vonmne 7 20 Merk) SIAN A OVERNMENT PHARMACY COLLEGE SONG | oe ee ARE G Pharm, | SESSIONAL EXAMINATION, Ob 2024 PHARMACEUTICAL ORGANIC CHEM GW | Time: hour Mo 1 ek rximum Marks: 30 ‘Answer al questions Bo 1. Write a reaction to convert phenol to salicylaldehyd 2. Write a Gatterman Reaction, eee 3. Draw the structure of Cumene and Lindane. 3 4 Write the structure and use of Saccharin and DDT. 5. Atrange the following in order of decreasing acidity: [4-Chlorophenol, Picric acid, 4-Nitrophenol}, SECTION -B White notes on ANSWER ANY 2 (TWO) QUESTIONS (2X5=10 marks) | 5. Explain in detait the qualitative test for phenols. | 7 Explain the molecular structure of benzene with structural representation. \ 8. — Priedel craft's alkylation with its limitation. | SECTION ~ | ANSUIER ADIY 1 (ONE) QUESTION (1X10=10 Marks) | 9. Elaborate on theory of directing, activating and deactivating effects of ‘substituents on benzene reactivity with relevant examples. 10. © the acidity of phenol and alcohol. Explain in detail the effect and tion of substituent on acidity of phenol with relevant examples | ier InEeaa aaa - | a | GOVERNMENT PHARMACY COLLEGE SAJONC \ | AN SEMESTER B.Pharm, Il SESSIONAL EXAMINATION obo 2022 \ Pharmaceutical Organic Chernistry-II (BP301-T) 4 Time: 7 hour \ es 3 roa SECTION — A \ ANSWER ANY 5 (FIVE) QUESTIONS 2x 5= 10 Mark J 7 SMISTRY - IL 1. Give two smthetic uses of ary! diazonium sats | wry ydroxy id dic than para hydroxy benzol | Maximum Marks : 7 3. Give any two methods for preparation of Aromatic add |) | 4 Why benzoic acid is meta directing group \ 5. Carbylamines reaction of aromatic amines. SECTION -B \ ANSWER ANY 2 (TWO_) QUESTIONS (5 X 2= 10 Marks) \ acid. 6. Important reactions of benzoic acid. 7. Why aromatic amines are weaker bases than ammonia and aliphatic amines. | 8. Effect of substituent’s on acidity of aromatic acids. sieity of compow SECTION ~C \ ANSWER ANY I(ONE) QUESTION (10X1=10 Marks) | 9. What are oils & fats? Enlist the analytical constant of fats and oils w } their significance. 10. What are aromatic amines? Give any three method aromatic amines. Write a note on basicity of aromatic amines. reparation of | | of phosphori46301 Odd Semester End-Term Bxamination 2023-24 B.Pharm, — 1 Semester [BP017 : PHARMACEUTICAL ORGANISATION CHEMISTRY - 11 ‘Time : Thres hours ‘Maximum Marks: 75 % SECTION A ~ (10 x2= 20 marks) Answer ALL questions, Draw structures with IUPAC names for styrene and anisole, Name any one monoenoie and one dienoic unsaturated fatty acid. hybridization and acidity/basicity of compounds? What is the correlation between “Write any one synthetic application of ary! diazonium salt. Define RM value. Write its significance. Write the reaction to convert bromobenzene to benzoic acid. What is partial hydrogenation of oils? Write Dow's reaction to synthesize phenol acid value and saponification value. Differentiate between andl propene in presence of phosphoric acid. Write the reaction between benzone SECTION B - (7x 5 = 35 marks) ‘Answer any SEVEN of the following. energy diagram. Enumerate on “stabilization energy of benzene” using and stability of polynuclear Write a note on classification, nomenclature, hydrocarbons. {Turn over26, Write a note on ieee en a es de, Sarucrur end non of diphonyimetbane pate v9 bon? 419, How doos bene position contribute gporion ¢- @x10= 20maris) “Answer any TWO of the follow!nE: romatic amines with PA Desoetbo the factore and aubetitvonts that affect basicity of aromatic ami examples. 