Pharmaceutical and Biotechnology

S A N I TA RY M I X E R S BY L I G H T N I N
A World Leader in Industrial Mixing since 1923,
Lightnin Expertise meets your
Lightnin has 90 years of unrivaled experience
in industrial mixing technology, process Sanitary needs
knowledge, and technological innovation.
Lightnin enjoys a global reputation for durable,
Utilizing our experience and technical expertise, we engineer products to meet
long-lasting mixers, agitators, aerators, and
the demands of sanitary equipment for Pharmaceutical and Biotechnology and
flocculators for fluid process systems. We offer
other industries where clean design is critical. For virtually any pharmaceutical,
a full spectrum of impeller designs for diverse
biotech, personal care, animal care, or medical application from just a few liters
applications. In addition, we offer a worldwide
to fermentation reactors in excess of 120 m3 (31,700 gal), we have impeller and
service network, mixer repair, gearbox repair,
mixer drive solutions to meet your needs.
and replacement parts programs. Look to
Lightnin for knowledge, technology, and
The standards for current Good Manufacturing Practices (cGMP) set by the FDA
service excellence.
are more stringent than those for the general Chemical Industry. As a supplier
of equipment to cGMP facilities, Lightnin has instituted several procedures and
systems to assist engineering contractors, system suppliers, and end-users in
meeting these requirements, including:
SPX FLOW, Inc. (NYSE:FLOW) is a leading
manufacturer of innovative flow technologies, • A team of in-house experts with experience in aseptic manufacturing: Lightnin’s
many of which help define the industry standard team of experts includes people with knowledge in processing, mechanical
in the market segments they serve. From its
design, quality assurance, production, installation, service, and documentation.
headquarters in Charlotte, North Carolina, it
operates a sales and support network, centers
• An order plan specific to aseptic mixers: On large projects, a Lightnin team
of manufacturing excellence, and advanced
of experts led by a project coordinator oversees the entire project. Internally,
engineering facilities, throughout the world. Its
cutting-edge flow components and process Lightnin creates a detailed project plan that controls the order from order entry
equipment portfolio includes a wide range through shipping to assure that all specifications are met exactly.
of pumps, valves, heat exchangers, mixers,
homogenizers, separators, filters, UHT, and • Enhanced finish standards and verification: Lightnin’s standard finishes are
drying technology that meet many application defined both by Roughness Average (Ra) and by whether the raw material is
needs. Its expert engineering capability also cast or fabricated. Verification of specified finishes is available in the QAD.
makes it a premium supplier of customized
solutions and complete, turn-key packages to
• Compliance to ASME BPE (American Society of Mechanical Engineers
meet the most exacting of installation demands.
BioProcess Equipment).
Incorporating many leading brands, SPX FLOW
has a long history of serving the food and
beverage, power and energy, and industrial
market sectors. Its designs and engineered
solutions help customers drive efficiency and
productivity, increase quality and reliability, and
meet the latest regulatory demands. In-depth
understanding of applications and processes,
state-of-the-art Innovation Centers, and
advanced pilot/testing technology further assist
in optimizing processes and reducing timescales
to reliably meet production targets.
To learn more about SPX FLOW capabilities,
its latest technology innovations and complete
service offerings, please visit www.spxflow.com.
P R O C E S S , Q UA L I T Y A N D T E C H N O LO GY
Lightnin Knowledge applied to
We can match our many years of experience in mixing technology to
the rheology of your product to ensure you obtain your process needs. Sanitary Industries
But it doesn’t end there. We recognize the importance of material
traceability and can provide a comprehensive QAD package with the
mixer. We can include: MTRs, FDA Conformity, CE Conformity, PMI,
Quality Plan, Welder Qualifications and Surface Finish Certificates

For these industries we can offer equipment with an all

For applications where clean-in-place (CIP) or sterilize-in-place (SIP)
stainless steel construction and features designed to
we design the features of the equipment to ensure your cleanliness
meet ASME BPE Standards and other industry standards,
requirements can be met. Engineered to meet your needs, we can
our mixers can be used in a variety of sanitary mixing
offer:
applications and extend into other industries outside of
• Crevice free design to allow clean-in-place (CIP) services Pharmaceutical and Biotechnology. We have clarity around
• Highly polished surfaces typically 0.5μm Ra (20μin Ra) or better the key requirements for success; Cleanability, Containment,
and electropolishing where needed Contamination Resistance and Traceability.

