CodeNo: F-7193/PCI

FACULTYOFPHARMACY
B.PharmacyVII-Semester (PCI)(Main &Backlog)Examination, March 2024
Subject:PharmacyPractice
Time:3Hours Max.Marks:75

PART-A
Note:Answer all the questions. (10x2 = 20 Marks)
1. Define Hospital.
2. Define Hospital Pharmacy.
3. Define ADR.
4. Define controlled drugs.
5. Define Hospital formulary.
6. Mention few drugs which require TDM.
7. What do you mean by automatics top order?
8. Define OTC drugs.
9. What do you mean by investigational new drug?
10. What is the significance of ESR?

PART-B
Note: Answer any two questions. (2x10 =20 Marks)

11. Define clinical pharmacy, explain the functions and responsibilities of clinical pharmacist.
12. Define inventory control? Explain in detail any one method of inventory control
technique used in the procurement of drugs
13. Explain in detail therapeutic drug monitoring.

PART-C
Note:Answer any seven questions. (7 x5=35 Marks)

14. Explain functions of hospital pharmacy.

15. Describe different types of adverse drug reactions.
16. What are the legal requirement for establishing a community pharmacy?
17. Explain in detail procedure for dispensing of controlled drugs.
18. Whatdoyoumeanbyrationaluseofdrugs?HowtheconceptofRationalusecanbe
implemented for OTC drugs
19. Explain salient features of hospital budget preparation.
20. Explain in detail various drug purchasing procedure in a hospital pharmacy
21. Explain in detail any four blood tests and their significance.
22. What do you mean by adherence? What are the methods to improve the patient adherence
towards chronic therapy.

******
 CodeNo: F-7191/PCI
FACULTYOFPHARMACY
B. Pharmacy VII-Semester (PCI)(Main &Backlog) Examination, March2024
Subject: Instrumental Methods of Analysis

Time:3Hours Max.Marks:75
PART-A
Note: Answer all the questions. (10x2 = 20 Marks)
1. Explain bathochromic shift and Hypsochromic shift with examples.
2. What are chromophores and auxochromes. Give examples.
3. Write the principles of absorption in IR spectroscopy.
4. Write the principles of partition and adsorption chromatography.
5. Write the different fuel gases and oxidants used in the flame photometry technique.
6. Writethedifferenttypesofstationaryphasesusedingelpermeationchromatography
separations.
7. Write the ion exchange mechanism inion exchange chromatography.
8. Define the Capacity factor.
9. Write the effect of solvent on the absorption maximum of compounds.
10. Write the applications of affinity chromatography.

PART-B
Note: Answer any two questions. (2x 10 = 20 Marks)

11. Describe different components of IR spectro photo meter with an eat labelled diagram.
12. Explain the principles and experimental details of Paper chromatography.
13. Explain the principles and instrumentation of the HPLC technique.

PART-C
Note:Answer any seven questions. (7 x5=35 Marks)

14. Describe the Jablonski diagramand explain different internal and external processes in
fluorescence emission.
15. Explain the factors affecting Ion exchange Chromatography and applications of
the technique.

16. Explain different sample handling techniques used in IR spectroscopy.

17. Write the Instrumentation and applications of the flame photometry technique.
18. Write short notes on nepheloturbidometry.
19. Describe the different types of detectors used in UV spectrophotometers.
20. Explain the different development techniques used in paper chromatography.
21. Write the principles and applications of Atomic absorption spectroscopy.
22. Discussthetheoryandprinciplesofseparationincapillaryelectrophoresis.

******
 CodeNo:F-7192/PCI
FACULTYOFPHARMACY
B. Pharmacy VII-Semester (PCI)(Main & Backlog) Examination,March2024
Subject: Industrial Pharmacy
Time:3Hours Max.Marks:75

PART-A
Note: Answer all the questions. (10x2=20Marks)

1. Write a note on SUPAC guidelines.

2. What is pilot plant and scale-up?
3. Explain the importance of validation.
4. What is Technology transfer?
5. Write the role of regulatory affairs.
6. Mention five important data documents for ANDA.
7. Write a note on different stages of clinical trials.
8. What is informed consent?
9. Write a note onISO9000.
10. Write the role of CDL.
PART-B
Note: Answer any two questions. (2x10=20 Marks)

11. Write about pilot plant and scale up requirements for Tablets and Capsules.
12.(a)What is technology transfer? Write general principles of TechnologyTransfer.
(b)Write the role and responsibility of regulatory affairs professionals.

13.(a)Explain the principles of QBD and applications of QBD.

(b)Write a note on NABL and GLP.

PART-C
Note: Answer any seven questions. (7x5=35 Marks)

14. Write a note on pilot plant scale-up for liquid dosage forms.
15. Write a note on Technology Transfer procedure from R&D to production (Process,
packaging and cleaning).
16. Write brief lyon Investigational New Drug(IND)Application.
17. Write the role of biostatistics in pharmaceutical product development
18. What is QRM? Describe the principle and process of QRM.
19. Write a note on six sigma concept.
20. Write brief lyon TQM.
21. Write a note on Indian Regulatory. Write CDSCO functions.
22. Write a note on COPP.

