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3 Hours Total Marks: 100

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1. Attempt all questions.

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2. All questions carry equal marks.

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3. Draw neat labeled diagrams wherever necessary.

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4. Use of log tables and non-programmable calculator is allowed.

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Q.1 a. Answer the following : (Any six) 06

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1. Explain the term: Therapeutic index

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2. Salts of EDTA form a complex with lead or arsenic is an example of which

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type of antagonism ?
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3. What is the specificity of a drug ?
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5. What are receptors ?

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6. What is the potency of a drug ?
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7. Give one example of the study of effect of drug by quantal response curve.
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Q.1 b. Answer the following questions: (Any Two) 14

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1. What are GPRS ? explain their role in in drug response

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2. Explain giving suitable examples, non-competitive antagonism. Explain its

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effect on the drug response curve of an agonist. A9

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3. Explain giving suitable example the construction of a quantal dose response

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curve
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Q.2 a. Do as instructed: [MCQ] (Any six) 06

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1. Several drugs have an affinity for retinal pigment and thus may accumulate
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in the eye. The pigment is

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a.melanin
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b. xanthene
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c. rhodopsin
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d. carotenoid
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2. Stomach emptying time can be altered by

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a.volume of ingested material

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b. viscosity of ingested material

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c. both
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d. neither
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3. The closer the pKa of a drug to the tissue pH, diffusion of drug
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a. will not be affected

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b. will be slower across the membrane

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c. will be faster across the membrane

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d. will not take place

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Paper / Subject Code: 86403 / Pharmacology & Neurochemistry

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4. The rate at which the drug reaches the site of action depends on

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a. rate of intake

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b. rate of absorption

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c. rate of metabolism

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d. rate of absorption and distribution

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retarded. This route of drug administration is

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a. Intravenous

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b. oral

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c. subcutaneous

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d. intramuscular

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c. diffusion
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d. adsorption

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7. The active efflux transporter in the blood brain barrier is
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a. cytochrome p450
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8. Since the pH of CSF is about 7.35, drugs which tend to concentrate in the
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a. neutral drugs
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b. weak organic acids

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c. weak organic bases

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d. strong organic acids

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9. The rate at which the drug penetrates the tissues and other body fluids
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depends on
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a. capillary permeability
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b. transport mechanisms available

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c. both
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d. neither
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Q.2 b. Answer the following questions: (Any Two) 14

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2. Elaborate on absorption of drugs from large intestine and rectum.

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3. Influence of pH on drug absorption and distribution of drug.

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Paper / Subject Code: 86403 / Pharmacology & Neurochemistry

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Q.3 a. Do as directed: (Any Six) 06

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2. Anaphylaxis is an example of ____________ hypersensitivity.

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3. Give one example of the drug that causes pulmonary reaction.

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4. State true or false-Prolonged administration of Gold salts causes cancer.

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5. Give one example of the antidote given to cure methanol poisoning.

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6. What do you mean by Drug Addiction?

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7. Assign one supportive treatment for accelerated elimination of the absorbed

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poison from the blood.

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8. Assign one antidote for lead poisoning.

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Q.3 b. Answer the following: (Any Two) 14

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1. Explain the term Misuse Drug. Elaborate- Alcohol as an Abused Drug.

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2. Discuss in detail the use of Supportive treatments being given to treat the

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pulmonary toxication.
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3. What do you understand by the term- Adverse Drug Reaction. Elaborate on 4

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any 3 elements attributing to the Adverse drug Reaction.

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Q.4 a. Do as directed: (Any six) 06

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1.
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Fill in the blank: The fatty acid sheath which surrounds and insulates most of
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the axons is called ________

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2. Give any one role of autonomic nervous system
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3. Name the neurotransmitter that regulates sleep-wake cycle.
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4. Name the neurotoxin produced by banded krait.

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5. What is synapse?
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Fill in the blank : several “islands” of gray matter, buried deep within the
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white matter of the cerebral hemispheres are called ______

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7. Which region of the brain controls breathing?

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8. Name any one compound that inhibits nicotinic receptors.

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9. Fill in the blank : Deficiency of L-DOPA causes ______

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Q.4 b. Discuss the following: (Any Two) 14

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1. Different types of synaptic vesicle proteins with their functions.

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2. Cerebrum with suitable diagram.

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3. Propagation of nerve impulses with suitable diagram.

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Q.5 Write Short notes on the following (Any four) 20

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a. Measurement of drug safety

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b. Drug distribution across the placental barrier.

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c. Absorption of drugs through skin.

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d. Adverse effects of the drugs on Male reproductive system.

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e. Electrical synapses
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f. Cerebellum
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______________
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