9 Teratogens
9 Teratogens
9 Teratogens
pregnancy
Ano ang TERATOGENS
Any agent that can disturb the development of an embryo
or fetus. Teratogens may cause a birth defect in the child.
T OOXOPLASMOSIS
R UBELLAO
C CYTOMEGALOVIRUS
Opthalmia neonatorum
Treponema pallidum
Mother---mild rash
Droplet infection
Dx—blood serum
No treatment/vaccine
1st trimester:
Severe congenital anomalies, spontaneous miscarriage
2nd/3rd trimester:
Premature birth, IUGR, continuing infection
Fetus may contact the virus from direct exposure when genital
lesion present at time of birth
Formaldehyde, Hg
Radiation
Rapidly growing cells are extremely vulnerable to
destruction by radiation
Range of malformation –depending on the stage of
development of the embryo or fetus
Maternal fever
-4-6 weeks causes abnormal fetal brain development, seizure
disorders, hypotonia,skeletal deformities
Hypothermia
Not well known
Teratogenic Maternal Stress