******
 CodeNo: F-7194/PCI
FACULTYOFPHARMACY
B. Pharmacy VII-Semester PCI)(Main & Backlog) Examination, March2024
Subject:Novel drug delivery systems
Time: 3Hours Max.Marks:75

PART-A
Note:Answer all thequestions. (10x2 = 20 Marks)
1. Differentiate between matrix and reservoir system.
2. Define polymers. Classify them with examples.
3. Define micro encapsulation. Write its applications.
4. Write the advantages and disadvantages of mucoadhesive drug delivery system.
5. Define micro spheres and microcapsules.
6. Write note on permeation enhancers used in Trans dermal drug delivery system
with examples.
7. What is floating time and floating lag time.
8. Write the applications of targeted drug delivery system.
9. Explain the basic structural components of liposomes.
10. Explain about intraocular barriers.
PART-B
Note: Answer any two questions. (2x10 =20 Marks)

11. Explain the approaches used in development of gastrore tentive drug delivery systems.
12. Explain in detail any two methods of micro encapsulation.
13. Explain the basic components and formulation approaches used intransdermaldrug
delivery system.
PART-C
Note: Answer any seven questions. (7 x5=35 Marks)

14. Discuss the physic chemical factors affecting controlled drug delivery system.
15. Explain the principles of mucoadhesion.
16. Write a note on nebulizers.
17. Discuss about intrauterine devices.
18. Explain about preparation methods of liposomes.
19. Write about production of monoclonal antibodies.
20. Explain about ocular inserts.
21. Explain about osmotic pump.
22. Explain about the inflatable and gastro adhesive systems.

******
 Code No: E-12328/PCI
FACULTY OF PHARMACY
B. Pharmacy VII Semester (PCI) (Backlog) Examination, July-2023

Subject: Novel drug delivery systems

Time: 3 Hours Max. Marks: 75
PART - A
Note: Answer all the questions. (10 x 2 = 20 Marks)
1. Define terms sustained, controlled and targeted release dosage forms.
2. List out pharmacokinetic parameters suitable for selection of drug for controlled drug
delivery system.
3. Explain about inflatable systems.
4. Explain the Nasal and Pulmonary routes of drug delivery.
5. Write the advantages and disadvantages of gastroretentive drug delivery system.
6. Describe various coating materials used in microencapsulation.
7. Write note on transmucosal permeability.
8. Explain advantages and development of intrauterine devices.
9. Write the applications of monoclonal antibodies.
10. Differentiate between liposomes and niosomes

PART - B
Note: Answer any two questions. (2 x 10 = 20 Marks)

11. Explain in detail physicochemical and biological factors affecting controlled release
formulations.
12. Explain in detail coacervation phase separation method with suitable examples.
13. Discuss about in detail a) Alzet osmotic pump b) Dry powder inhaler

PART - C
Note: Answer any seven questions. (7 x 5 = 35 Marks)

14. Discuss the classification and applications of polymers used in controlled drug delivery
system.
15. Explain the theories of mucoadhesion.
16. Explain about factors affecting permeation in transdermal drug delivery system..
17. Discuss the approaches used in development of gastroretentive drug delivery system.
18. Explain about nasal sprays and nebulizers.
19. Write a note on niosomes.
20. Discuss the ocusert with neat sketch.
21. Explain the preparation methods of nanoparticles.
22. Explain metered dose inhalers.

****
 Code No: E-12327/PCI
FACULTY OF PHARMACY
B. Pharmacy VII Semester (PCI) (Backlog) Examination, July 2023
Subject: Pharmacy Practice
Time: 3 Hours Max. Marks: 75
PART - A
Note: Answer all the questions. (10 x 2 = 20 Marks)
1. Classify Hospitals based on the system of medicine and speciality.
2. Define community Pharmacy
3. Mention any two pharmacokinetic drug interactions
4. Define rational use of medicines
5. Mention few principles for the inclusion of drugs in hospital formulary
6. Define TDM.
7. Mention any two functions of DTC
8. Define DIC.
9. Mention two tertiary references used for drug information center?
10. What is the significance of C-reactive protein?

PART - B
Note: Answer any two questions. (2 x 10 = 20 Marks)

11. Define clinical pharmacy, What are the roles and responsibilities of a clinical pharmacy
department.
12. Define adherence. What are the factors affecting patient adherence. How adherence
can be improved?
13. Explain in detail organisation and functions of DTC

PART - C
Note: Answer any seven questions. (7 x 5 = 35 Marks)

14. Explain schedule N of drugs and cosmetics act 1940.

15. Describe different types of drug interactions with examples
16. What are the legal requirement for establishing a community pharmacy
17. Explain economic order quantity.
18. What are OTC drugs? How OTC drugs to be counselled?
19. Explain salient features of hospital budget preparation.
20. Explain the importance of communication skill for the pharmacist
21. Explain various urine test and its significance
22. What is patient counselling? What are the barriers of patient counselling?

******
 Code No: E-12325/PCI
FACULTY OF PHARMACY
B. Pharmacy VII Semester (PCI) (Backlog) Examination, July / August 2023
Subject: Instrumental Methods of Analysis
Time: 3 Hours Max. Marks: 75
PART - A
Note: Answer all the questions. (10 x 2 = 20 Marks)
1. Explain different types of electronic transitions.
2. What is fluorescence quenching? Give examples.
3. Write the applications of Nephelometry and turbidometry techniques.
4. What are the different types of molecular vibrations in IR spectroscopy?
5. Write the principles of separation in Electrophoresis.
6. What is chromophore and auxochrome. Give examples.
7. What are the different types of Ion exchange resins used in Ion-exchange
chromatography?
8. Define theoretical plate and give the formula for calculating theoretical plates.
9. Write the principle involved in affinity chromatography.
10. State and explain Beer-Lamberts law.

