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Shinu
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Q: A 60 years old woman has diabetes and hyperlipidemia, for which he takes

metformin 500 mg and atorvastatin 20 mg daily. She has no prior events indicative of
cardiovascular disease but had a gastrointestinal bleed 2 months ago. She wants to
take aspirin to prevent heart attacks. What should the pharmacist recommend?

A: The US Preventive Services Task Force (USPSTF) recommends low-dose aspirin for
adults aged 40 to 59 years with a 10-year risk of atherosclerosis heart disease of at least
10% and an increased risk of CVD. Patients with a high risk of bleeding and those
unable to take low-dose aspirin every day are less likely to benefit.

The USPSTF advises against the use of low-dose aspirin for primary prevention of CVD in
adults 60 years and older because of the higher risk of bleeding. Similarly, the American
College of Cardiology and the American Heart Association discourage low-dose aspirin
use in individuals older than 70 and those who have an increased risk of bleeding. A
history of gastrointestinal bleeding, bleeding at other sites, thrombocytopenia, and
anticoagulant or nonsteroidal anti-inflammatory drug use places adults at greater risk of
bleeding.

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