• Hygienic shaft couplings

• Hygienic impeller connections and blade joints
• Self-draining surfaces
• Hygienic, (GRAS) mechanical seal designs with FDA compliant
Pharmaceutical &
materials Biotechnology
• Material Certification and Quality Assurance Documentation
• Accurate fixed or variable speed drives with shaft speed
monitoring

Personal Care,
Home Care &
Cosmetics

Select SPX FLOW’s Mixing equipment and you get more than Dairy, Prepared
Foods & Beverage
an efficient and cost effective process. You get over 90 years of
experience in superior processing technology. We were amongst
the first to use computational fluid dynamics (CFD). This experience
has enabled us to design and develop products specifically for
pharmaceutical and biotechnology into the 21st century.

Our laboratory is a standard for the business, and allows us to

optimize your process, from pilot to full-scale testing. Your benefits are
higher reliability, lower production costs, greater output, resulting in
higher profits.

Processing.....we perfected it.

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 Reliability By Design
SPX FLOW understands that when it comes to efficient process plant operations, equipment reliability is of paramount importance.
As a long-standing member of AGMA (American Gear Manufacturers Association) SPX FLOW’s Lightnin brand recognizes that
multi-purpose commercial gearboxes are poorly suited to Agitator service. For more than 50 years the Lightnin products have utilized
proprietary, purpose designed agitator gear drives to ensure dependability and lowest cost of ownership. SPX FLOW’s agitator drive
designs are continually evolving to take advantage of latest materials technologies and manufacturing techniques.

Magnetic Coupling, Seal-less Mixer

• Seal –less technology: Magnetically coupled impeller. No shaft entering vessel.
• Food grade Ceramic product lubricated bearings, other bearing types available
• Electro polished 316SS Hyperflo impeller (0.2µm Ra) for easy cleaning
• Tri-clover flange mount
• Flexible power and speed ranges and globally compliant.
• OSHA & CE compliant, Meets ASME BPE

Lightnin GP2 & Lightnin LB2 - Bench Top and Small Industrial Mixers
• Brushless DC motor which is maintenance free and has overload protection
• Sealed Keypad that is easy to use, intuitive and water tight
• Through shaft design making impeller adjustment easy
• Safety Approved, Tested to IEC 61010-1-04 2nd edition and -2-0-0451
• IP42 Environmental Rating

Stainless Steel H-Series - Small and Lightweight Stainless Steel Mixer

• Meets EC1935 Standards for food machinery, OSHA & CE compliant, ATEX
(2G IIc T4)
• Stainless Steel housings with Clamp Mount, Beam Mount, Tri-clover flange
mount
• Stainless Steel Air motor

Nettco S-Series - All Stainless Steel Configurable Mixers

• Meets 3A and EC1935 Standards, OSHA & CE compliant
• Clamp Mount, Beam Mount, Plate Mount, ANSI or DIN or Tri-clover flange
mount
• Stainless Steel IEC TEFC, XP Inverter ready or Air Motors
• Cast Stainless Steel housings
• Single Mechanical Seal w/ UPS Class VI elastomers, Lip Seal available

SR - Low Head Room Stainless Steel Mixer

• Meets ASME BPE, OSHA & CE compliant
• ANSI, DIN or Tri-clover flanges
• IEC or NEMA motors TEFC 0.37kw (½HP) 50/60Hz. Stainless Steel available
• Stainless Steel Gearbox drive,
• Hygienic in tank screwed couplings available
• Food grade Single Mechanical Seal w/ UPS Class VI elastomers

SSi / SSO - All Stainless Steel Configurable Mixers

• Meets ASME BPE, OSHA & CE
• Beam Mount, Plate Mount, ANSI or DIN or Tri-clover flange mount
• Stainless Steel IEC or NEMA motors TEFC, XP or Air Motors. ATEX motors
Epoxy painted
• Stainless Steel Polished Cast housings
• Food grade Single Mechanical Seal w/ UPS Class VI elastomers, Lip Seal
available
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Impeller Technology for Pharmaceutical and
Biotechnology
Lightnin has a full range of impellers for each mixing step of the process. We match our impellers
to the specific duty accomplishing optimized and guaranteed results. Our impellers can be used in
combination to allow multifunctional processes in production and pilot plants.

