Gluconeogenesis
Gluconeogenesis
metabolic energy.
For the human brain and nervous system, as well as the erythrocytes, testes, renal
medulla, and embryonic tissues, glucose from the blood is the sole or major fuel
source.
The brain alone requires about 120 g of glucose each day—more than half of all the
glucose stored as glycogen in muscle and liver.
the supply of glucose from these stores is not always sufficient; between meals and
during longer fasts, or after vigorous exercise, glycogen is depleted.
This is accomplished by a pathway called gluconeogenesis (“formation of new
sugar”), which converts pyruvate and related three- and four-carbon compounds to
glucose.
Conversion of Fructose 1,6- Conversion of Glucose 6-Phosphate
Bisphosphate to Fructose 6- to Glucose Is the Third Bypass
Phosphate Is the Second Bypass
glucose 6-phosphatase
Glycolysis equation