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    W06 Imm2011

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    ansherinalimbo
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    W06 Imm2011

    Uploaded by

    ansherinalimbo
    2 views1 page
    revision material

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    W06 IMM2011

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    2 views1 page

    W06 Imm2011

    Uploaded by

    ansherinalimbo
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    © All Rights Reserved
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    of 1

    The benefits of two types of inside immunity is that we can have a tailored response to

    different types of pathogens. Some pathogens live inside our cells, some live in immune cells
    such as Mycobacterium tuberculosis that lives in macrophages. In this case, antibodies
    generated as part of the humoral response will not be effective as they cannot cross the cell
    membrane, so a cell-mediated response is necessary, particularly a cytotoxic T cell response
    and a T helper 1 response.

    Capability Immature DC Mature DC


    Phagocytosis Great Poor
    Antigen Presentation Poor, low MHC expression Great, high MHC expression
    T cell activation Poor, low costimulatory Great, high costimulatory
    (B7) molecule expression (B7) molecule expression
    Migration Poor, low CCR7 expression Great, high CCR7
    expression

    1. True or False? DCs are the only professional APCs that can activate a naïve T cell?
    True.
    2. What causes a DC to mature? Recognition of microbes via PRRs, and also cytokines
    from other innate immune cells.
    3. How does a DC get to the lymph node (LN)? Where does it localise to in the LN?
    How does it know where to go? It migrates and localises to the T cell zone due to
    expression of the chemokine receptor CCR7 which recognises chemokines in the T
    cell zone.
    4. What does a DC do in the LN? Presents antigen to and activates T cells.
    5. The antigen-specific T cell receptor chains directly couple to signal transduction
    pathways. False.
    6. The cytoplasmic domains of the antigen-specific T cell receptor are phosphorylated
    by the coreceptor associated tyrosine kinase Lck. False.
    7. Second messengers are unique features of T cells. False.
    8. Naive T cells express both CD4 and CD8, and following activation in the lymph node,
    they differentiate into CD4+ or CD8+ T cells. False, T cell selection and
    differentiation occurs in the thymus.
    9. The ligands of CD8 are MHC class I and the tyrosine kinase Lck. False.
    10. Antigen receptor signalling leads to the generation of second messengers and the
    activation of transcription factors. True.

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