A 50-year-old patient is suffering from pernicious anemia.

Which of the following

laboratory data are most likely for this patient?
a. RBC= 2.5 × 1012/L; WBC= 12.5 x 109/L; Platelet= 250 x 109/L
b. RBC= 2.5 × 1012/L; WBC= 2.5 x 109/L; Platelet= 50 x 109/L
c. RBC= 4.5 × 1012/L; WBC= 6.5 × 109/L; Platelet= 150 x 109/L
d. RBC= 3.0 × 1012/L; WBC= 5.0 x 109/L; Platelet= 750 x 109/L
The following inherited leucocyte disorder is caused by a mutation in the lamin B receptor.
a. Alder-Reilly anomaly
b. Chediak-Higashi disease
c. Pelger-Huet anomaly
d. May-Hegglin anomaly
Which type of anemia is usually present in a patient with acute leukemia?
a. microcytic, hypochromic
b. normocytic, normochromic
c. macrocytic, normochromic
d. microcytic, hyperchromic
An increase in which one of the following determines whether an anemia is due to an
RBC production defect or to a shortened survival defect and premature hemolysis?
a. Hematocrit
b. Hemoglobin
c. Reticulocyte count
d. Red cell distribution width
When the osmotic fragility test is performed visually, the salt concentrations are recorded
for the two tubes that show:
a. 0 percent and 50 percent hemolysis.
b. 0 percent and 100 percent hemolysis.
c. Initial hemolysis and first complete hemolysis.
d. Least and greatest hemolysis.
What is the most common type of inherited aplastic anemia that is prevalent in Ashkenazi
Jews and South African Afrikaners?
a. Shwachman-Bodian-Diamond Syndrome
b. None of the option
c. Dyskeratosis
d. Fanconi anemia
If 15 reticulocytes are counted in a total of 1,000 erythrocytes, what percentage of
reticulocytes should be reported?
a. 1.5 percent
b. 1.15 percent
c. 0.015 percent
d. 2.5 percent
Reticulocytes can often be detected in Wright’s-stained smears provided examination is
carried out under dimmed light.
False
True
The altered shape of the spherocyte in Hereditary Spherocytosis is due to:
a. Defective RNA synthesis
b. Abnormality in the globin composition
c. An extrinsic factor in the plasma
d. Abnormal RBC membrane protein
The normal adult female values for the ESR using Wintrobe - Lansberg method is:
a. 24 -48 mm/hr
b. 0 - 20 mm/hr
c. 0 - 9 mm/hr
d. 0 - 10 mm/hr
Wright's stain contains eosin and:
a. Brilliant cresyl blue
b. Basic fuchsin
c. Gentian violet
d. Methylene blue
A low total white blood cell count, when accompanied by a percent increase in the number
of band cells in the differential blood smear, is called:
a. Regenerative shift to the left
b. Shift to the right
c. None of the option
d. Degenerative shift to the left
The predominant hemoglobin present in B-thalassemia major is:
a. Hb C
b. Hb A
c. Hb F
What growth factor is produced in the kidneys and is used to treat anemia associated with
kidney disease?
a. KIT Ligand
b. G-CSF
c. EPO
d. ТРО
What is the aplastic anemia classification of a 15-year-old female with a bone marrow
cellularity of 50%, Hemoglobin of 7 g/dl, absolute neutrophil count of 1.0 x 109/L, and
platelet count of 50 x 109/L?
a. Moderate
b. Nonsevere
c. Very Severe
d. Severe
A megaloblastic cell is caused by what deficiency?
a. Vitamin B10
b. Vitamin B6
c. Vitamin B2
d. Vitamin B12
This leucocyte inclusion is composed of ribosomal RNA.
a. Primary granules
b. Dohle bodies
c. Toxic granules
d. Howell-Jolly bodies
Bone marrow examination is not usually required for diagnosis of anemia but is indicated
in cases of unexplained anemia, fever of unknown origin, or suspected hematologic
malignancy.
False
True
When fresh blood is mixed with 0.85% salt solution the RBCs will:
a. Lyze
b. Swell
c. None of the option
d. Shrink
Reticulocytosis usually indicates:
a. Red cell regeneration
b. Aplastic anemia
c. Neoplastic process
d. Response to inflammation
The situations wherein reduced red blood cell contents lead to target cell formation
except:
a. Iron deficiency anemia
b. Some forms of hemoglobinopathy (C disease)
c. Pernicious anemia
d. Thalassemia
The osmotic fragility of erythrocytes is increased in:
a. Iron deficiency anemia
b. Congenital spherocytic anemia
c. Sickle cell anemia
d. Thalassemia major
A false-positive Ham test may occur in:
a. Severe iron deficiency anemia.
b. Sickle cell anemia.
c. Paroxysmal nocturnal hemoglobinuria
d. Congenital spherocytic anemia.
The Ham test is positive in:
a. Polycythemia
b. All hemoglobinopathies
c. Paroxysmal Nocturnal hemoglobinuria
d. Chronic lymphocytic leukemia
Which of the following findings is consistent with a diagnosis of megaloblastic anemia?
Absolute increase in reticulocytes
a. None of the option
b. Increased serum LDH level
c. All of the option
d. Hyposegmentation of neutrophils
What stage in neutrophilic development in which the cytoplasm has secondary granules
that are lavender in color?
a. Metamyelocyte
b. Band
c. Myelocyte
d. Promyelocyte
In aplastic anemia you would expect the platelet count to be:
a. Low
b. Normal
c. High
A "shift to the left" which is accompanied by a high total white cell count is a:
a. None of the option
b. Degenerative shift
c. Regenerative shift
In men and postmenopausal women whose diets are adequate, iron deficiency anemia
is relatively rare because the body conserves iron and they lose only about 5mg/ day.
False
True
Common clinical symptoms of anemia include:
a. Jaundice and enlarged lymph nodes
b. Shortness of breath and fatigue
c. Chills and fever
d. Splenomegaly
Which of the cell is particularly characteristic of congenital hemolytic anemia?
a. Crenated erythrocyte
b. Target cell
c. Spherocyte
d. Siderocyte