DR Pradhan
DR Pradhan
DR Pradhan
National awards:
1. Padma Shri – from President of India
2. Shanti Swaroop award – from Prime Minister of India
3. ICMR awards – three times – one of them from Prime Minister of India
4. Awarded Fellowships by two National Science Academies (FAMS, FNASc)
5. Awarded DSc (Honaris causa) by Rani Durgavati University, Jabalpur.
International Awards:
1. Fellow of Royal College of Physicians (awarded honaris causa by Edinburgh University, UK)
2. Vocational excellence award – Rotary International.
3. Pride of India award – International friendship forum.
Scientific research:
1. Two new discoveries are adopted internationally by his name as:
a) Pradhan Sign in Duchenne Muscular Dystrophy.
b) Pradhan’s Method of Intercostal Nerve conduction studies.
2. Discovered 5 new clinical signs in muscular dystrophy – all are internationally acclaimed
3. Given a new physiotherapy technique for stroke patients
4. Discovered the presence of a disease described from Japan (Hirayama disease) in Indian patients and
gave diagnostic criteria on MRI which are adopted now world over.
5. Worked on different aspects on diseases prevalent in India such as Cysticercosis (tape worm),
tuberculosis of brain, Japanese encephalitis and Leptospirosis.
6. Described two new rare Epilepsies in Indian patients.
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Recent felicitations of Dr. Sunil Pradhan by the Governor of
Uttar Pradesh Honarable Shri Ram Naik Ji
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Dr. Sunil Pradhan Bio-data (Curriculum Vitae
Specialization:
(a) Subject of work: Clinical Medicine
(b) Field of Specialization: Neurology
(c) Areas of Research:
(i) Neuromuscular diseases
(ii) Clinical Neurophysiology
(iii) Epilepsy
(iv) Infectious and parainfectious diseases of the nervous system
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King George’s Medical College
MBBS (Lucknow) 1979
Lucknow University, Lucknow
King George’s Medical College
MD (Medicine) 1983
Lucknow University, Lucknow
King George’s Medical College
DM (Neurology) 1986
Lucknow University, Lucknow
King George’s Med. College and G.M. & A. Full time PG Std / Senior
2. Sept 84-Sept 86
Hospitals, Lucknow. Resident (Neurology)
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Sanjay Gandhi Postgrad. Inst. Med. Sci., Professor
12. April 09- April 2017
Lucknow (Neurology)
13. April 2017- till now Sanjay Gandhi Postgrad. Inst. Med. Sci., Professor & Head
Lucknow (Neurology)
1. A clinical trial of Centpiperalone on maturity onset diabetic patients. Pradhan S, Tandon OP, Mukherjee SK (1981-
1983).
2. A clinical study of stroke patterns in Uttar Pradesh. Pradhan S, Nag D, Kar AM, Shukla R, Misra UK (1984-1986).
3. Clinical, electrophysiological, histochemical and genetic studies in Duchenne muscular dystrophy. Pradhan S, Mittal B
(1990-1992).
4. Clinical, electrophysiological and cytochemical studies in patients of mitochondrial cytopathies. Pradhan S, Mittal B,
Mittal RD (1993-1995).
5. Role of ultrasound in the diagnosis of neuromuscular diseases. Hasan A, Gujral R, Baijal S, Pradhan S (1996-1998).
6. Prospective evaluation of magnetization transfer MR imaging in the diagnosis of infectious meningitis. Kamra P, Gupta
RK, Pradhan S, Prasad KN, Kathuria MK (1999-2001).
7. Outcome of single CT enhancing lesions with special reference to optimisation of duration of antiepileptic therapy.
Kumar M, Govil YC, Pradhan S, Garg RK, Kumar S, Agnihotri A (2001-2003).
8. Role of Compylobacter jejuni in Guillain Barre’ Syndrome. Prasad KN, Pradhan S, Ayyagari A (2001-3).
9. Assay of mono amine oxidase-B activity in platelets of patients with primary headache disorders. Singh HO, Singh MM,
Maheshwari PK, Pradhan S, Agarwal AK, Khanna VK, Pursnani ML, Singh JB (2002-5).
10. Outcome of single CT enhancing lesions with special reference to optimisation of duration of antiepileptic therapy.
Kumar M, Govil YC, Pradhan S, Garg RK, Kumar S, Agnihotri A (2001-2005).
11. Role of Compylobacter jejuni in Guillain Barre’ Syndrome. Prasad KN, Pradhan S, Ayyagari A (2001-6).
12. Assay of mono amine oxidase-B activity in platelets of patients with primary headache disorders. Singh HO, Singh MM,
Maheshwari PK, Pradhan S, Agarwal AK, Khanna VK, Pursnani ML, Singh JB (2002-5).
13. A pilot study of epidemiological correlates of dementia in rural areas around Lucknow. The project sanctioned by
Council of Science & Technology (U.P.) in 2007-2008.
14. Characterization of neuromuscular disorders (muscular dystrophies / myopathies) by NMR (nuclear magnetic
resonance) spectroscopy. Synopsis submitted for the partial fulfillment of Ph.D. by Niraj Kumar Srivastava at Sanjay
Gandhi PGI of Medical Sciences, Lucknow – 2004 –2009.
15. Study of gene polymorphism and mutations in Alzheimer’s disease and other dementias in a North Indian Cohort.
Thesis submitted for the fulfillment of Ph.D. by Miss Pratima Pandey at DDU Gorakhpur University, Gorakhpur – 2005 –
2010.
16. Project titled “A phase III, double-blind, placebo-controlled study to determine the efficacy and safety of a low (50
mg/day) and high (100 mg/day) dose of Safinamide, as add-on therapy, in patients with idiopathic Parkinson’s disease
with motor fluctuations, treated with a stable dose of levodopa and who may be receiving concomitant treatment with
stable doses of dopamine agonist and/or an anticholinergic agent. A project sponsored by Clinirix India Ltd., Gurgaon.
N. Delhi – 2008 –2010.
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6. Clinical Neurology and Neurosurgery (CNN)
7. Journal of the Neurological Sciences
8. Neurology India / Annals of Indian Academy of Neurology
9. Indian Journal of Medical Research (IJMR)
National Achievements
1. National Awards:
1. Shanti Swaroop Bhatnagar Prize(Medical Council of Scientific and Industrial Research, New 2002
Sciences) Council of Science & Technology, Uttar Pradesh
2. Vigyan Gaurav Award 2011
3. Amrut Mody Unichem Award Indian Council of Medical Research, New Delhi 2007
4. Dr. H. B. Dingley Memorial Award Indian Council of Medical Research, New Delhi 1994
5. Shakuntala Amirchand Memorial Award Indian Council of Medical Research, New Delhi 1996
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12. Felicitated by Hanuman Mandir Society, Aliganj, Lucknow, 2007.
13. Felicitated by the Arogya Bharti Sanstha, Lucknow, 2017
14. Felicitated by the Swayam Siddha Society for Women Empowerment, Lucknow, 2018
3. Examiner/Expert in academic examinations & selection committees:
1. Member of the Interview Board (Advisor), Combined Civil Services Examination (IAS, IPS, IRS etc), Union Public
Service Commission, New Delhi, 2012
2. Member of the expert committee for interviewing SRF/RA (Medical & Pharmaceutical Sciences) at CSIR (HRD group),
New Delhi, 2004 to 2010.
3. Member of the expert committee, Combined Medical Examination for Central Medical Services, Union Public Service
Commission, New Delhi, 2006 and 2012
4. External Examiner for DM (Neurology/Pediatric Neurology) final exam at:
a) King George’s Medical University, Lucknow, 2001-2007 & 2010-2011.
b) G. B. Pant Hospital, New Delhi, 2008-2010.
c) All India Institute of Medical Sciences, New Delhi, 2010 - cont.
d) Nizam’s Institute of Medical Sciences, Hyderabad, 2011-2012.
e) The Bangur Institute of Neurological Sciences, Kolkata, 2011-2012.
f) Institute of Medical Sciences, BHU, Varanasi, 2012.
5. Internal Examiner for DM (Neurology) final examination at Sanjay Gandhi Postgraduate Institute of Medical Sciences,
Lucknow (intermittently for last 10 yrs.).
6. Guide for PhD on Medical Subjects: Registered as to undertake PhD program at Kanpur University, Kanpur, 2006
onwards.
7. Examiner for MBBS final examination (Medicine) at King George Medical Univ., Lucknow, 2005.
8. Member of the selection committee for combined DM Entrance examination of Uttar Pradesh held at GSVM Medical
College, Kanpur, 1997.
9. Member of the selection committee for the selection of lecturers in Neurology under Rajasthan Public Service
Commission, 2001.
10. Member of the selection committee for the selection of lecturers in Neurology at Banaras Hindu University, Varanasi,
2006.
11. Member of the expert committee, for the selection of Assistant Professor in Neurology at Central Government Institutes,
Union Public Service Commission, New Delhi, 2008.
12. Member of the expert committee for the selection of SS Bhatnagar awardee (Medical Sciences category) at Council of
Scientific and Industrial Research, CSIR (HRD group), New Delhi, 2016.
13. Member of the expert committee for the marketing of new drugs in Neurology, Directorate of Drug Controller of India,
New Delhi, 2017.
14. Member of the expert committee for the evaluation of research projects at all the ICMR centers of the country,Indian
Council of Medical Research (ICMR), New Delhi, December, 2018.
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International Achievements
1. Awards:
1. Rotary International: Vocational Excellence Prize, 2002.
2. Pride of India Award: Indo-US Friends Association, 2007.
1. Fellowship on “Neuromuscular Diseases” under Japan International cooperation Agency, Tokyo to work at Nagoya
University, Nagoya, Japan, 1991-1992.
2. Member of the New York Academy of Sciences, New York, 1997.
3. Fellow of Royal College of Physicians (FRCP), Edinburgh -- 2014
4. Member of American Academy of Neurology -- 2015
1. Biographee – Marquis Who’s Who in the World, 15th-19 th Editions, USA, 1997 – 2003 & 2008.
2. Biographee – International directory of distinguished leadership (American Biographical Institute, USA), 2003.
3. Biographee – Marquis Who’s Who in Science & Engineering, 7th edition, 2003-4.
4. Biographee – Marquis Who’s Who in Asia, 1st edition, 2007.
5. Biographee – Asia Pacific Who’s Who (Vol. VII), Rifacimento International - 2007.
6. Biographee – Asian Admirable Achievers (Vol. I), Rifacimento International – pp. 399, 2007.
1. Invited to deliver lecture on “Valley sign in Duchenne muscular dystrophy” at Oxford Muscle symposium, Marion
Society of Muscle Dis. Oxford, UK. (1999).
2. Invited to deliver lecture on “Poly-hill sign in facioscapulohumeral dystrophy” at Oxford Muscle symposium, Marion
Society of Muscle Diseases, Oxford, UK. (2002).
3. Invited to deliver lecture on “Recent progress in Japanese encephalitis in India” in 7 th Japanese Neuro-infectious
disease congress at Tokyo Women’s Medical University, Tokyo, Japan (2002).
4. Invited to deliver lecture on “Virology of Japanese encephalitis – emerging & re-emerging pattern” at Department of
Microbiology, Tokyo Metropolitan City Hospital, Tokyo Women’s Medical University, Tokyo, Japan (2002).
5. Invited to deliver lecture on “Neurocysticercosis and other Infective causes of Epilepsy” in the session “Prevention of
Epilepsy” at 5th Asian and Oceanian Epilepsy Congress, Bangkok, Thailand, 28th – 31 st August 2004.
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6. Overseas visits
9. 28-06-2002 29-06- Oxford, U.K. To present a paper poly-hill sign in FSHD at Marion
2002 Society meeting on muscle diseases.
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Complete list of publications
1. Goel R, Manglik A, Pradhan S. Role of co-trifamol in the treatment of chloremphenicol resistant and other cases of
enteric fever - a comparative study. Ind Med Gaz 1986; 120 (3): 81-83.
2. Manglik A, Goel R, Pradhan S. Clinical efficacy trial of nalidixic acid vs co-trimoxazole in urinary tract infection. Ind Med
Gaz 1986; 120 (4): 130-132.
3. Manglik A, Ghatak A, Pradhan S. Efficacy and safety of Piroxicam, a new NSAID, in rheumatoid arthritis. Ind Med Gaz
1987; 121 (9): 302-304.
4. Manglik A, Ghatak A, Pradhan S. Clinical efficacy of rhumalya in rheumatoid arthritis. Probe 1987; 4: (Oct-Dec) 21-24.
5. Ghatak A, Manglik A, Pradhan S. Efficacy trial of diclofenac sodium -- a new NSAID in rheumatoid arthritis. The Indian
Practitioner 1988; (Oct): 743-748.
6. Kar A M, Mittal P, Pradhan S. Cerebrospinal fluid fistula following a lumbar puncture. Brit Med J 1987; 295: 528.
7. Agarwal A, Nag D, Kar AM, Pradhan S. Post viral acute cerebellar ataxia (letter). J Assoc Physicians India 1987; 35.
8. Pradhan S*, Manglik A, Ghatak A. A comparative study of antihypertensive effect of nifedipine retard and metoprolol.
Ind Med Gaz 1987; 121 (6): 217-219.
9. Pradhan S*, Nag D, Kar AM, Misra UK. Role of computed tomography in stroke in the Indian context. J Assoc
Physicians India 1988; 36: 428-430.
10. Pradhan S*, Taly A. Intercostal nerve conduction study in man. J Neurol Neurosurg Psychiatry 1989; 52: 763-766.
11. Taly A, Pradhan S, Subbakrishna DK, Nagaraja D. Sural sensory conduction study: comparison between the needle
and the surface recording electrodes. Neurology India 1990; 38: 343-346.
12. Misra UK, Pandey BN, Pradhan S, Bal S, Mittal A, Bhatia E. Malignant insulinoma presen-ting as recurrent episodic
loss of consciousness. J Assoc Physicians India 1991; 39: 771-773.
13. Sinha S, Pradhan S, Mittal RD, Mittal B. Detection of gene deletion in patients of Duchenne muscular dystrophy/Becker
muscular dystrophy using polymerase chain reaction. Indian J Med Res (B) 1992; 96: 297-301.
14. Pradhan S*. Focal sheathing of retinal arteries in tuberous sclerosis. Pediatr Neurosurg 1991-92; 17: 279-280.
15. Pradhan S*. Tibialis anterior R-1 response: standardisation of technique, normative data and clinical utility in L4-L5
radiculopathy. Electroencephalogr Clin Neurophysiol 1993; 89: 10-21.
