,

-~ - Departm ent of Microbiology, Medi cal College Kolkata

2nd professional M.B.B.S. Examination
(4lh Semeste r Examination, 2024)
MlCROBIOLOGY THEORY - Paper: ll
Time: 3 hrs
Full Marks: 100
Answer All Questions
f
Q1 A. A 30 year old male was admitted to the chest department of a hospital with symptom of cough '"
with expectoration, thoracic pain, weight loss and a \ow grade fever at night for last 3 months. On
examination he had \aterocervica\ \ymphadenopathy. What is the probable condition? What is the
causative agent? Describe the investigations you will carry out to arrive at a conclusive diagnosis.
Discuss the antibiotic regimen for treatment of the condition . (1+1+7+6=15)
01 B. A 43 yr old dental surgeon presented to Medicine OPD with low grade fever and oral thrush. He
complained of having unexplained chronic diarrhea, malaise, fatigue and weight loss of around 10 kg in
last one month. What is the most probable diagnosis? Write down the strategic plans followed in India
to diagnose the disease? How will you diagnose the case in pediatric patients? How to monitor the
response to the therapy provided to the patient? What are the measures taken to prevent the
transmission of the infection in health care personnel following an accidental exposure? How to,R_revent
rin al transmission? (1+4+2+2+4+2=15)
Mention the c?mmo~ fungi causin~ meningi_tis in immunocompromised patients . Describe the
~s ps of laboratory d1agnos1s of such fungi. ~ . s- (2+8=10)
02B . A 40 year old lady who had received multiple blood transfusions over previous six months
presented with persistant fatigue, loss of appetite , nausea, vomiting and abdominal pain for duration of
10 days . She had history of passing high coloured urine, her LFT showed elevated serum bilirubin and
liver enzyme. What specific tests are required to be done to know the causative viruses? What are the
diagnostic relevance of various markers of the virus. (5+5=10)
02C . What is bioterrorism? Enumerate the pathogens of bioterrorism . What are the prerequisites for
agents to 'b ecome bioterrorism candidates? ine the preparedness for bioterrorism attack.
(2+ 3+3+2=~ 0)
03A. What are t e virulence factors of N. gonorrhoeae?
B. Define zoonos1s? Enumerate the impor an p / s causing zoonosis
l5+(2+ 3)= 101
Q4. Comment on :
(4x5=20)
a) Staphylococcus aureus has several toxins
b) Encephalitis can be caused by many viruses bearing no similarity in morphology
c) Cyst of E histolytica differs from that of E coli 1

d) Fungi can be classified in various ways I

e) Ascaris lumbricoides may cause surgical complications

0 5. MCO
 .\ Medical College Kolkata
~e\lartment oi M1crob\o\ogy, i tton
ind \lroiess\ona\ M.B.B.S. Exam na
( 4th Sem este r Examination, 202 4)
M.llJlQUlW ..Q.GY TllEQBY Paper: l
Time: 3 hrs
Full Marks: 100