21. Explain the stereochomistry of fatty acids. ‘Fischer ostorification 22, Elaborate on theory of directing, substituents on benzone reactivity. Write the mechanism involved in activating and deactivating effects of Panter i : a i zg PAYSICa,ranacenis-1 04/11/2024 11:44GOVERNMENT PHARMACY COLLEGE SAJON 41 SEMESTER B Pham Il SESSIONAL EXAMINATION, Sot voa.23, PHARMACEUTICAL ORGANIC CHEMISTRY. (8301-1) = ‘Maximum Marks: 30 MULTIPLE CHOICE QUESTIONS 1510=10 Marks) —_ the degree of unsaturation in fats & oils, b._| Ester value REE a d._| todine Value ul Tay ea inate poset Este aoe Taine Vato b._| Healthy for consumption 4-itrophenol j 3 4._| Phenol>4-nitrophenol 3 ‘of acidity willbe in the order : b [O>p>m : 4. |O>m>p 4 = (5x2=10 Marks) n value and Ester value. oF Fisher Esterification, ls and its substituted derivatives. (10X1=10 Marks) ‘of substituent’s on acidity of aromatic carboxylic acids, Jes the effect of substituent’s on basicity of aromatic ana y ‘Maximum M '=20 Marks) “Disadvantages fo = swith example. ‘nt monitoring sy (10Xx1: Tdinieal pharm(ar4=5) ee (18-5) © paration (@43=5) @+3=5) 2+3=5) Odd Semester 1 er End-Torm 5 Examination 2022-2023 (March 2029) 8. PhArM. — ‘Third Sontonter BP 301 T- Puan, IMAC ric, CEUTICAL ORGANIC CHEMISTRY. Maximum Marks 76 SECTION A~ (10x 26 9 0 marks) Answer ALL parts, ‘Define acid value, Give the structure and uses of DDT. : : ity Define rancidity. Write the structure and uses of naphthol. ‘Write the significance of Iodine valuo. Write the synthetic usos of aryl diazonium chloride. aw the structure of diphenylmethane and triphenylmethane. two examples of electron releasing group. e the reaction for nitration of benzene. SECTION B - (7x 5 = 35 marks) Write notes on (Any Seven). ibe the Friedel Craft alkylation reaction of benzene, Write the limitations of sicity of aromatic amines, [Turn overje acid. substitutents on avidity of bonz0l is and oil8. ion value, Also mention it's 18. Bxplain the offect of 5 14, Weite short note on physiochemical properties of fa! 15. Describe the mothod for determination of saponificat's importance. 16, Dosoribo tho mochaniem of Haworth synthesis of naphthalene 17. Write about Baeyer Strain theory and it's limitations. 18. Write any two ring opening reactions of cyclopropane 19. Weite any two methods for the preparation of aromatic amines SECTION C - (2 x 10 = 20 marks) Attempt any TWO of the following. 20. Describe the structure of Benzene. Explain the aromaticity of benzene emphasizing Huckets rule a e cae 21 Write the synthesis and chemical properties of phenol. 22, Describe the structure, preparation, reactions and modicinal uses of naphthalone.= — = vtuon 2921 coop semester 2020) diya Urey Ee « 2. arm od Pull Marks: 75 aes. EK Ras, : bASr. nT stk _ Dat te: uy Mi New: 2029 GOVERMENT PHARMACY OLE NON, » su seaMSSTOR B Phorm, | SESSIONAL EXAMINATION, OOD 2022 SARMACEUTICAL ORGANIC CHEMISTRY-Ht (OP301-T) how Ss ‘Maximum Marks: 30 pio=10 7 ame Tor ‘Chioramine’T | DHE | in iy Uvodiation eadeto | DidVorogydohexane = Tetrachloroeydohexane: ale acid gives | nits methylberaoic id 2 eel -einathiyi2, aietrobenzoic acd | ltration of be nic acd gives 'nitrobenzenesulphonic aid Zenitrobenzenessiphonieackd | re | 4-nirobenzenesilphonic acid 26 4niiroberzenssulphonic edd Soraveredinte ants ‘acid from toluene ‘| Step I. nitration step 2. oxidation. Step oxidation ep 2. nation = fa, semen fF [= | Sap en er aon estion as alogers are | (Oaho-para director ‘Orthexpara director/ deactivating “th 3 mele of ale <| “Tation of meth eid ale o|Figlale| Oxhorpara director ‘Ortho-para rector and acival ss or gerrates Bae Strongly elecron donating | Secondary carbocation fone pair isnot the