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Bioinformatics Principles

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287 views

Bioinformatics Principles

Uploaded by

saurabhgupta0088
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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Core Principles of Bioinformatics

There are five core principles of bioinformatics:

1. Data Analysis and Interpretation


2. Computational Tools and Algorithms
3. Genomics and Sequence Analysis
4. Structural Biology and Protein Modelling
5. Systems Biology and Network Analysis

Let us learn about each one of them in detail.

Alt text: Scientist doing genetic research in lab


1. Data Analysis and Interpretation

Data Collection
Collecting biological data from various
sources, including experiments and
databases.

Data Processing
Filtering, cleaning and processing raw
data to extract useful information.

Data Interpretation
Analysing and interpreting the
processed data to draw meaningful
conclusions and make scientific
Alt text: DNA data-collection, processing, interpretation
inferences.
2. Computational Tools and Algorithms

Sequence Alignment
Involves comparing DNA, RNA and protein
sequences to find similarities and differences
using advanced algorithms.

Phylogenetic Analysis
Uses computational tools to study the
evolutionary relationships among biological
species.

Structural Prediction
Alt text: Analysis using computational tools
Predicts protein 3D structures using
computational models and algorithms.
3. Genomics and Sequence Analysis
Whole Genome Sequencing
Determines an organism's complete DNA sequence
for comprehensive genetic studies.

Functional Genomics
Explores gene functions and interactions within a
genome to understand biological processes.

Comparative Genomics
Compares genetic information across species to
identify evolutionary similarities and differences.

Sequence Alignment
Compares genetic sequences to find conserved Alt text: Genome Sequencing
regions and variations among organisms.
4. Structural Biology and Protein Modelling

Protein Structure Prediction


Uses computer models to predict the 3D
protein shapes, crucial for drug design and
disease research.

Molecular Docking
Uses computational tools to study how
proteins interact with potential drugs, aiding
in drug discovery.

Alt text: Protein data bank Structural Bioinformatics Databases


Provide access to protein structures and
annotations for valuable structural biology
information.
5. Systems Biology and Network Analysis

Network Interactions
Studying complex biological networks to
understand cellular processes and
interactions among biomolecules.

Gene Regulatory Networks


Analysing large gene networks to
decipher gene expression patterns and
regulatory mechanisms.

Alt text: Biology network system

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