16. Pradhan S*, Kalita J. Micturition induced reflex epilepsy. Neurology India 1993; 41: 221-223.
17. Pradhan S*. New clinical sign in Duchenne muscular dystrophy. Pediatr Neurol 1994; 11: 298-300.
18. Pradhan S*, Singh MN, Mathur VN, Phadke RV. Pontine and extra-pontine myelinolysis presenting with acute
parkinsonism during recovery. Neurology India 1994; 42: 163-167.
19. Pradhan S*, Mittal B. Infraspinatus muscle hypertrophy and axillary folds’ wasting as the important signs in Duchenne
muscular dystrophy. Clin Neurol Neurosurg 1995; 97: 134-138.
20. Pradhan S*, Jha R, Singh MN, Gupta S, Phadke RV, Kher V. Central pontine myelinolysis following “slow” correction of
hyponatremia. Clinical Neurol Neurosurg 1995; 97: 340-343.
21. Pradhan S*, Gupta A. Iaterogenic median and femoral neuropathy. J Assoc Physicians India 1995; 43: 141.
22. Pradhan S*, Kalita J. Tickling seizures. Neurology India 1996; 44: 27-29.
23. Pradhan S*. F-response multiplicity in lower motor neuron disorders. Electromyogr Clin Neurophysiol 1996; 36: 441-
448.
24. Pradhan S*, Pandey N, Phadke RV, Kaur A, Sharma K, Gupta RK. Selective involvement of basal ganglia and occipital
cortex in acute endosulfan poisoning. J Neurol Sci 1997; 147: 209-213.
25. Pradhan S*, Ghosh D, Kumar S. Leigh’s disease: analysis of clinical and imaging characteristics with possible
therapeutic implications. Neurology India 1997; 45: 177-181.
26. Pradhan S*, Gupta RK. Magnetic resonance imaging in juvenile asymmatric segmental spinal muscular atrophy. J
Neurol Sci 1997; 146: 133-138.
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27. Pradhan S*, Gupta RK, Ghosh D. Parainfectious myelitis: three clinico-imagiological patterns with prognostic
implications. Acta Neurol Scand 1997; 95: 241-247.
28. Ghosh D, Pradhan S. Ante-mortem diagnosis of Leigh’s disease: role of magnetic resonance studies. Indian J Pediatr
1997: 683-691.
29. Mittal B, Singh V, Misra S, Sinha S, Mittal RD, Chaturvedi LS, Danda S, Pradhan S, Agarwal SS. Genotype-phenotype
correlation in Duchenne/Becker muscular dystrophy patients seen at Lucknow. Indian J Medical Res 1997; 105: 32-38.
30. Singh V, Sinha S, Misra S, Chaturvedi LS, Pradhan S, Mittal RD, Mittal B. Proportion and pattern of dystrophin gene
deletions in North Indian Duchenne and Becker muscular dystrophy patients. Hum Genet 1997; 99: 206-208.
31. Phadke SR, Pahi J, Phadke RV, Pradhan S, Agarwal SS. Importance of etiologic diagnosis of hydrocephalus as
illustrated by a case of Walker Warburg Syndrome. Indian Pediatrics 1997; 34: 1037-1038.
32. Pradhan S*, Singh MN, Pandey N. Kluver Bucy syndrome in young children. Clin Neurol Neurosurg 1998; 100: 254-
258.
33. Ghosh D, Pradhan S. Extensor toe sign by various methods in spastic children with cerebral palsy. J Child Neurol 1998;
13: 216-220.
34. Pradhan S*. Time dependent selective recurrent discharge of motor units in F-response. Electroencephalogr Clin
Neurophysiol 1998; 109: 341-349.
35. Kathuria MK, Gupta RK, Roy R, Gaur V, Husain N, Pradhan S. Measurement of magnetization transfer in different
stages of neurocysticercosis. JMRI 1998; 8: 473-479.
36. Pradhan S*, Gupta RK, Kapoor R, Shashank S, Kathuria MK. Parainfectious conus myelitis. J Neurol Sci 1998; 161:
156-162.
37. Pradhan S*, Pandey N. Acute disseminated encephalomyelitis presenting as ataxic hemiparesis. Neurology India 1998;
46: 156-158.
38. Pradhan S*, Gupta RP, Shashank S, Pandey N. Intravenous immunoglobulin therapy in acute disseminated
encephalomyelitis. J Neurol Sci 1999; 165: 56-61.
39. Gupta R, Kathuria MK, Pradhan S. Magnetization transfer MR imaging in central nervous system tuberculosis. Am J
Neuroradiol 1999; 20: 867-875.
40. Gupta R, Kathuria MK, Pradhan S. Magnetization transfer magnetic resonance imaging demonstration of perilesional
gliosis – relation with epilepsy in treated and healed neurocysticercosis. The Lancet 1999; 354 (July 3): 44-45.
41. Pradhan S*, Pandey N, Shashank S, Gupta RK, Mathur A. Parkinsonism due to predominant involvement of substantia
nigra in Japanese encephalitis. Neurology 1999; 53: 1781-1786.
42. Pradhan S*, Kathuria MK, Gupta RK. Perilesional gliosis and seizure outcome: a study based on magnetization transfer
magnetic resonance imaging in patients with neurocysticercosis. Annals of Neurology 2000; 48 (2): 181-187.
43. Ogata A, Matsumura T, Pradhan S*. Parkinsonism due to predominant involvement of substantia nigra in Japanese
encephalitis [letter]. Neurology 2000; 55: 602.
44. Pradhan S*, Gupta RK, Singh MB, Mathur A. Biphasic illness pattern due to early relapse in Japanese-B virus
encephalitis. J Neurol Sci 2001; 183: 13-18.
45. Pradhan S*, Gupta RK. Cervical dural sac and spinal cord in juvenile muscular atrophy of distal upper extremity.
Neurology [letter] 2001; 56: 575.
46. Chaturvedi LS, Srivastava S, Mukherjee M, Mittal RD, Phadke SR, Pradhan S, Mittal B. Carrier detection in non-
deletional Duchenne / Becker muscular dystrophy families using polymorphic dinucleotide (CA) repeat loci of dystrophin
gene. Indian J Med Res 2001; 113: 19-25.
47. Prasad KN,Pradhan S, Nag VL. Campylobacter infection in Guillain Barre’ syndrome. Southeast Asian J Trop Med
Public Health 2001; 32: 527-530.
48. Srivastava S, Mukherjee M, Panigrahi I, Shanker Pandey G, Pradhan S, Mittal B. SMN2 - deletion in childhood - onset
spinal muscular atrophy. Am J Med Genet, 2001; 101: 198-202.
49. Kamra P, Vatsal DK, Hussain M, Pradhan S, Venkatesh SK, Gupta RK. MRI demonstration of unsuspected
intraventricular rupture of pyogenic cerebral abscess in patients on treatment for meningitis. Neuroradiology 2002; 44:
114-117.
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50. Pradhan S*. “Valley sign” in Duchenne muscular dystrophy: importance in patients with inconspicuous calves. Neurol
India 2002; 50: 184-186.
51. Prasad KN, Chawla S, Jain D, Pandey CM, Pal L, Pradhan S, Gupta RK. Human and porcine Taenia solium infection in
rural North India: a pilot study. Trans Roy Soc Trop Med Hyg 2002; 96: 515-516.
52. Srivastava S, Mukherjee M, Panigrahi I, Shanker Pandey G, Mittal B, Pradhan S. Reply to correspondence from
Cobben and Visser – “SMN2 - deletion in childhood - onset spinal muscular atrophy”. [letter] Am J Med Genet 2002;
109: 247.
53. Srivastava S, Mukherjee M, Panigrahi I, Shanker Pandey G, Mittal B, Pradhan S. Reply to correspondence from Ogino
et al. -- “SMN2 - deletion in childhood - onset spinal muscular atrophy”. [Letter] Am J Med Genet 2002; 109: 245.
54. Panigrahi I, Pradhan S*. Utility of database and information technology in paediatric neurology. Neurology India 2002;
50:123-127.
55. Kumar R, Gupta RK, Rathore RKS, Rao SB, Chawla S, Pradhan S. Multiparametric quantitation of the perilesional
region in patients with healed/healing solitary cysticercus granuloma. Neuroimage 2002; 15 (4): 1015-1020.
56. Chawla S, Gupta RK, Kumar R, Garg M, Pradhan S, Pal L, Hussain N, Gupta A, Rathore RKS. Demonstration of scolex
in calcified cysticercus lesion using gradient echo with or without corrected phase imaging and its clinical implications.
Clinical Radiology 2002; 57: 826-834.
57. Gupta RK, Kumar R, Chawla S, Pradhan S. Demonstration of scolex within the calcified cysticercal cyst: its possible
role in the pathogenesis of peri lesional oedema. Epilepsia 2002; 43: 1502-1508.
58. Vastava PB, Pradhan S, Jha S, Prasad KN, Kumar S, Gupta RK. MRI features of toxoplasma encephalitis in the
immunocompetent host: a report of two cases. Neuroradiology 2002; 44: 834-838.
59. Pradhan S*, Poly-hill sign in facioscapulohumeral dystrophy. Muscle & Nerve 2002; 25: 754-755.
60. Kumar R, Gupta RK, Husain M, Vatsal DK, Chawla S, Rathore RK, Pradhan S. Magnetisation transfer MR imaging in
patients with post-traumatic epilepsy. AJNR Am J Neuroradiol 2003; 24: 218-224.
61. Pradhan S*, Gupta RK. Juvenile asymmetric segmental spinal muscular atrophy (Hirayama disease). Acta Neurol
Scand [letter] 2003; 101: 74-75.
62. Pradhan S*, Kumar R, Gupta RK. Intermittent symptoms in neurocysticercosis: could these be epileptic? Acta Neurol
Scand 2003; 101 (4): 241-247.
63. Sharma K. Pradhan S, Varma A, Rathi B. Irreversible blindness due to multiple tuberculomas in the supraseller cistern.
J Neuroophthalmol 2003; 23: 211-212.
64. Kumar R, Gupta RK, Rao SB, Chawla S, Husain M, Pradhan S, Rathore RKS. Assessment of tissue damage with
magnetization transfer ratio and T2 quantitation in traumatic brain injury. Magn Reson Imaging 2003; 21: 893-899.
65. Kishore J, Mukhopadhayay C, Pradhan S, Ayyagiri A. Gupta RK. Neurocysticercosis in clinically suspected and MRI
proven cases: evidence of sub-optimal antibody response. Indian J Pathol Microbiol 2004; 47: 290-294.
66. Sinha S, Prasad KN, Pradhan S, Jain D, Jha S. Detection of preceding Campylobacter jejuni infection by polymerase
chain reaction in patients with Guillain Barre’ syndrome. Trans R Soc Trop Med Hyg 2004; 98: 342-346.
67. Kamra P, Azad R, Prasad KN, Jha S, Pradhan S, Gupta RK. Infectious meningitis: prospective evaluation with
magnetization transfer MRI. Brit J Radiol 2004; 77: 387-394.
68. Pradhan S*. Valley sign in Becker muscular dystrophy and DMD/BMD outliers. Neurol India 2004; 52: 203-205.
69. Pradhan S*, Mishra VN. A central demyelinating disease with atypical features. Multiple Sclerosis 2004; 10: 308-315.
70. Kesari A, Misra UK, Kalita J, Mishra VN, Pradhan S, Patil SJ, Phadke SR, MittalB. Deletion analysis of SMN and NAIP
gene in consecutive SMA patients from India. J Neurol 2005; 252: 667-671.
71. Pradhan S*. “Calf-heads on a trophy sign” in Miyoshi Myopathy. Arch Neurol 2006; 63: 1414-1417.
72. Kumar R, Wani AA, Reddy J, Pal L, Pradhan S. Development of anaplastic carcinoma in Rasmussen’s encephalitis:
review of literature and case report. Childs Nerv Syst 2006; 22: 416-419.
73. Pradhan S*, Yadav R, Mishra VN, Aurangabadkar K, Sawlani V. Amyotrophic lateral sclerosis with predominant
pyramidal signs – early diagnosis by magnetic resonance imaging. Magnetic Resonance Imaging (MRI) 2006; 24: 173-
179.
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74. Pradhan S*, Yadav R, Diwakar H, Phadke RV. Subarachnoid haemorrhage following chronic dural venous sinus
thrombosis. Angiology 2006 (in press)
75. Pradhan S*, Ghosh D, Srivastava NK, Kumar A, Mittal B, Pandey CM, Singh U. Prednisolone in Duchenne Muscular
dystrophy with imminent loss of ambulation. J Neurol 2006; 253: 1309-1316.
76. Srivastava NK, Pradhan S*, Mittal B, Kumar R, Nagana Gowda GA. An improved single step standardized method of
lipid extraction from human skeletal muscle tissue.Analytical Letters 2006; 39: 297-315.
77. Rastogi L, Godbole MM, Ray M, Pradhan S, Gupta SK, Pandey CM. Reduction of oxidative stress and cell death
explains hypothyroidism induced neuroprotection subsequent to ischemia/reperfusion insult. Experimental Neurology
2006; 200: 290-300.
78. Pradhan S*, Yadav RK, Maurya PK, Mishra VN. Focal myelomalacia and syrinx formation after accidental
intramedullary lidocaine injection during lumbar anesthesia: a report of 3 cases. J Neurol Sci 2006; 251: 70-72.
79. Sinha S, Prasad KN, Jain D, Pandey CM, Jha S, Pradhan S*. Preceding infections and anti-ganglioside antibodies in
patients with Guillain-Barré syndrome: a single centre prospective case-control study. Clin Microbiol Infect 2007; 13:
334-337.
80. Pandey P. Pradhan S*, Mittal B. Presenilin gene predisposes for degenerative but not vascular dementia: a North
Indian population based study. Dement Geriatr Cogn Disord. 2007; 24: 151-161.
81. Pradhan S*. Shank sign in myotonic dystrophy type-1. J Clin Neurosci 2007; 14: 27-32.
82. Pradhan S*, Yadav RK, Mishra VN. Toxoplasma meningoencephalitis in HIV-seronegative patients: clinical patterns,
imaging features and treatment outcome. Trans R Soc Trop Med Hyg. 2007; 101: 25-33.
83. Pradhan S*, Yadav R. Invasive aspergillosis of the brain: improvement with lyposomalAmphoterecin B and itraconazole.
Neurology India 2007; 55: 289-290.
84. Pradhan S*. An extra hill in a poly-hill sign in a patient with facioscapulohumeral dystrophy. Neurology India 2007: 55;
436-437.