PART - B
Note: Answer any two questions. (2 x 10 = 20 Marks)

11. Describe different components of a UV-Visible spectrophotometer.

12. Explain the principles and experimental details of thin layer chromatography.
13. Explain the principles and instrumentation of Gas chromatography technique.
PART - C
Note: Answer any seven questions. (7 x 5 = 35 Marks)

14. Explain in brief the gel electrophoresis technique.

15. Describe different methods for quantitative analysis of single component samples by
UV spectrophotometry.

16. Explain the principles, advantages and disadvantages, and applications of paper
chromatography.

17. Describe different types of detectors used in HPLC.

18. Write the principles and applications of atomic absorption spectroscopy.

19. Explain different sample handling techniques used in IR spectroscopy.

20. Explain the principles of fluorescence and Phosphorescence with the help of the
Jablonski diagram.

21. Explain the principles and applications of partition and adsorption chromatography.

22. Write the different factors affecting electrophoretic mobility of ions in electrophoresis
Separations.
****
s
e
 Code No: E-12326/PCI
FACULTY OF PHARMACY
B. Pharmacy VII Semester (PCI) (Backlog) Examination, July 2023
Subject: Industrial Pharmacy
Time: 3 Hours Max. Marks: 75
PART - A
Note: Answer all the questions. (10 x 2 = 20 Marks)

1. What is technology transfer?

2. Write a note on raw materials importance in pilot plant.
3. Write a note on analytical method transfer procedure in technology transfer.
4. Write a note on legal issues in technology transfer.
5. What is Investigator’s Brochure (IB)?
6. What is quality assurance?
7. Write a note on GLP.
8. Write a note on role of ISO in quality management.
9. Write a note on COPP.
10.Write a note on state licensing authority responsibilities.

PART - B
Note: Answer any two questions. (2 x 10 = 20 Marks)

11.What is pilot plant? Write the general considerations for pilot plant and scale up for
Tablets and Liquid dosage forms.

12.Write a note on the i) Principles of QBD ii) Six sigma concept.

13.(a) Write a note on Indian Regulatory. Write CDSCO functions.

(b) Explain about Central Drugs Laboratory and its function.

PART - C
Note: Answer any seven questions. (7 x 5 = 35 Marks)

14. Write the significance of personnel requirements and space requirements in pilot
plant and scale up.
15. Write a note on documentation in pilot plant and scaleup.
16.Write general principles of technology transfer.
17. Write a note on technology transfer agencies in India.
18. Write the role and responsibility of regulatory affairs professionals.
19.Write about IND and NDA application.
20.Write the role of biostatistics in pharmaceutical product development.
21.Write the applications of QbD in formulation development.
22.Write the SUPAC guidelines for various dosageforms.

******
 Code No. D-8258/PCI

FACULTY OF PHARMACY
B. Pharmacy VII-Semester (PCI) (Backlog) Examination, August 2022
Subject: Industrial Pharmacy
Time: 3 Hours Max. Marks: 75
Note: Answer all questions PART – A, any two questions from PART – B
and any seven question from PART – C.
PART – A (10 x 2 = 20 Marks)
1 Write a note on SUPAC.
2 What is validation?
3 Write a note on DQ, IQ, OQ and PQ.
4 What is QRM?
5 Define API and excipient.

4
6 What are various phases of clinical trials?

70
7 What is the aim of NDA?
8 Define Bioavailability and Bioequivalence.

-1
9 Write a note on CDSCO.
10 What is RDTL and its functions?

PART – B (2 x 10 = 20 Marks)
U
O
11 (a) Write the General considerations for pilot plant and scale up.
(b) Write a note on platform technology.
4

12 (a) Write a note on six sigma concept.

70

(b) Write a note on ISO 14000.

13 (a) Discuss Regulatory requirements and approval procedures for New Drugs.
-1

(b) Write the responsibilities of State Licensing authorities.

PART – C (7 x 5 = 35 Marks)
U

14 Explain the procedure for pilot plat scale-up for semisolid dosage forms.
O

15 What is technology transfer? Write general principles of Technology Transfer.

16 Write the role and responsibility of regulatory affairs professionals.
17 Write a note on technology transfer agencies in India.
18 Write briefly on Investigational New Drug (IND) Application.
19 Write about QbD and its applications.
20 Write about the Certificate of Pharmaceutical Product (COPP).
21 Write a note on the principle and process of QRM.
22 Write NDA Review process.
*****
 Code No. D-8257/PCI
FACULTY OF PHARMACY
B. Pharmacy VII-Semester (PCI) (Backlog) Examination, August 2022
Subject: Instrumental Methods of Analysis

Time: 3 Hours Max. Marks: 75

Note: Answer all questions PART – A, any two questions from PART – B
and any seven question from PART – C.

PART – A (10 x 2 = 20 Marks)

1. Define auxochrome and chromophore with example.
2. What is Quenching and types of quenching?
3. Write the interferences in Flame photometry and types of interference.

4
4. Name the Infra-Red radiation source.

70
5. Define the term chromatography and the general principle involved in it.
6. Mention the factors affecting Electrophoretic Mobility.
7. Write about the temperature program in Gas chromatography.

