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    Hemed-MD4-CR-

    Uploaded by

    Mohammed Sibghatullah Haidar

    Copyright:

    © All Rights Reserved
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    Hemed-MD4-CR-

    Uploaded by

    Mohammed Sibghatullah Haidar
    3 views5 pages

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    © © All Rights Reserved

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    Copyright:

    © All Rights Reserved
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    3 views5 pages

    Hemed-MD4-CR-

    Uploaded by

    Mohammed Sibghatullah Haidar

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 5

    1. Transketolase activity is affected in 5.

    The following metabolic abnormalities


    occur in Diabetes mellitus except
    (A) Biotin deficiency
    (A) Increased plasma FFA
    (B) Pyridoxine deficiency
    (B) Increased pyruvate carboxylase activate
    (C) PABA deficiency
    (C) Decreased lipogenesis
    (D) Thiamine deficiency
    (D) Decreased gluconeogenesis
    2. Which of the following compound is a
    positive allosteric modifier of the 6. An essential for converting Glucose to
    enzymepyruvate carboxylase? Glycogen in Liver is

    (A) Biotin (A) Lactic acid

    (B) Acetyl CoA (B) GTP

    (C) Oxaloacetate (C) CTP

    (D) ATP (D) UTP

    3. A substance that is not an intermediate in 7. The ratio that approximates the number of
    the formation of D-glucuronic acid from net molecule of ATP formed per mole of
    glucose is Glucose oxidized in presence of O2 to the
    net number formed in absence of O2 is
    (A) Glucoss-1-p
    (A) 4 : 1
    (B) 6-Phosphogluconate
    (B) 10 : 2
    (C) Glucose-6-p
    (C) 12 : 1
    (D) UDP-Glucose
    (D) 18 : 1
    4. The hydrolysis of Glucose-6-P is catalysed
    by a phosphatase that is not formed in which 8. Which of the following is a substrate for
    of the following? aldolase activity in Glycolytic pathway?

    (A) Liver (A) Glyceraldehyde-3-p

    (B) Kidney (B) Glucose-6-p

    (C) Muscle (C) Fructose-6-p

    (D) Small intestine (D) Fructose1, 6-bisphosphate


    9. Dehydrogenases involved in HMP shunt 13. Which of the following enzyme is not
    are specific for involved in HMP shunt?

    (A) NADP+ (A) Glyceraldehyde-3-p dehydrogenase

    (B) NAD+ (B) Glucose-6-p-dehydrogenase

    (C) FAD (C) Transketolase

    (D) FMN (D) Phosphogluconate dehydrogenase

    10. The “Primaquin sensitivity types of 14. An allosteric enzyme responsible for
    haemolytic anaemia has been found to controlling the rate of T.C.A cycle is
    relate to reduced R.B.C activity of which
    (A) Malate dehydrogenase
    enzyme?
    (B) Isocitrate dehydrogenase
    (A) Pyruvate kinase deficiency
    (C) Fumarase
    (B) Glucose-6-phosphatase deficiency
    (D) Aconitase
    (C) Glucose-6-p dehydrogenase deficiency
    15. The free energy change, ΔG
    (D) Hexokinase deficiency
    (A) Is directly proportional to the standard
    11. Out of 24 mols of ATP formed in TCA
    free energy change, ΔG
    cycle, 2 molecules of ATP can be formed at
    “substrate level” by which of the following (B) Is equal to zero at equilibrium
    reaction?
    (C) Can only be calculated when the
    (A) Citric acid→ Isocitric acid reactants and products are present at
    1mol/1 concentrations
    (B) Isocitrate→ Oxaloacetate
    (D) Is equal to –RT in keq
    (C) Succinic acid→ Fumarate
    16. The more positive the E0, the greater the
    (D) Succinylcat→ Succinic acid
    tendency of the oxidant member of that pair
    12. The glycolysis is regulated by to

