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PP II EXPERIMENT 7 Sedimentation Volume With Multiple Suspending Agent

Pharmaceutics 2

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firujzamal011989
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212 views2 pages

PP II EXPERIMENT 7 Sedimentation Volume With Multiple Suspending Agent

Pharmaceutics 2

Uploaded by

firujzamal011989
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© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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EXPERIMENT – 7

Determination of sedimentation volume with the effect of different concentration of single


suspending agent.
Aim:
Determination of Sedimentation volume With Effect of Different Concentration of Single
Suspending Agent
Principle:
SUSPENSION
Pharmaceutical suspension may be defined as a coarse dispersion in which insoluble solids
are suspended in a liquid medium. It is also known as a heterogeneous system (or) more
precisely biphasic system. The insoluble solids may have a size range from 10-10000µm
and the liquid medium is normally water or a water-based vehicle.
SUSPENDING AGENT
Suspending agent is defined as a physiologically inert substance which increases the
viscosity when added to suspensions. It helps in keeping the dispersed particles.
Suspended thus there enhanced the physical stability and re-dispersion of the sediment or
shaking.
PHYSICAL STABILITY
Physical stability may be defined as a condition in which particles remain uniformly
distributed throughout the dispersion with any signs of sedimentation.
In practice, Physical stability may be defined as a condition in which particles should be
easily re- suspended by a moderate shaking. If they settle suspensions when kept aside.
The solids tend to settle at the bottom of the container due to gravitational pull on the
particles of higher size. It is not possible to prevent the sedimentation volume and its case
of re-dispersion is the common evaluation procedure for assessing the physical stability.
The two sedimentation parameters are employed such as
1. Sedimentation volume
2. Degree of flocculation
SEDIMENTATION VOLUME:
• When a suspension is taken in a measuring cylinder volume and height is proportional
and height can be conveniently measured through the term volume is included in the
terminology sedimentation volume “F” is a dimension less number. The most
pharmaceutical suspension has an “F” value of less than one. If f=1 the product has no
sediment and no clear supernatant on standing which is an ideal condition. Normally “F”
value lies between 0 and 1. Sometimes the network of flow is loose and fluffy and the
ultimate volume of sediment increases. In this situation, “F” value will be greater than one.
PROCEDURE:

1. Separately prepare 5% w/v of calcium carbonate suspension with0.5%, 1%, 1.5%, 2


% of single suspending agent such as (bentonite) in different vessel. Add a small
quantity of water and triturate well. After the powder is uniformly suspended transfer
the suspension into a separate 100ml measuring cylinder.
2. Makeup the volume to 100ml with distilled water
3. Shake the suspension simultaneously and kept aside
4. Note the volume of sediment at time periods 0, 10, 20, 30,…60 minutes. Calculate the
sedimentation volume
5. Draw the plot by taking “F” values on the “Y” axis and the time on the “X” axis.

REPORT:

 Increase the concentration of suspending agent and also increase the viscosity so
lower the sedimentation volume
 The concentration of single suspending agent bentonite has more physical stable.

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