-1
8. Explain different types of pumps used in HPLC and their brief working principle.
9. Explain the principle involved in Ion Exchange Chromatography.
10. Write the theory involved in Gel Chromatography.
U
PART – B (2 x 10 = 20 Marks)
O
11. (a) Explain in detail about the construction and working principle of detectors
used in UV-Vis spectroscopy.
(b) Write about the Methodology involved in Paper Chromatography.
4

12. (a) Describe the sources and sampling techniques in IR spectroscopy.

(b) Explain the factors affecting in exchange methodology in ion exchange
70

chromatography.
13. (a) Explain the applications of HPLC with examples.
(b) Write about the Instrumentation of Affinity chromatography.
-1

PART – C (7 x 5 = 35 Marks)
U

14. Explain the technique of Capillary Electrophoresis.

15. Write about electronic transitions and solvent effect on absorption spectra.
O

16. Describe the theory involved in fluorimetric technique.

17. Explain the instrumentation of Nephelotubiodmetry.
18. Write the factors affecting vibration in IR spectroscopy.
19. Differentiate between single and multi-component analysis in UV-Vis
spectroscopy with examples.
20. Explain the principle and Interference in Atomic Absorption spectroscopy.
21. (a) Write the principle involved in column chromatography.
(b) Explain the working principle of Thermocouple Detector.
22. Write about the Detectors used in HPLC.

*****
 Code No. D-8260/PCI

FACULTY OF PHARMACY
B. Pharmacy VII - Semester (PCI) (Backlog) Examination, September 2022
Subject: Novel Drug Delivery Systems
Time: 3 Hours Max. Marks: 75

PART – A
Note: Answer all questions. (10 x 2 = 20 Marks)

1. Define terms sustained, controlled and targeted release dosage forms.

2. Write ideal characters suitable for selection of drug for controlled drug delivery
system.
3. Explain about inflatable systems.

4
4. Explain the Nasal and Pulmonary routes of drug delivery.
5. Write the advantages and disadvantages of gastroretentive drug delivery system.

70
6. Explain various coating materials used in microencapsulation.
7. Write a note on transmucosal permeability.

-1
8. What is floating time and floating lag time.
9. Write the applications of monoclonal antibodies.
10. Compare and contrast liposomes and niosomes.
U
PART – B
O
Note: Answer any two questions. (2 x 10 = 20 Marks)

11. Explain in detail physiochemical and biological factors affecting controlled release
4

formulations.
12. Explain in detail coacervation phase separation method with suitable examples.
70

13. Discuss about advantages and disadvantages and development of intra uterine
devices and applications.
-1

PART – C
Note: Answer any seven questions. (7 x 5 = 35 Marks)
U

14. Discuss the classification and applications of polymers used in controlled drug
delivery system.
O

15. Explain the theories of mucoadhesion.

16. Explain about factors affecting permeation in transdermal drug delivery system.
17. Discuss the approaches used in development of gastroretentive drug delivery
system.
18. Explain about nasal sprays and nebulizers.
19. Explain about osmotic pump.
20. Discuss the ocusert with neat sketch.
21. Explain the preparation methods of nanoparticles.
22. Explain dry powder and metered dose inhalers.

***
 Code No. D-8259/PCI
FACULTY OF PHARMACY
B. Pharmacy VII-Semester (PCI) (Backlog) Examination, September 2022
Subject: Pharmacy Practice
Time: 3 hours Max Marks: 75
PART - A
Note: Answer all the questions. (10 x 2 = 20 Marks)

1. Define Primary, Secondary and Tertiary hospital.

2. Mention the functions of hospital pharmacy
3. Mention the classification of ADR
4. Define idiosyncrasy.

4
5. Mention few examples of pharmacokinetic drug interactions
6. Mention few drugs which require TDM

70
7. Define patient counselling.
8. Define lead time.

-1
9. Define investigational drug.
10. Give a general patient counselling information for NSAIDs
PART - B
U
Note: Answer any two questions (2 x 10 = 20 Marks)
O
11. Describe different types of drug interactions. Add a note on reporting and
management of ADR
12. Describe organisation, structure, type and design of wholesale and community
4

pharmacy outlet
13. Explain different types of drug distribution system in a hospital. What do you
70

mean by satellite pharmacy?

PART - C
Note: Answer any seven questions (7 x 5 = 35 Marks)
-1

14. Define hospital formulary. What are the contents of hospital formulary? What is
the difference between hospital formulary and essential drugs list?
U

15. Explain the role of pharmacist in improving medication adherence and highlight
few counselling barriers.
O

16. Describe schedule N of drugs and cosmetics act rules 1945.

17. Describe the policies of pharmacy and therapeutic committee.
18. Explain the systematic approach of handling a drug information query.
19. Explain the role of a pharmacist in training and education.
20. Explain hospital budget preparation and implementation.
21. Define OTC drugs. What is the role of pharmacist in implementing rational use
OTC drugs.
22. Classify investigational drugs. Explain haematological tests and its significance.

******
 Code No. D-8182/PCI

FACULTY OF PHARMACY
B. Pharmacy VII - Semester (PCI) (Main & Backlog) Examination,
February / March 2022

Subject: Instrumental Methods of Analysis

Time: 3 Hours Max. Marks: 75

PART - A
Note: Answer all questions: (10 x 2 = 20 Marks)

1. State and explain Beer-Lambert equation.

2. What is fluorescence quenching? Give examples.
3. Write the principles of Flame photometry technique.

4
4. Write the applications of Nephelometry and turbidometry techniques.