85. Srivastava NK,Pradhan S*, Mittal B, Raj Kumar, Pandey CM and Nagana Gowda G.A. Novel correlative equations for
complete estimation of human tissue lipids following their partial destruction by PCA pre-treatment: High-resolution 1H-
NMR based study. NMR in Biomedicine. 2008: 21; 89-100.
86. Pradhan S*. Diamond on quadriceps sign in dysferlinopathy. Neurology 2008: 70; 322.
87. Prasad A, Gupta RK, Pradhan S,Tripathi M, Pandey CM, Prasad KN. What triggers seizures in neurocysticercosis? A
MRI based study in pig farming community from a district of North India. Parasitol Int 2008; 57:166-171.
88. Prasad A, Prasad KN, Yadav A, Gupta RK, Pradhan S, Jha S, Tripathi M, Hussain-M. Lymphocytic transformation test:
a new method for the diagnosis of neurosysticercosis. Diagn microbial infect Dis 2008; 61: 198-202.
89. Pandey P, Pradhan S, Mittal B. LRP-associated protein gene (LRPAP1) and susceptibility to degenerative dementia.
Genes Brain Behav. 2008; 7: 943-950.
90. Srivastava NK, Pradhan S, Mittal B, Roy R. High resolution NMR based analysis of serum lipids in Duchenne Muscular
Dystrophy patients and its possible diagnostic significance (Proceedings of the ISMRM: International Society for
Magnetic Resonance in Medicine, 2008.
91. Prasad A, Prasad KN, Gupta RK, Pradhan S. Increased expression of ICAM-1 among symptomatic
neurocysticercosis.J Neuroimmunol. 2009; 206: 118-120.
92. Lakhan R, Misra UK, Kalita J, Pradhan S, Gogtay NJ, Singh MK, Mittal B. No association of ABCB1 polymorphisms with
drug-refractory epilepsy in a north Indian population.Epilepsy & Behav. 2009; 14: 78-82.
93. Joshi G, Pradhan S, Mittal B. Role of ACE 1D and MTHFR C677T polymorphism in genetic susceptibility of migraine in
a north Indian population. J Neurol Sci 2009; 277: 133-137.
94. Pardasani V, Pradhan S. Finger drop following a potassium drop. J Assoc Physians India. 2009; 57, 419-420.
95. Pradhan S. Clinical and magnetic resonance features of “diamond on quadriceps” sign in dysferlinopathy. Neurology
India 2009; 57: 140-143.
96. Pradhan S. Finger drop sign in Guillain Barre syndrome, a commentary. Neurology India, 2009 (in press).
97. Pradhan S, Pardasani V, Ramteke K. Azithromycin-induced myasthenic crisis: Reversibility with calcium gluconate.
Neurology India 2009, 57: 352-353.
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98. Pradhan S. Bilaterally symmetrical form of Hirayama disease. Neurology 2009,72: 2083-2089.
99. Pandey P, Pradhan S, Modi DR, Mittal B. MTHFR and ACE gene polymorphisms and risk of vascular and degenerative
dementias in the elderly. Brain Cogn. 2009 Aug 26. [Epub ahead of print]
100. Pradhan S.Invited Commentary. Selectivity of weakness among different muscles or muscle groups has always
fascinated the clinicians in arriving at specific diagnosis of motor system disease. Neurol India. 2009; 57(3): 286-287.
101. Lakhan R, Kumari R, Misra UK, Kalita J, Pradhan S, Mittal B. Differential role of sodium channels SCN1A and SCN2A
gene polymorphisms with epilepsy and multiple drug resistance in the north Indian population. Br J Clin Pharmacol.
2009; 68: 214-220.
102. Pandey P, Pradhan S, Mody, Mittal D. MTHFR and ACE gene polymorphisms and risk of vascular and degenerative
dementias in the elderly. Brain and Cognition 2009; 71: 295-299.
103. Prasad KN, Prasad A, Gupta RK, Nath K, Pradhan S,Tripathi M, Pandey CM. Neurocysticercosis in patients with active
epilepsy from pig farming community of Lucknow district of North India. Trans Roy Soc Trop Med Hyg 2009; 103: 144-
150.
104. Pradhan S. Invited Commentary on "Finger drop sign" in Guillain-Barré syndrome. Selectivity of weakness among
different muscles or muscle groups has always fascinated the clinicians in arriving at specific diagnosis of motor system
disease. Neurol India. 2009; 57: 282-286.
105. Joshi G; Pradhan S; Mittal B. Role of the oestrogen receptor (ESR1 PvuII and ESR1 325 C->G) and progesterone
receptor (PROGINS) polymorphisms in genetic susceptibility to migraine in a North Indian population. Cephalalgia:
2010; 30(3): 311-320.
106. Ghosh J, Joshi G, Pradhan S, Mittal B. Investigation of TNFA 308G > A and TNFB 252G > A polymorphisms in genetic
susceptibility to migraine. J Neurol 2010; 257: 898-904.
107. Joshi G, Pradhan S, Mittal B. No direct association of serotonin transporter (STin2 VNTR) and receptor (HT 102T>C)
gene variants in genetic susceptibility to migraine. Dis Markers. 2010; 29: 223-229.
108. Nyati KK, Prasad KN, Verma A, Singh AK, Rizwan A, Sinha S, Paliwal VK, Pradhan S. Association of TLR4 Asp299Gly
and Thr399Ile polymorphisms with Guillain-Barré syndrome in Northern Indian population. J Neuroimmunol. 2010 Jan
25;218(1-2):116-9. Epub 2009 Nov 13.
109. Nyati KK, Prasad KN, Rizwan A, Verma A, Paliwal VK, Pradhan S. Lymphocyte transformation test detects a response
to Campylobacter jejuni antigens in patients with Guillain-Barré syndrome. Med Microbiol Immunol. 2010
May;199(2):109-16. Epub 2010 Feb 16.
110. Paliwal VK, Gupta PK, Pradhan S. Gabapentin as a rescue drug in D-penicillamine-induced status dystonicus in
patients with Wilson disease. Neurol India. 2010; 58: 761-763.
111. Srivastava NK, Pradhan S, Mittal B, Gowda GA, Roy R, Khetrapal CL. High resolution NMR based analysis of serum
lipids in Duchenne Muscular Dystrophy patients of Northern India and its possible diagnostic significance. NMR Biomed
2010;23: 13-22.
112. Srivastava NK, Pradhan S, Gowda GA, Kumar R. In vitro, a high-resolution 1H & 31P NMR based analysis of the lipid
components in the tissue, serum and CSF of the patients with primary brain tumors: one possible diagnostic view. NMR
Biomed 2010; 23: 113-122.
113. Pradhan S.Limb-girdle muscular dystrophy type 2A (Editorial). Neurology India, 2010; 58: 509-511.
114. Pradhan S and Goyal G. Teaching NeuroImages: Honeycomb appearance of the brain in a patient with Canavan
diseas. Neurology 2011; 76; e68.
115. Paliwal V K, Goel G, Vema R, Pradhan S, Gupta R K. Acute disseminated encephalo-myelitis following filarial infection.
J Neurol Neurosurg Psychiatry 2011;-:1e2. doi: 10.1136/jnnp-2011-300007
116. Joshi G, Pradhan S, Mittal B. Vascular Gene Polymorphisms (EDNRA -231 G>A and APOE HhaI) and Risk for
Migraine. DNA Cell Biol. 2011; 30:577-84.
117. Paliwal VK, Kumar A, Rahi SK, Pradhan S. Charcot foot in post-tubercular spinal arachnoiditis may indicate emerging
dorsal cord syringomyelia. Neurol India. 2011; 59: 299-301.
118. Mishra AK, Agarwal SK, Pradhan S, Agarwal A. Association of unilocular thymic cyst and myasthenia gravis. Neurol
India. 2012 Jan-Feb;60(1):103-5.
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119. Ghosh J, Pradhan S, Mittal B. Role of dopaminergic gene polymorphisms (DBH 19 bp indel and DRD2 Nco I) in genetic
susceptibility to migraine in North Indian population. Pain Med. 2011 Jul; 12 (7): 1109-11. doi: 10.1111/j.1526-
4637.2011.01153.x. Epub 2011 Jun 13.
120. Ghosh J, Joshi G, Pradhan S, Mittal B. Potential role of aromatase over estrogen receptor gene polymorphisms in
migraine susceptibility: a case control study from North India. PLoS One. 2012;7(4):e34828. doi:
10.1371/journal.pone.0034828. Epub 2012 Apr 12.
121. Pradhan S, Tandon R, Kishore J. Combined involvement of muscle, nerve, and myoneural junction following leptospira
infection. Neurol India. 2012 Sep-Oct;60(5):514-6.
122. Paliwal VK, Pradhan S. Management options in neuropathic pain. J Indian Med Assoc. 2012 Sep;110(9):639-43.
123. Ghosh J, Pradhan S, Mittal B. Genome-wide-associated variants in migraine susceptibility: a replication study from
North India. Headache. 2013 Nov-Dec;53(10):1583-94
124. Ghosh J, Pradhan S, Mittal B. Identification of a novel ANKK1 and other dopaminergic (DRD2 and DBH) gene variants
in migraine susceptibility. Neuromolecular Med. 2013 Mar;15(1):61-73.
125. Pradhan S, Tandon R.Acute disseminated encephalomyelitis mimicking leukodystrophy. Pediatr Neurol. 2014
Nov;51(5):749
126. Pradhan S, Tandon R. N-hexane neuropathy with vertigo and cold allodynia in a silk screen printer: A case study. Int J
Occup Med Environ Health. 2015;28(5):915-9.
127. Pradhan S, Tandon R. Progressive supra-nuclear palsy: frequency of cardinal extrapyramidal features at first
presentation. Postgrad Med J. 2015 May;91(1075):274-7.
128. Kumar A, Agarwal S, Pradhan S. Haplotype analysis and LD detection at DM1 locus. Gene. 2015 Aug 1;567(1):45-50.
129. Tandon R, Pradhan S. Autonomic predominant multiple system atrophy in the context of Parkinsonian and cerebellar
variants. Clin Neurol Neurosurg. 2015 Mar;130:110-3.
130. Kumar A, Agarwal S, Pradhan S. Assessment of Premutation in Myotonic Dystrophy Type 1 Affected Family Members
by TP-PCR and Genetic Counseling. Case Rep Med. 2014;2014:289643. doi: 10.1155/2014/289643. Epub 2014 Feb
23.
131. Pradhan S, Kumar A. Lower motor neuron paralysis with extensive cord atrophy in parainfectious acute transverse
myelitis. Ann Indian Acad Neurol. 2014 Jul;17(3):347-8. doi: 10.4103/0972-2327.138525.
132. Kumar A, Agarwal S, Phadke SR, Pradhan S. Application of a reliable and rapid polymerase chain reaction based
method in the diagnosis of myotonic dystrophy type 1 (DM1) in India. Meta Gene. 2014 Jan 15;2:106-13
133. Pradhan S. Hydrocephalus and vasculitis delay therapeutic responses in tuberculous meninigitis: The neurologist's
perspective. Neurol India. 2016 Sep-Oct;64(5):860-1.
134. Pradhan S, Choudhury SS, Das A. Tumefactive acute disseminated encephalomyelitis. Neurol India. 2017 May-
Jun;65(3):558-560.
135. Pradhan S, Choudhury SS, Paliwal VK. Complete middle cerebral artery block without brain infarction. Neurol India.
2016 Mar-Apr;64 Suppl:S95-7
136. Pradhan S, Tandon R. Relevance of non-specific MRI features in multiple system atrophy. Clin Neurol Neurosurg. 2017
Aug;159:29-33.
137. Rastogi L, Godbole MM, Sinha RA, Pradhan S. Reverse triiodothyronine (rT3) attenuates ischemia-reperfusion injury.
Biochem Biophys Res Commun. 2018 Nov 30;506(3):597-603.
138.Pradhan S, Mulmuley M. 'Stance' in epilepsy - our stance on the current classification of seizures. Neurol India. 2018
Mar-Apr;66(2):323-325.
139.Pradhan S, Das A.Change in the natural profile of Duchenne muscular dystrophy with the judicious use of steroids.
Neurol India. 2018 May-Jun;66(3):893-895.
140.Pradhan S, Choudhury SS. Clinical characterization of neck pain in migraine. Neurol India. 2018 Mar-Apr;66(2):377-
384.
141.Pradhan S, Bansal R. Sieve-like basal ganglia: A rare MRI presentation of vascular parkinsonism. Neurol India. 2018
May-Jun;66(3):878-879.
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142.Pradhan S, Bansal R. Role of corrected-assisted-synchronized-periodic therapy in post-stroke rehabilitation. Neurol
India. 2018 Sep-Oct;66(5):1345-1350.
143.Pradhan S, Das A, Mani VE. Immunotherapy in autoimmune encephalitis - A need for "presumptive" diagnosis and
treatment. Neurol India. 2018 Nov-Dec;66(6):1584-1589
144.Pradhan S, Bansal R. Role of corrected-assisted-synchronized-periodic therapy in post-stroke rehabilitation: Additional
facts. Neurol India. 2018 Nov-Dec;66(6):1859-1860. doi: 10.4103/0028-3886.246296.
145.Pradhan S, Das A. Tigroid and leopard skin appearance in acute disseminated encephalomyelitis. Neurol India. 2018
Jul-Aug;66(4):1172-1174.
146.Pradhan S, Das A, Anand S. Benign Acute Childhood Myositis: A Benign Diseasethat Mimics More Severe
Neuromuscular Disorder. J Pediatr Neurosci. 2018 Oct-Dec;13(4):404-409.
147.Pradhan S, Das A, Anand S, Deshmukh AR. Clinical characteristics of migrainein patients with calcified
neurocysticercosis. Trans R Soc Trop Med Hyg. 2019 Jul1;113(7):418-423.
148.Pradhan S, Anand S, Choudhury SS. Cognitive behavioural impairment withirreversible sensorineural deafness as a
complication of West Nile encephalitis. J Neurovirol. 2019 Jun;25(3):429-433.
149.Tandon R, Pradhan S. Autistic features in Unverricht-Lundborg disease.Epilepsy Behav Rep. 2019 Jun 6;12:100323.
150.Pradhan S, Das A. Gray variant of acute disseminated encephalomyelitis and itsresponse to immunomodulatory drugs.
Neurol India. 2019 Jan-Feb;67(1):284-286.
151.Pradhan S, Das A, Das A, Mulmuley M. Antibody Negative Autoimmune Encephalitis- Does it Differ from Definite One?