~\ Ans we r All Qu<' stion s

~ . =~ ---8~1,- - ~
Q\A A 38 years otd man from ,ar came .~0 o
~P~D ~w
~l~lh~hZig~h~g~ra~de~~~ve;r~w~ith~twricire~ d;;ailvly~s.olpi~ke;s~roorrTc1aIBSt
~~ On •. tlon ii was found that he has severe anaemia, d~rkly plgme d h k.
• ~X>nths. exemma , nte roug s rn ,
al'l\\ ~~iVP ~ -,,,r~1:1Iy. What Is the clinica~condltion? . t ~d vGJC1.or "1 0 It:
Name the caus~trve ageM rlf briefly the
d ~ Oescnbe the laboratory diagnostic procedures to confir
m lll<> disease. 8 J " )
0
·
~ protocol of the disease. (1+1+1+8+4=15
1
0,8 A female patient complained of purulent discharge soaki
ng the dressing of surgical wound from
ii 3,d post
r Q'M\Btisopera tive day.
the ~~~ L'Offl1IOOn known as?
, ;J w,at ~ the predisposing factors ?f this clinicr'l l condition?
Ii} Which bacteria may be the causative agent of such condi
tion?
, i\1 How will you proceed for laboratory diagnosis?
v) Mention few measures to prevent such condition. (1+2+2+6+4=15)
Q2A aassify the immunocompetent cells present in our body
and briefly mention the role each of them
plays to provide immunity.
(5+5=10)
028. i} Enumerate the agents used for disinfection in hospitals.
I
ii} Describe the process and use of pasteurization.
iii) Describe methods of cold sterilization.
v) Testing of disinfectants.
(2+3+3+2=10
02C. A 40-yei:1"-0ld man attended the OPD with complaints of
vague abdominal discomfort, chronic
indigestion with cfiarrhoea alternating with constipation. He also gave
the history of pass~ng something
in stool a few days back which looked like a whitish rectangular
segment
What could be the causative agents? What complication may arise
duatdltt1is condition? How shall you
proceed for tht. laboratory diagnosis of such a condition? 1
1
· , / ' (2+4+4=10)
\ . \
03A. Discuss four ethical rules_of autonomy and 1Specimep reject
ion criteria
B. What are the treatment and final disposal methods ofcBiomedic
al wastes?
Q4. \\\ife briefly on:
a) LJ nlooia /
b) Bacterial flagella
c) Transformation
,, . d) Widal test
\
\
e) Enterotoxins of E. coli

QS. MCQ l1X10=10)

 Medical College, Kolkata
4th Semester MBBS Examination, 2024
Subject: Pharmacology
Paper I

(Attempt all the questions)

Time - 3 hours
Total marks - 100

I
~o
A A ., year o
Id "'armer was brought to the emergency room of the hospital with frothing from mouth,
i ; . . b h . . th
· bl~UTing of vision with spontaneous passage of~ine and st0<?l. His family mem ers ave given e
history of consumption of insecticide by the patient.
[I]
a. What is the clinical diagnosis of the case? . ? [3]
b. What other symptoms and signs can help you diagnose the case .
[6]
c. How will you manage the case clinically?
d. How will you clinically know the patient is recovering? [3]
[2]
-
e. What do you mean by "a_ging" of the enzyme in this case?

B. A patient presented with shortness of breath, pedal edema, basal crepitations and fatiguability. On
examination, his BP is 15~, pulse rate 112 beats/min, SPO 2 94%, LVEF 40% and subsequently the
patient was diagnosed as congestive~ failure.
a. How will you clinically manage this case? [5]
b. Mention the role of beta blockers in congestive heart failure . [5] ;(
c. How are ARNI and SGLT2 inhibitors useful in such a case? [5] \__

2. Answer all the following :

a.Classify hypolipidaemic agents. Mention the mechanism of action of statins and their
advantages~ ~ [5+3+2]
b. Enume~ate oral and ~enter~l anticoa~lants. State ~e advantages_of LMW heparin over the
unfractionaredhepann. Mention the antidote ofhepann and warfarm overdose. [4+4+2]
c. State the various site of action of different diuretic agents. Why is spironolactone preferred in
hepatic edema? ~ [6+4]

3. Write short notes on : [5X2 = 10]

a. Inhalational corticosteroids
b. The approach of the physician about the disclosure of HIV status to the patient

4. Justify the following : [5X4 = 20]

a. Clonidine should not be withdrawn suddenly after long term use in hypertensive patients
b. Th~ v9I1:1m~ 9f di~1:I"il?t:1ti9n m~y ~x~~~~ ~~ ~lc~9~ v9hµ:n~
c. Both a. and~ blockers are used in inoperable pheochromocytoma
d. Sildenafil is avoided in patients receiving nitrates within 24 hours
e. Dobutamine is used in refractory heart failure
·,I
 Medical Colleae, Kolka
ta
De pa rtm en t of Pa tho log
l'e rlo dlc al ass es sm en y
t (4 1h Se me ste r) Ph ase
II Exam ination {Session: ZOZZ
Pa tho log y -23)