70
5. Write different types of stationary phase column packing materials used in HPLC.
6. Write Van Deempter equation.
7. What are the different types of Ion exchange resins used in Ion-exchange

-1
chromatography?
8. Define theoretical plate and give formula for calculating theoretical plates.
9. What is an electronic transition and types?
10. Write the principle involved in affinity chromatography.
U
O
PART - B
Note: Answer any two questions: (2 x 10 = 20 Marks)

11. Describe different components of IR spectrophotometer.

4

12. Explain the principles and experimental details of paper chromatography for
70

Quantitative analysis.
13. Explain the principles and instrumentation of Gas chromatography technique.
-1

PART - C
Note: Answer any seven questions: (7 x 5 = 35 Marks)

14. Explain in brief about Paper electrophoresis technique.

U

15. Describe different methods for quantitative analysis of single component samples
by UV spectrophotometry.
O

16. Explain the principles, advantages and disadvantages and applications of thin
layer chromatography.
17. Write about Gel Permeation chromatography.
18. Write the principles and applications of Atomic absorption spectroscopy.
19. Explain different sample handling techniques used in IR spectroscopy.
20. Explain the principles of fluorescence and Phosphorescence with help of
Joblonski diagram.
21. Explain the principles and applications of partition and adsorption
chromatography.
22. Write the different factors affecting electrophoretic mobility of ions in
electrophoresis separations.

*****
 Code No. D-8183/PCI

FACULTY OF PHARMACY
B. Pharmacy VII - Semester (PCI) (Main & Backlog) Examination,
February / March 2022

Subject: Industrial Pharmacy – II

Time: 3 Hours Max. Marks: 75
PART - A
Note: Answer all questions: (10 x 2 = 20 Marks)

1 What is the need of pilot plant studies in pharmaceutical industries?

4
2 Write the level of changes expected under SUPAC.

70
3 Explain the quality risk management to technology transfer.
4 Describe the role of project team in the technology transfer.
5 Enlist at least four names of regulatory authorities functioning all around the

-1
world.
6 Enumerate the categories and type of INDs.
7 What are the benefits of NABL accreditation?
U
8 Mention the difference between corrective actions and preventive actions in
quality system.
O
9 Write the functions of state regulatory authority.
10 What are the regulatory requirements for new drug approval?
4

PART - B
70

Note: Answer any two questions: (2 x 10 = 20 Marks)

-1

11 Explain the steps involved in scale-up technology.

12 Define TQM and explain its key elements.
13 Discuss IND approval process in detail with help of flow diagram.
U

PART - C
O

Note: Answer any seven questions: (7 x 5 = 35 Marks)

14 Discuss the scale-up considerations for liquid oral pharmaceuticals.

15 Define the following: (a) Quality (b) QC (c) QA (d) Technology transfer
(e) QbD
16 Discuss business process benchmarking as a tool of quality management.
17 What are the roles of regulatory affairs personnel in pharmaceutical industry?
18 Describe different models for the statistical design of clinical trials.
19 Discuss transfer of technology between R & D and manufacturing unit.
20 Differentiate between GMP and GLP.
21 Discuss importance of non-clinical drug development.
22 Describe the terms “QTPP” and “CQA” concerning QbD.
*****
 Code No. D-8184/PCI

FACULTY OF PHARMACY
B. Pharmacy VII - Semester (PCI) (Main & Backlog) Examination,
February / March 2022

Subject: Pharmacy Practice

Time: 3 Hours Max. Marks: 75

PART - A
Note: Answer all questions: (10 x 2 = 20 Marks)

1. What are the roles of clinical pharmacist in ward rounds?

2. Write the classification of drug related problems.
3. Mention the requisites & objectives for management of materials in hospital

4
pharmacy.

70
4. Describe the significance of Drug Information Center.
5. Explain the important considerations for Therapeutic Drug Monitoring.

-1
6. Give a brief note on the factors affecting drug variability.
7. Write a short note on material requirement for community pharmacy.
8. Give definition of drug integrations and classify them accordingly.
9. Enumerate the types of drug ADRs with examples.
U
10. Write a note on rational use of drugs.
O
PART - B
Note: Answer any two questions: (2 x 10 = 20 Marks)
4

11. Define P & T Committee and write its objectives, organization and various
functions.
70

12. Define Hospital and enumerate the organization and functions of hospital.
13. What is meant by clinical pharmacy? Explain functions and responsibility of
-1

clinical pharmacy.
PART - C
Note: Answer any seven questions: (7 x 5 = 35 Marks)
U

14. Give a comprehensive note on factors affecting Therapeutic Drug Monitoring.

O

15. Explain the roles and responsibility of hospital pharmacist.

16. Describe the procurement or purchasing procedure for pharmaceuticals in detail.
17. Explain various hematologic tests and their significance.
18. Explain the steps involved in the preparation of hospital formulary.
19. Elaborate the requirements for establishment of Drug Information Center.
20. Provide the detailed role of pharmacist in medication adherence.
21. Write all the inclusive steps involved in patient counseling.
22. Define Inventory Control. Specify the methods of Inventory Control.

