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    Pharmacological Activities of Mentha Piperita- Mini Review

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    Pharmacological Activities of Mentha Piperita- Mini Review

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    Pharmacological Activities of Mentha Piperita- Mini Review

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    of 3

    Ethnobotanical Leaflets 13: 213-14. 2009.

    Pharmacological Activities of Mentha piperita- Mini Review


    S. Meenatchisundaram1*, G. Parameswari1, Diana Sunny1, M. Brinda2, T. Subbraj1, T.
    Suganya1 and A. Michael1

    1
    Department of Microbiology, PSG College of Arts and Science, Coimbatore, India
    2
    Department of Microbiology, GRD College of Science, Coimbatore, India
    *Corresponding author: Dr.S.Meenatchisundaram, E-Mail: [email protected]

    Issued 30 January 2009

    Peppermint (Mentha × piperita) is a hybrid mint, a cross between watermint (Mentha aquatica)
    and spearmint (Mentha spicata). The plant is indigenous in Europe and now widespread in cultivation
    throughout all regions of the world. It is found wild occasionally with its parent species

    Pharmacological Activities of Mentha piperita


    Antimicrobial activity
    Extracts of Folium Menthae Piperitae have antibacterial and antiviral activity in vitro. Addition of
    ground leaves to the agar medium inhibited the growth of Salmonella typhimurium, Staphylococcus
    aureus and Vibrio parahaemolyticus at concentrations of 0.1–2.0% (w/v). Aqueous and ethanol
    extracts of the leaves reduced the number of plaques of the rinderpest virus at concentrations of 4–8mg/
    ml1. Aqueous extracts of the leaves demonstrated activity against the following viruses in egg and cell
    culture: Newcastle disease, herpes simplex, vaccinia, Semliki Forest and West Nile2.

    Smooth muscle contraction


    A 31% ethanol extract of the leaves inhibited both acetylcholine- and histamine-induced smooth
    muscle contractions in guinea-pig ileum in vitro at a concentration of 10 ml/l. The results were similar
    ,4
    to those obtained with 0.13 mg atropine3 . An aqueous flavonoid fraction isolated from a leaf extract
    inhibited barium chloride-induced muscle contractions of guinea-pig ileum in vitro at a concentration
    corresponding to 0.5 g leaves/ml5.

    Choleretic activity
    Injection of a leaf infusion (0.5 ml) or a flavonoid fraction (equivalent to 3.3 g leaves/kg body weight)
    increased the amount of bile acids in cannulated rats and dogs (dose 0.4 mg/kg body weight)5,6. A
    mixture of flavonoids, isolated from the leaves, had choleretic activity in dogs (2mg/kg body weight)7.
    Flavomentin, a flavonoid isolated from the leaves, stimulated bile secretion and the synthesis of bile
    acids in dogs (2mg/kg body weight)8. Intragastric administration of a 30% ethanol extract of the leaves
    to rats (1ml/kg body weight) increased bile flow by 43%. The extract did not induce sedation in mice at
    doses up to 10 ml/kg body weight4.

    Anti-oedema activity
    Topical application of a methanol leaf extract to mice (2.0mg/ear) inhibited ear oedema induced by 12-
    O-tetradecanoylphorbol-13-acetate9.

    Analgesic activity
    Intragastric administration of a 30% ethanol extract of the leaves inhibited phenylbenzoquinone-
    induced writhing in mice (ED50 2.1 ml/kg body weight)4.

    Toxicology
    Intragastric administration of a leaf extract (50 g leaves infused with 500 ml hot water for 10 minutes,
    then spray-dried) to 12 mice (4 g/kg body weight as a single dose) did not result in central nervous
    system depression, toxic effects or mortality10.

    References
    1. Alwan AH. Antiviral activity of some Iraqi indigenous plants. International
    Journal of Crude Drug Research, 1988, 2:107–111.
    2. Herrmann EC Jr, Kucera LS. Antiviral substances in plants of the mint family
    (Labiatae). III. Peppermint (Mentha piperita) and other mint plants. Proceedings of the
    Society for Experimental Biology and Medicine, 1967:874–878.

    3. Forster HB. Antispasmodic effects of some medicinal plants. Planta Medica,


    1980, 40:309–319.
    4. Leslie GB. A pharmacometric evaluation of nine Bio-Strath herbal remedies. Medita,
    1978, 8:3–19.
    5. Lallement-Guilbert N, Bézanger-Beauquesne L. Recherches sur les flavonoides
    quelques Labiees médicinales (romarin, menthe poivrée, suage officinale). Plantes
    médicinales et Phytothérapie, 1970, 4:92–107.
    6. Steinmetzer K. Experimentelle Untersuchungen über Cholagoga. Wiener Klinische
    Wochenschrift, 1926, 39:1418–1422, 1455–1457.
    7. Pasechnik IK. Study of choleretic properties specific to flavonoids from Mentha
    piperita leaves. Farmakologiia Toksikologiia, 1966, 21:735–737.
    8. Pasechnik IK, Gella EV. Choleretic preparation from peppermint. Farmatsevtychnyi
    Zhurnal (Kiev), 1966, 21:49–53.
    9. Yasukawa K. Inhibitory effect of edible plant extracts on 12- Otetradecanoylphorbol- 13-
    acetate-induced ear edema in mice. Phytotherapy Research, 1993, 7:185–189.
    10. Della Loggia R. Evaluation of some pharmacological activities of a peppermint
    extract. Fitoterapia, 1990, 61:215–221.

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