Cube Root of %

cumulative % % drug Square root log Cumu % log Cumu % % Drug

Time (Hr) log time drug Wo-Wt
drug released remaining time drug remaining drug released released
Remaining(Wt)
0 0 100 0.000 2.000 0.000 0.000 100 4.642 0.000
2 14 86 1.414 1.934 0.301 1.146 14 4.414 0.228
4 20 80 2.000 1.903 0.602 1.301 6 4.309 0.333
6 32 68 2.449 1.833 0.778 1.505 12 4.082 0.560
8 58 42 2.828 1.623 0.903 1.763 26 3.476 1.166
10 85 15 3.162 1.176 1.000 1.929 27 2.466 2.176
12 92 8 3.464 0.903 1.079 1.964 7 2.000 2.642
16 95 5 4.000 0.699 1.204 1.978 3 1.710 2.932
24 99 1 4.899 0.000 1.380 1.996 4 1.000 3.642

First Order Kinetics Korsmeyer Peppas

2.500
Log Cumulative % drug remaining

2.500
2.000 f(x) = − 0.0907593001826491 x + 2.16819561185561

Log cumulative % drug released

R² = 0.959631815581666 f(x) = 1.37359811256779 x + 0.402964126314609
2.000 R² = 0.875080286988741
1.500
First Order Kinetics 1.500 Korsmeyer Peppas
1.000 Linear (First Order Kinet- Linear (Korsmeyer
ics) Peppas)
1.000
0.500
0.500
0.000
0 4 8 12 16 20 24
Time (Hrs) 0.000
0.000 0.500 1.000 1.500
Log Time
 Zero Order kinetics Higuchi
120 120
f(x) = 4.68712871287129 x + 12.2950495049505
R² = 0.803464136539123 f(x) = 25.1122317999917 x − 12.5728002413926
100 100
Cumulative % drug released

Cumulative % drug released

R² = 0.864953011072652
80 80
Zero Order kinetics
Higuchi
60 Linear (Zero Order kinet- 60
ics) Linear (Higuchi)
40 40

20 20

0 0
0 4 8 12 16 20 24 0.000 1.000 2.000 3.000 4.000 5.000
Time (Hrs) SQRT of Time

Hixson Crowell
4.000
f(x) = 0.172932354726034 x − 0.0556885775390728
3.500 R² = 0.918198713286009
3.000
CBR(Wo)-CBR(Wt)

2.500
Hixson Crowell
2.000
Linear (Hixson Crowell)
1.500
1.000
0.500
0.000
0 4 8 12 16 20 24 28
Time (Hrs)
 Cube
log Cumu Root of %
cumulativ % drug log Cumu drug
e % drug % drug Square remainini % drug % Drug Remainin
Time (Hr) released remaining root time ng log time released released g(Wt) Wo-Wt
0 0 100 0.000 2.000 0.000 0.000 100 4.642 0.000
1 10.28 89.72 1.000 1.953 0.000 1.012 10.28 4.477 0.165
3 16.85 83.15 1.732 1.920 0.477 1.227 6.57 4.365 0.277
5 21.89 78.11 2.236 1.893 0.699 1.340 5.04 4.275 0.367
7 24.67 75.33 2.646 1.877 0.845 1.392 2.78 4.223 0.419
9 28.21 71.79 3.000 1.856 0.954 1.450 3.54 4.156 0.486
11 32.46 67.54 3.317 1.830 1.041 1.511 4.25 4.072 0.570
13 36.12 63.88 3.606 1.805 1.114 1.558 3.66 3.997 0.645
15 40.63 59.37 3.873 1.774 1.176 1.609 4.51 3.901 0.741
17 45.81 54.19 4.123 1.734 1.230 1.661 5.18 3.784 0.858
19 48.21 51.79 4.359 1.714 1.000 1.683 2.4 3.727 0.915
21 52.68 47.32 4.583 1.675 1.322 1.722 4.47 3.617 1.025
23 55.11 44.89 4.796 1.652 1.362 1.741 2.43 3.554 1.088
25 100 5.000 2.000 1.398 Err:502 -55.11 4.642 0.000

Zero order Higuchi

35 35
cumulative %drug released

f(x) = 2.60691218130312 x + 5.78730878186969

cumulative %drug release

30 30 f(x) = 9.49400442819885 x + 0.30054569438218

R² = 0.916473221363099
25 25 R² = 0.997583971058182
20 Zero order 20
15 Linear (Zero order) 15
10 10
5 5
0 0
0 2 4 6 8 10 12 0.000 0.500 1.000 1.500 2.000 2.500 3.000
Time (hrs.) SQRT of Time

hixson
0.600
f(x) = 0.0461680762650418 x + 0.088849219150223
0.500 R² = 0.936019187313961
CBR(Wo)-CBR(Wt)

0.400
hixson
0.300 Linear (hixson)

0.200

0.100

0.000
0 2 4 6 8 10 12
Time (hrs.)
 hixson

CBR(Wo)-CBR(
0.300 Linear (hixson)

0.200

0.100

0.000
0 2 4 6 8 10 12
Time (hrs.)

40 86.35 13.65 6.325 1.135 1.602 1.936 40.54 2.390 2.252

50 98.01 1.99 7.071 0.299 1.699 1.991 11.66 1.258 3.384
 Kors-peppas
35
log cumulative %drug release

30
f(x) = 24.8206097509214 x + 4.95142382924812
25 R² = 0.922981285999828
20 Kors-peppas
15 Linear (Kors-peppas)
10
5
0
0.000 0.200 0.400 0.600 0.800 1.000 1.200
log time

Higuchi First order

Log Cumulative % drug remaining

2.050
19885 x + 0.300545694382187 2.000
58182 1.950 f(x) = − 0.013878350564679 x + 1.97538167909509
1.900 R² = 0.945069098426488
Higuchi First order
Linear (Higuchi) 1.850 Linear (First order)
1.800
1.750
1.700
1.500 2.000 2.500 3.000 3.500 0 2 4 6 8 10 12
QRT of Time time (hrs.)
8167909509
First order
Linear (First order)
Batch No. HR1 HR2 HR3 HR4 HR5
Model name R2 R2 R2 R2 R2
Zero order 0.9722 0.9722 0.9409
fist order 0.9286 0.9286 0.9822
Huguchi model 0.8079 0.8079 0.9245
Hixson 0.9507 0.9507 0.9726
Kor's peppas 0.942 0.942 0.9865
HR6 HR7 HR8 HR9 HR10
R2 R2 R2 R2 R2
0.7741 0.8965 0.9718 0.9697 0.8742
0.923 0.9817 0.9789 0.9846 0.9834
0.9078 0.9163 0.9057 0.917 0.9262
0.9046 0.9636 0.988 0.9873 0.963
0.8483 0.9669 0.9934 0.9915 0.9449