Ann Indian Acad Neurol. 2019 Oct-Dec; 22(4):401-408. doi: 10.4103/aian.AIAN_206_19. Epub 2019 Oct 25.
152.Pradhan S, Das A, Bansal R. Cluster Headache in a Case of Ophthalmic Cysticercosis. Neurol India. 2019 Sep-
Oct;67(5):1365-1366
153.Das A, Pradhan S. Cardiovascular and sudomotor dysfunction in Hirayamadisease. Acta Neurol Belg. 2019 Dec 12.
154.Pradhan S, Das A, Anand S, Deshmukh AR. Clinical characteristics of migrainein patients with calcified
neurocysticercosis. Trans R Soc Trop Med Hyg. 2019Jul 1;113(7):418-423. doi: 10.1093/trstmh/trz018. PMID:
30953442.
155.Pradhan S, Das A. Gray variant of acute disseminated encephalomyelitis andits response to immunomodulatory drugs.
Neurol India. 2019 Jan-Feb;67(1):284-286. doi: 10.4103/0028-3886.253652. PMID: 30860138.
156. Pradhan S, Anand S, Choudhury SS. Cognitive behavioural impairment withirreversible sensorineural deafness as a
complication of West Nile encephalitis.J Neurovirol. 2019 Jun;25(3):429-433. doi: 10.1007/s13365-019-00733-2. Epub
2019Mar 22. PMID: 30903400.
157.Pradhan S, Das A, Ghosh J. Step-Headache: A Distinct Symptom of Migraine. JNeurosci Rural Pract. 2020
Jan;11(1):89-94. doi: 10.1055/s-0039-3400197. Epub2020 Jan 27. PMID: 32140009; PMCID: PMC7055603.
158.Pradhan S, Tandon R. PSP-FTD Complex: A Possible Variant of PSP. Am JAlzheimers Dis Other Demen. 2020 Jan-
Dec;35:1533317520922383. doi:10.1177/1533317520922383. PMID: 32648477.
159. Pradhan S, Das A, Mulmuley M, Das A. Neurocysticercosis or tuberculoma -Which one has more epileptic potential?
Seizure. 2020 May;78:91-95. doi:10.1016/j.seizure.2020.03.007. Epub 2020 Mar 16. PMID: 32278296.
160.Pradhan S, Das A, Singh H, Chaturvedi S, Singh K, Mishra R, Misra DP, AgarwalV. Steroid Responsiveness in
Duchenne Muscular Dystrophy - Predictive Value ofEpigenetic Regulator Histone Deacetylase 2. Indian J Pediatr.
2020Sep;87(9):692-698. doi: 10.1007/s12098-020-03183-5. Epub 2020 Apr 20. PMID:32314166.
161. Pradhan S, Anand S. Respiratory Assessment of Myasthenia Gravis PatientsUsing Repetitive Nerve Stimulation of
Phrenic and Intercostal Nerves. NeurolIndia. 2020 Nov-Dec;68(6):1394-1399. doi: 10.4103/0028-3886.304128.
PMID:33342875.
162. Mulmuley M, Pradhan S. Leprous myelitis: A rare case presentation. Indian JMed Res. 2020
Nov;152(Supplement):S116. doi: 10.4103/ijmr.IJMR_2190_19. PMID:35345156; PMCID: PMC8257145.
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[2] Scientific review articles published in Journals/CME books:
1. Pradhan S. Idiopathic brachial plexus neuropathy. In: Murthy JMK, ed., Reviews in Neurology, Vol. 2. Hyderabad:
Indian Academy of Neurology, 1995: 105-113.
2. Pradhan S. Electrophysiological evaluation of nerve root lesions. In: Murthy JMK, ed., Reviews in Neurology, Vol. 3.
Hyderabad: Indian Academy of Neurology, 1996: 77-88.
3. Pradhan S. Investigation of visual loss: a neurologist’s perspective. In: Mohandas S, Borgohain R, eds., Reviews in
Neurology, Vol. 4. Hyderabad: Indian Acad. of Neurol, 1997.
4. Panigrahi I, Pradhan S*. Utility of database and information technology in pediatric neurology. Neurology India 2002;
50:123-127.
5. Pradhan S. Valley sign in Duchenne muscular dystrophy. In: Mehendiratta MM, Katrak SM, Choudhury D, eds.,
Reviews in Neurology, Vol. 9. New Delhi: Indian Academy of Neurology, 2002: 245-248.
6. Pradhan S, Yadav RK. Scenario of epilepsy in the developing countries. CME book – 14th UP Neurocon, Meerut. 2005:
23-31.
7. Srivastava NK, Yadav RK, Pradhan S. Metabolic myopathies: clinical, biochemical and histopathological basis of
diagnosis. Ann Neurosci 2005; 12: 87-98.
8. Pandey P and Pradhan S*. Homocysteine: A possible modifiable risk factor in vascular dementia. Ann Neurosci 2006;
13: 12-18.
9. Pradhan S, Yadav RK. Seizures and epilepsy in central nervous system infection. Neurology Asia 2004; 9: 4-9.
10. Srivastava NK, Yadava R, Pradhan S. Metabolic myopathies: Clinical, Biochemical, Genetic and Histopathological
basis of diagnosis. Annals of Neurosciences.2005; 12:87-98.
11. Pradhan S, Malhotra HS. Diagnosis of acquired chronic demyelinating neuropathy with special reference to
electrodiagnosis. In: Radhakrishnan K, ed. Reviews in Indian Neurology. IANCON Kerala 2005, vol 5, pp. 233-281.
12. Pradhan S. Vasculitic neuropathy. In: Khadilkar SV, Gingh G, eds. Reviews in Indian Neurology, IANCON, Pune 2011,
vol 11.
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1. Pradhan S and Gupta RK. Parainfectious and other infectious diseases. Gupta RK, Lufkin J, eds., MR Imaging and
Spectroscopy of central nervous system infection. New York: Kluwer Academy / Planum Publishers, 2001: 273-296.
2. Pradhan S. Muscular dystrophy: the Indian perspective. In: Garg RK, ed., Reviews in Tropical Neurology. Lucknow:
Shivam Arts, 2002: 213-225.
3. Pradhan S, Wadia NH. Disorders of muscle (Myopathies). In: Wadia NH, ed., Neurological practice: an Indian
perspective. New Delhi: Elsevier, 2005: 612-636.
4. Wadia NH and Pradhan S. Peripheral neuropathies. In: Wadia NH, ed., Neurological practice: an Indian perspective.
New Delhi: Elsevier, 2005: 591-611.
5. Pradhan S, Mani VE. Muscular dystrophy. In: Mukherjee A, bhattacharya K, Singh G. IAN Textbook of Neurology. The
Health Sciences Publisher, New Delhi, 2018, pp 642-653.
6. Pradhan S, Meena AK. Congenital Muscular Dystrophy. In: Gupta P, Mennon PSN, Ramji S, Lodha R. PG Text Book
of Pediatrics, 2 nd Adition, J P Brothers Medical Publishers, New Delhi, 2018: pp 2628-2639.
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20. Pradhan S. Role of perilesional gliosis in the pathogenesis of secondary epilepsy due to infections and trauma. J
Neurol Sci 2005; 238 (Suppl): S141.(Presented at 18 th World Congress of Neurology, Sydney, Australia, 2005)
21. Pradhan S. Recurrent episodic central demyelinating disease with myelo-optic predilection. J Neurol Sci 2005; 238
(Suppl): S241.(Presented at 18th World Congress of Neurology, Sydney, Australia, 2005)
22. Pradhan S. Evolution of clinical features in Dementia with Lewy-body during long-term follow-up. J Neurol Sci 2005;
238 (Suppl): S298..(Presented at 18th World Congress of Neurology, Sydney, Australia, 2005)
23. Pradhan S. Patterns of blood pressure during acute phase of hypertensive intracerebral hemorrhage. J Neurol Sci
2005; 238 (Suppl): S431.(Presented at 18 th World Congress of Neurology, Sydney, Australia, 2005)
24. Pradhan S. Progress in Japanese Encephalitis in India. J Neurol Sci 2005; 238 (Suppl): S472. (Presented at 18th
World Congress of Neurology, Sydney, Australia, 2005)
List of activities in the public field i.e., health education in community, policy formulation, continuing medical
education programs etc.
Organized medical camps and delivered guest lectures to medical and general community; some important ones are listed
below:
1. Delivered a lecture on “diagnosis and management of low back pain” in the CME program of Indian Medical
Association (Lucknow chapter) on 20th May, 1990.
2. Invited to talk on “recent advances in myasthenia gravis” in the CME program at Command Hospitals, Lucknow on 28th
Feb. 1993.
3. Delivered lecture on “recent advances on the diagnosis and management of epilepsy”, at the refresher course of Indian
Medical Association - College of General Practitioners (sub-faculty Kanpur), which was widely covered by most of the
regional daily newspapers.
4. Talked about the management of epilepsy in a CME program of Shahjahanpur Medical Association at Shahjahanpur,
UP in Dec. 1994.
5. Invited for a question-answer session on neurological diseases at IFFCO general hospital, Jagdishpur, UP in Jan.
1995.
6. Invited to talk on diagnosis and management of spastic children with or without mental retardation during the silver
jubilee annual day celebration (18 th Feb. 1995) at Swami Vivekanand Hospital, Lucknow.
7. Participated in the CME for the doctors of Uttar Pradesh Provincial Medical Services in Sep. 1995 and talked about
management of epilepsy.
8. Participated in the CME for the doctors of Uttar Pradesh Provincial Medical Services in Feb. 1996 and talked about
common neurological problems.
9. Appeared on Lucknow Doordarshan and talked about new dimensions in the management of headache on 7 th Nov.
1995.
10. Invited to talk on enhancing ring lesions in the brain on Sept. 1996 by Allahabad Medical Association.
11. Invited by Indian Academy of Neurology in Oct. 1996 to deliver a lecture on electrophysiology of spinal root lesions, in
the national continuing medical education program.
12. Invited by Association of Neuroscientists of Eastern India at Ranchi to talk on “new concepts in acute transverse
myelitis” in Oct. 1997.
13. Invited to give a lecture on “Muscular Dystrophies with special reference to Duchenne muscular dystrophy” at the
Kanpur chapter of Indian Academy of Pediatrics, in Oct. 1997.
14. Invited to give a lecture on “intra-operative monitoring of operations at cranio-vertebral junction” at an update on cranio-
vertebral anomalies at Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, in Oct. 1997.
15. Delivered a guest lecture on “Epilepsy-Clinical aspects and localization” on 01-10-1999 at National workshop on
magnetic resonance imaging and spectroscopy with emphasis on neurosciences (23-09-1999 to 12-10-1999),
SGPGIMS, Lucknow, India.
16. Delivered a guest lecture on ‘Headache and Epilepsy’ on 18-03-2000, at National Academy of Sciences, NASc Bldg,
Allahabad.
17. Delivered a guest lecture on “Management of epilepsy in the pediatric age group with special reference to newer anti-
epileptic drugs” at Lucknow chapter of the Indian Academy of Pediatrics, Hotel Clarks Awadh, Lucknow, India, on 10-
08-2000.
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18. Delivered a guest lecture on “Management of epilepsies and epileptic syndromes” at Allahabad chapter of Indian
Academy of Pediatrics, Hotel Presidency, Allahabad on 10-09-2000.
19. Participated in the interactive session and lecture with bright students of science under CPYLS program of CSIR at
Central Institute of Medicinal and Aromatic Plants (CIMAP), Lucknow on 20-12-2003.
20. Invited to deliver Lecture on “Beauty of Science” under CSIR Program on Youth for Leadership in Science (CPYLS) at
National Botanical Research Institute (NBRI), Lucknow to be held on 15-01-2004.
21. Delivered lecture on “New personal observations in Neurology” at Kurukshetra University, Kurukshetra, during Goyal
Award Ceremony, 02-03-2004.
22. “Infection related epilepsy” Invited guest lecture delivered at 7th National CME – Allahabad Medical Association
Neurosciences Update, 5th September, 2004, Allahabad, Uttar Pradesh, India.
23. “Diagnostic Criteria of Demyelinating Neuropathies – a critical appraisal” Invited guest lecture at “National
Neuroscience Conference – NIMHANS Golden Jubilee Celebrations” at National Institute of Mental Health & Neuro-
Sciences, 10-12 October, 2004, Bangalore, Karnataka, India.
24. “Neuro-otological considerations in head injury – panel discussion” 26 th Annual Conference of Neuro-otological &
Equilibrimetric Society of India, at Sanjay Gandhi Post-graduate Institute of Medical Sciences, 8-10 October, 2004,
Lucknow, Uttar Pradesh, India.
25. Delivered guest lecture on “Metabolic myopathy including mitochondrial cytopathies” at CME of KGMU centenary
celebrations at King George’s Medical University, 2 nd April, 2005.
26. Delivered guest lecture on “Proximal Muscle Weakness” at the Meeting of the Lucknow Orthopedic Club, 2005.
27. Delivered guest lecture on “NMR in Muscular Dystrophy” at the 1st Foundation Day Symposium held at the “Centre of
Biomedical Magnetic Resonance, SGPGIMS Campus, Lucknow, 9th& 10th March, 2007.
28. Delivered guest lecture on “Primary and Secondary Prevention of Stroke” at the International Congress of Indian
Hypertension Society at Central Drug Research Institute, Lucknow, 15th March, 2007.
29. Delivered guest lecture on “Screening and Management of Cerebrovascular Accidents in Type II Diabetes Mellitus” at
the Diabetes – Endocrinology Update – 2007, held at Sanjay Gandhi PGI of Medical Sciences, Lucknow, 17 th& 18th
March, 2007.
30. Delivered guest lecture on “Management of Stroke with stress on preventive aspect” Amity University, NOIDA, 2008,
17th April, 2008.
31. “Muscle cramps” Invited guest lecture delivered at 8th meeting of Asian & Oceanian myology centre at Leela
kampinsky, Mumbai, on 23rd and 24th May 2009.
32. “Non-compressive myelopathy” Invited guest lecture delivered at 58th Annual Conference of Neurological Society of
India, Lucknow, 17-20 th December 2009.
33. “Nutritional neuropathy” International symposium on Peripheral Nerve Disorders held in Hyderabad under the aegis of
“Foundation for Neuromuscular Diseases” Hyderabad, India in association with Twin Cities Neurological Society, on
March 6 th& 7 th , 2010.
34. “Intravenous immunoglobulins in peripheral nervous system disorders” Invited guest lecture delivered at 19th Annual
Conference of the Indian Academy of Neurology, 22nd to 25th September, 2011.