Fllll m. irk s .· \ 00 Paper-I

Ti me- 3 h 1~1rs
Att em pt all qu est ion s
A 45 yea rs ma le pre
se nted with occipital he
pulst• rat e is high bo un di~ ad ~ch e, ex~ ssl ve sw e~
1g, res pl!:_at lon rat e no rm ng & diz zin ess . On ex am
al!. 8~hlg ~ imo.,,n his
.1) Wh at is· yo ur pro
vision al dia gn osi s?
b) Wha t a re the etiolo
gical fac tor s for thi s co
c) Dis cus s a bo ut the nd itio n?
sys tem ic effect of the co
nd itio n?
z. A 28 ye ars lad y de ve
lop s sev ere pro gre ssi ve
Ultraso no gra ph ic ex am pa in ov er rig ht hy po ch
ina tio n sh ow s tw o lar ge on dri um wi th na us ea an
sto ne s in gall bla dd er. d vo·•ti
a) W ha t is yo ur pro vis ion
al dia gn osi s? ' ng.
b) Discuss ab ou t the sys tem
ic eff ect of the co nd itio
c) Wh at are the pri nc ipa l n?
me dia tor s of thi s co nd
d) Wh at are the ex pe cte d itio n?
ou tco me s of thi s co nd itio
n?
1 +6 +5 +3 =1S
3. Write short notes on ·
a) On co ge ne s
2:x.1:;10
b) Pa nc yto pe nia

4 . Expla in the fol low

ing sta tem en ts:
a) All typ es of cell inj
ury ha ve co mm on co nse qu
b) Th ere is no dif fer en ce en ces .
be tw ee n co ag ula tiv e an
c) Dy str op hic & me tas tat d cas eo us ne cro sis .
ic cal cif ica tio n ha ve sam
d) Fo rm ati on of gra nu lom e eti olo gy .
a an d gra nu lat ion tis sue
e) At he ros cle ros is an d art follow sim ila r pa thw ay
eri osc ler osi s are sam e. .

5. An sw er the fol low ing s:

a) De fin e em bo lis m. 3x 10 =3 0
De scr ibe the cau se & eff
b) De scr ibe the tra ns ect of fat em bo lis m.
mi ssi on pa tte rn of sin 2+ 4+ 4= 10
gle ge ne dis ord ers . En
dis ord ers an d the ir ma um era te the au tos om al
nif est ati on in pa tie nts do mi na nt
c) W ha t is am ylo ido .
sis ? De scr ibe the me tho 3+ 3+ 4= 10
d of de tec tio n of am ylo
3+ 7= 10 id in aff ect ed ind ivi du als
.

6 . Ch oo se the co rre ct
op tio n for eac h of the
\. Pe rip he ral blo od of (3- fol low ing :
tha las sem ia pa tie nts ha llx to= 10 1
a . Po lyc hro ma sia ve all fea tur es ex ce pt
b. NRBC
V {3-chain inc lus cio ns
d. An iso po iki loc yto sis

l I. All are fea tur es o( h~ Ertro

_gbic obstructiy Jc ar di om
a. As ym m etr ~e pt al hy yo pa th y except
pe rtr op hy
1 . Dilatation of atria '
✓ Dilatation of ventricles
d. Outflow ob str uc tio n
 Athl' romatu11s pl11q11<· n1n luln ull cxt:
II cpt
.1. Pln1t•lrlt•~t
~ Ni•111 rc1phils -
s ,11c1111 h 11111s dr
d. M<ll l{ll'YI~·

, d', dise
\I
Von Wl\\ebrnn . s ~ ase
·
Is cha rac teri zed by abn orm al pla tele t
agg reg atio n wh en the y are exp os,
a. Streptomycin-
b. Fibrinogen
~ •. Collage n
d. Ristocetin

"o-.o rnal acc um ula tion of S,p.b ingomy'elin

l.vs . ' occ urs in
I •
V t
Gau che r's dis eas e --- ~

✓Niemann- Pick dis eas e

' c. Tay-Sach's dis eas e
d. Von Gie rke dis eas e

I. Haemolyt ic dis eas e of new bor n is an •.-•

xample of
a. Typ e I hyp ers ens itiv ity reactior ,
1 /T ype II hyp erse nsit ivit y rea ctic
n
c. Typ e Ill hyp ers ens itiv ity rea cti -,n
d. Typ e IV hyp erse nsit ivit y reactic n

