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Syllabus - PH3002 Analysis

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42 views5 pages

Syllabus - PH3002 Analysis

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prisharathod925
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© © All Rights Reserved
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Uka Tarsadia University

B.Pharm.
PH3002: Pharmaceutical Analysis - I

Semester - III

EFFECTIVE FROM June-2023


Uka Tarsadia University
SEMESTER-III
PHARMACEUTICAL ANALYSIS - I
(Subject code: PH3002)

Credits: 4: Theory Contact Hours: 45 hrs

Instructional Methods and Pedagogy:


Faculty members shall explain in a class room using black board and multimedia projector
through PowerPoint presentation.

Minimum No. of
Unit No Approx. Weightage %
Contact Hours
Unit 1 8 17.78
Unit 2 8 17.78
Unit 3 7 15.55
Unit 4 8 17.78
Unit 5 7 15.55
Unit 6 7 15.55
Total 45 100 %
Uka Tarsadia University
Sr. No. Subject Hours
3rd Sem PH3002 Pharmaceutical Analysis -I 3 hrs/week
1 hr/week Tutorial
(Theory) 4 Credits
Scope: This course deals with the fundamentals of analytical chemistry and principles of
electrochemical analysis of drugs
Objectives: Upon completion of the course student shall be able to
 understand the principles of volumetric and electro chemical analysis
 carryout various volumetric and electrochemical titrations
 develop analytical skills
Sr. No. Topic Hours
Unit - I
1 (a) Pharmaceutical analysis- Definition and scope 8
i) Different techniques of analysis
ii) Methods of expressing concentration
iii) Primary and secondary standards
iv) Preparation and standardization of various molar and normal
solutions - oxalic acid, sodium hydroxide, hydrochloric acid, sodium
thiosulphate, sulphuric acid, potassium permanganate and ceric
ammonium sulphate
(b) Errors: Sources of errors, types of errors, methods of minimizing
errors, accuracy, precision and significant figures
(c) Pharmacopoeia, Sources of impurities in medicinal agents, limit
tests.
Unit – II
2 Acid base titrations: Theories of acid base indicators, classification 8
of acid base titrations and theory involved in titrations of strong,
weak, and very weak acids and bases, neutralization curves
Unit – III
3 Non aqueous titrations: Solvents, acidimetry and alkalimetry 7
titration and estimation of Sodium benzoate and Ephedrine HCl
Complexometric titrations: Classification, metal ion indicators,
masking and demasking reagents, estimation of Magnesium
sulphate, and calcium gluconate
Unit – IV
4 Redox titrations 8
(a) Concepts of oxidation and reduction
(b) Types of redox titrations (Principles and applications)
Cerimetry, Iodimetry, Iodometry, Bromatometry, Dichrometry,
Titration with potassium iodate
Uka Tarsadia University
Diazotization titration: Basic principle, methods and applications
Unit – V
5 Precipitation titrations: Mohr’s method, Volhard’s method, 7
Modified Volhard’s method, Fajan’s method, estimation of sodium
chloride
Gravimetry: Principle and steps involved in gravimetric analysis.
Purity of the precipitate: co-precipitation and post precipitation,
Estimation of barium sulphate
Unit – VI
6 Electrochemical methods of analysis 7
Conductometry - Introduction, Conductivity cell, Conductometric
titrations, applications
Potentiometry - Electrochemical cell, construction and working of
reference (Standard hydrogen, silver chloride electrode and calomel
electrode) and indicator electrodes (metal electrodes and glass
electrode), methods to determine end point of potentiometric
titration and applications
Polarography - Principle, Ilkovic equation, construction and working
of dropping mercury electrode and rotating platinum electrode,
applications

Sr. No. PH3002 Pharmaceutical Analysis - I 4hrs/week


(Practical) 2 Credits
1 Limit Test of the following
(1) Chloride (2) Sulphate (3) Iron (4) Arsenic
2 Preparation and standardization of
(1) Sodium hydroxide (2) Sulphuric acid (3) Sodium thiosulfate
(4) Potassium permanganate (5) Ceric ammonium sulphate
3 Assay of the following compounds along with Standardization of
Titrant
(1) Ammonium chloride by acid base titration
(2) Ferrous sulphate by Cerimetry
(3) Copper sulphate by Iodometry
(4) Calcium gluconate by complexometry
(5) Hydrogen peroxide by Permanganometry
(6) Sodium benzoate by non-aqueous titration
(7) Sodium Chloride by precipitation titration
4 Determination of Normality by electro-analytical methods
(1) Conductometric titration of strong acid against strong base
(2) Conductometric titration of strong acid and weak acid against
Uka Tarsadia University
strong base
(3) Potentiometric titration of strong acid against strong base
Text Book:
1. K.A. Connors; A Textbook of Pharmaceutical Analysis, third edition, A Wiley
Interscience publication, John Wiley and Sons, New York
2. R.A. Day, A.L. Underwood; Quantitative Analysis, sixth edition, Prentice-Hall private
Ltd., New Delhi
Reference books:
1. A.H. Beckett & J.B. Stenlake's, Practical Pharmaceutical Chemistry Vol I & II, Stahlone
Press of University of London
2. A.I. Vogel, Text Book of Quantitative Inorganic analysis
3. P. Gundu Rao, Inorganic Pharmaceutical Chemistry
4. Bentley and Driver's Textbook of Pharmaceutical Chemistry
5. John H. Kennedy, Analytical chemistry principles
6. Indian Pharmacopoeia.

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