A200
Recommended for low to medium viscosity blending and solids suspension applications:
• Classic 45 degree pitch bladed turbine (PBT) design
• Although replaced by the A510, this impeller still is applicable in cases where some fluid shear is
required (e.g. solids make down and viscous applications)
• Can be customized with varying blade widths and blade angles and with 2, 4, or 6 blades (A201)
• Hygienic bolted construction is available for tanks with small diameter manways

A 3 1 0 /A 5 1 0
Low blade solidity hydrofoil, recommended for low viscosity blending and solid
suspension applications:
• Varying tip chord angle allows for further optimization of mixer selection
• Maximizes flow generation while minimizing fluid shear
• The A310 is standard for all Lightnin gear drive portable mixers
• Generates the same flow as a pitched bladed turbine (A200) for 60% of the power and 50% of the
torque
• Hygienic bolted construction is available for tanks with small diameter manways

A320
High solidity hydrofoil design recommended for high viscosity blending applications:
• High efficiency wide bladed impeller design with high flow/power ratio
• Improved axial flow at low Reynolds numbers (Nre < 500) reduces power requirements up to 50%
over a pitch bladed turbine (A200) for equal blending performance
• Has also been successfully used for gas handling applications
• Hygienic bolted construction is available for tanks with small diameter manways

R135
Parabolic radial flow impeller recommended for high shear mixing and gas dispersion
applications:
• Optimized parabolic blade shape improves gas handling ability by 20% and reduces torque
requirements by 40% over an R130
• Radial design provides shear to achieve good contacting for liquid-liquid and gas-liquid dispersions
and emulsions

M AG N E T I CA L LY C O U P L E D I M P E L L E R
Recommended for stirring low viscosity fluids to maintain flow:
• A magnetically coupled impeller that permits mixing without the need of a shaft entering the tank and
is completely seal-less – it does not require a mechanical seal.
• Choice of bearing type to suit your application
• Patented Hyper-Flo bearing system to allow CIP fluids to clean the bearings
• Integral lifting loop permits easy installation and removal of the impeller

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 K N OW L E D G E A B L E A B O U T YO U R N E E D S
Pharmaceutical and Biotechnology require a
high degree of process understanding to achieve
optimized results

Understanding and optimizing the results is one

part of the production needs; it is also essential to
understand the operational requirements of the
production or pilot plant to ensure the product being
produced meets the expectations of consumers.

At SPX FLOW we understand the production needs

of the equipment that serves these markets. We
offer hygienic clean designs that meet the current
E N H A N C E D F E AT U R E S F O R
good manufacturing practices (cGMP) for the food
I M P R OV E D P R O D U CT I O N
industry, Personal Care, Home Care all the way through to the exacting demands
PROCE SS E S
of the Pharmaceutical and Bio-science industries including FDA and ASME BPE
To meet the need for cleanliness in reducing the
conformance. We can offer a solution that meets your production needs while
sites where bacterial action can initiate, many
offering the most economical solutions.
features can routinely be added in to the design of
our Lightnin mixers. Such features include: Matching our process and product knowledge with your requirements, we are
also able to provide you with the Quality Assurance Documentation (QAD) that
• Mechanical Polished shaft, impellers, flanges and you need to support your processes and validation requirements. Depending on
seal areas to reduce the hang-up of product on the product and the level of documentation required for production, we can offer
wetted parts. This can be combined with electro- an economic document package or we can tailor the QAD package to meet your
polish if required validation needs.
• Crevice free designs that eliminate ‘bug traps’
Documentation that can be offered includes:
from interface points

• Self-draining features on wetted parts on top and • Material Conformity Certification

bottom surfaces. This assists the prevention of • Food Grade Certification
product hang-up on the wetted parts and also
• Polish Certification
assists with Clean-in-Place (CIP) systems
• Passivation Certification
• Mechanical seals with sanitary features that
• Weld Procedures and Qualification to required Codes
can be provided with FDA compliant material
• FDA Compliance
requirements for faces and elastomers.
Mechanical seals can also be provided with Other forms of documentation are available.
a debris well to capture any seal face wear
product, this when combined with appropriate
CIP regimes can enhance seal cleaning.

