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Elixir

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radja arrafi
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80 views14 pages

Elixir

Uploaded by

radja arrafi
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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ELIXIR

Dr. apt. Widyastuti, S.Si., M.Farm.


• Elixir are clear sweetened,
hydroalcoholic preparation
intended for oral use and
usually flavored for palatability
• Alcoholic content vary from
10% to 12% and up to 40%
DIFFERENCE BETWEEN SYRUPS AND ELIXIR

• An elixir must always contain alcohol, whereas a syrup may


or may not use an alcohol for solubility purposes

• Elixirs are mean to always be a clear liquid, whereas syrups


can contain various natural or artificial dyes

• In general, elixirs are less viscous than syrups due to their


higher alcohol content and their minimal use of sucrose and
other viscosity-improving agents

• When used as a pharmaceutical preparation, it contains an


active ingredient that is dissolved in a solution that contains
some percentage (usually 10 – 12%) of ethyl alcohol and is
designed to be taken orally
• Some drug are insoluble in water so in this
case we can’t use syrups and suspension

• So we have to make a dosage form which


could dissolve non polar compounds

• Aid in masking the unpleasant taste of the


active ingredients
NON MEDICATED
ELIXIR
• These are simple elixirs
MEDICATED ELIXIR that do not contain
• Medicated elixirs are medicated agents
a solution of the
active ingredient • These only contain:
dissolved in water alcohol, sweetening
and an alcohol often agent, coloring agent,
along with other they are self preserving
excipients such as and use as diluent or
preservatives vehicle
AROMATIC ELIXIR

MIXTURES
NON MEDICATED BENZALDEHIDE
ELIXIR

ISO-ALCOHOL
ELIXIR

ELIXIR ANTIHISTAMIN
ELIXIR

PHENOBARBITAL
ELIXIR

MEDICATED

THEOPHYLLINE
ELIXIR

DIGOXIN ELIXIR
• Sugar or sugar substitutes like the
sugar e.g. polyglycerol or sorbitol
• Alcohol
• Water
• Flavoring agents and flavor enhancers
• Coloring agents
• Although it is self preserving but
preservating agents may be added
• Often, an elixir has more ingredients than just
the drug, water and ethanol, elixirs often contain
glycerin, sorbitol, polyethylene glycol (PEG) or
syrups

• These are sweetening agents and can mediate


the pharmacological effects of the ethanol

• PEG may be used in an elixir as a substitute for


both glycerin and ethanol
• Elixir are always sweetened, but rarely contain
sucrose
• This is because sucrose make a solution much
more viscousor thick, an undesirable property in
an elixir
• Many other sweetener can be used, including
aspartame, carboxy methyl cellulose and its
derivatives, saccharin, cyclamate, and
acesulfame potassium
• However, none of these sweetener are
considered truly safe, in fact, cyclamate and
saccharin are banned in several countries
• Alcohol soluble and water soluble components
are generally dissolved separately in alcohol and
water
• Aqueous solution is added to the alcoholic
solution, so minimal separation of alcohol soluble
components occurs
• Mixture is made up to the volume by the specific
solvent or vehicle
• Talc o remove excess amount of oil
• Filter the preparation
• Pour it in clean bottle
• Lable the bottle
ADVANTAGES OF
ELIXIR DISADVANTAGES
• Taste masker OF ELIXIR
• Self preservative • Addiction
• Liver sclerosis
• Sedation
• Dizziness
• Large amount of
alcohol cause
burning sensation
to the tongue
THANK YOU

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