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    comprehensive pharmacy review 299

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    Rashid Hussain

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    comprehensive pharmacy review 299

    Uploaded by

    Rashid Hussain
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    comprehensive pharmacy review 299

    Uploaded by

    Rashid Hussain

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    © All Rights Reserved
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    of 1

    Drug–Drug and Drug–Nutrient Interactions 277

    Table 13-3 DRUG/HERB/FOOD ACTIONS WITH CYTOCHROME P450 ENZYMES

    Enzyme Inhibitor Inducer Substrate

    CYP1A2 Ciprofloxacin Phenytoin Naproxen


    Levofloxacin Carbamazepine Amitriptyline
    Cimetidine Charbroiled foods Verapamil
    Citalopram Tobacco Clopidogrel
    Ketoconazole Ritonavir Duloxetine
    Paroxetine St. John’s wort Ramelteon
    CYP2C9 Cimetidine Rifampin Tamoxifen
    Fluoxetine Carbamazepine Losartan
    Voriconazole Phenytoin S-Warfarin
    Fluconazole Celecoxib
    Amiodarone Phenytoin
    Efavirenz Carvedilol
    Metronidazole Voriconazole
    Glyburide
    Sildenafil
    CYP2C8 Gemfibrozil Phenobarbital Paclitaxel
    Nicardipine Rifampin Carbamazepine
    Atazanavir Carbamazepine Amiodarone
    Trimethoprim Pioglitazone
    CYP2C19 Ketoconazole Rifampin Diazepam
    Omeprazole Carbamazepine Phenytoin
    Topiramate Phenytoin Citalopram
    Fluoxetine Omeprazole
    Fluvoxamine Diphenhydramine
    Duloxetine
    R-Warfarin
    CYP2D6 Methadone Carbamazepine Amitriptyline
    Cimetidine Phenytoin Metoprolol
    Fluoxetine Ethanol Paroxetine
    Ritonavir St. John’s wort Duloxetine
    Haloperidol Ritonavir Haloperidol
    Amiodarone Venlafaxine
    Paroxetine Tramadol
    Quinidine Trazodone
    Sertraline Narcotic analgesics
    CYP2E1 Cimetidine Ritonavir Acetaminophen
    Disulfiram Isoniazid Caffeine
    Ethanol Venlafaxine
    CYP3A family Erythromycin Carbamazepine Atorvastatin
    Ketoconazole Phenobarbital Warfarin
    Saquinavir St. John’s wort Lidocaine
    Verapamil Nevirapine Ethyl estradiol
    Efavirenz
    Metronidazole Carbamazepine Cyclosporine
    Amiodarone Rifampin Alprazolam
    Cimetidine Garlic supplements Ziprasidone
    Diltiazem Grapefruit Doxorubicin
    Posaconazole Seville orange Amitriptyline
    Metronidazole Bitter orange Methadone

    (Continued on next page)

    Shargel_8e_CH13.indd 277 07/09/12 10:44 PM

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