Shubhrajyoti
Shubhrajyoti
Shubhrajyoti
ENDOCRINE SYSTEM
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Principal functions of the endocrine
system
• Maintenance of the internal environment in the body
(maintaining the optimum biochemical environment).
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Endocrine System
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Endocrine versus Nervous system
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Endocrine system
• Includes all cells and endocrine tissues that produce hormones or
paracrine factors
• Following are important endocrine glands
• Hypothalamus
• Pituitary gland
• Pineal Gland
• Thyroid gland
• Parathyroid gland
• Thymus
• Adrenal Gland
• Gonads (testes/ovaries)
• Pancreatic Islet
• Heart
• Kidney
• Digestive Tract
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The Endocrine System
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Hormone structure
1) Amino acid derivatives hormones e.g. epinephrine
Structurally similar to amino acids
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General characteristics of hormones
A. Stability
1. Half-life: The length of time it takes for half a dose of substance
to be eliminated from circulatory system
2. Long half-life: regulate activities that remain at a constant rate
through time. Usually lipid soluble and travel in plasma attached
to proteins
3. Short half-life: water-soluble hormones as proteins, epinephrine,
norepinephrine. Have a rapid onset and short duration
B. Communication
1. Interaction with target cell
2. Lipid soluble hormones pass through cell membrane and usually
travel to nucleus
3. Water soluble hormones generally attach to a receptor site on
cell membrane
C. Distribution
1. Hormones dissolve in blood plasma and are transported in
unbound or are reversibly bound to plasma proteins.
2. Hormones are distributed quickly because they circulate in the
blood.
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Mechanisms of hormone action
• Each hormone’s shape is specific and can be
recognized by the corresponding target cells
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G Proteins and Hormone Activity
• Hormones that can not cross the membrane (e.g. Peptide hormones) bind to the receptor on the surface of the cell
• Binding of hormones to the receptor activate secondary messenger (in this figure binding of hormone activates G protein, and activated G protein
activates adenylcyclase or activate PDE or activates PLC
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Hormone Effects on Gene Activity
Hormones that can cross the membrane (e.g. steroid hormones) bind to the receptor inside the cell, at the
cytoplasm, or they will enter the nucleus and bind to the receptor at the nucleus and initiate transcription)
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Control of Hormone Synthesis and
Release
• Blood levels of hormones:
• Are controlled by negative feedback systems
• Vary only within a narrow desirable range
• Neural stimuli
• Hormonal stimuli
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Control by Humoral Stimuli
Humoral stimuli – secretion of hormones in
response to changing levels of ions or
nutrients in the blood.
• Example: concentration of calcium ions in
the blood
• Declining blood Ca2+ concentration stimulates
the parathyroid glands to secrete PTH
(parathyroid hormone)
• PTH causes Ca2+ concentrations to rise and the
stimulus is removed
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Control by Neural Stimuli
Neural stimuli – nerve fibers stimulate
hormone release
• Preganglionic sympathetic nervous system
(SNS) fibers stimulate the adrenal medulla to
secrete catecholamines
Figure 17.3b
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Control by Hormonal Stimuli
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Feedback control of
hormone secretion
1) Negative feedback: Prevents over secretion of the
hormone or over activity at the target tissue.
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Feedback Control of Hormone
Production
Feedback loops are used
extensively to regulate
secretion of hormones in the
hypothalamic-pituitary axis. An
important example of a negative
feedback loop is seen in control of
thyroid hormone secretion
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Negative feedback effects of cortisol
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Learn the 2 endocrine glands on this slide:
Hypothalamus
Pituitary (hyophysis)
Hypothalamus__
Anterior pituitary__ _____________Posterior pituitary
(adenohypophysis) (neurohypophysis)
Hypothalamus___________
Pituitary__________
(hypophysis)
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The Pituitary
Pituitary secretes 9 hormones
• Anterior pituitary 4. LH
________
5. GH
(adenohypophysis) 6. PRL
7. MSH
_________________________________________________________________
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What the letters stand for…
• TSH: thyroid-stimulating hormone
• ACTH: adrenocorticotropic hormone
• FSH: follicle-stimulating hormone
• LH: luteinizing hormone
• GH: growth hormone
• PRL: prolactin
• MSH: melanocyte-stimulating hormone
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PITUITARY HORMONES FUNCTION
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From the posterior pituitary (neurohypophysis)
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Summary
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Summary
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Thank you for your attention
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Questions?
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Questions?