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Hadzic’s Textbook of
Regional Anesthesia and
Acute Pain Management
Self-Assessment and Review
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This book is dedicated to all students of anesthesiology and regional anesthesia and acute pain medicine.
SECTION 5 POSTDURAL PUNCTURE HEADACHE 135 PART 3E Local and Regional Anesthesia for
Oral and Maxillofacial Surgery 231
26 Postdural Puncture Headache ..................................137
35 Oral and Maxillofacial Regional Anesthesia ...........233
PART 3D Ultrasound-Guided Nerve
Blocks 141 PART 3F Local and Regional Anesthesia
for the Eye 237
SECTION 1 F UNDAMENTALS OF ULTRASOUND-
36 Local and Regional Anesthesia for
GUIDED REGIONAL ANESTHESIA 141 Ophthalmic Surgery ....................................................239
27 Physics of Ultrasound .................................................143
28 Optimizing an Ultrasound Image .............................147 PART 4 Ultrasound Imaging of Neuraxial
29 Introduction to Ultrasound-Guided and Perivertebral Space 243
Regional Anesthesia ...................................................151
37 Sonography of the Lumbar Paravertebral Space
and Considerations for Ultrasound-Guided
SECTION 2 ULTRASOUND-GUIDED HEAD Lumbar Plexus Block ...................................................245
AND NECK NERVE BLOCKS 155 38 Lumbar Paravertebral Sonography and
Considerations for Ultrasound-Guided
30 Nerve Blocks of the Face ............................................157
Lumbar Plexus Block ...................................................249
39 Spinal Sonography and Applications of
SECTION 3 U LTRASOUND-GUIDED NERVE BLOCKS Ultrasound for Central Neuraxial Blocks .................255
FOR THE UPPER EXTREMITY 161
PART 5 Obstetric Anesthesia 261
31A Ultrasound-Guided Cervical Plexus Block ..............163
31B Ultrasound-Guided Interscalene 40 Obstetric Regional Anesthesia ..................................263
Brachial Plexus Block...................................................167
31C Ultrasound-Guided Supraclavicular PART 6 Pediatric Anesthesia 271
Brachial Plexus Block ..................................................169
31D Ultrasound-Guided Infraclavicular 41 Regional Anesthesia in Pediatric Patients:
Brachial Plexus Block ..................................................173 General Considerations ..............................................273
31E Ultrasound-Guided Axillary Brachial 42 Pediatric Epidural and Spinal Anesthesia
Plexus Block ..................................................................177 and Analgesia ...............................................................277
31F Ultrasound-Guided Blocks at the Elbow .................181 43 Peripheral Nerve Blocks for Children .......................283
31G Ultrasound-Guided Wrist Block ................................185 44 Acute and Chronic Pain Management
in Children ....................................................................285
SECTION 4 ULTRASOUND-GUIDED NERVE
BLOCKS FOR THE LOWER EXTREMITY 187 PART 7 Anesthesia in Patients with
Specific Considerations 287
32A Ultrasound-Guided Femoral Nerve Block ...............189
32B Ultrasound-Guided Fascia Iliaca Block ....................195 45 Perioperative Regional Anesthesia
32C Ultrasound-Guided Lateral Femoral in the Elderly ................................................................289
Cutaneous Nerve Block ..............................................201 46 Regional Anesthesia and Cardiovascular
32D Ultrasound-Guided Obturator Nerve Block ...........203 Disease ..........................................................................295
32E Ultrasound-Guided Saphenous 47 Regional Anesthesia and Systemic Disease ...........299
(Subsartorius/Adductor Canal) Nerve Block ..........205 48 Regional Anesthesia in the Patient
32F Ultrasound-Guided Sciatic Nerve Block ..................207 with Preexisting Neurologic Disease .......................303
32G Ultrasound-Guided Popliteal Sciatic Block .............213 49 Acute Compartment Syndrome of the Limb:
32H Ultrasound-Guided Ankle Block ...............................215 Implications for Regional Anesthesia ......................307
50 Peripheral Nerve Blocks for
SECTION 5 ULTRASOUND-GUIDED NERVE Outpatient Surgery .....................................................309
51 Neuraxial Anesthesia and Peripheral
BLOCKS FOR ABDOMINAL AND Nerve Blocks in Patients on Anticoagulants ..........313
THORACIC WALL 217 52 Regional Analgesia in the Critically Ill .....................317
53 Acute Pain Management in the
33 Ultrasound-Guided Transversus Abdominis Opioid-Dependent Patient ........................................319
Plane and Quadratus Lumborum Blocks ................219 54 Regional Anesthesia in Patients