35. Delivered Radio talk on Radio City on Parkinson’s Disease on World Parkinson Day, May, 2011.
36. Delivered Radio talk on All India Radio on Dementia on World Dementia Day, June , 2011.
37. Delivered a public lecture on “Stroke prevention and management” at Hindi Bhawan, Lucknow, October,2011.
38. Delivered several radio talks at “Health & Fitness”, All India Radio on medical subjects in 2015, 2016, 2017 and 2018.
39. Dr. Sunil Pradhan participated in National Webinar on “Corona challenges & opportunities” organized by “Yuva Chetna”
National platform, New Delhi and participated in Covid-Awareness programs of Doordarshan and Aakashwani,
Lucknow.
(Sunil Pradhan)
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Elaborate description of Dr. Sunil Pradhan’s Biodata
Dr. Sunil Pradhan is one of the most eminent teachers in the field of Neurology in the northern
India. After completing his MBBS, MD (Medicine) and DM (Neurology) courses from King
George’s Medical College, Lucknow, he preferred to gain more experience in Neurology before
settling down and chose to work in various capacities under the most eminent Neurologists of
that time. He worked under late Dr. Anil D. Desai (an eminent myologist), Dr. Noshir H Wadia
(regarded as the father-figure of Neurology in India as of now) and Dr. Sarosh M Katrak, as
senior registrar at Jaslok Hospital & Research Center, Mumbai. As clinical neurophysiology was a
new upcoming branch of Neurology at that time with very few trained persons in India, he
received 2 months short training on this subject under Dr. Piroza N Wadia in the same hospital
and then proceeded to National Institute of Mental Health & Neuro-Sciences (NIMHANS),
Bangalore as CSIR Scientist Pool Officer, to complete this training under another stalwart of that
time Dr. M. Gouri-Devi. Thereafter, he worked under Prof. JMK Murthy (currently Editor-in-Chief
of Neurology India, which is a highly indexed official journal of the Neurological Society of India)
as a young faculty at Nizam’s Institute of Medical Sciences, Hyderabad. After finally settling
down as Assistant Professor of Neurology at Sanjay Gandhi Postgraduate Institute of Medical
Sciences, Lucknow, he further proceeded to Nagoya, Japan (as JICA fellow) to receive 6 months
training in Neuromuscular diseases and Neuropathology.
Dr. Sunil Pradhan’s eminence as a medical teacher can be judged by the following parameters –
1. Teacher for students pursuing DM (Neurology) course
2. Research guide to students pursuing DM (Neurology) & PhD in basis neuroscience
3. Starting and establishing DM (Neurology) course at IHBAS, Delhi
4. Teaching medical fraternity through lectures organized by regional societies
5. Participating as a guest lecturer in National level Neurology conferences
6. Delivering named orations on invitation
7. Delivering invited and conference sponsored lectures at International platform
8. Delivering public lectures to create disease awareness among the general public
9. Writing chapters in the annual proceedings of the national societies
10. Writing book chapters in National and International books
11. Examining the students at various centers of India as examiner for final DM examination
12. Screening of research articles written by other authors as reviewer / Editor
13. Presenting research work in International conferences
14. Pursuing original research work for better understanding of Neurology
21
2) Research guide to students pursuing DM (Neurology) & PhD in basic
neuroscience
Pradhan is guiding the research work of DM students as they are supposed to write 2 papers
publishable in indexed journals as part of their DM curriculum. In addition he has roped in
several of his students in his own research work as is reflected in his publications where most of
his national as well as international papers contain names of his students as co-authors. He also
had been thesis guide and co-guide to students pursuing PhD in basic neuroscience. Following is
the list of papers that came out of his guidance:
(a) As thesis guide – the papers published:
Thesis: Characterization of neuromuscular disorders (muscular dystrophies / myopathies) by
NMR (nuclear magnetic resonance) spectroscopy. Synopsis submitted for the partial
fulfillment of Ph.D. by Niraj Kumar Srivastava at Sanjay Gandhi PGI of Medical Sciences,
Lucknow – 2004 –2009.
Papers published (Pradhan is second and corresponding author in all of them):
1. Srivastava NK, Pradhan S*, Mittal B, Kumar R, Nagana Gowda GA. An improved single step
standardized method of lipid extraction from human skeletal muscle tissue.Analytical
Letters 2006; 39: 297-315.
2. Srivastava NK, Pradhan S*, Mittal B, Raj Kumar, Pandey CM and Nagana Gowda G.A. Novel
corrective equations for complete estimation of human tissue lipids following their
partial destruction by PCA pre-treatment: High-resolution 1H-NMR based study. NMR in
Biomedicine. 2008: 21; 89-100.
3. Srivastava NK, Pradhan S*, Mittal B, Roy R. High resolution NMR based analysis of serum lipids in
Duchenne Muscular Dystrophy patients and its possible diagnostic significance (Proceedings of
the ISMRM: International Society for Magnetic Resonance in Medicine, 2008.
4. Srivastava NK, Pradhan S*, Mittal B, Gowda GA, Roy R, Khetrapal CL. High resolution NMR based
analysis of serum lipids in Duchenne Muscular Dystrophy patients of Northern India and its
possible diagnostic significance. NMR Biomed 2010;23:13-22.
5. Srivastava NK, Pradhan S*, Gowda GA, Kumar R. In vitro, a high-resolution 1H & 31P NMR based
analysis of the lipid components in the tissue, serum and CSF of the patients with primary brain
tumors: one possible diagnostic view. NMR Biomed 2010; 23: 113-122.
22
3. Pandey P, Pradhan S*, Modi DR, Mittal D. MTHFR and ACE gene polymorphisms and risk
of vascular and degenerative dementias in the elderly. Brain and Cognition 2009; 71:
295-299.
Thesis: Role of Compylobacter jejuni infection in Guillain Barre’ Syndrome. Sinha S, Prasad
KN, Pradhan S, Ayyagari A (2001-2006). Thesis submitted for the fulfillment of Ph.D. by
Sinha S.
Papers published:
17. Sinha S, Prasad KN, Pradhan S, Jain D, Jha S. Detection of preceding Campylobacter jejuni
infection by polymerase chain reaction in patients with Guillain Barre’ syndrome. Trans R
Soc Trop Med Hyg 2004; 98: 342-346.
18. Sinha S, Prasad KN, Jain D, Pandey CM, Jha S, Pradhan S. Preceding infections and anti-
ganglioside antibodies in patients with Guillain-Barré syndrome: a single centre
prospective case-control study. Clin Microbiol Infect 2007; 13: 334-337.
23
1. Joshi G, Pradhan S, Mittal B. Role of ACE 1D and MTHFR C677T polymorphism in genetic
susceptibility of migraine in a north Indian population. J Neurol Sci 2009; 277: 133-137.
2. Joshi G; Pradhan S; Mittal B. Role of the oestrogen receptor (ESR1 PvuII and ESR1 325 C-
>G) and progesterone receptor (PROGINS) polymorphisms in genetic susceptibility to
migraine in a North Indian population. Cephalalgia: 2010; 30(3): 311-320.
3. Joshi G, Pradhan S, Mittal B. No direct association of serotonin transporter (STin2 VNTR)
and receptor (HT 102T>C) gene variants in genetic susceptibility to migraine. Dis Markers.
2010; 29: 223-229.
Thesis: Investigation of gene polymorphisms in genetic susceptibility to migraine. Ghosh J,
Joshi G, Pradhan S, Mittal B. Thesis submitted for the fulfillment of Ph.D. by Ghosh J.
Papers published:
1. Ghosh J, Joshi G, Pradhan S, Mittal B. Investigation of TNFA 308G > A and TNFB 252G > A
polymorphisms in genetic susceptibility to migraine. J Neurol 2010; 257: 898-904.
2. Ghosh J, Pradhan S, Mittal B. Role of dopaminergic gene polymorphisms (DBH 19 bp indel
and DRD2 Nco I) in genetic susceptibility to migraine in North Indian population. Pain
Med. 2011 Jul; 12 (7): 1109-11. doi: 10.1111/j.1526-4637.2011.01153.x. Epub 2011 Jun
13.
24
1. Delivered a lecture on “diagnosis and management of low back pain” in the CME program of
Indian Medical Association (Lucknow chapter) on 20th May, 1990.
2. Invited to talk on “recent advances in myasthenia gravis” in the CME program at Command
Hospitals, Lucknow on 28th Feb. 1993.
3. Delivered lecture on “recent advances on the diagnosis and management of epilepsy”, at the
refresher course of Indian Medical Association - College of General Practitioners (sub-faculty
Kanpur), which was widely covered by most of the regional daily newspapers.
4. Talked about the management of epilepsy in a CME program of Shahjahanpur Medical
Association at Shahjahanpur, UP in Dec. 1994.
5. Invited for a question-answer session on neurological diseases at IFFCO general hospital,
Jagdishpur, UP in Jan. 1995.
6. Invited to talk on diagnosis and management of spastic children with or without mental
retardation during the silver jubilee annual day celebration (18th Feb. 1995) at Swami
Vivekanand Hospital, Lucknow.
7. Participated in the CME for the doctors of Uttar Pradesh Provincial Medical Services in Sep.
1995 and talked about management of epilepsy.
8. Participated in the CME for the doctors of Uttar Pradesh Provincial Medical Services in Feb.
1996 and talked about common neurological problems.
9. Invited to talk on enhancing ring lesions in the brain on Sept. 1996 by Allahabad Medical
Association.
10. Invited to give a lecture on “Muscular Dystrophies with special reference to Duchenne
muscular dystrophy” at the Kanpur chapter of Indian Academy of Pediatrics, in Oct. 1997.
11. Delivered a guest lecture on “Epilepsy-Clinical aspects and localization” on 01-10-1999 at
National workshop on magnetic resonance imaging and spectroscopy with emphasis on
neurosciences (23-09-1999 to 12-10-1999), SGPGIMS, Lucknow, India.
12. Delivered a guest lecture on ‘Headache and Epilepsy’ on 18-03-2000, at National Academy of
Sciences, NASc Bldg, Allahabad.
13. Delivered a guest lecture on “Management of epilepsy in the pediatric age group with special
reference to newer anti-epileptic drugs” at Lucknow chapter of the Indian Academy of
Pediatrics, Hotel Clarks Awadh, Lucknow, India, on 10-08-2000.
14. Delivered a guest lecture on “Management of epilepsies and epileptic syndromes” at
Allahabad chapter of Indian Academy of Pediatrics, Hotel Presidency, Allahabad on 10-09-
2000.
15. Delivered lecture on “New personal observations in Neurology” at Kurukshetra University,
Kurukshetra, during Goyal Award Ceremony, 02-03-2004.
16. “Neuro-otological considerations in head injury – panel discussion” 26th Annual Conference
of Neuro-otological & Equilibrimetric Society of India, at Sanjay Gandhi Post-graduate
Institute of Medical Sciences, 8-10 October, 2004, Lucknow, Uttar Pradesh, India.
17. Delivered guest lecture on “Metabolic myopathy including mitochondrial cytopathies” at
CME of KGMU centenary celebrations at King George’s Medical University, 2nd April, 2005.
18. Delivered guest lecture on “Proximal Muscle Weakness” at the Meeting of the Lucknow
Orthopedic Club, 2005.
19. Delivered guest lecture on “NMR in Muscular Dystrophy” at the 1st Foundation Day
Symposium held at the “Centre of Biomedical Magnetic Resonance, SGPGIMS Campus,
Lucknow, 9th& 10th March, 2007.
20. Delivered guest lecture on “Primary and Secondary Prevention of Stroke” at the International
Congress of Indian Hypertension Society at Central Drug Research Institute, Lucknow, 15th
March, 2007.
25
21. Delivered guest lecture on “Screening and Management of Cerebrovascular Accidents in Type
II Diabetes Mellitus” at the Diabetes – Endocrinology Update – 2007, held at Sanjay Gandhi
PGI of Medical Sciences, Lucknow, 17th& 18th March, 2007.
22. Delivered lecture on “Management of migraine” at a lecture organized by “Johnson &
Johnson” at Hotel Clarks Awadh, Lucknow in January 2011.
23. Delivered lecture on “Mechanisms of migraine” at a Migraine symposium organized by
“Johnson & Johnson” at Hotel Taj, Lucknow, in March 2011.
26
Because of his original contributions in the field of Neurology and his articulate speech Pradhan
has been awarded two orations so far which he delivered at respective places. These are:
1. Invited to deliver lecture on “Valley sign in Duchenne muscular dystrophy” at Oxford Muscle
symposium, Marion Society of Muscle Dis. Oxford, UK. (1999).
2. Invited to deliver lecture on “Poly-hill sign in facioscapulohumeral dystrophy” at Oxford Muscle
symposium, Marion Society of Muscle Diseases, Oxford, UK. (2002).
3. Invited to deliver lecture on “Recent progress in Japanese encephalitis in India” in 7th Japanese Neuro-
infectious disease congress at Tokyo Women’s Medical University, Tokyo, Japan (2002).
4. Invited to deliver lecture on “Virology of Japanese encephalitis – emerging & re-emerging pattern” at
Department of Microbiology, Tokyo Metropolitan City Hospital, Tokyo Women’s Medical University,
Tokyo, Japan (2002).
5. Invited to deliver lecture on “Neurocysticercosis and other Infective causes of Epilepsy” in the session
“Prevention of Epilepsy” at 5th Asian and Oceanian Epilepsy Congress, Bangkok, Thailand, 28th – 31st
August 2004.
27
2. Participated in the interactive session and lecture with bright students of science under
CPYLS program of CSIR at Central Institute of Medicinal and Aromatic Plants (CIMAP),
Lucknow on 20-12-2003.
3. Invited to deliver Lecture on “Beauty of Science” under CSIR Program on Youth for
Leadership in Science (CPYLS) at National Botanical Research Institute (NBRI), Lucknow to
be held on 15-01-2004.
4. Delivered guest lecture on “Management of Stroke with stress on preventive aspect” Amity
University, NOIDA, 2008, 17th April, 2008.
5. Participated in discussion on Epilepsy in “Krishi Darshan” program of Doordarshan, New
Delhi, 2008.
6. Delivered Radio talk on All India Radio, Lucknow on Dementia on World Dementia Day, June,
2010.
7. Delivered talk on Radio City Lucknow on Parkinson’s disease on World Parkinson Day, May,
2011.
8. Delivered Radio talk on All India Radio, Lucknow on Dementia on World Dementia Day, June,
2011.