• We have special Impeller coupling designs that

allow cleanable impellers that can be adjusted on
the shaft. Being able to adjust the impeller up or
down on the shaft can be an important feature
for pilot plants and on universal systems for
production.

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C O N S U LT I N G S E R V I C E S
SPX FLOW’s Lightnin brand has long supported the need of providing
full service mixing support to our valued customers. In today’s business
environment of “doing more with less,” local resources at your operation
have been stretched or eliminated. At SPX FLOW, we recognized
this and have increased the level of process support available to our
customers. Evaluation and resolution of our customer’s mixing issues
has been a core strength for many years at our Lightnin facilities.

You can leverage the resources and knowledge base of Lightnin by 3 Ways to Test for the Best
optimizing your mixing processes and solving any mixing problems. As the world’s premier mixing expert, we serve a tremendous
Lightnin’s Process Technology Laboratory enables this support to be variety of industries and applications - everything from
efficiently executed to minimize your costs. pharmaceuticals to minerals extraction operations. And the
testing involved with each of these applications is just as
Lightnin’s team will evaluate your existing mixer design and process
diverse. Flexibility is key to success. That’s why we specifically
goals to determine opportunities for improvement. Lightnin will
designed the lab to accommodate a broad range of tests.
team with your technical group to reduce the time and expense for
developing new mixing applications. 1. We’ll test your actual materials. We’ll perform a
variety of scaled-down tests using your actual materials. No
Lightnin’s experts can assist in the specification of mixer design,
matter what your mixing process is - gas dispersion, slurry
tank internals, feed stream locations and product draw-off position to
suspension, paper stock agitation, blending, or nearly anything
optimize your operation. Lightnin has extensive experience in scaling up
else - we’ll analyze it for optimal flow and shear. That’s the
lab designs and achieving guaranteed full-scale performance.
best way to find out in advance which impeller will maximize
not only mixing, but also the process itself.

2. We’ll test an acceptable simulant of your material.

While actual materials’ testing is preferable to ensure optimum
mixing performance, we realize it isn’t always possible. So,
at the Lightnin Process Technology Laboratory we offer
a number of options for materials and process simulation,
or computational fluid dynamics (CFD) modelling. We also
conduct tests in water to measure mass transfer coefficients
and flow/shear ratios and then scale to your process.

Lightnin’s consulting work starts with a discussion of your needs and 3. We’ll run full-scale performance tests for you on
process information. Then a proposal is created to define the project or off-site. If your application demands it, Lightnin provides
scope, responsibilities, deliverables, cost and schedule. A path forward scale-up testing capabilities in our test tanks. Or, if necessary,
is then concisely and clearly written, and agreed to by both parties. Bi- we’ll come to your location for full-scale testing to determine
directional confidentiality agreements are frequently a necessary and the best configuration for your actual process.
common course for doing business.

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 Lightnin Mixers and
Impellers
P H A R M AC E U T I CA L A N D
B I OT E C H N O LO GY

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E: [email protected] • www.spxflow.com/lightnin

SPX FLOW, Inc. reserves the right to incorporate our latest design and material changes without notice or obligation.

Design features, materials of construction, and dimensional data, as described in this bulletin, are provided for your information only and should not be relied upon unless confirmed
in writing. Please contact your local sales representative for product availability in your region. For more information, visit www.spxflow.com.
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LIG_Pharma & Biotech Sanitary Mixers_B-966_US Version: 04/2019 COPYRIGHT © 2019 SPX FLOW, INC.