*****
 Code No. D-8185/PCI

FACULTY OF PHARMACY
B. Pharmacy VII-Semester (PCI) (Main & Backlog) Examination,
February / March 2022

Subject: Novel Drug Delivery Systems

Time: 3 Hours Max. Marks: 75

PART - A
Note: Answer all questions: (10 x 2 = 20 Marks)

1. Define terms sustained, controlled and targeted release dosage forms.

4
2. Enlist ideal characters suitable for selection of drug for controlled drug delivery
system.

70
3. Define microencapsulation, write its applications.
4. What are implantable drug delivery system with examples?

-1
5. Write the advantages and disadvantages of mucoadhesive drug delivery system.
6. Explain various coating materials used in microencapsulation.
7. Write a note on permeation enhancers with examples.
U
8. What is floating time and floating lag time?
9. Write the applications of monoclonal antibodies.
O
10. Write the methods of evaluation of liposomes.

PART - B
4

Note: Answer any two questions: (2 x 10 = 20 Marks)

70

11. Explain in detail physicochemical and biological factors affecting controlled

release formulations.
-1

12. Explain the methods of microencapsulation.

13. Discuss the basic components, formulation approaches for development of
transdermal drug delivery system.
U

PART - C
Note: Answer any seven questions: (7 x 5 = 35 Marks)
O

14. Discuss the classification and applications of polymers used in controlled drug
delivery system.
15. Explain the theories of mucoadhesion.
16. Write a note on osmotic pump.
17. Discuss the approaches used in development of gastroretentive drug delivery
system.
18. Explain about nasal sprays and nebulizers.
19. Write a note on niosomers.
20. Discuss the ocuserts with neat sketch.
21. Explain the applications of intrauterine devices.
22. Explain the formulation considerations of buccal drug delivery system.

*****
 Code No. 12332/PCI
FACULTY OF PHARMACY
B. Pharmacy VII-Semester (PCI) (Backlog) Examination,
September 2021
Subject: Instrumental Method of Analysis
Time: 2 Hours Max. Marks: 75

PART – A
Note: Answer any seven questions. (7 X 3 = 21 Marks)

1. Explain the principle involved in Silicon photodiode detector in UV-Vis

spectroscopy?
2. What are Singlet, Doublet and Triplet electronic states in Fluorimetry?
3. Define the term Retention time and Resolution in HPLC?
4. Explain the principle involved in Bolometer Detector?
5. Define the term Rf value.
6. Write the principles involved in Gel electrophoresis?
7. Mention different types of columns used in Gas chromatography?
8. Write different detectors compatible to HPLC?
9. Classify the Ion exchange chromatography?
10. Write about the deviations of Beer-Lamberts Law?
PART – B
Note: Answer any one questions. (1 X 14 = 14 Marks)

11. (a)Explain Theory and Instrumentation of Affinity Chromatography?

(b) Derive Beer-Lamberts Law?
12. Explain in detail the Instrumentation and Derivatization technique in Gas
Chromatography?
13. (a) Write about the Spectrophotometric titrations with examples?
(b) Explain the Internal and External conversions in fluorimetry?

PART – C
Note: Answer any five questions. (5 X 8 = 40 Marks)

14. Write about the fundamental modes of Vibrations in polyatomic

molecules?
15. Explain the Applications of Atomic Absorption spectroscopy with example?
16. Write in detail about the factors affecting Electrophoretic Mobility?
17. Describe the methodology of Adsorption Column Chromatography?
18. Write about the Interferences and their types in Flame Photometry?
19. Write a note on Wavelength selectors and sources of IR spectroscopy?
20. Describe the Principle involved in different sources of radiation of UV-Vis
spectroscopy?
21. Write the methodology and application of Thin Layer Chromatography?
22. What is Quenching and explain the types of Quenching with examples?

********
 Code No.12333/PCI
FACULTY OF PHARMACY
B. Pharmacy VII-Semester (PCI) (Backlog) Examination,
September 2021
Subject: Industrial Pharmacy - II

Time: 2 Hours Max. Marks: 75

PART – A
Note: Answer any seven questions. (7 X 3 = 21 Marks)

1. What is Pilot Plant?

2. Write a note on SUPAC.
3. What is Technology Transfer?
4. Name few approved regulatory bodies and Technology Transfer agencies in
India.
5. What is the role of regulatory affairs?
6. What are various phases of clinical trials?
7. What is Quality Assurance?
8. Write a note on GLP.
9. Write a note on Indian regulatory.
10. What is the role of Drug control laboratory?
PART – B
Note: Answer any one questions. (1 X 14 = 14 Marks)
11. What is Pilot plant and scale-up? Explain in detail about the scale up
techniques for Solid dosage forms (Tablets/Capsules).
12. (a) Write a note on Indian Regulatory. Write C D S C O functions.
(b) Write short note on State Licensing authorities.
13. (a) Write the principles of TQM.
(b) Explain the principles of QBD.
PART – C
Note: Answer any five questions. (5 X 8 = 40 Marks)

14. Explain the procedure for pilot plant scale-up for liquid dosage form.
15. What is technology transfer? Write general principles of Technology Transfer.
16. Write the role of regulatory affairs department in drug approval.
17. What is QRM? Describe the principle and process of QRM.
18. Write briefly on Master Formula Record and its importance.
19. Write a note on ICH guidelines.
20. Explain about Central Drugs Laboratory and its function.
21. Write brief note on (i) IND (ii) NDA.
22. Write protocol for technology transfer.