9. Delivered talk on All India Radio on Headache, Epilepsy & Dementia 21st Sept., 2011.
10. Delivered a public lecture on “Stroke prevention and management” at Hindi Bhavan,
Lucknow, October, 2011.
11. Delivered several radio talks at “Health & Fitness”, All India Radio on medical subjects in 2015, 2016,
2017 and 2018.
28
7. Pradhan S. Muscle disorders with special reference to pseudomuscular hypertrophy. In: Kapoor
R, ed., Pediatric Neurology Update. Kanpur: Indian Academy of Pediatrics (Kanpur chapter),
1997: 41-51.
8. Gupta RK, Kathuria MK, Pandey R, Dev R, Hussain M, Pradhan S, Malhotra H Magnetization
transfer MR in CNS tuberculosis, Fifth scientific meeting, Internat. Soc. for MR in Med., Vancouver,
B.C., Canada, 1997: April 12-18.
9. Mamta B Singh, Pradhan S. Approach to a case with proximal muscle weakness. XIth Prof. N. N.
Gupta Oration and Neurology Update, 1999: 129-146.
10. Pradhan S. Metabolic myopathy. XVIth Prof. N. N. Gupta Oration and Neurology Update, 2004:
129-146.
11. Pradhan S, Yadav RK. Scenario of epilepsy in the developing countries. CME book – 14th UP
Neurocon, Meerut. 2005: 23-31.
12. Pandey P, Pradhan S and Mittal B. ApoE and PS1 gene polymorphisms in Alzheimer’s disease and
other dementias in regional North Indian population “ proceedings of All India Cell Biology
Conference, ITRC, Lucknow, 2005.
13. Pradhan S, Mani VE. Muscular dystrophy. In: Mukherjee A, bhattacharya K, Singh G. IAN Textbook
of Neurology. The Health Sciences Publisher, New Delhi, 2018, pp 642-653.
14. Pradhan S, Meena AK. Congenital Muscular Dystrophy. In: Gupta P, Mennon PSN, Ramji S, Lodha
R. PG Text Book of Pediatrics, 2ndAdition, J P Brothers Medical Publishers, New Delhi, 2018: pp
2628-2639.
29
4. Wadia NH and Pradhan S. Peripheral neuropathies. In: Wadia NH, ed., Neurological practice: an
Indian perspective. New Delhi: Elsevier, 2005: 591-611.
5. Pradhan S. Idiopathic brachial plexus neuropathy. In: Murthy JMK, ed., Reviews in Neurology,
Vol. 2. Hyderabad: Indian Academy of Neurology, 1995: 105-113.
6. Pradhan S. Electrophysiological evaluation of nerve root lesions. In: Murthy JMK, ed., Reviews in
Neurology, Vol. 3. Hyderabad: Indian Academy of Neurology, 1996: 77-88.
7. Pradhan S. Investigation of visual loss: a neurologist’s perspective. In: Mohandas S, Borgohain R,
eds., Reviews in Neurology, Vol. 4. Hyderabad: Indian Acad. of Neurol, 1997.
8. Pradhan S. Valley sign in Duchenne muscular dystrophy. In: Mehendiratta MM, Katrak SM,
Choudhury D, eds., Reviews in Neurology, Vol. 9. New Delhi: Indian Academy of Neurology, 2002:
245-248.
9. Pradhan S, Yadav RK. Scenario of epilepsy in the developing countries. CME book – 14th UP
Neurocon, Meerut. 2005: 23-31.
10.Pradhan S, Malhotra HS. Diagnosis of acquired chronic demyelinating neuropathy with special
reference to electrodiagnosis. In: Radhakrishnan K, ed. Reviews in Indian Neurology. IANCON
Kerala 2005, vol 5, pp. 233-281.
11.Pradhan S. Vasculitic neuropathy. In: Khadilkar SV, Gingh G, eds. Reviews in Indian Neurology,
IANCON, Pune 2011, vol 11.
11. Examining the students at various centers of India as examiner for final
DM (Neurology) and other examinations
Pradhan’s teaching skills are reflected in the fact that he is regularly called to take final DM
(Neurology) examination at different premier Institutions of India. The Exams taken and the
Institutions are as follows:
(a) External Examiner for DM (Neurology/Pediatric Neurology) final exam at:
1. King George’s Medical University, Lucknow, 2001-2007 & 2010-2011.
2. G. B. Pant Hospital, New Delhi, 2008-2010.
3. All India Institute of Medical Sciences, New Delhi, 2010.
4. Nizam’s Institute of Medical Sciences, Hyderabad, 2011.
5. The Bangur Institute of Neurological Sciences, Kolkata, 2011.
(b) Examiner for MBBS final examination (Medicine) at King George Medical Univ., Lucknow,
2005.
(c) Other national level exam-related activities
1. Member of the expert committee for interviewing SRF/RA (Medical & Pharmaceutical
Sciences) at CSIR (HRD group), New Delhi, 2004-2010.
2. Member of the expert committee, Combined Medical Examination for Central Medical
Services, Union Public Service Commission, New Delhi, 2006.
3. Member of the selection committee for combined DM Entrance examination of Uttar
Pradesh held at GSVM Medical College, Kanpur, 1997.
4. Member of the selection committee for the selection of lecturers in Neurology under
Rajasthan Public Service Commission, 2001.
5. Member of the selection committee for the selection of lecturers in Neurology at
Banaras Hindu University, Varanasi, 2006
6. Member of the expert committee, for the selection of Assistant Professor in Neurology at
Central Government Institutes, Union Public Service Commission, New Delhi, 2008.
30
12. Screening of research articles written by other authors as reviewer /
Editor
Due to his research activities in 4 major areas of Neurology, Pradhan has been constantly asked
to review articles sent to different journals. Currently he is reviewer/editor of the following
journals:
Pradhan presented his research work in several international conferences in India as well as
abroad and most of them are abstracted in supplements of international journals:
1. Pradhan S (1990) Electrical assesment of respiratory dysfunction in Guillian Barre
syndrome. J Neurol Sci 98 (suppl): 343. (Presented at 7th International Congress of
Neuro-muscular Diseases, Munich, Germany)
2. Sinha S, Misra KP, Pradhan S, Mittal B, Agarwal SS (1993) Preferential gene deletion at the
central hot spot in Indian BMD patients. Am J Hum Genet 53: 1758.
3. Pradhan S, Gupta RK, Jain VK, Pandey R (1994) MR imaging in Juvenile asymmetric
segmental spinal muscular atrophy. Neurology Update – 1st International conference on
ODNS, New Delhi, November 19-22, 14d.1.
4. Pradhan S, Gupta RK, Rana PVS (1997) Magnetic resonance imaging in wasted leg
syndrome. J Neurol Sci 150 (suppl): S 140. (Presented at 16th World Congress of
Neurology, Buenos Aires, Argentina).
5. Pradhan S (1997) A morphometric study of the influence of motor unit recurrence pattern
on various F-response parameters. J Neurol Sci 150 (suppl): S 299. (Presented at 16th
World Congress of Neurology, Buenos Aires, Argentina).
6. Pradhan S (1997) Importance of new clinical sign in DMD patients with inconspicuous calf
hypertrophy. J Neurol Sci 150 (suppl): S 52. (Presented at 16th World Congress of
Neurology, Buenos Aires, Argentina).
7. Pradhan S (1997) Intercostal nerve somatosensory evoked potentials - a new technique for
the localisation of spinal cord lesions. Electroencephalogr Clin Neuro-physiol 103: S 142.
31
(Presented at 14th International Congress of EEG and Clinical Neurophysiology,
Florence, Italy).
8. Pradhan S (2000) Normotensive state during acute phase of hypertensive intracerebral
haemorrhage., Stroke 31: 2883.(Presented at 16th World Congress of Neurology, Sydney,
Australia, 2005)
9. Pradhan S, Gupta RK (2001) Pathogenesis of perilesional gliosis in neurocysticercosis. J
Neurol Sci 187 (suppl-1): S 410. .(Presented at 16th World Congress of Neurology,
Sydney, Australia, 2005)
10. Pradhan S (2005) Diagnostic approach to a patient with proximal muscle weakness. Current
trends in neuromuscular diseases – an international symposium, New Delhi, 5-7 March 2005:
pp 49.
11. Pradhan S (2005) Metabolic myopathy. Current trends in neuromuscular diseases – an
international symposium, New Delhi, 5-7 March 2005: pp 50.
12. Pradhan S. Neurocysticercosis and infective causes of epilepsy. (Presented at 5th Asian and
Oceanian Epilepsy Congress, Bangkok 2004: pp 2.)
13. Pradhan S. Clobazam in the treatment of Juvenile Myoclonic Epilepsy. J Neurol Sci 2005; 238
(Suppl): S141. .(Presented at 18th World Congress of Neurology, Sydney, Australia,
2005)
14. Pradhan S. Role of perilesional gliosis in the pathogenesis of secondary epilepsy due to
infections and trauma. J Neurol Sci 2005; 238 (Suppl): S141. (Presented at 18th World
Congress of Neurology, Sydney, Australia, 2005)
15. Pradhan S. Recurrent episodic central demyelinating disease with myelo-optic predilection.
J Neurol Sci 2005; 238 (Suppl): S241.(Presented at 18th World Congress of Neurology,
Sydney, Australia, 2005)
16. Pradhan S. Evolution of clinical features in Dementia with Lewy-body during long-term
follow-up. J Neurol Sci 2005; 238 (Suppl): S298. .(Presented at 18th World Congress of
Neurology, Sydney, Australia, 2005)
17. Pradhan S. Patterns of blood pressure during acute phase of hypertensive intracerebral
hemorrhage. J Neurol Sci 2005; 238 (Suppl): S431. (Presented at 18th World Congress of
Neurology, Sydney, Australia, 2005)
18. Pradhan S. Progress in Japanese Encephalitis in India. J Neurol Sci 2005; 238 (Suppl): S472.
(Presented at 18th World Congress of Neurology, Sydney, Australia, 2005)
32
seen in areas endemic for JE, raising the possibility that subclinical JE infection (which is expected to be
9 times more common than overt infection in endemic areas) might be responsible for either reduced
number or early abiotrophy of the nigral cells resulting in Parkinson disease later in life.[2] This viral
theory of Parkinson disease got further support from Pradhan’s another paper on this subject
showing latency of JE virus for several months in some patients who had second phase of illness
before the complete recovery from first phase. The second phase with increase in size and number of
brain lesions on MRI however, had more significant movement disorders compared to first phase.[3]
Previously, evidence for viral theory of Parkinson’s disease was confined to autopsy findings
of patients with encephalitis lethargica, a disease that exists no more. Following Pradhan’s
documentation of Parkinson-like disease after JE infection, several authors showed selective
involvement of substantia nigra with other viral infections e.g., West Nile, Epstein-
Barr,Coxsackie B4 and St. Louis viruses (Bosanko et al. West Nile virus encephalitis
involving the substantia nigra …..Arch Neurol 2003; Guan et al.Reversible parkinsonism due
to involvement of substantia nigra in Epstein-Barr virus encephalitis. Mov Disord 2011; Cree
et al.A fatal case of coxsackievirus B4 meningoencephalitis.Arch Neurol 2003; Cerna et al. St.
Louis encephalitis and the substantia nigra…AJNR Am J Neuroradiol 1999).
These reports give further credence to Pradhan’s work on viral theory of Parkinson’s
disease. Based on this work, Pradhan was invited and sponsored by the 7th Japanese Neuro-
infectious disease congress, 2002, Tokyo, Japan, to talk on “Progress of Japanese encephalitis
in India”.[4]
b. Herpes simplex encephalitis and Kluver Bucy syndrome in children: Kluver Bucy syndrome
(KBS) is known to occur after bilateral temporal lobe affection in Herpes simplex encephalitis.
Manifestations in adults are well known and include among others psychic blindness, placidity (with
loss of normal anger and fear), hyper-orality, hyper-metamorphosis and hyper-sexuality. Pradhan
described for the first time the KBS symptomatology in young children who had no environmental
learning of sex. He hypothesized that psychic blindness manifests in young children as marked
indifference towards the parents. Placidity would manifest as easy mix-up of these children with
strangers. As expected from young children, hyper-orality was the most prominent feature.
Hypersexuality manifested as rhythmic hip movement, rubbing genitals over the bed and excessive
manipulation of genitals with hands. Recognition of these symptoms was important to diagnose these
children as having KBS.[5]
2) Hirayama Disease:
Hirayama disease predominantly affects male adolescents with progressive muscular
weakness and atrophy of distal upper limbs, followed by spontaneous arrest within several
years. Although it was known that there is tight dural canal and asymmetric atrophy of the
cervical spinal cord, suggesting cervical pathology in this disease, the diagnosis was clinical
and no confirmatory test was available to diagnose this disorder.
Pradhan and coworkers were the first to provide diagnostic MRI criteria for Hirayama
disease that included features in neutral and completely flexed positions of neck. In neutral
position there was atrophy of the lower cervical spinal cord with T2 hyper-intensities in
anterior horn cell region. During neck flexion, there was forward displacement of the
posterior cervical dural sac resulting in enhancing crescent shaped epidural space and
forward displacement of spinal cord that gets flattened against the C5-C6 vertebral bodies. It
was also suggested that selective anterior horn cell involvement could be related to local
ischemia secondary to dynamic alterations in the cervical region.[6] Three years after the
publication of this paper, Hirayama (in whose name this disease is eponymed) himself
33
published exactly similar findings without quoting Pradhan’s original work (Hirayama K,
Tokumaru Y. Cervical dural sac and spinal cord in juvenile muscular atrophy of distal upper
extremity. Neurology 2000; 54: 1922-6). Pradhan responded with a correspondence
claiming originality of his work which was duly acknowledged and he also reported for the
first time the use of collar therapy (to prevent neck flexion) [7], a modality that is till date the
only treatment available for this disease apart from some anecdotal reports of surgical
stabilization of neck. Pradhan’s claim for the originality of this work also comes from the fact
that the original observation from first 9 patients of Hirayama disease (named at that time as
“Juvenile asymmetric segmental spinal muscular atrophy” were reported and presented at
1st International Conference on ODNS New Delhi – India on November 19-22, 1994.[8] There
had been some attempts to downplay the diagnostic MRI findings reported by Pradhan and
the latter had given the thoughtful rebuttal to the same.[9]
Since the initial description of Hirayama disease, the disease is known for its unilateral
presentation. Hirayama himself described it in the beginning as “juvenile muscular atrophy
of one upper extremity”. Due to this reason Indian authors coined a new term to describe
this disease as “Monomelic amyotrophy”. Pradhan was the first person in the world to
describe the fact that the disease is mostly bilateral but asymmetrical and the less affected
limb is taken as normal as there is no limb left to compare with. He was also the first to
describe bilaterally symmetrical form of the disease (which formed about 10% of his cases
with MRI based confirmation) and highlighted the fact that these cases remain undiagnosed
due to the wrong notion of unilateral affection of this disease.[10]
Later on, Pradhan discovered an unusual site for PIM at conus – epiconus region of the spinal
cord and coined the term parainfectious conus myelitis (PICM) to denote this disease entity
that presents with acute urinary retention and with no conventional signs of myelitis. Due to
involvement of lower most part of the spinal cord these patients did not have upper motor
34
neuron signs. Several of them presented to urologists with isolated urinary symptoms and on
examination a few showed altered sensations in sacral dermatomes which the patients
themselves were often not aware of. Interestingly, MRI of several of these patients was
normal in the conventional saggital plane (a situation where axial planes are never viewed)
and it was only a careful search in the axial plane that the lesion was often found in one half
of conus medullaris.[12]
b. Atypical central demyelinating disease: In the year 2004, Pradhan described 6 patients of an
atypical central demyelinating disease who had features not fitting into any of the 3 well known
central demyelinating diseases – multiple sclerosis, neuromyelitis optica and acute disseminated
encephalomyelitis.[13] They had recurrent myelo-optic presentation with long spinal segment
involvement, long duration of months to years between the recurrences and a fairly good outcome.
