Female Menstrual Cycle

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MENSTRUAL CYCLE

Menstrual cycle – a series of


physiological changes
controlled by hormones that
help prepare the female uterus
for pregnancy
Menstruation is the shedding of
MENSTRUAL the lining of the uterus
CYCLE (Endometrium) accompanied
by bleeding.
Under the control of the
endocrine system
Females are born with approximately 2 to 4
million primary follicles.
These fetal follicles contain a developing egg
called a primary oocyte surrounded by a
layer of granulosa cells.
These primary oocytes are part way through
PHYSIOLOGY a cell division.
This process of division doesn’t resume until
the time of ovulation.
With each ovarian cycle, a handful of
ovarian follicles are recruited, and usually
only one of these ovulates, the remaining
unrecruited follicles remain in an inactive
state. Development of follicles occurs until
menopause.
DEFINMENSTRUAL CYCLEITION

• Menarche: a woman's first menstruation


• typically occurs around age 12
• occurrence depends on overall health and diet
• Menopause: end of a woman's reproductive phase,
commonly occurs between ages 45 and 55
• age of menopause is largely the result of
genetics
MENSTRUAL CYCLE
Duration of the MC
Mean 28 days (only 15% of ♀)
Range 21-35
The average duration of menses?
5 days range 3-7 days
Normal estimated blood loss?
Approximately 30 ml
when does ovulation occur?
Usually, day 14
36 hrs after the onset of mid-cycle LH
MENSTRUAL CYCLE

• The two “cycles” of the female


1.The “ovarian” cycle = (changes in the ovary)
2.The “uterine” cycle = (changes in the mucosa of
the uterus)
OVARIAN CYCLE

• stage 1 - Follicle stage


• Stage 2 – Ovulation
• Stage 3 – Corpus Luteum (Luteal Phase)
STAGE 1 - FOLLICLE STAGE

• Follicle-stimulating hormone produced by the pituitary


gland which causes a follicle (egg cell capsule) to form
and mature
• As the follicle grows it makes increased amounts of
estrogen
• Estrogen has negative feedback on the pituitary to stop
FSH
• Estrogen causes the uterine lining (endometrium) to
grow thicker
STAGE 2 - OVULATION

• Increased estrogen from the follicle


stimulates the pituitary gland to
produce Luteinizing hormone
• The Luteinizing hormone surge
causes the follicle to rupture, and the
egg cell is sent to the oviduct
STAGE 3 – LUTEAL PHASE (CORPUS
LUTEUM)
• The ruptured follicle heals inside the
ovary forming the corpus luteum
(Yellow body)
• The corpus luteum produces
progesterone
• Estrogen and progesterone maintains
the added growth of the uterine lining
STAGE 3 – CORPUS LUTEUM (LUTEAL
PHASE)

• An embryo in the uterus will secrete a chemical called


Human Chorionic Hormone (HCG)
• HCG prevents the corpus luteum from decomposing which
maintains progesterone levels
• The endometrium is not shed
• HCG is the chemical that is detected by pregnancy tests
PHASES OF MENSTRUAL CYCLE

1. Menstrual Phase
2. Proliferative Phase
3. Luteal Phase(Phase)
4. Ischemic Phase
1. MENSTRUAL PHASE

• Starts with 1st day of menstrual cycle


• Lasts for 3-7 days
• Functional layer of uterine wall is
sloughed off and discarded with the
menstrual flow
• Blood discharge from vagina is combined
with small pieces of endometrial tissue
2.PROLIFERATIVE PHASE

• Is a phase of repair and proliferation


• Lasts for 9 days
• Coincides with the growth of an ovarian
follicle
• Controlled by estrogen secreted by follicles
• Increase thickness of the endometrium
• The glands increase in number and length
and the spiral arteries elongate
3.LUTEAL PHASE (SECRETORY)

• Is a secretory or progesterone phase


• Lasting about 13 days
• Coincides with formation, functioning, and growth of
corpus luteum
• Glandular epithelium secrete glycogen rich material
• Endometrium thickens under the influence of estrogen
and progesterone
4.ISCHEMIC PHASE

• Decreased levels of estrogen & progesterone


• Stoppage of glandular secretion
• Loss of interstitial fluid
• Marked shrinking of the endometrium
• Spiral arteries become constricted
• Venous stasis & Ischemic necrosis
• Rupture of the damaged vessel wall
• Blood seeps into the surrounding connective tissues
CYCLE ABNOCYCLE ABNO
MENSTRUAL ABNORMALITIES
ABNORMALITIESMALITIES

• Anovulation: is a menstrual cycle during which the ovaries do not release


an oocyte
• Hypomenorrhea: short or scanty periods, is extremely light menstrual blood flow.
• Metrorrhagia: Uterine bleeding at irregular intervals, particularly between the
expected menstrual periods
• Amenorrhea:is the absence of menstruation
• Polymenorrhea: cycles with intervals of 21 days or fewer. Irregular menstruation
is where there is variation in menstrual cycle length of more than approximately
eight days for a woman.

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