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    Acetyl Hexamethyl Indan (AHMI) - 085

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    Arfianda Bachtiar

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    Acetyl Hexamethyl Indan (AHMI) - 085

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    Arfianda Bachtiar
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    Acetyl hexamethyl indan (AHMI)_085

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    Acetyl Hexamethyl Indan (AHMI) - 085

    Uploaded by

    Arfianda Bachtiar

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    © All Rights Reserved
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    of 4

    Amendment 49 IFRA STANDARD

    Acetyl hexamethyl indan (AHMI)

    CAS-No.: 15323-35-0
    The scope of this Standard includes, but is not limited to the CAS number(s) indicated
    above; any other CAS number(s) used to identify this fragrance ingredient should be
    considered in scope as well.

    Synonyms: 5-Acetyl-1,1,2,3,3,6-hexamethyl indan


    6-Acetyl-1,1,2,3,3,5-hexamethylindane
    1-(2,3-Dihydro-1,1,2,3,3,6-hexamethyl-1h-inden-5-yl)ethanone
    Ethanone, 1-(2,3-dihydro-1,1,2,3,3,6-hexamethyl-1H-inden-5-yl)-
    1,1,2,3,3,6-Hexamethylindan-5-yl methylketone
    Phantolid (commercial name)

    History: Publication date: 2020 (Amendment 49) Previous 1978


    Publications: 1987
    2001
    2015

    Implementation For new creation*: February 10, 2021


    dates: For existing creation*: February 10, 2022
    *These dates apply to the supply of fragrance mixtures (formulas) only, not to the
    finished consumer products in the marketplace.

    RECOMMENDATION: RESTRICTION

    MAXIMUM ACCEPTABLE CONCENTRATIONS IN THE FINISHED PRODUCT (%):

    Category 1 2.0 % Category 7A No Restriction

    Category 2 2.0 % Category 7B 2.0 %

    Category 3 2.0 % Category 8 2.0 %

    Category 4 2.0 % Category 9 No Restriction

    Category 5A 2.0 % Category 10A No Restriction

    Category 5B 2.0 % Category 10B 2.0 %

    Category 5C 2.0 % Category 11A No Restriction

    Category 5D 2.0 % Category 11B 2.0 %

    Category 6 2.0 % Category 12 No Restriction

    2020 (Amendment 49) 1/4


    Amendment 49 IFRA STANDARD

    Acetyl hexamethyl indan (AHMI)

    Fragrance ingredient restriction - Note box


    The Standard is set due to the phototoxic effects of Acetyl hexamethyl indan (AHMI). For more detailed
    information on the application of this Standard, please refer to the note on phototoxic ingredients in
    chapter 1 of the Guidance for the use of IFRA Standards.

    FLAVOR REQUIREMENTS: Due to the possible ingestion of small amounts of


    fragrance ingredients from their use in products in
    Categories 1 and 6, materials must not only comply
    with IFRA Standards but must also be recognized
    as safe as a flavoring ingredient as defined by the
    IOFI Code of Practice (www.iofi.org). For more
    details see chapter 1 of the Guidance for the use of
    IFRA Standards.

    CONTRIBUTIONS FROM OTHER SOURCES: NONE TO CONSIDER BEYOND TRACES (SEE


    ALSO THE SECTION ON CONTRIBUTIONS
    FROM OTHER SOURCES IN CHAPTER 1 OF
    THE GUIDANCE FOR THE USE OF IFRA
    STANDARDS)

    INTRINSIC PROPERTY DRIVING RISK PHOTOTOXICITY


    MANAGEMENT:

    RIFM SUMMARIES:

    Human studies – phototoxicity


    The IFRA Standard is based upon two photoirritation studies in humans. In the first study, 10 volunteers
    were treated with 10% solution of Acetyl hexamethyl indan (AHMI) in 75% ethanol plus 25% diethyl
    phthalate on each forearm. Twenty-four hours later, one arm was irradiated (UVA) and the other served as
    a control. Observations immediately after radiation, at 24 hrs, and at 48 hours showed no phototoxic
    effects (RIFM, 1986). In the second study, 10 volunteers were treated with a 10% solution in 75% ethanol
    plus 25% diethyl phthalate on the back. After 30 minutes, the site was irradiated (UVA and UVB).
    Observations at 5 minutes after irradiation, and at 3, 24, 48, and 72 hours showed no phototoxic effects
    (RIFM, 1987).

    Animal studies – phototoxicity


    • 5, 20, 50 % in guinea pigs, photoirritation observed 20 and 50% (RIFM, 1978a).
    • 5, 20% in rabbits, photoirritation observed at 5 and 20% (RIFM, 1978a).
    • 1, 5, 10, 20% in guinea pigs and rabbits, photoirritation observed in guinea pigs and rabbits at 5, 10, and
    20% (Ogoshi et al., 1980; Ohkoshi et al., 1981).
    • 10% in guinea pigs, no photoirritation observed (Guillot et al., 1985).
    • 1% in rabbits, photoirritation observed (RIFM, 1978).
    • 1, 2, 4 % in rabbits, photoirritation observed (RIFM, 1985a; 1985b).
    • 0.01, 1, 10, 25, 50% in hairless mice, photoirritation observed at 10, 25, 50% (RIFM, 1978c).