34 Pectoralis and Serratus Plane Blocks .......................225 with Trauma ..................................................................325
Catherine Vandepitte, MD, PhD Tom C. Van Zundert, MD, PhD, EDRA, FANZCA
Consultant Anaesthesiologist Udayana University, Bali, Indonesia
Kritieke Diensten Ziekenhuis Oost Limburg
Ziekenhuis Oost-Limburg Genk, Belgium
Genk, Belgium
Alexandru Visan, MD, MBA
Cedric Van Dijck, MD CEO, Executive Cortex Consulting
Dept. of Anesthesiology, Emergency Medicine & Critical Care Miami, Florida
Ziekenhuis Oost-Limburg
Genk, Belgium Alexander Vloka, MD
Internal Medicine Resident
Pascal Vanelderen, MD, PhD Boise VA Medical Center
Head of the Emergency Department Boise, Idaho
Ziekenhuis Oost-Limburg
Genk, Belgium Philippe Volders, MD
Professor at the Faculty of Medicine and Life Sciences Department of Anesthesia and Critical Care
Hasselt University Regional Anesthesia
Diepenbeek, Belgium Algemeen Ziekenhuis Diest
Diest, Belgium
Astrid Van Lantschoot, MD
Staff member anesthesiology Christopher Wahal, MD
ZOL Genk Assistant Professor of Anesthesiology
Genk, Belgium Department of Anesthesiology
Sidney Kimmel Medical College at Thomas Jefferson University
Thibaut Vanneste, MD Philadelphia, Pennsylvania
Anesthesiologist
Hospital Oost-Limburg Takayuki Yoshida, MD, PhD, EDRA
Genk, Belgium Assistant Professor
Department of Anesthesiology
André Van Zundert, MD, PhD, FRCA, EDRA, FANZCA Kansai Medical University Hospital
Professor & Chairman Discipline of Anesthesiology Hirakata, Osaka, Japan
The University of Queensland—Faculty of Medicine &
Biomedical Sciences Adam C. Young, MD
Chair, University of Queensland, Burns, Trauma & Critical Care Assistant Professor of Anesthesiology & Pain Medicine
Research Centre Co-Director, Acute Pain Service Assistant Professor
Chair, RBWH/University of Queensland, Centre for Excellence Anesthesiology & Interventional Pain Medicine
& Innovation in Anaesthesia, Department of Anaesthesia & Rush University Medical Center
Perioperative Medicine Chicago, Illinois
Queensland, Australian
Regional anesthesia and acute pain medicine protocols are organized in specific sections, whereas the answers are provided
rapidly changing. Introduction of ultrasound in interventional from NYSORA’s textbooks and relevant additional literature
pain management and regional anesthesia has led to substantial citations.
changes in practice management, protocols, techniques, and To our knowledge, this is the first question book that focuses
applications, and their effects on patient safety and efficacy. on the rapidly developing subspecialty of regional anesthesia and
Nearly all anesthesiology journals now incorporate a section acute pain management and point-of-care ultrasound-guided
on regional anesthesia and acute pain medicine. This evolu- interventional analgesia and anesthesia. With this volume we
tion of the practice and expansion of new knowledge mandates primarily aim at students of anesthesiology, but the question
frequent updates through continuous medical education. bank can also be used to assess knowledge acquisition of fellows
While the didactic knowledge of regional anesthesia and acute in regional anesthesia and acute pain medicine, and/or to test
pain medicine is available in anesthesiology textbooks, a compen- the knowledge of applicants for the diploma in regional anesthesia
dium of information for the purpose of knowledge assessment (eg, EDRA, European Diploma of Regional Anesthesia, adminis-
in the subspecialty does not exist. Hence, NYSORA’s Textbook of tered by ESRA, the European Society for Regional Anesthesia).
Regional Anesthesia and Acute Pain Management aims to fill this We hope that this question book will be useful in assessing
gap by providing a comprehensive databank of questions that knowledge acquisition. We invite comments and suggestions for
can be used to test students’ knowledge and clinical reasoning future editions and also look forward to developing this ques-
regarding new developments in the field. In making this book, tion book into a global knowledge assessment test.
we have selected a team of opinion leaders throughout the
world and paired them with students of anesthesiology in order Sincerely,
to prepare the questions and logical answers. The questions are Prof. Admir Hadzic
Writing a book is always a large undertaking that is Coppens at KUL, as well as René Heylen and the leadership of
difficult to accomplish without collaboration and support. ZOL, Genk, Belgium. Your wisdom and vision have created a
I would like to thank all NYSORA team members who have platform to make scholarly endeavors, such as completing this
donated their time, knowledge, and wisdom to this volume. book writing, possible.