All are tru e abo ut dys trop hic calcificatio

n exc ept
a. Abn orm al dep osit ion of calcium sal
t
b . .,,,Serum level of calcium rem ain s nor
mal
V- Ass ocia ted wit h ren al failure
d. Mostly enc oun tere d in are as of nec
ros is

Rot her a's tes t cari det ect all ket one bod
ies exc ept
a. Ace ton e
b. Acetoacetic acid
~p -hy dro xy but yric acid
d. All of the abo ve

Diluating fluid of RBC cou nt is

✓• Tur k's fluid
b. Dacie's fluid
c. Gen tian vio let
d. 1% Eosin

Tou rniq uet should not be used dur ing

phlebotomy
✓.' Detection of ser um pot ass ium leve
l
b. Detection of ser um calcium level
c. Detection of ser um glucose level
d. Detection of ser um sod ium level
 Ocp i1rt, n o nt o f Comm un ity M di
o clna
M odl c11 I Coll oJ(o Ko llrnti
rlr,t f' urlodl rn l I 1C t1mln r1 110 11 o f Pho..o-l (ll
otch 20 22 23 )
Full m arks: 50
Group A Ti m e: 9 0 m inutes

, .. ,,,
, 1111 "' ' 1 In'' "" '"" 1l w 11 ,"nt 1.1 110 11 n l cl11 11n• 1t r• •1m ok ir 111 wi th ' ' lllv,• iq
L11 •nt d PvP lo pm c nt o f
, •11 1 , l',\\l' N,rn 1t' I 111• l yp1• o f 0pl<lflin lolo11lcnl •,tucly whi ch wl ll b,. , It bl t
, 1, 1("11 \ ,11,,11,,, dt
" ,u ,J e or
,H hH'' , i,:
11 11 11 , , 111 t1v ,,llll't t1 Vt'. I 11u 111 0 1i1lf' l hl' •,lt• p~ o l th e• i,tudy. How wi ll you a,; •,c-,', th e
, , , ,tH l IH• IW('('II clftMl' llt' 1, mokl ng nnd coro nary hea rt di <,Pasc?
,trt'nl~ II l 11 f " ' 1 1 111 ' 2+5+3
•

'- t' \ i' ' ,,t l ,1'l' '- ol 1r11.',1"h-' hdv e bcc'n rcpor t~d fro m o sub-ce ntre area. Describ e the line
of
'1, ,:~,,t \_'" 11! , t11.h ,ncnslcs o utbrea k. 10

Group • B

\\ tt -~,, rt k'tt' , on t he fo llowing: 5 X 2 = 10

,, \ au. ne via.I moni tor(VVM )
t- '\l cptl\ e predict ive val ue

Group · C

5 X 2 = 10
1 Chroni c ca rri ers are more importa nt source of infectio n than cases
.
2 A screeni ng test is not synony mous with a diagnos tic test.

Group • D

Mu 1 pie choice Questio ns : Choose the most approp riate answer .

10x1 =10
Wh 1s:r{of th e fo llowing is the first step in investig ation of an epidem
ic?
\v/De fining t he popula tion at risk
b) Confirm ation of existen ce of an epidem i c
c) Ra pid sea rch for all cases
d) Verifica tio n of diagnosis
" } In wni ch of the followi ng, Herd Immun ity cannot. protect
the inq ividual
a) /6 iphther ia
~ Tetanus
c) Pol iom yeliti s
d) Al l of t he abov e
lit ) Which of the fo llowing is not a sporicida l age nt?
) uta raldehyd e
hlo rine dioxide
orm aldehyd e
d) Creso l
iv ) Sa lk vaccine is a
a) Liv e vaccin e
b) /Liv e atte nu at ed vaccine
~ Ki lled vacci ne
d) Toxold
, ) 1\.1.Hl\ \ '''""'q ,,t I jl.\ll' tl l '-.,\ll( ll ,t h lldn \11 •1IJSCl' rH lblfllnmP 1•1 0, rh •
' ' '· ere occurs a pr Imary
'1\\ I' 1)f m,~.1, I ' \ .ind \ \ I' ( rnH Lll V ( , l ',1 1\ wi thin , 1 r,horl r>rrlo(I of tim e,
1
,1 hO~ Srcondar y attack rate is
t,1 t• '~
'-)
dI 1
,~ \
,l)I).,