*******
 Code No.12334/PCI
FACULTY OF PHARMACY
B. Pharmacy VII-Semester (PCI) (Backlog) Examination,
September 2021
Subject: Pharmacy Practice
Time: 2 Hours Max. Marks: 75
PART – A
Note: Answer any seven questions. (7 X 3 = 21 Marks)

1. Define Hospital. Classify it based on clinical ground.

2. What is Idiosyncrasy? Give examples.
3. Differentiate hospital formulary and drug list.
4. Enlist the types of drug distribution systems.
5. Mention the specific objectives of health education.
6. Discuss the interpretation of the prescription.
7. Define Budget. Mention the approaches involved in the budget preparation.
8. Explain the significance of OTC drugs.
9. Classify drug store based on design.
10. Mention the role of hospital pharmacist in the investigational use of drugs.

PART – B
Note: Answer any one questions. (1 X 14 = 14 Marks)

11. Define Therapeutic Drug Monitoring (TDM). Mention its objectives and
explain the process involved in TDM.
12. (a) Explain in detail the objectives of Pharmacy and Therapeutic
Committee (PTC).
(b) Discuss the role of PTC in adverse drug monitoring.
13. Define Clinical Pharmacy. Explain in detail the functions and
responsibilities of clinical pharmacist.

PART – C
Note: Answer any five questions. (5 X 8 = 40 Marks)

14. Discuss in detail the functions of hospital pharmacy.

15. Explain the role and responsibilities of community pharmacist.
16. Mention the role of Pharmacist in the medication adherence.
17. Describe the various systems involved in the dispensing of drugs to
inpatients.
18. Illustrate the criteria for addition or deletion of drugs from hospital
formulary.
19. Define patient counseling. Enlist the steps involved in patient counseling.
20. Discuss the role of Pharmacist in the interdepartmental communication
and community health education.
21. Describe in brief the rational use of common over the counter medications.
22. Mention the various laboratory blood tests. Explain their significance.

*******
 Code No.12335/PCI
FACULTY OF PHARMACY
B. Pharmacy VII-Semester (PCI) (Backlog) Examination,
September 2021
Subject: Novel Drug Delivery Systems
Time: 2 Hours Max. Marks: 75
PART – A
Note: Answer any seven questions. (7 X 3 = 21 Marks)

1. Define the following dosage forms?

(a) Controlled drug delivery systems (b) Targeted drug delivery system.
2. Differentiate between matrix and reservoir systems?
3. List out the methods used for microencapsulation?
4. Define the following: (a) Implants (b) Transdermal drug delivery system.
5. Types of permeation enhancers used in TDDS with examples?
6. Define the following: (a) Liposomes (b) Niosomes
7. Differentiate between Zero Order and First Order release kinetic?
8. List out the different types of nanoparticles?
9. Enumerate the applications of monoclonal antibodies?
10. Write the advantages of Ocuserts?

PART – B
Note: Answer any one questions. (1 X 14 = 14 Marks)

11. Discuss the formulation of Transdermal drug delivery systems with the
components and examples? Add a note on factors affecting permeation?
12. Write in detail about the coacervation phase separation technique with
examples?
13. Write in detail about the following:
(a) Explain about the Alzet osmotic pump?
(b) Mucoadhesive drug delivery system?

PART – C
Note: Answer any five questions. (5 X 8 = 40 Marks)

14. Discuss about the factors influencing formulation of controlled drug

delivery system?
15. Write the polymerization techniques?
16. Explain the Wuster process for microencapsulation with an example?
17. Explain the different theories of mucoadhesion?
18. Describe the formulation of floating drug delivery systems?
19. Discuss about the metered dose inhalers?
20. Write a note on intraocular barriers? Describe the methods to overcome
the problem?
21. Write about the different types and applications of Intra-uterine devices?
22. Write about the elementary osmotic pump?

********
 Code No. 12224/PCI
FACULTY OF PHARMACY
B. Pharmacy VII-Semester (PCI) (Main) Examination, March 2021

Subject: Instrumental Methods of Analysis

Time: 2 Hours Max. Marks: 75

PART – A
Note: Answer any seven questions. (7 X 3 = 21 Marks)
1. Define chromophore and Auxochrome and give examples.
2. Explain the phenomenon of Fluorescence and Phosphorescence.
3. What are the different types of fundamental modes of vibration in molecules after
absorption of IR radiations?
4. Write the principles of partition and adsorption chromatography.
5. Write the different fuel gases and oxidants used in flame photometry technique.
6. Write the applications of gel permeation chromatography.
7. Write the ion exchange mechanism of ion exchange chromatogramphy.
8. Define retardation factor.
9. What is Bathochromic and Hypsochromic shift?
10. Write the principle involved in affinity chromatography.

PART – B
Note: Answer any one questions. (1 X 14 = 14 Marks)
11. Describe different components of UV spectrophotometer with a labeled
diagram.
12. Explain the principles and experimental detail of thin layer chromatography
for Quantitative analysis.
13. Explain the principles and instrumentation of HPLC technique.

PART – C
Note: Answer any five questions. (5 X 8 = 40 Marks)

14. Discuss the factors influencing intensity of fluorescence and applications

of Fluorimetry technique.
15. Explain about gel electrophoresis.
16. Explain different sample handling techniques used in IR spectroscopy.
17. Write the theory and principle involved in flame photometry technique.
18. Write short notes on nepheloturbidometry.
19. Describe the different types of detectors used in Gas Chromatography.
20. Explain the different techniques used in paper chromatography.
21. Write the principles and applications of Atomic absorption spectroscopy.
22. Write the different factors affecting electrophoretic mobility of ions in electrophoresis
separations.

