physiological changes controlled by hormones that help prepare the female uterus for pregnancy Menstruation is the shedding of MENSTRUAL the lining of the uterus CYCLE (Endometrium) accompanied by bleeding. Under the control of the endocrine system Females are born with approximately 2 to 4 million primary follicles. These fetal follicles contain a developing egg called a primary oocyte surrounded by a layer of granulosa cells. These primary oocytes are part way through PHYSIOLOGY a cell division. This process of division doesn’t resume until the time of ovulation. With each ovarian cycle, a handful of ovarian follicles are recruited, and usually only one of these ovulates, the remaining unrecruited follicles remain in an inactive state. Development of follicles occurs until menopause. DEFINMENSTRUAL CYCLEITION
• Menarche: a woman's first menstruation
• typically occurs around age 12 • occurrence depends on overall health and diet • Menopause: end of a woman's reproductive phase, commonly occurs between ages 45 and 55 • age of menopause is largely the result of genetics MENSTRUAL CYCLE Duration of the MC Mean 28 days (only 15% of ♀) Range 21-35 The average duration of menses? 5 days range 3-7 days Normal estimated blood loss? Approximately 30 ml when does ovulation occur? Usually, day 14 36 hrs after the onset of mid-cycle LH MENSTRUAL CYCLE
• The two “cycles” of the female
1.The “ovarian” cycle = (changes in the ovary) 2.The “uterine” cycle = (changes in the mucosa of the uterus) OVARIAN CYCLE
• Follicle-stimulating hormone produced by the pituitary
gland which causes a follicle (egg cell capsule) to form and mature • As the follicle grows it makes increased amounts of estrogen • Estrogen has negative feedback on the pituitary to stop FSH • Estrogen causes the uterine lining (endometrium) to grow thicker STAGE 2 - OVULATION
• Increased estrogen from the follicle
stimulates the pituitary gland to produce Luteinizing hormone • The Luteinizing hormone surge causes the follicle to rupture, and the egg cell is sent to the oviduct STAGE 3 – LUTEAL PHASE (CORPUS LUTEUM) • The ruptured follicle heals inside the ovary forming the corpus luteum (Yellow body) • The corpus luteum produces progesterone • Estrogen and progesterone maintains the added growth of the uterine lining STAGE 3 – CORPUS LUTEUM (LUTEAL PHASE)
• An embryo in the uterus will secrete a chemical called
Human Chorionic Hormone (HCG) • HCG prevents the corpus luteum from decomposing which maintains progesterone levels • The endometrium is not shed • HCG is the chemical that is detected by pregnancy tests PHASES OF MENSTRUAL CYCLE
• Lasts for 3-7 days • Functional layer of uterine wall is sloughed off and discarded with the menstrual flow • Blood discharge from vagina is combined with small pieces of endometrial tissue 2.PROLIFERATIVE PHASE
• Is a phase of repair and proliferation
• Lasts for 9 days • Coincides with the growth of an ovarian follicle • Controlled by estrogen secreted by follicles • Increase thickness of the endometrium • The glands increase in number and length and the spiral arteries elongate 3.LUTEAL PHASE (SECRETORY)
• Is a secretory or progesterone phase
• Lasting about 13 days • Coincides with formation, functioning, and growth of corpus luteum • Glandular epithelium secrete glycogen rich material • Endometrium thickens under the influence of estrogen and progesterone 4.ISCHEMIC PHASE
• Decreased levels of estrogen & progesterone
• Stoppage of glandular secretion • Loss of interstitial fluid • Marked shrinking of the endometrium • Spiral arteries become constricted • Venous stasis & Ischemic necrosis • Rupture of the damaged vessel wall • Blood seeps into the surrounding connective tissues CYCLE ABNOCYCLE ABNO MENSTRUAL ABNORMALITIES ABNORMALITIESMALITIES
• Anovulation: is a menstrual cycle during which the ovaries do not release
an oocyte • Hypomenorrhea: short or scanty periods, is extremely light menstrual blood flow. • Metrorrhagia: Uterine bleeding at irregular intervals, particularly between the expected menstrual periods • Amenorrhea:is the absence of menstruation • Polymenorrhea: cycles with intervals of 21 days or fewer. Irregular menstruation is where there is variation in menstrual cycle length of more than approximately eight days for a woman.