Long spinal segment involvement with spinal swelling and absence of cerebral lesions were the
features against the multiple sclerosis. Multiple recurrences all confined to spinal cord and optic
nerves with no cerebral involvement at any stage were the features against the acute disseminated
encephalomyelitis. The long gap of months to years between the recurrences of optic neuritis and
myelitis, unilateral optic nerve involvement at a time and a relatively good outcome were the features
against the then prevalent definition of neuromyelitis optica.[13] A year later, Pradhan presented his
experience with 13 such patients at 18th World Congress of Neurology, Sydney, Australia, who had
similar presentation but with additional solitary brain lesion in 3 and spill over from cervical cord
lesion to brain stem in 5 of them.[14]
Later on, the definition of neuromyelitis optica was extended and Pradhan’s cases fitted well into
this new broadened definition based on the presence of anti-aquaporin-4 antibodies, a test that was
not available at the time of Pradhan’s reporting.
c. Intravenous Immunoglobulin (IVIg) therapy in Acute Disseminated Encephalomyelitis:
Pradhan reported for the first time in the world literature the beneficial effect of IVIg therapy in
Acute Disseminated Encephalomyelitis (ADEM). Four patients with fulminant ADEM including 2 on
ventilator support who were non-responsive to methyl prednisolone therapy showed dramatic
response to IVIg therapy.[15]
Now a day this mode of treatment is recommended in several textbooks of Neurology.
d. Central pontine myelinolysis:
i) CPM & Parkinsonism: Previously central pontine myelinolysis (CPM) used to be an autopsy
diagnosis and the mild cases largely remained undiagnosed. With the advent of magnetic resonance
imaging it became possible to diagnose these cases during life. Pradhan reported a case of central
pontine and extra-pontine myelinolysis based on MR imaging and showed that the patient had
Parkinsonian features during recovery which gradually vanished in about 9 months. He conjectured
that with the resolution of pontine lesion during recovery, basal ganglia lesions start manifesting as
Parkinsonism.[16] This paper was perhaps the first report of Parkinsonism during recovery from
CPM but as it was published in the then un-indexed “Neurology India”, it remains unquoted even
though there are several reports of this kind now available in the world literature.
ii) CPM & correction of hyponatremia: Hyponatremia may cause central pontine myelinolysis
(CPM) if corrected rapidly or by a large amount from a very low initial level to a normal or very high
level. Pradhan reported for the first time that even when the hyponatremia is mild to moderate and
the correction slow and small, myelinolysis may develop if the hyponatremia had been there for a
considerably long duration.[17] With the help of 2 patients who were chronically hyponatremic on
record, and who developed CPM under Pradhan’s own care after judicious and documented slow
correction of hyponatremia, he concluded that the then existing recommendation for correction of
hyponatremia were perhaps too liberal (25 mmol/l over 48 hrs and 12 mmol/l over 24 hrs) and that
35
the patients who are predisposed to CPM with underlying pre-conditions such as malnutrition,
chronic renal failure, other chronic debilitating and stressful conditions such as burns and septicemia
(CRF in two cases described here), the rate of sodium correction should be still slower. This is
because in chronic hyponatremia, brain cells gradually become isotonic to extracellular fluid and any
attempt to correct it even judiciously, may be stressful to tightly cris-crossing myelinated fibers.[17]
Subsequent to this paper, gradually the recommendations for correction of hyponatremia have
become more stringent.
4) Epilepsy:
Pradhan’s work in the field of epilepsy has led to the first ever description of 1 new epileptic
symptom complex, 1 new reflex mode of epilepsy precipitation and elucidation of 1 new cause of
seizure-intractability in neurocysticercosis.
a. Tickle-seizures: Pradhan described a new mode of seizure manifestation in the form of a
sensory feeling of tickle along with its motor and psychic components manifesting as laughter.[18]
The laughing (gilastic) epilepsy was already well known but a true feeling of tickle-sensation prior to
laughter was never described before. The lesion (cysticercal cyst) was localized to trunk area of
somatic sensory cortex and the symptom complex was explained by the development of seizure
circuitry involving limbic and hypothalamic areas.[18]
b. Micturition induced reflex epilepsy: Pradhan also described a new mode of reflex seizure
precipitation following the act of micturition.[19] The phenomenon could be differentiated from
complicated micturition syncope by precipitation even in sitting posture of passing urine and by
post-ictal electroencephalographic abnormalities.
c. Seizure intractability due to perilesional gliosis in neurocysticercosis (NCC): Pradhan’s co-
workers involved in neuro-imaging demonstrated peri-lesional gliosis around cysticercal cyst in the
brain in a case with “difficult to treat” epilepsy, using magnetization transfer imaging sequence and
correlating it with conventional sequences (Gupta RK, Kathuria MK, Pradhan S. Magnetization
transfer magnetic resonance imaging demonstration of perilesional gliosis – relation with epilepsy in
treated and healed neurocysticercosis. The Lancet 1999; 354 (July 3): 44-45). Based on this
observation Pradhan selected 108 patients with single NCC in the brain and correlated seizure
outcome in patients with and without peri-lesional gliosis and found much higher seizure
intractability in those who developed gliosis suggesting peri-lesional gliosis playing a role in the
development of epileptic focus in patients with NCC who, without gliosis, generally have only “acute
symptomatic seizures”.[20]
This paper published in “Annals of Neurology” was included in the “Epilepsy Monitor” edited
by some of the world authorities in epilepsy.[21]
d. Intermittent minor symptoms in epileptic patients with neurocysticercosis: Pradhan
described for the first time persistence of some annoying minor symptoms in patients with
neurocysticercosis (NCC). The symptoms which were transient episodic in nature included heaviness,
dystonic posturing, weightlessness, numbness and alien limb phenomenon contra lateral to the side
of lesion and headache. [22] As these symptoms were observed mainly in those patients who had
peri-lesional gliosis on MR imaging, it was conjectured that bizarre electrical activity in this abnormal
glia may be responsible for these symptoms as these got controlled with increased dose of prescribed
anti-epileptic drugs.
Preliminary works on these subjects were presented in 17th and 18th World Congress of
Neurology [23, 24] and at6th European Congress of Epileptology, Vienna, Austria, 2004.[25]
Based on the above two papers on NCC, Pradhan was invited and sponsored to deliver
36
lecture on “Neurocysticercosis and other Infective causes of Epilepsy” in the session
“Prevention of Epilepsy” at 5th Asian and Oceanian Epilepsy Congress, Bangkok, Thailand,
28th – 31st August 2004.[26]
7) Muscular Dystrophy:
Dr. Sunil Pradhan has a unique distinction of discovering 5 new clinical signs in Neurology
that were reported for the first time in reputed international journals. This is important
because most of the world scientists who could do so, have described only 1 clinical sign in
their life-time. These signs are specific to, and are helpful in the diagnosis of 5 different
muscle diseases just by looking at them in a specific body posture. As no sophisticated test is
required, these discoveries are most suited for application on poor patients. These signs are:
I. “Valley sign” in Duchenne muscular dystrophy (Published in the journal “Pediatric
Neurology”, USA).[29]
II. “Poly-hill sign” in facioscapulohumeral dystrophy (Published in the journal “Muscle &
Nerve”, USA).[30]
III. “Shank sign” in myotonic dystrophy (Published in Journal of Clinical Neurosciences,
Australia).[31]
IV. “Calf-head sign” in Miyoshi Myopathy (Published in the journal “Archives of Neurology”,
USA).[32]
V. “Diamond on quadriceps sign” in dysferlinopathy (Published in “Neurology” ‘Green
Journal’, USA).[33]
The valley sign has been proposed to be called “Pradhan Sign” by the President of the
American Board of Pediatrics as mentioned in the “Year Book of Pediatrics 1996” [34] and
has been acknowledged by Indian Council of Medical Research in its citation of Dr. H. B.
Dingley memorial award of the “Indian Council of Medical Research (ICMR)” that was
conferred on Dr. Pradhan for the year 1994.[35]To look for the specificity of valley sign,
Pradhan examined the patients of other forms of muscular dystrophy in the similar posture
as adopted for valley sign. He found a very peculiar appearance around the shoulder girdle in
patients with Facio-scapulo-humeral dystrophy, which he termed as “Poly-hill sign” because
37
of the 4 bulges each separated by a trough on either side (Muscle & Nerve, 2002). [30] He
has been invited twice at the expense of Marion Society – Oxford Muscle Symposium, Oxford,
UK; once in 1999 to demonstrate his “valley sign” in Duchenne Muscular dystrophy [36] and
at other time in 2002 to show his “poly-hill sign” in facioscapulohumeral dystrophy.[37]
For last 20 years, Pradhan is continuously involved in clinical research on muscular
dystrophy. His initial clinical observations stretching over a span of 5 years (1989-1994),
indicated morphometric peculiarities around the shoulder girdle that showed-up only when
the muscle around the shoulder were in action. Though the enlargement and wasting of
specific muscles were already known, he showed for the first time that in muscular
dystrophy, some muscle may exhibit enlargement of one part and wasting of another part
(Clin Neurol Neurosurg, 1995).[38]Based on these initial observations he discovered a new
clinical sign in Duchenne muscular dystrophy called “valley sign” (Pediatr Neurol, 1994).
[29] Though initially thought to be specific for this disorder, it was also observed later to be
present in a subtle manner in genetically similar but adult form of this disease called Becker
muscular dystrophy and also in out-liars of Duchenne/Becker muscular dystrophy (Neurol
India,2004).[39] The importance of this sign lay in the fact that it could be demonstrated
nicely even in the late chair-bound stage of the disease when more classical signs such as calf
muscle enlargement had disappeared and Gowers’ sign could not be tested (Neurol
India,2002).[40] This utility of new clinical sign in DMD patients was presented in Buenos
Aires, Argentina in 1997 [40a].
Pradhan is also involved in rehabilitative and palliative treatments in muscular
dystrophy and in this respect he has evolved a method of judicious use of corticosteroids
(essentially concerned with the stage of the disease at which to start steroids and at what
dose) that may provide nearly 3 more years of ambulation to 50% of the patients with
Duchenne muscular dystrophy.[41]
For his research work on muscular dystrophy Pradhan received Amrut Mody Unichem
award of Indian Council of Medical Researchfor the year 2007.[42]
8) Clinical neurophysiology:
Dr. Pradhan invented a new technique for the electrophysiological study of the
intercostal nerves. Before this there existed no non-invasive surface technique to study the
intercostals nerves. Published first in the Journal of Neurology, Neurosurgery & Psychiatry,
UK, [43] the study is subsequently included in several of the international books on this
subject and is quoted as “Pradhan’s method” in one of the books published from USA.[44]
Subsequently Pradhan presented work on its utility in respiratory dysfunction in Guillain
Barre Syndrome at VIIth International Congress on Neuromuscular diseases. Sept. 16-
22,1990, Munich, Germany [44a]. He also developed and standardized the technique of
recording somatosensory evoked potential over the scalp after the stimulation of intercostals
nerves and showed its utility in the localization of spinal cord lesions.[45]
He also described new mechanisms of electrophysiological F-response generation
using self-designed experiments. Normal F response is a proximal rebound response from
fast conducting motor nerve fibers. Through this paper he showed that the delay in the F-
response (which was known to denotes delayed conduction in the proximal segment of the
fast conducting motor nerve fibers) was in fact, due to loss of early components of F
response (i.e., no rebound conduction in fast conducting large fibers) and appearance of late
components from slow conducting fibers. These late components never participate in the
38
generation of normal F response but appear after the loss of fast components. This meant
that what appears to be a delayed conduction is actually an absent participation by fast fibers
and de-novo participation by otherwise non-participating slow fibers.[46] With the help of
other experiments he showed that constantly changing morphology of F response is due to
constant participation by some motor nerve fibers with superimposed irregular
participation by other motor fibers. He further showed a kind of rotation of participating
alpha motor neurons at different time intervals suggesting nature’s way to provide rest for
rejuvenation to its elements during apparent continuous activity. [46, 47, 47a]
Four parameters are studied for F response abnormality. These are F-minimal latency, F-
persistence, F-dispersion and F/M ratio. Pradhan discovered fifth parameter that is F-
multiplicity which, when present, was always indicative of lower motor neuron disorder
particularly anterior horn cell disease. Multiple F response was most frequently observed in
patients with old poliomyelitis.[48, 49]
H-reflex provides good status of the proximal segment of sensory motor nerve. In adult
human beings however, H-reflex can only be elicited over the solius and Gastrocnemius
muscles. In other muscles it appears on voluntary contraction of the same muscle, but
remains buried in the muscle activity. Taking advantage of the fixed latency of H-reflex,
Pradhan averaged several responses over contracting Tibialis anterior muscle, time-locked
to the given electrical stimulation that cancelled random muscle activity and made H
response stand out clearly. Terming it Tibialis anterior R-1 response (TAR-1), he showed its
utility in L4-L5 spinal root lesions.[50] The preliminary work on this subject was presented
in the 14th World Congress of Neurology, New Delhi, 1989.[50a] Subsequently, German
authors compared this technique with other existing techniques to study the L4-L5 spinal
roots such as EMG and direct electrical stimulation of the roots, and found TAR-1 to be
superior to all others. [51]
For his research work on clinical neurophysiology he receivedShakuntala Amirchand
award of Indian Council of Medical Researchfor the year 1996.[52]
9) Nuclear Magnetic Resonance studies on biological extracts:
As a thesis guide Pradhan tried to find out specific bio-markers for the diagnosis of
different muscle diseases using proton NMR based analysis of human serum and
homogenate derived from muscle biopsy tissue and brain tissue. During standardization of
the process, a new lipid extraction technique was invented by using different permutations
and combinations of the currently used technique. The new technique yielded nearly 30%
more lipids compared to the existing technique and corrective equations were developed to
determine the true yield of lipids even when these got partially destroyed by perchloric acid
during extraction of water soluble substances from the same tissue. Some significant
markers were found for Duchenne muscular dystrophy and brain tumors. Following 5
papers were published by Pradhan (as a second and corresponding author) on this subject.
