.
• For students who have not established accommodations with the Office of Accessibility
and Disability Resources and are experiencing disability access barriers or are interested
in a referral to health care resources for a potential disability, please connect with the office
by calling 419-530-4981 or sending an email to [email protected].

Academic Policies:
• The university academic policies including those outlining attendance, academic
dishonesty and adding/dropping classes, for example, can be accessed at:
https://www.utoledo.edu/policies/academic/undergraduate/.
• Students are expected to follow the student code of conduct:
http://www.utoledo.edu/policies/main_campus/student_life/pdfs/3364_30_04_Student_cod
e_of_conduct.pdf
• Answering “clicker” questions for someone else is considered academic dishonesty for
both students involved. Both students will be sanctioned according to university policy.
• Do not talk to other students or use electronic devices during examinations. Keep your
eyes on your own work. Those who violate these rules will receive an F for the course.
• If you are concerned about your ability to succeed in the course, please come speak with
me instead of considering academic dishonesty.

Academic and Support Services:

• Please follow this link to view a comprehensive list of student academic and support
Services (http://www.utoledo.edu/studentaffairs/departments.html) available to you as a
student. This link includes information on federal Title IX regulations.

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Safety and Health Services:

• Rocket Health provides comprehensive, integrated health and wellness services.
• Click here for information on the Office of Public Safety, including access to the Rave
Guardian safety app: https://www.utoledo.edu/publicsafety/
• Any student who has difficulty securing food/groceries or who lacks a safe and stable place
to live, and believes this may affect their performance in the course is urged to contact the
Office of Student Advocacy and Support (https://www.utoledo.edu/studentaffairs/student-
advocacy/) to discuss on/off-campus resources. Students are reminded that the UToledo
Student Food Pantry exists on both campuses (SU2514 and HEB112). Furthermore, I
suggest contact me if you have concerns about your situation.

Keys to Success
1. Do your best to attend every lecture. Material presented during the lectures will be
emphasized for the exams and clicker points contribute to your final grade. Interactions
with me help strengthen your understanding of the material. The textbook, which
provides additional context and a great overall perspective, contains extra material that
you are not responsible for.
2. Stay focused during lectures. Avoid texting and checking social media during the
lecture. You may think you are good at multitasking, but research indicates that
distracted students do not perform as well as those that stay focused on the material.
3. Do not wait until a day or two before the exam to study. This is one of the worst and
most common mistakes students make. Go over your notes as often as you can between
exams and make sure you understand the material before your last planned exam study
session. Ask questions about topics you don’t understand as soon as possible, either
during lecture or office hours or by email.
4. Be active with your studying. Reading the textbook before lectures, taking notes during
lectures, and making a separate set of study notes at the end of the day will aid in your
ability to understand and retain the presented concepts. Passively reading the textbook
and listening to the lectures without being engaged in the material will not lead to
success. Meet with a Learning Enhancement Center (LEC) tutor to reinforce the material.
Yes, developmental biology specific tutors are available; check the LEC schedule!
5. Attend my office hours. It is important that you review your exam results and take notes
on the exams. The comprehensive final exam will address the same topics you were
tested on through the semester and I will make sure you understand the important topics.
Or come by to review any of the course material or to just chat. I will help you succeed!
6. Attend the TA’s office hours. A BIOL3090-specific teaching assistant will also be
available to answer your questions. They will be available at times and a location TBD.
7. Test yourself. Have someone ask you questions about the material in your notes. Take
advantage of the textbook website (the link is under “Supplemental Material” on
Blackboard), which has a glossary, multiple-choice questions and other activities. Review
the clicker questions using the Study Tools on the iClicker app. It is important that you
test yourself after you have already studied and spent time committing material to
memory. You need to practice retrieving information from your brain (recall) as this is
what you do during exams and testing yourself in this way will let you know where you
might have to spend more time studying the details.
8. Form a study group. It helps with number seven above and you will find out how well
you know the material when you try to explain it to someone else.

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9. Read the “Study Tips” document under the “Study Tips” link on Blackboard.
10. Other resources are available. A list of valuable resources to help you with your
academic and social life can be found at www.utoledo.edu/studentaffairs/departments.
This includes free course-specific tutoring and writing center services among others.

The course schedule is on the next page.

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 Course Schedule

Textbook
Date Lecture Topic Chapter
(6th ed)
Aug 27 1 Introduction and History 1
Aug 29 2 Concepts in Development 1
Sept 3* 3 Development of the Drosophila Body Plan I 2
Sept 5 4 Development of the Drosophila Body Plan II 2
Sept 10 5 Vertebrate Models of Development 3
Sept 12 6 Patterning the Vertebrate Body: Axis Formation 3/4
Sept 17 Exam 1 (Lectures 1-6)
Sept 19 7 Patterning the Vertebrate Body: Forming Germ Layers 4
Sept 24 8 Patterning the Vertebrate Body: Somite Formation 5
Sept 26 9 Patterning the Vertebrate Body: Neural Induction 5
Oct 1 10 C. elegans Development 6
Oct 3 11 Plant Development 13
Oct 8 12 Morphogenesis: Adhesion and Cleavage 7
Oct 10 Exam 2 (Lectures 7-12)
Oct 15 Fall Break
Oct 17 13 Morphogenesis: Gastrulation, Neurulation and Migrations 7
Oct 22 14 Cell Differentiation: Control of Gene Expression 8
Oct 24 15 Cell Differentiation: Models of Differentiation I 8
Oct 29 16 Cell Differentiation: Models of Differentiation II 8
Oct 31 17 The Plasticity of Gene Expression (Stem Cells) 8
Nov 5 18 The Vertebrate Limb 10
Nov 7 Exam 3 (Lectures 13-18)
Nov 12 19 Organogenesis 10
Nov 14 20 Nervous System Development I 11
Nov 19 21 Nervous System Development II 11
Nov 21 22 Gamete Production 9
Nov 26 23 Fertilization and Sex Determination 9
Nov 28 Thanksgiving Break
Dec 3 24 Growth and Human Development 12
Dec 5 25 Review
Dec 10 Final Exam (8-10 am) (All lectures covered)

The pace of the lectures varies from year to year so the exact day a particular topic is
discussed may differ from this schedule. However, the topic order and the exam dates will
not change.

Other Important Dates: *Deadline for iClicker registration: Sept. 3

*Graded clicker questions begin: Sept. 3
First discussion post due: Sept. 8
Last day to drop: Sept. 9
Last day to withdraw: Nov. 1

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