***
 Code No.12227/PCI
FACULTY OF PHARMACY
B. Pharmacy VII-Semester (PCI) (Main) Examination, March 2021

Subject: Novel Drug Delivery Systems

Time: 2 Hours Max. Marks: 75

PART – A
Note: Answer any seven questions. (7 X 3 = 21 Marks)

1. Write the advantages and disadvantages of controlled release dosage forms.

2. Explain various pharmacokinetic properties for selection of drug for controlled drug delivery
system.
3. What are niosomes, write its structural components.
4. What are transdermal drug delivery system. Write its applications.
5. Write the advantages and disadvantages of mucoadhesive drug delivery system.
6. Define microspheres and microcapsules.
7. Write note on permeation enhancers with examples.
8. What is floating time and floating lag time.
9. Write the applications of targeted drug delivery system.
10. Write about classification of liposomes.

PART – B
Note: Answer any one question. (1 X 14 = 14 Marks)

11. Explain the approaches used in development of gastro retentive drug delivery systems.
12. Explain in detail coacervation phase separation with suitable examples.
13. Discuss classification, properties and applications of polymers used in controlled drug delivery
system.

PART – C
Note: Answer any five questions. (5 X 8 = 40 Marks)

14. Discuss the physicochemical factors affecting controlled drug delivery system.
15. Explain the principles of mucoadhesion.
16. Write a note on metered dose inhaler.
17. Discuss the basis used in development of transdermal drug delivery system.
18. Explain about intra-uterine devices.
19. Write about production of monoclonal antibodies.
20. Discuss the ocular barriers, methods to overcome barriers.
21. Explain the approaches used in development of controlled drug delivery systems.
22. Explain the formulation considerations of buccal drug delivery system.

***
 Code No. 12226/PCI
FACULTY OF PHARMACY
B. Pharmacy VII-Semester (PCI) (Main) Examination, March 2021

Subject: Pharmacy Practice

Time: 2 Hours Max. Marks: 75

PART – A
Note: Answer any seven questions. (7 X 3 = 21 Marks)

1. Describe the role of clinical pharmacist in health care setting?

2. Enumerate the types of drug related problems.
3. Mention the requisite Objectives for management of materials in hospital
pharmacy.
4. Indicate the advantages and disadvantages of Unit Dose Distribution System.
5. Provide four examples of TDM drugs with their therapeutic range.
6. Give a brief note on Factors which influence drug variability?
7. Write a short note on the Material requirement for community pharmacy.
8. Define ADR and classify.
9. Explain types of drug interactions with example.
10. Write a note on rational use of drugs.

PART – B
Note: Answer any one question. (1 X 14 = 14 Marks)

11. Define hospital formulary and elaborate the stepwise procedure involved
in the preparation of hospital formulary.
12. What is clinical pharmacy? Elucidate functions and responsibility of clinical pharmacy.
13. Give a detailed account on the factors affecting Therapeutic Drug Monitoring.

PART – C
Note: Answer any five questions. (5 X 8 = 40 Marks)

14. Explain the roles and responsibility of hospital pharmacist.

15. Write down the legal requirements for establishment and maintenance of drug store.
16. Enumerate the organization and functions of hospital.
17. Explain in detail about the role of pharmacist in medication adherence.
18. Define Pharmacy and Therapeutic Committee & explain the objectives, organization
and functions.
19. Give comprehensive note on the steps involved in patient counseling.
20. Define Inventory Control. Specify the methods involved in Inventory Control.
21. Describe the procurement or purchasing procedure for pharmacists in detail.
22. Explain the various hematologic tests and their significance.
***
 Code No. 12225/PCI
FACULTY OF PHARMACY
B. Pharmacy VII-Semester (PCI) (Main) Examination, March 2021

Subject: Industrial Pharmacy - II

Time: 2 Hours Max. Marks: 75

PART – A
Note: Answer any seven questions. (7 X 3 = 21 Marks)

1. What is platform technology?

2. Define: (a) Pilot Plant (b) Scale-up.
3. ‘Technology transfer means physical transfer of goods’. True or false, explain.
4. Write the roles of regulatory affairs department.
5. Explain the term “Technology transfer”.
6. Differentiate between IND and NDA.
7. Write the applications of Quality by Design.
8. What is OOS? How does OOS apply only to finished products?
9. Enlist functions of regulatory authorities.
10. Write the vision and mission of CDSCO.

PART – B
Note: Answer any one question. (1 X 14 = 14 Marks)

11. Explain the process of Change control with the help of flow-chart.
12. Discuss the NDA approval process in detail, illustrate with the help of flow
diagram.
13. Explain the features of finished product technology transfer as per WHO
guidelines.

PART – C
Note: Answer any five questions. (5 X 8 = 40 Marks)

14. Discuss the stages of pharmaceutical product life-cycle.

15. Explain the principles of Good Laboratory Practice (GLP).
16. Describe in detail the barriers to technology transfer.
17. What is Investigator’s Brochure (IB)? Comment on the content of IB.
18. Discuss the objectives of pilot plant.
19. Explain SUPAC guidelines.
20. Write about ISO 9000 series.
21. Describe the phases of clinical trials.
22. Enlist the key elements of TQM and explain any one of them.

***