LIPIDS
LIPIDS
Simple lipids which are esters of fatty acids with various alcohol and
include:
1. Neutral fats – ester of fatty acids with glycerol
- liquid fats are known as oil
2. Waxes – ester of fatty acids with higher molecular weight non-hydric
alcohol
Fatty acids
- Most abundant naturally occurring lipids.
- building blocks of several classes of lipids like the neutral fats,
phosphoglycerides, glycolipids, cholesterol esters, and waxes
- possessed long hydrocarbon chain and a terminal carboxyl group
- chain may be saturated (without double bonds) or unsaturated (with
1or more double bonds)
- with few exceptions, they have an even number of carbon atoms.
Butyric Acid, Caproic Acid, Capric Acid, Lauric Acid, Palmitic Acid,
Stearic acid, Arachidic acid, Lignoceric acid
Each carbon in the chain has two hydrogen atoms attached to it. It is
"saturated" with hydrogen atoms.
- Oleic acid is the most abundant fatty acid in nature forming about
50% of the total fatty acids in many fats and is found in all naturally existing
fats.
With low Molecular Weight and with the occurrence of double bonds
Neutral fats
2. Waxes
- neutral fats that are ester of fatty acids and high molecular weight
of alcohols, the most important of which is cholesterol.
- alcohols range in length from 14-34 carbon atoms
Example: sperm oil, bees wax, lanolin
Complex lipids
1. Phosphoglycerides
- sometimes called phospholipids
- esters formed by the union of different alcohols with phosphatidic
acid in which the alpha and beta positions are esterified with fatty
acids and the alpha position with phosphoric acid
- fatty acid in alpha’ position is usually a long chain saturated fatty
acid, such as palmitic or stearic; fatty acid in beta position usually
unsaturated such as oleic, linoleic, or arachidonic acid.
- phospholipids of physiological importance are:
3. Sphingolipids (glycolipids)
- formed by some fatty acids called ceramides and sphingosine
- generally structure of sphingolipids indicated below where
ceramides are in either linkage to different compounds
a. sphingomyelins – found in all tissues but very abundant in brain
and nervous tissues
b. cerebrosides – found in membranes of brain tissues, particularly in
the white tissue
c. gangliosides - usually found on the surface of cell
membranes, especially of nerve cells
3. Prostaglandins
- family of compounds comprising 14 fatty acids each containing 20
carbon atoms and having the same basic skeleton prostanoic acid
- involved in a number of biochemical interactions like regulation of
blood supply, development of inflammatory response, regulation of
ions influx across epithelial membrane, etc.
4. Steroids
- found in association with fats and separated from the fats after
saponification in the “unsaponifiable residue”
- all possess similar cyclic nucleus resembling phenanthrene (rings A,
B, and C) to which a cyclopentane ring attached
a. cholesterol
- widely distributed in all cells particularly in the nervous tissue
- major component of the plasma membrane
- also found underneath the skin and serves as the precursor of
vitamin D synthesis.
c. coprosterol
- occurs in faces as a result of the reduction of the double bonds of
cholesterol by bacteria in the intestine
d. bite salts
- constituent of bile
- strong emulsifying agent that help disperse fatty materials
- stimulate intestinal motility
e. steroidal hormones
- sex hormones; testosterone, estrogen, progesterone
- ACTH
B. Physical properties:
1. Greasy.
2. Penetrate some materials like paper producing a translucent effect.
3. Neutral fats when pure are odorless, tasteless, and colorless.
4. Insoluble in ordinary in solvent but soluble in organic solvent.
5. Non – volatile.
6. Produce characteristic crystals with definite melting point.
7. maybe solid or liquid (oil) at ordinary temperature.
8. Floats on water because of its low specific gravity. When
shaken with water, fast break into fine particles forming a temporary
emulsion.
C. Chemical Properties:
FUNCTIONS
DEEPEN
KEY POINTS
Lipids are non-polar substances wit key function as energy storage, signaling
and acting as structural components of cell membranes. Major types include
fats, and oils, waxes and phospholipids and steroids. Fats are stored form of
energy and are also known as triglycerides or triglycerols. Fats are made up
of fatty acids and either glycerol or sphingosine.
WORK ON THIS
Direction: Read and analyze the given questions before answering. Write
your answers in the space provided after each question.
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3. Describe what is being formed with the combination of glycerol and fatty
acids by a dehydration reaction.
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