part of playsen? EB Pyrrole ._ | Cyelohexadiene faa bond to2 accent carbons byte ove S| = elgleleilels| ale) b._| Sp2ss hybrid orbital $p2-sp2 hybrid orbital (5X2-10 Marks) icalSOONT PAO __FBVERET @ —_omaOTIE 220304 aoa a9) vane CHT SID REUSE O | /me nom na Tart Se nee& Anewer any TWO of the following, 30. Explain Baeyer strain theory with 31. Synthesis, chemical reaction and uses 32. Explain reactions and effect of substi (10 marks x2[GOVERNMENT PHARMACY COLLEGE SONG {WSRMESTER Pharm SESSIONAL EXAMINATION, 000 2023 (11910 orks vase pen aC | pe Baa -viopieet re [perl &_[Phencl reacts wh wk 150°C wt 3OAim ine presence oTNI catalog “a Gelonexne b. | ydohevene re [town a. No reacion ecu Seer groups wn lcron wiharaing group de to a. | resonance | inductive fect | Resonance and nduetie effet —|-d-_| hypeeorjuston ae -E_] Phenols converted to socyaoenyce won trated wih eorofrm and KOM, the reaction snownas ey) | Fide reaction 1] Rosenmondveaaton | oles reacton | Reimer-temann eatin S| Which of the folowing is more ade? a. | meres B| pred ce] Phenol a. | orsol “E_| enzane undergoes reactions 2. | Addition &&imiation | Subation & Adon 1 ‘| Biminaton aSubsituon | Only Subsittion 7._| Friedel craft alkylation takes place in presence of Tews base | Aljihatide =| acy hal 6 | tews sod B._| Eramiple ofret drectng group hbenene zi a. NH, bon PE [chs z ofthe flowing used asa swing pool disinfectant? va_[ oor 1b] Saccharn re | chloramine 30, {gas0 known as Lindane. zi 3] chtoramines [oor 1c [iseechoria J [ene ‘SECTION=B (8X 2= 10 Marks) halogens, although ortho-para directors, are rng deactivator. vy methyl eroup are ortho-pae directors, Fc} resorcino), d) chloramines, e) napthols. for the synthesis of 3-Nitro & 4-Nitrobenzolc acid from benzene (10x1=10 Marks)iat ‘COUEGESAJONG 7 4 {U EAMINATION, NOV-2021 SO PHARM ORGANIC CHEMISTRY (BFOOI-T) Time 1 hour SECTION= A. Masson Marks: 30 MENS squLTIPLE CHOICE QUESTIONS {Uxi0-10 Mark) ca ped to a 1b, | Decreases Ta | Stabilies ican ‘mine i known a8. reaction, Tet Reaction ase meta director, 50 the ESR will take place mainly in nec! e pan’ace area re& lation? ‘tion ion volume by one of th separator up ar to escape mot exceed lowing mec tion ssure 1e pipe aid ow °' POCO X5 PRO 5G | AD_ROCKS 04/11/2024 11:49“Rabiect: Pharm: aceutieal Or j Date 30/03/3055 USM! Organte Chemiatey Time: 2:90 PM-8:30 PM a 10. 12. 13. 14. Section ~ A. Multiple Choice Questi ice Questions (Ans ewer atl) Stricture oF cnzerie wes propose a. August Kekule men © August J. Thicke Which ofthe compound is more alae a. p-cresol c. o-cresol Resonance energy of Napthalene is a. 61kcal/mol v. 4 ¢. 60keal/mol Which of the following is used as a swimming pool disinfectant fa. Saccharin ¢. Chloramine Cyclopropane reacts with bromine in dark to form a. 1,4-dibromopropane ¢. 1,1-bromopropane Phenanthrene undergo addition reaction and give products of... b. 9 subsituted a. 9,10 disubsituted ¢. 8,10 disubsituted All carbon atoms in Anthracene are... a. sp Hybridised c. sp2 Hybridised d. p orbital Electrophilic substitution reaction of naphthalene takes place in acl b.C-3 C2 aca Electron withdrawing group in aromatic acids a. Inerease the acid strength b, Decrease the acid strength c. No effects d. Both a and b ‘Sachse Mohr's theory was proposed in the year... a. 1931 b. 1930 ¢. 1890 4. 1918 ince of nitric acid at 165°C to produce Napthalene undergo sulphonation reaction in prese >, 6-Napthalene-Sulphonie acid a, 2-Napthalene-Sulphonic acid ¢. 