(In these research works actual lab work was done by the first author and Pradhan was
involved in conceptualization of idea, selection of patients, analysis of results, and writing of
discussion). These papers (not attached with this document) are as follows:
1. Srivastava NK, Pradhan S*, Mittal B, Kumar R, Nagana Gowda GA. An improved single step
standardized method of lipid extraction from human skeletal muscle tissue.Analytical Letters
2006; 39: 297-315.
2. Srivastava NK,Pradhan S*, Mittal B, Raj Kumar, Pandey CM and Nagana Gowda G.A. Novel
corrective equations for complete estimation of human tissue lipids following their partial
39
destruction by PCA pre-treatment: High-resolution 1H-NMR based study. NMR in Biomedicine.
2008: 21; 89-100.
3. Srivastava NK, Pradhan S*, Mittal B, Roy R. High resolution NMR based analysis of serum lipids in
Duchenne Muscular Dystrophy patients and its possible diagnostic significance (Proceedings of
the ISMRM: International Society for Magnetic Resonance in Medicine, 2008.
4. Srivastava NK, Pradhan S, Mittal B, Gowda GA, Roy R, Khetrapal CL. High resolution NMR based
analysis of serum lipids in Duchenne Muscular Dystrophy patients of Northern India and its
possible diagnostic significance. NMR Biomed 2010;23: 13-22.
5. Srivastava NK, Pradhan S, Gowda GA, Kumar R. In vitro, a high-resolution 1H & 31P NMR based
analysis of the lipid components in the tissue, serum and CSF of the patients with primary brain
tumors: one possible diagnostic view. NMR Biomed 2010; 23: 113-122.
References:
1. Pradhan S*, Pandey N, Shashank S, Gupta RK, Mathur A. Parkinsonism due to predominant
involvement of substantia nigra in Japanese encephalitis. Neurology 1999; 53: 1781-1786.
2. Ogata A, Matsumura T, Pradhan S*. Parkinsonism due to predominant involvement of substantia
nigra in Japanese encephalitis [letter]. Neurology 2000; 55: 602.
3. Pradhan S*, Gupta RK, Singh MB, Mathur A. Biphasic illness pattern due to early relapse in Japanese-
B virus encephalitis. J Neurol Sci 2001; 183: 13-18.
40
4. Pradhan S*, Singh MN, Pandey N. Kluver Bucy syndrome in young children. Clin Neurol Neurosurg
1998; 100: 254-258.
5. Pradhan S*, Gupta RK. Magnetic resonance imaging in juvenile asymmatric segmental spinal
muscular atrophy. J Neurol Sci 1997; 146: 133-138.
6. Pradhan S*, Gupta RK. Cervical dural sac and spinal cord in juvenile muscular atrophy of distal upper
extremity. Neurology [letter] 2001; 56: 575.
7. Pradhan S*, Gupta RK, Jain VK, Pandey R (1994) MR imaging in Juvenile asymmetric segmental
spinal muscular atrophy. Neurology Update – 1st International conference on ODNS, November 19-22,
14d.1.
8. Pradhan S*, Gupta RK. Juvenile asymmetric segmental spinal muscular atrophy (Hirayama disease).
Acta Neurol Scand [letter] 2003; 101: 74-75.
9. Pradhan S. Bilaterally symmetrical form of Hirayama disease. Neurology 2009,72: 2083-2089.
10. Pradhan S*, Gupta RK, Ghosh D. Parainfectious myelitis: three clinico-imagiological patterns with
prognostic implications. Acta Neurol Scand 1997; 95: 241-247.
11. Pradhan S*, Gupta RK, Kapoor R, Shashank S, Kathuria MK. Parainfectious conus myelitis. J Neurol
Sci 1998; 161: 156-162.
12. Pradhan S*, Mishra VN. A central demyelinating disease with atypical features. Multiple Sclerosis
2004; 10: 308-315.
13. Pradhan S. Recurrent episodic central demyelinating disease with myelo-optic predilection.
J Neurol Sci 2005; 238 (Suppl): S241.
14. Pradhan S*, Gupta RP, Shashank S, Pandey N. Intravenous immunoglobulin therapy in acute
disseminated encephalomyelitis. J Neurol Sci 1999; 165: 56-61.
15. Pradhan S*, Singh MN, Mathur VN, Phadke RV. Pontine and extra-pontine myelinolysis presenting
with acute parkinsonism during recovery. Neurology India 1994; 42: 163-167.
16. Pradhan S*, Jha R, Singh MN, Gupta S, Phadke RV, Kher V. Central pontine myelinolysis following
“slow” correction of hyponatremia. Clinical Neurol Neurosurg 1995; 97: 340-343.
17. Pradhan S*, Kalita J. Tickling seizures. Neurology India 1996; 44: 27-29.
18. Pradhan S*, Kalita J. Micturition induced reflex epilepsy. Neurology India 1993; 41: 221-223.
19. Pradhan S*, Kathuria MK, Gupta RK. Perilesional gliosis and seizure outcome: a study based on
magnetization transfer magnetic resonance imaging in patients with neurocysticercosis. Annals of
Neurology 2000; 48 (2): 181-187
20. Neurocysticercosis: Clinical features. In: Shorvon SD, Nashef L, Cross H, Kitchen N, Walker M (Eds)
Epilesy Monitor 2001; 5: pp 11.
21. Pradhan S*, Kumar R, Gupta RK. Intermittent symptoms in neurocysticercosis: could these be
epileptic? Acta Neurol Scand 2003; 101 (4): 241-247.
22. Pradhan S*, Kumar R, Gupta RK. Minor epileptic symptoms in patients with perilesional gliosis
secondary to neurocysticercosis. J Neurol Sci 2001; 187 (suppl -1): S 415
23. Pradhan S*. Role of perilesional gliosis in the pathogenesis of secondary epilepsy due to infections
and trauma. J Neurol Sci 2005; 238 (Suppl): S141.
24. Pradhan S*. Effect of healing patterns on seizure outcome in patients with neurocysticercosis.
Epilepsia 2004, 45 (suppl): p185
41
25. Pradhan S*. Focal sheathing of retinal arteries in tuberous sclerosis. Pediatr Neurosurg 1991-92; 17:
279-280.
26. Pradhan S*, Pandey N, Phadke RV, Kaur A, Sharma K, Gupta RK. Selective involvement of basal
ganglia and occipital cortex in acute endosulfan poisoning. J Neurol Sci 1997; 147: 209-213.
27. Pradhan S*. New clinical sign in Duchenne muscular dystrophy. Pediatr Neurol 1994; 11: 298-300.
28. Pradhan S*, Poly-hill sign in facioscapulohumeral dystrophy. Muscle & Nerve 2002; 25: 754-755.
30 a. Pradhan S*.Extra hill on a poly-hill in a patient with facioscapulohumeral dystrophy. Neurology
India 2007; 55: 436-437.
29. Pradhan S*. Shank sign in myotonic dystrophy type-1. J Clin Neurosci 2007; 14: 27-32.
30. Pradhan S*. “Calf-heads on a trophy sign” in Miyoshi Myopathy. Arch Neurol 2006; 63: 1414-1417.
31. Pradhan S*. Diamond on quadriceps sign in dysferlinopathy. Neurology 2008: 70; 322.
33a. Pradhan S*. Clinical and magnetic resonance imaging features of “diamond on quadriceps” sign
in dysferlinopathy. Neurology India 2009; 57: 172-175.
32. Stockman JA. A new clinical sign in Duchenne muscular dystrophy. In Stockman JA (Ed) Year book of
Pediatrics. Mosby, New York, 1994, pp 304-306.
33. Award citation: Dr. H. B. Dingley memorial award of the “Indian Council of Medical Research
(ICMR)” conferred on Dr. Sunil Pradhan (for the year 1994), Vigyan Bhawan, New Delhi, 1996.
34. Pradhan S. Clinical utility of a new clinical sign in Duchenne/Becker muscular dystrophy. Marion
Society – Oxford Muscle Symposium, Oxford, UK, July, 1999.
35. Pradhan S. Poly-hill sign in Facioscapulohumeral dystrophy. Marion Society – Oxford Muscle
Symposium, Oxford, UK, June, 2002.
36. Pradhan S*, Mittal B. Infraspinatus muscle hypertrophy and axillary folds’ wasting as the important
signs in Duchenne muscular dystrophy. Clin Neurol Neurosurg 1995; 97: 134-138.
37. Pradhan S*. Valley sign in Becker muscular dystrophy and outliers of Duchenne/Becker muscular
dystrophy. Neurol India 2004; 52: 203-205.
38. Pradhan S*. “Valley sign” in Duchenne muscular dystrophy: importance in patients with
inconspicuous calves. Neurol India 2002; 50: 184-186.
40a. Pradhan S (1997) Importance of new clinical sign in DMD patients with inconspicuous
calf hypertrophy. J Neurol Sci 150 (suppl): S 52.(Presented in Buenos Aires, Argentina).
39. Pradhan S*, Ghosh D, Srivastava NK, Kumar A, Mittal B, Pandey CM, Singh U. Prednisolone in
Duchenne Muscular dystrophy with imminent loss of ambulation. J Neurol 2006; 253: 1309-1316.
40. Award citation: Amrut Mody Unichem award of the “Indian Council of Medical Research (ICMR)”
conferred on Dr. Sunil Pradhan (for the year 2007), DRDO Auditorium, New Delhi, 8th Nov., 2011.
41. Pradhan S*, Taly A. Intercostal nerve conduction study in man. J Neurol Neurosurg Psychiatry 1989;
52: 763-766.
42. Pradhan’s Method: Intercostal Nerve conduction. In: Oh SJ (Ed), Clinical Electromyography: Nerve
conduction study. 2nd Edition, Baltimore, Williums & Wilkins, 1993, pp 212-213.
43. Intercostal nerve distal latency and conduction velocity – Intercostal nerve motor latency. In: De Lisa
JE, Lee HJ, Baran EM, Lai KS, Spielholz N (Eds) Manual of Nerve Conduction Velocity and Clinical
Neurophysiology (3rd Edition). New York: Raven Press 1994, pp. 108-109.
42
44. Pradhan S. Electrical assessment of respiratory dysfunction in Gullian Barre Syndrome [4.6.15]. J
Neurol Sci 1990; Suppl to Vol 98: S 343.
44 (a) Pradhan S (1997) Intercostal nerve somatosensory evoked potentials - a new technique for the
localisation of spinal cord lesions. Electroencephalogr Clin Neuro-physiol 103: S 142. (Presented in
Florence, Italy).
45. Pradhan S*. Time dependent selective recurrent discharge of motor units in F-response.
Electroencephalogr Clin Neurophysiol 1998; 109: 341-349.
46. Pradhan S (1997) A morphometric study of the influence of motor unit recurrence pattern on
various F-response parameters. J Neurol Sci 150 (suppl): S 299. (Presented in Buenos Aires,
Argentina).
47. Pradhan S*. F-response multiplicity in lower motor neuron disorders. Electromyogr Clin
Neurophysiol 1996; 36: 441-448.
47 (a) Pradhan S. F-response multiplicity in lower motor neuron disorders [PS-35-5].
Electroencephalogr Clin Neurophysiol 1996; 97: S173
48 Pradhan S. Time dependent selective recurrent discharge of motor units in electrophysiological F-
response. Presented at Satellite symposium on Clinical Neurophysiology and Rehabilitation, Rome,
Italy, 1st-2nd Sept. 1997 (14th International Congress of EEG and Clinical Neurophysiology, Florence,
Italy, 1997. pp. 35.
49 Pradhan S. Clinical utility of multiple F-response. Muscle & Nerve 2003; 12 (suppl): S 107.
50 Pradhan S*. Tibialis anterior R-1 response: standardisation of technique, normative data and
clinical utility in L4-L5 radiculopathy. Electroencephalogr Clin Neurophysiol 1993; 89: 10-21.
50a. Pradhan S.A study of L-5 selective R-1 response in the evaluation of L-5 radiculopathy.Abstract
from 14th World Congress of Neurology, New Delhi, 1989.Abstr. 304E05
51 Linden D, Berlit P. Comparison of late responses, EMG studies and motor evoked potentials (MEPs)
in acute lumbosacral radiculopathies. Muscle & Nerve 1995; 18: 1205-1207.
52 Award citation: Shankuntala Amirchand Award of the “Indian Council of Medical Research (ICMR)”
conferred on Dr. Sunil Pradhan (for the year 1996), Vigyan Bhawan, New Delhi, 1999.
53 Fellowship of National Academy of Medical Sciences, New Delhi (FAMS) conferred on Dr. Sunil
Pradhan during the Annual conference of National Academy of Medical Sciences at Hyderabad, 2006.
54 Fellowship of National Academy of Sciences (India), Allahabad, (FNASc) conferred on Dr. Sunil
Pradhan during the Annual conference of National Academy of Sciences at Allahabad, 2003.
55 Fellowship of Indian College of Physicians, Mumbai (FICP) conferred on Dr. Sunil Pradhan during the
Annual conference of Association of Physicians of India, Bangalore, 2004
56 Citation of Vigyan Ratna Award (2003 - 4) of Council of Science & Technology, Uttar Pradesh,
conferred on Dr. Sunil Pradhan at Award Ceremony, CMS Auditorium, Gomti Nagar, Lucknow, 2004.
57 Citation of Vigyan Gaurav Award (2003 - 4) of Council of Science & Technology, Uttar Pradesh,
conferred on Dr. Sunil Pradhan at Award Ceremony, CV Raman Auditorium, Suraj Kund Park,
Lucknow, 2004.
Certified that the facts given in this document are true to the best of my knowledge and are
provided along with the appropriate evidence.
43
(Sunil Pradhan)
44