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    Ambrisentan Uses, Side Effects & Warnings

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    Ambrisentan Uses, Side Effects & Warnings

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    Ambrisentan Uses, Side Effects & Warnings

    Uploaded by

    emad ali

    Copyright:

    © All Rights Reserved
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    Download as pdf or txt
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    Ambrisentan

    Generic name: ambrisentan [ AM-bri-SEN-tan ]


    Brand name: Letairis
    Dosage form: oral tablet (10 mg; 5 mg)
    Drug class: Agents for pulmonary hypertension

    Medically reviewed by Drugs.com on Aug 20, 2024. Written by Cerner Multum.

    What is ambrisentan?
    Ambrisentan lowers blood pressure in your lungs, helping your heart pump blood more efficiently.

    Ambrisentan is used to treat pulmonary arterial hypertension (PAH) in adults. It improves your ability to
    exercise and prevents your condition from getting worse. Ambrisentan is sometimes used with a
    medicine called tadalafil (Adcirca).

    For women, ambrisentan is available only from a certified pharmacy under a special program. You must
    be registered in the program and sign agreements to use birth control and undergo pregnancy and blood
    testing.

    Ambrisentan may also be used for purposes not listed in this medication guide.

    Ambrisentan side effects


    Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling
    of your face, lips, tongue, or throat.

    Ambrisentan may cause serious side effects. Call your doctor at once if you have:

    severe shortness of breath, wheezing, cough with foamy mucus, chest pain;

    swelling, tiredness, rapid weight gain;

    low red blood cells (anemia)--pale skin, unusual tiredness, feeling light-headed or short of breath,
    cold hands and feet; or

    liver problems--loss of appetite, stomach pain (upper right side), nausea, vomiting, fever, itching,
    dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

    Common side effects of ambrisentan may include:


    swelling in your hands, legs, ankles, or feet;

    stuffy nose, sinus pain; or

    hot flashes, redness in your face.

    This is not a complete list of side effects and others may occur. Call your doctor for medical advice
    about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Ambrisentan side effects (more detail)

    Warnings
    Do not use if you are pregnant or think you might be pregnant. You will need to take a pregnancy test
    before, during, and after treatment with ambrisentan. Use highly effective birth control while using
    ambrisentan and for at least 30 days after your last dose.

    You should not use ambrisentan if you have idiopathic pulmonary fibrosis.

    Before taking this medicine


    You should not use ambrisentan if you are allergic to it, or if you have idiopathic pulmonary fibrosis (IPF).

    Do not use ambrisentan if you are pregnant or think you might be pregnant. This medicine can cause
    serious birth defects. Tell your doctor right away if you miss a menstrual period or think you may have
    become pregnant.

    You will need to have a negative pregnancy test before starting this treatment. You will be re-tested every
    month during your treatment, and 1 month after your last dose.

    Even if you are not planning a pregnancy, you are considered able to become pregnant if:

    you have entered puberty (even if you have not yet started having periods);

    you have never had a hysterectomy or had your ovaries removed; or

    you have not gone through menopause (you have never gone 12 months in a row without a
    menstrual period).

    While taking ambrisentan and for at least 30 days after your last dose, you must use a highly effective
    form of birth control or two methods together.

    Recommended forms of birth control forms include:

    a tubal ligation, or a copper IUD (intrauterine device) or progesterone implant;


    one hormone form (birth control pill, skin patch, implant, vaginal ring, or injection) plus 1 barrier form
    (condom, diaphragm with spermicide, or cervical cap with spermicide);

    a condom and a female barrier form together (diaphragm with spermicide, or cervical cap with
    spermicide); or

    a partner's vasectomy plus 1 hormone form or 1 barrier form.

    Ambrisentan comes with patient instructions about acceptable forms of birth control to use while
    taking this medicine. Follow these directions carefully. Ask your doctor about emergency contraception
    if you have unprotected sex or if you believe your contraception has failed.

    Tell your doctor if you have ever had:

    liver disease; or

    anemia (low red blood cell counts).

    You should not breastfeed while you are using ambrisentan.

    Ambrisentan may lower a man's sperm count and could affect fertility (your ability to have children).

    How should I take ambrisentan?


    Follow all directions on your prescription label and read all medication guides or instruction sheets. Your
    doctor may occasionally change your dose. Use the medicine exactly as directed.

    Take the medicine at the same time each day, with or without food.

    Swallow the tablet whole and do not crush, chew, or break it.

    You will need frequent medical tests.

    Store ambrisentan in its original container at room temperature, away from moisture and heat.

    Ambrisentan dosing information


    Usual Adult Dose for Pulmonary Hypertension:

    Initial dose: 5 mg orally once a day.

    Comments:
    -Consider increasing the dose to 10 mg orally once a day if 5 mg is tolerated.
    -When used with tadalafil, the dose of either drug can be increased as needed and tolerated at 4-week
    intervals.

    Uses:
    -For the treatment of pulmonary arterial hypertension (WHO Group 1) to improve exercise ability and
    delay clinical worsening.
    -For the treatment of pulmonary arterial hypertension (WHO Group 1) in combination with tadalafil to
    reduce the risks of disease progression and hospitalization for worsening pulmonary arterial
    hypertension, and to improve exercise ability.

    Detailed Ambrisentan dosage information

    What happens if I miss a dose?


    Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose.
    Do not take two doses at one time.

    What happens if I overdose?


    Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

    What should I avoid while using ambrisentan?


    Follow your doctor's instructions about any restrictions on food, beverages, or activity.

    What other drugs will affect ambrisentan?


    Tell your doctor about all your other medicines, especially:

    cyclosporine.

    This list is not complete. Other drugs may affect ambrisentan, including prescription and over-the-
    counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

    Ambrisentan drug interactions (more detail)

    Related/similar drugs

    sildenafil, tadalafil, Adcirca, Revatio, Opsumit, Adempas

    Was this page helpful?


    Further information
    Remember, keep this and all other medicines out of the reach of children, never share your medicines
    with others, and use this medication only for the indication prescribed.

    Always consult your healthcare provider to ensure the information displayed on this page applies to your
    personal circumstances.

    Copyright 1996-2024 Cerner Multum, Inc. Version: 10.01.

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