1-Napthalene-Sulphonic acid ‘The degree of unsaturation of a fat can be dete} a. Saponfication number c. Ester value Benzene when added with 3) a. Cycloheptane ¢. Cyclopropane COOH group is will take place mainly at a. Ist c. 3rd Sweet of2 opps. —— AoC End Term Beamiaation 2021 perch 202 -PHARM - Semester IIL - H in presence of nickel as catalyst will give . considered as a meta director, position 2 BPIOIT (120-20) b.N, Dewar 4.7. Ladenburg b, p-nitrophenol 4. o-chlorophenol ‘91kcal/mol ‘71keat/mol , Phenol 4, BHC , 1,3-dibromopropane 4, 1,2-dibromopropane d. 10 subsituted b. sp3 Hybridised d. None of the above srmined by means of its b, Acid value d, Iodine Number b, Hydrobenzene d, Cyclohexane so the electrophilic substitution reaction b, 2nd d. 4thabject: Pharm, B.PHARM. sation 2021 (March Git Sapeateetin Oreane GRAM Semen maa ‘Time: 2:30 PM-8:30 pay Paper: BP301T “wo (02) hours for writing pius on Z2!tl TES® (0) hourse ne (01) hour for down Leal eee ) hows for download and email of Anewer Sergi ee ~aromatic polynuclear hydrocarbons compound ©. Non-Benzenoid b, Angular eee: t0 an aantpcagearh ieee 8. Naphthalene Spear ©: Phenanthrene deen ° 4. Anthraquinone +-~-n8 one of the major reasons that _ ae maj that foods deteriorates caused by the reaction of &. Hydrolysis b, Dryin ¢. Lipid oxidation ae 18. Isopropyibenzene also known as ee a Benzoyl e titans Eee 19. _Diphenylmethane undergo dehydration to giv@ so. a Benzophenone bs, Fluorene ¢Dipheny! methyl bromide 4. None of the above 20, Identify the structure of Resorcinol pea or b es cS A ea Sectio: Short type Questions (Answer any seven) 21, Saponification and Reichert-Meiss! value 22. Coulson and Moffitt’s modification 23, Effects of substituents on acidity of benzoic acid 24. Structure and uses of DDT end Saccharin 25. Pschorr’s Synthesis and medicinal uses of phenanthrene 26. Friedal Craft Alkylation reactivity 27. Haworth’s synthesis of Naphthalene 28. Hydrogenolysis and Hydrogenation. 29. Huckle’s Rule Section - C Long type Questions (Answer any two) 30, What are cylcoalkanes? Explain the relative stabi theory? 31, Write the different reactions of benzene with mechanism? | 32. Add a brief note on acidity of phenols. Discuss briefly the effect of substituer j acidity j weepngee Page 2of 2 POCO X5.PRO 5G | AD_ROCKSS ——4 Choose the correct option : Ai a & Total No. of printed pages = 5 QP. Code + 46301 Odd Semester End term Examination ~ 2019 Semester ~ II Course : B. Pharm PHARMACEUTICAL ORGANIC CHEMISTRY ~ It Paper : BP-301T Full Marks—75 Time — Three hours ‘The figures in thé margin indicate full marks : for the questions. ‘SECTION — A ~ = he . ” Multiple choice questions : 1x10=10 ‘The homologues of benzene having a'single alkyl group is called (a) Alkyl. benzenes (©) Both (a) and (b) nt | Q3 viva (10) 17 DEC 2019 ne) | | IMACY COLLEGE jt SIKKIM |AL EXAMINATION 2019 \c CHEMISTRY 11(BP305P) ra Marks:35 pn? (10) RMACY COLLEGE ST SIKKIM IL EXAMINATION 2019 C CHEMISTRY Il (BP30SP) yours Marks: 35 distillation? (10)| 23 . -_ . ben | 2024 2. Oils and fats when Pure they are i (a) Colorless (b) Odorless 4, Ammonotysis of aryl < | (c) Tasteless (@) All of these (a) Phenol (@) Benzoie acid se 3. The source of peanut oil is 46 eit. sweetenet Give examples (a) Arachidonic acid (b) Oleic acid (@ Sacebarin (© Linoleic acid (@ All of these (c) Fructose ee 9, DDT was syntuesiz ee nen lear hydrocarbons electrophili a tution occur preferentially at philic substi se oe © fa) 2 iti (@) 2 and 4 position __(b) 2 and 3 positions @1 fe . 