    (A) Hexokinase (A) Lose electrons

    (B) Phosphofructokinase (B) Gain electrons

    (C) Pyruvate kinase (C) Lose (or) gain electrons

    (D) All of these (D) Lose and gain electrons


    17. All of the following statements about the (A) Lactate to Pyruvate
    enzymatic complex that carries out the
    (B) Phosphoenol pyruvate to pyruvate
    synthesis of ATP during oxidative
    phosphorylation are correct except (C) Oxaloacetate to phosphoenol pyruvate
    (A) It is located on the matrix side of the (D) Glucose-6-phosphate to Fructose-6-
    inner mitochondrial membrane phosphate
    (B) It is inhibited by oligomycin 21. Which one of the following would be
    expected in pyruvate kinase deficiency?
    (C) It can exhibit ATPase activity
    (A) Increased levels of lactate in the R.B.C
    (D) It can bind molecular O2
    (B) Hemolytic anemia
    18. An uncoupler of oxidative
    phosphorylation such as dinitrophenol (C) Decreased ratio of ADP to ATP in R.B.C
    (A) Inhibits electron transport and ATP (D) Increased phosphorylation of Glucose to
    synthesis
    Glucose-6-phosphate
    (B) Allow electron transport to proceed
    without 22. Which one of the following compounds
    cannot give rise to the net synthesis of
    ATP synthesis Glucose?
    (C) Inhibits electron transport without (A) Lactate
    impairment of ATP synthesis
    (B) Glycerol
    (D) Specially inhibits cytochrome b
    (C) α-ketoglutarate
    19. Under standard conditions
    (D) Acetyl CoA
    (A) The free energy change ∆G°, is equal to
    0 23. Reduced glutathione functions in R.B.Cs
    to
    (B) The standard free energy change ∆G, is
    equal to 0 (C) The free energy change, ∆G°, (A) Produce NADPH
    is equal to the standard free energy change,
    (B) Reduce methemoglobin to hemoglobin
    ∆G°
    (C) Produce NADH
    (D) Keq is equal to 1
    (D) Reduce oxidizing agents such as H2O2
    20. Which of the following reactions is unique
    to gluconeogenesis?
    24. The conversion of pyruvate to acetyl CoA 28. Triglycerides are transported from liver to
    and CO2 extrahepatic tissues by

    (A) Is reversible (A) Chylomicrons

    (B) Involves the participation of lipoic acid (B) VLDL

    (C) Depends on the coenzyme biotin (C) HDL

    (D) Occurs in the cytosol (D) LDL

    25. Increased urobilinogen in urine and 29. Which of the following is required as a
    absence of bilirubin in the urine suggests reductant in fatty acid synthesis?

    (A) Obstructive jaundice (A) NADH

    (B) Hemolytic jaundice (B) NADPH

    (C) Viral hepatitis (C) FADH2

    (D) Toxic jaundice (D) FMNH2

    26. Cholesterol is transported from liver to 30. De hovo synthesis of fatty acids occurs in
    extrahepatic tissues by
    (A) Cytosol
    (A) Chylomicrons
    (B) Mitochondria
    (B) VLDL
    (C) Microsomes
    (C) HDL
    (D) All of these
    (D) LDL
    31. Which of the following transfers acyl
    27. A jaundice in which serum alanine group from co-A to cys residue of KS?
    transaminase and alkaline phosphatase are
    a) Acyl carrier protein
    normal is
    b) Acetyl co-A ACP transacetylase
    (A) Hepatic jaundice
    c) Enoyl-ACP reductase
    (B) Hemolytic jaundice
    d) Malonyl co-A ACP transferase
    (C) Parenchymatous jaundice
    32. Which of the following carries acyl groups
    (D) Obstructive Jaundice
    in thio-ester linkage?

    a) Acyl carrier protein


    b) Acetyl co-A ACP transacetylase

    c) Enoyl-ACP reductase

    d) Malonyl co-A ACP transferase

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