I would also like to acknowledge the outstanding students of I would also like to thank the entire Department of Anesthe-
medicine, anesthesiology residents of the Catholic University siology, Intensive Care Emergency Medicine and Pain Therapy
of Leuven and Katholieke Universiteit Leuven (KUL), and at ZOL—your dedication to clinical care and teaching clinical
NYSORA Europe fellows in regional anesthesia at Ziekenhuis medicine is inspiring. Finally, much appreciation to Professor
Oost-Limburg (ZOL), Genk, Belgium. Several talented Dr. Jan Van Zundert for his advice, wisdom, and coaching me to
and resourceful anesthesiologists are richly deserving of join this inspiring group of anesthesiologists in bettering edu-
specific mention: Drs. Angela Lucia Balocco, Ana Lopez, and cation and clinical care in perioperative medicine and for an
Catherine Vandepitte. opportunity to develop the orthopedic anesthesia and research
Special thanks to NYSORA’s research team: Drs. Ingrid Meex unit at ZOL, in Limburg, Belgium.
PhD, Gülhan Özyürek, and Marijke Cipers. Likewise, a big
THANK YOU to Professor Marc Vandevelde, and Dr. Steven Prof. Admir Hadzic
9. Our understanding of pain has progressed over time, 6. D is correct. Bier was able to demonstrate that small
through evolution of several influential theories. Which amounts of local anesthetic (cocaine) injected into the
of the following was not instrumental in arriving at subarachnoid space could provide surgical anesthesia
our current concepts of nerve conduction and pain for over 67% of the body. Bier concluded that Corning’s
management? injection was extradural, and that he (Bier) deserved to be
A. Specificity theory acknowledged for introducing spinal anesthesia.
B. Choleric theory
C. Spinal gate theory 7. A is correct. Inadvertent change in the baricity of the
D. Intensive pain theory solution when tetracaine is used is not a potential com-
plication of spinal anesthesia. Lincoln Sise began using
tetracaine because of its longer duration of action but
was concerned about controlling the height of the block.
ANSWERS AND EXPLANATIONS Following Arthur Barker’s recommendations regarding
hyperbaric solutions, Sise added 10% glucose with success.
Options B, C, and D are known complications.
1. B is correct. Bernabé Cobo, who spent his life bringing
Christianity to the Incas, was the first to describe the 8. C is correct. In 1947, Manuel Martinez Curbelo of Cuba is
anesthetic effects of coca. credited with using the Tuohy needle and a small ureteral
catheter to provide continuous lumbar epidural analgesia.
2. D is correct. Carl Koller performed the first ophthalmo- Corning inadvertently described extradural anesthesia.
logic surgical procedure using local anesthesia on a patient The epidural space was first described by Achille Dogliotti.
with glaucoma. Sise experimented with adding glucose to tetracaine to
increase the baricity to control the block height after
3. B is correct. Lidocaine is an amino amide derivative,
subarachnoid blocks.
a stable compound not influenced by exposure to
high temperatures, and, most importantly, one that does 9. B is correct. The Choleric theory was not instrumental in
not have the allergic potential of the ester-type local arriving at our current concepts of nerve conduction and
anesthetics. The metabolite of prilocaine is implicated pain management. The Choleric theory is part of “The four
in methemoglobinemia. Ropivacaine is an S-enantiomer temperament theory” described by Hippocrates. Options A,
formulation. Procaine has the same allergic potential as C, and D were instrumental theories in arriving in our
tetracaine; both are ester anesthetics. current concepts of nerve conduction and pain management.
4. B is correct. Karl Ludwig Schleich’s approach still seems to
be relevant, particularly with the recent European enthu- Suggested Reading
siasm for tumescent anesthesia, in which sometimes-huge Hadzic A.The history of local anesthesia. In: Chuan A, Harrop-
volumes of very dilute local anesthetic are used for surface Griffiths W, eds. Textbook of Regional Anesthesia and Acute Pain
surgery. Management. 2nd ed. New York, NY: McGraw-Hill Publishing;
2017:chap 1.
5. A is correct. Corning’s successes with prolonging the
action of local anesthetic with a physical tourniquet
inspired Heinrich F. W. Braun to substitute epinephrine, a
“chemical tourniquet,” for the Esmarch tourniquet.