    Animal studies – photoallergy


    2% in guinea pigs, no photoallergy observed, 1/10 showed sensitization (RIFM, 1985c).

    EXPERT PANEL FOR FRAGRANCE SAFETY RATIONALE / CONCLUSION:

    2020 (Amendment 49) 2/4


    Amendment 49 IFRA STANDARD

    Acetyl hexamethyl indan (AHMI)

    The Expert Panel for Fragrance Safety reviewed all the available data for Acetyl hexamethyl indan (AHMI)
    and recommends the concentrations for the 12 different product categories, which are the maximum
    acceptable concentrations of Acetyl hexamethyl indan (AHMI) in the various product categories.

    REFERENCES:

    The IFRA Standard on Acetyl hexamethyl indan (AHMI) is based on at least one of the following
    publications:

    • The RIFM Safety Assessment on Acetyl hexamethyl indan (AHMI) is available at the RIFM Safety
    Assessment Sheet Database:
    http://fragrancematerialsafetyresource.elsevier.com/.

    • Api A.M., Belsito D., Bruze M., Cadby P., Calow P., Dagli M. L., Dekant W., Dent M., Ellis G., Fryer A. D.,
    Fukayama M., Griem P., Hickey C., Kromidas L., Lalko J., Liebler D.C., Miyachi Y., Politano V.T., Renskers
    K., Ritacco G., Salvito D., Schultz T.W., Sipes I. G., Smith B., Vitale D., Wilcox D.K. (2015). Criteria for the
    Research Institute for Fragrance Materials, Inc. (RIFM) safety evaluation process for fragrance ingredients.
    Food Chem Toxicol. 2015 Aug;82 Suppl:S1-S19 (doi: 10.1016/j.fct.2014.11.014).
    (http://fragrancematerialsafetyresource.elsevier.com/sites/default/files/Criteria_Document_Final.pdf).

    • IDEA project (International Dialogue for the Evaluation of Allergens) Final Report on the QRA2: Skin
    Sensitisation Quantitative Risk Assessment for Fragrance Ingredients, September 30, 2016
    (http://www.ideaproject.info/uploads/Modules/Documents/qra2-dossier-final--september-2016.pdf).

    • Salvito D.T., Senna R. J., Federle T.W. (2002). A framework for prioritizing fragrance materials for aquatic
    risk assessment. Environ Toxicol Chem. 2002;21:1301-1308.
    (https://www.ncbi.nlm.nih.gov/pubmed/12069318).

    • Guillot, J.P., Gonnet, J.F., Loquerie, J.F., Martini, M.C., Convert, P., and Cotte, J. (1985). A new method
    for the assessment of phototoxic and photoallergic potentials by topical applications in the albino guinea
    pig. J. Toxicol.-Cut. Ocu. Toxicol., 4(2), 117-133.

    • Ogoshi, K., Tanaka, N., and Sekine, A. (1980). A study on the phototoxicity of musk type fragrances.
    Unpublished. Presented at Society of Cosmetic Chemists, Japan. Report number 7465, 17 November.

    • Ohkoshi, K., Watanabe, A., and Tanaka, N. (1981). Phototoxicity of musks in perfumery. J. Society
    Cosmetic Chemists, Japan, 15(3), 207-213.

    • Research Institute for Fragrance Materials, Inc. (1978a). Phototoxicity of synthetic musks. Unpublished
    report from Shiseido laboratories. Report number 4415, 26 August.

    • Research Institute for Fragrance Materials, Inc. (1978b). Phototoxicity tests with 5-acetyl-1,1,2,3,3,6-
    hexamethylindan in albino rabbits. Unpublished report from Quest International. Report number 8055, 1
    January.

    • Research Institute for Fragrance Materials, Inc. (1978c). Phototoxicity studies. RIFM report number 2042,
    12 May.

    • Research Institute for Fragrance Materials, Inc. (1985a). Photosensitization test with 2% and 4% 5-acetyl-
    1,1,2,3,3,6-hexamethylindan in albino rabbits. Unpublished report from PFW Aroma Chemicals. Report
    number 29705, 1 November.

    • Research Institute for Fragrance Materials, Inc. (1985b). Photosensitization test with 1% 5-acetyl-

    2020 (Amendment 49) 3/4


    Amendment 49 IFRA STANDARD

    Acetyl hexamethyl indan (AHMI)

    1,1,2,3,3,6-hexamethylindan in albino rabbits. Unpublished report from PFW Aroma Chemicals. Report
    number 29706, 1 November.

    • Research Institute for Fragrance Materials, Inc. (1985c). Photosensitization test with 5-acetyl-1,1,2,3,3,6-
    hexamethylindan (17179) in guinea pigs. Unpublished report from PFW Aroma Chemicals. Report number
    29704, 1 November.

    • Research Institute for Fragrance Materials, Inc. (1986). Phototoxicity testing in human subjects. RIFM
    report number 5748, 19 December.

    • Research Institute for Fragrance Materials, Inc. (1987). Phototoxicity testing in human subjects. RIFM
    report number 5743, 23 January.

    Additional information on the application of IFRA Standards is available in the Guidance for the use of IFRA
    Standards, publicly available at www.ifrafragrance.org.

    2020 (Amendment 49) 4/4

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