10. The shape of © and 2 position _(d) 1 and 4 positi : - up position @ Triangle (©) Square 5. The reduced A z eee oes ealcnc is oF cae i ___ &) Decalin eee), ©), Antiracene (b) CHO @ All of these iad ah POCO X5 PRO 5G | AD_ROCKS \ Match the follow Benzene Cumene Cycloalka Lipids 5§/46301/P0wire they are (b) Odorless @ All of these il is ©) Oleic acia @ All of these electrophilic subst. 9 b) 2 and 3 positions ) 1 and 4 position 7. Ammonolysis of aryl chlorides produces caNCY COLLEGE (a) Phenol (b) Aniline \ StkKKIM (©) Benzoic acid (@) Toluene ALL EXAMINATION 201 8 Counterfeit sweetener is CHEMISTRY 11(8P305P) (@) Saccharin (b) Glucose aA (©) Fructose @ Ketose Marks:35. 9. DDT was synthesized for the first time in the year (@) 1874. (b) 1850 on? (a4 (©) 1910 (@) 1930 10. The shape of cyclopropane is (@) Triangle (b) Rectangle pee (c) Square (@) Cube Match the following columns : 55/46301/POCh-IL a Q3 viva (10) IRMACY COLLE auc compound ST SIKKIM Lice and scabies LL EXAMINATI Alicyclic compounds CHEMISTRY I Metabolic regulators LROUP B | Iso py!_benzene eS | (6)) {Tum over | distillation? (BRP Choice Questions canener Section — all tarts: 75 E Anal ibe rxa020 ; conn Amide - & Hydrogenation ‘ This he Following is Ravenel Pia 8 5 suitable solvent for f ation | {cloroform b Et Pedal craft alkyl ation tekes place in presenc Seam wore Lewis acid Presence of | Las base Alt hate ie ofthe Tolling is used as a swimming pool disinfect ee Sintec | ae Sascha | i pniene act as mec . Nucleophile eee Both a& 6 adr BM i sic ttc acidy otphenl are Ber Nature ofsubstiuent Postion of subsite Both a b None ofthe above. i eroake the correct order regarding city of phen BME ricoptenci>O-nivophenob>mivopierol b meivephercbo-is ai Ortirophenol>p-nitrophenol>m-nitrphenol __d._O-niuophena!>r-ntrophenol>p-ioph. jenol reacts with benzene diazonium chloride in alkaline solution to form azo-dye known as Kolbe’s reaction b. Williamson synthesis Pizzo-coupling d. Claisen reaction | xidlion of napthalein with KMnQy in basic medium gives Phhalic acid b, Pihalie anhydride , Pihalanoic acid 4d. Pthalaldehy lectron withdrawing group in aromatic acids Decrease the acid stret Both a and b 4. fLength of carbon-carbon bond in benzene is 14a" b. 154A" d. All ofthe above Long chan alcohols used in manufacturing detergents are obtained from = C i. Rancidification of fats or oils b. Cee, ee S of Hydrogenolysis of fats or oils d. Saponification nzyme responsible for hydrolysis of fat is id strength 134A? Seamed by Cayitceycr | POCO X5 PRO 5G | AD_ROCKSSLipose vr genation ie rie ¢. reductive PN" i ernie ab ‘hracene oodurs at ‘ 4. ‘All of the above: Both aand b Section -B seven) Short type Questions (Answer Write short note on Coulson Mofitt’s theory n value with examples. 22. Explain Haworth’s synthesis of naphthalene. 23. Define and explain the significance oFacid Value and saponificatio 24. Why electrophilic substitution reactions occur faster in toluene than benzene. ith reference to heat of hydrogenation of alkene Explain the resonance of benzeié ‘c amines are weaker bases than ammonia and aliphatic amines? 26. Why aroma 27. Define and explain the significance of iodine value and R.M value with example Explain electrophilic substitution of raphthalene takes place at which position’ and why? 2 2%, Explain Friedal-crafts alkylation with example and mention its limitation. Section —C 10X2=20 Long type Questions (Answer any fwa) 30. What are cycloalkanes? Explain the relative stabilities of cycloalkane with reference to Baye theory and Sachsé Mohr theory. Write syr i : Synthesis, chemical reactions and uses of tri phenyl-methane. Explain ar i i lain aromatic electrophilic substitution reaction of benzene, 31 AAtAN AE EAE SUA ees eeaeeTEstet Lr Mase 2 POCO X5 PRO 5G | AD_ROCKS=