\ I .... , I 1' \' IWlJt 1t' \t h ll l>t t'.l\l dlld f\l' ll ll.t l lrt1c l 111Jl1Rncin cy le;,
'\ii) l ,\ l 1 "1
t,) Off in' t'ndom~t11,1I tl \p11 tHion
l ) P,lp ~ll'll'J I
di MJmmot,11 Jphy
, ' P.cr"~sornan bias 1s J type of
,1) Informat ion bia s
~ , Selection bias
l \ lnten,1ew er bias
d) Recall bias
, A test has a high fa lse positive rate in a communi ty. True is
a) High prevalence
b) High sensitivit y
'f{ low prevalence
d) High specificity
\ 1 Best study design used for Exposure and Outcome association is:
a) Randomised controlle d trial
b!/'Ecological study
"1 Cohort study
d) Cross-sectional study
x ,, a population of 10000 people, the prevalence of a disease is 20%. The sensitivity of a
screening test is 95% specificit y is 80%. The positive predictive value of the test will be -
a) 15.3%
o) 45 .7%
c) 98.5%
\ij 54.3%

\
 Mt•tlln1I C:olloKo, lfoll<nln
l>op111·1naonl ol' p 11ll 10 I
Pt•rlodkal 11ss,•ssmont ('I-'" . ogy
Smncslor) Ph use II Examlru1tlon (SCHNl011 : 2022 -2:i J
Sub: Pathology
Papor-11
1 ull 111,11 k~ I \1\\ '/'i,n ,:: :1 hours

/\tt,•mpt all questions

\ •r, , ir-; ,11t- pa tient brought to OPO with high fever ' c:oug,h with mucoiJurul en t spu t um which j ~
' · 111
l'
- .
l,c,.,~ 1l111 ,1t1y h/otlll 111i x<' cl . Patient also compl,1lns ofpleuritic puin .,
.i i \\' h.1t 1s your pnivisional diagnosis'?
,,) lltsruss abo ut th e etiopathogcne sis of the condition?
( J \Vh ,1t arc th e mo rphological stages.

d l \\lh,1t are the \lsual outcome? 2+6+5+Z=1S

,\ 45 :,L',lrS male patient brought to the Emergency with haematem es1s · , II db . ·

_ . 10 owe
1
y un co ns c1ous n£:ss. fi e:
hc1d h1stor_v. ot alco holism ,.anorexia ·
nausea , weight loss, weak ness & m,'Id Jaun , Jast o ne: month.
' ior
d ice
. .,
d) Wha t 1s yo ur prov1s10nal diagnosis?
h) Discuss the etiopathogene sis of the condition?
c) Ho w do y ou investigate the case?
d) Wha t are tlie common complications ? Z+S+s ..,'3=15

\\'nrr short notes on:

a ) Chemi cal carcinogenesis
b) Hashi moto's thyroiditis

4 Explain the following statements: Sx4=20

a) Giant cell tumor is a misnomer.
b) Seco ndary pulmonary tuberculosis can be associated with cavity formation and massive
ha emoptysis.
c) Rapidly progressive glomeruloneph ritis(RPGN) has specific etiology.
d) Cro hn's disease and ulcerative colitis has similar features.
e) How do you· reveal a report of gastri~ carcinoma to a patient? (AETCOM)
Answer the followings : ' 3x10=30
aJ Discuss the role of hyperparathyr oidism in different bony abnormalities. 10
b) Classify primary bone tumor. Discuss in short about bone forming tumors.
5+5=10
c J Discuss the pathogenesis of diabetic nephropathy with its outcome.
7+3=10

[1x10 =10J
(> Chu osc the correct option for each of the following:
I. 1:ull ow ing type of H PV virus infection has high risk for carcinoma cervix
a. HPV - 6,8,11
b HPV - 13,14
V 11 rv- 16,18
c.J . IIPV- 25,26

II . 1•: llv associa tion is common in the following malignancies exc~ pt

;1. llod gkin lymphoma
h. ~ Nas orharyngeal carcinoma
c ./ llurkitt's lymphoma
~ Es or h"h"a l carc inoma /
 rma lity is papillary renal cell ca rci nom
mon genet\c abn o a
111.
7. Mu tated MEi proto oneoge
b. Loss of VII L gene
· ne

c. Inactlvatcd MET
d. llypcrmethylatlo n of VI IL

IV . Sterile py mea Is common In

a. Renal oncocytom a
~ Renal tub erculo sis
c. Renal stone form ation
c1. Cystic dise ase of kidn ey

V. Fib ros is in live r pa renchy ma

is con trib ute d by
✓. Kup fe r cell s
b. Eto cell
c. Histiocytes
:al d. Monocyte ma cr~ pha ges

Chloride level in CSF is ver y low

in
a. Bac teri al men ing itis
b. \Jira\ me nin giti s .
~ \ o../ Tub ercu \ar men ing itis
d. Fun gal 'me nin giti s

VI I. Pat ier ts wit h gas tric uJcl?r feel

s epig astr ic pai n wit h
a. Full sto ma ch (
·
✓. Em pty sto ma ch
e c. After con sum ing mil k
.e d. Aft er drin kin g wa ter
al

VIII. Which typ e of bre ast car cin om

a has bes t pro gno sis
~ ~NST)

c. ~ mm ato ry car cin om a

d. Mucinoms car cin om a

Wh '..'.;!r.of the following hea rt

con diti on is see n in Tur ner 's
a. Tri cus pid atre sia syndrome?
V " Coarctation of aorta
c. Tru ncu s arte rio sus
d. Patent duc tus a rter ios us
(PDA)

X. Casyis for me d in
'II. Pro xim al con vol ute d tub ul e
b. Nephron
C. DCT
d. Glom e rulu s
 Medical College, Kolkata
111
4 Sc111c11tcr MUDS Examination, 2024
Subject: Pharmacology
Pupcr - II

(Aflempt all the questions )

Time - 3 hours
Ans \\ e r thr foll lm mg que sti o ns

A) A patient presented with increased frequency , urgency and burning sensation

during micturitio n w;
dulls and rigor. The patient was diagnosed as uncomplicat.cd urinary tract infection.
--/ Enumerat e the drugs commonl y used in uncomplicated UTJ.
[5]
b Mention the mechanis m of action and common adverse effects of any two classes
of druos used in
UT! __, -- I [5 +~] -

B) A 56 year old obese female patient presents with unexplain ed weakness , itching at
the urethral
region, polyuria, increased thirst. Laborato ry investigat ions show that her fasting blood
sugar was
160 mg/d.L, HbA 1C 8.5% and was diagnosed as Type II diabetes.
a State the various classes of antidiabe tic drugs that can be used in this patient. t51
b. Compare the differenc e in treatment strategy between diabetic ketoacidosis and
hyperosmolar
coma.
[5)
C. State briefly about the newer insulin preparatio
ns. [5]
2 Answer the following :
a. Enumerat e the various classes of drugs used in acute attack of migraine. State briefly
about the
mechanis m, adverse effects and contraind ications of sumatript an.
f5 +5]
b. Enumerat e antiepilep tic drugs. State the managem ent of status epilepticus.
[5 +5]
C. State the p.h.annacotherapy of H.pylori infection . Illustrate the mech~m of action
of proton pump inhibitors in peptic ulcer disease.
[5 +5]

3. Write short notes on the following : . [5X2=10)

a. Pre-anaes thetic medicati on
b. Site of action of anti.fungal medicatio ns

4. E;;:,p
. why : _ __ [4X5=20)
.
. . preferred in initial HAART regunen

.
1
~~ . .
prepitan t is fused in post cancer vonutmg

fth generatio n ce phalospo nns are effective against MRSA

1
e.
Tric clic ant1depre ssan
y . . fi
Propylthi ourac1l is pre erre
_
ts takes atleast two weeks to sh9w therapeutic effect
d over carbimaz ole for the treatment of thyrotox1cos1S