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    E. Donnall Thomas

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    E. Donnall Thomas

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    E._Donnall_Thomas

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    E. Donnall Thomas

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    of 3

    E.

    Donnall Thomas
    Edward Donnall "Don" Thomas (March 15, 1920 –
    October 20, 2012)[1] was an American physician, E. Donnall Thomas
    professor emeritus at the University of Washington,
    and director emeritus of the clinical research division
    at the Fred Hutchinson Cancer Research Center. In
    1990 he shared the Nobel Prize in Physiology or
    Medicine with Joseph E. Murray for the development
    of cell and organ transplantation. Thomas and his wife
    and research partner Dottie Thomas developed bone
    marrow transplantation as a treatment for leukemia.

    Thomas was a lead investigator in a failed series of


    experimental treatments for leukemia and for Graft-
    versus-host disease at Seattle's Fred Hutchinson Thomas in 2000
    Cancer Research Center from 1981 to 1993.
    Born Edward Donnall Thomas
    Participants were not informed that Thomas and other
    March 15, 1920
    researchers had a potential financial conflict of interest Mart, Texas, U.S.
    in the trials, and were never properly informed of the
    Died October 20, 2012 (aged 92)
    risks. The study continued despite objections from
    Seattle, Washington, U.S.
    members of the Center’s Internal Review Board. 84 of
    the 85 participants in the study died.[2] Alma mater University of Texas at Austin
    (BA, MA)
    Harvard University (MD)
    Biography Known for Transplantation
    Awards Nobel Prize in Physiology or
    Born in Mart, Texas, Thomas often shadowed his Medicine
    father who was a general practice doctor. Later, he National Medal of Science
    attended the University of Texas at Austin where he
    Scientific career
    studied chemistry and chemical engineering,
    graduating with a Bachelor of Arts in 1941 and a Fields Medicine
    Master's degree in 1943. While Thomas was an Institutions Mary Imogene Bassett
    undergraduate he met his wife, Dorothy (Dottie) Hospital
    Martin while she was training to be journalist. They Notable Eloise Giblett
    had three children. Thomas entered Harvard Medical students
    School in 1943, receiving a Doctor of Medicine in
    1946. Dottie became a lab technician during this time to support the family, and the pair worked closely
    thereafter. He did his residency at Peter Bent Brigham Hospital before serving two years in the United
    States Army as an internist stationed in Germany.[3][4] "In 1955, he was appointed physician in chief at
    the Mary Imogene Bassett Hospital, now Bassett Medical Center, in Cooperstown, New York, an affiliate
    of Columbia University."[5]
    At Mary Imogene Bassett, he began to study rodents that received lethal doses of radiation who were then
    saved by an infusion of marrow cells. At the time, patients who underwent bone marrow transplantation
    all died from infections or immune reactions that weren't seen in the rodent studies. Thomas began to use
    dogs as a model system. In 1963, he moved his lab to the United States Public Health Service in
    Seattle.[6]

    Thomas also received National Medal of Science in 1990. In 2003 he was one of 22 Nobel laureates who
    signed the Humanist Manifesto.[7]

    He died of heart failure.[6]

    Awards and honors


    1965-1969 Hematology Study Section, National Institutes of Health
    1969-1973 Member, Board of Trustees and Medical and Scientific Advisory Committee,
    Leukemia Society of America, Inc.
    1970-1974 Clinical Cancer Investigation Review Committee, National Cancer Institute
    1974 First Annual Eugene C. Eppinger Lecture at Peter Bent Brigham Hospital and the
    Harvard Medical School
    1975 A. Ross McIntyre Award, University of Nebraska Medical Center
    1975 The Henry M. Stratton Lecture, American Society of Hematology, Dallas
    1977 The Lilly Lecture, Royal College of Physicians, London
    1979 The Philip Levine Award, American Society of Clinical Pathologists, New Orleans
    1980 American Cancer Society Award for Distinguished Service in Basic Research
    1981 Kettering Prize of the General Motors Cancer Research Foundation for contributions
    to the diagnosis and treatment of cancer
    1981 Honorary Doctorate of Medicine, University of Cagliari, Sardinia
    1981 Special Keynote Address Award, American Society of Therapeutic Radiologists
    1982 Stratton Lecture, International Society of Hematology
    1982 Paul Aggeler Lecturer, University of California, San Francisco
    1983 David A. Karnofsky Memorial Lecturer, Annual Meeting of the American Society of
    Clinical Oncology
    1983 Robert Roesler de Villiers Award, Leukemia Society of American
    1984 Sixty-fifth Mellon Lecturer, University of Pittsburgh School of Medicine, May 13
    1985 Stanley Wright Memorial Lecturer, Annual Meeting of the Western Society for Pediatric
    Research
    1987 Karl Landsteiner Memorial Award, Annual Meeting of the American Association of
    Blood Banks,
    1987-1988 President, American Society of Hematology
    1989 Elected Corresponding Member, Academie Royale de Medecine de Belgigue
    1990 Terry Fox Award, Canada
    1990 Gairdner Foundation International Award
    1990 North American Medical Association of Hong Kong Prize
    1990 Nobel Prize in Medicine
    1990 Presidential Medal of Science
    1991 Adolfo Ferrata Lecture, Italian Society of Hematology, Verona, Italy
    1991 Honorary Doctorate of Medicine, University of Verona
    1992 Kober Medal, American Association of Physicians
    1992 Honorary Member, The Royal College of Physicians and Surgeons of Canada
    1992 Honorary Doctorate of Medicine, University of Parma
    1993 Golden Plate Award of the American Academy of Achievement[8]
    1994 Honorary Member, National Academia of Medicine
    1994 Honorary Degree, University of Barcelona
    1996 Honorary Degree, University of Warsaw
    1998 Medal of Merit, State of Washington

    References
    1. Frederick R. Appelbaum. Perspective: E. Donnall Thomas (1920–2012) (https://www.scienc
    e.org/doi/abs/10.1126/science.1232395) Science 338(6111):1163, 30 November 2012
    2. Seattle, Times (2001). "He saw the tests as a violation of 'trusting, desperate human
    beings' " (https://special.seattletimes.com/o/uninformed_consent/whistleblower/story1.html).
    Seattle Times. Seattle Times. Retrieved May 27, 2024.
    3. Appelbaum, Frederick R. "Biographical Memoirs" (http://www.nasonline.org/publications/bio
    graphical-memoirs/memoir-pdfs/thomas-e-donnall.pdf), National Academy of Sciences.
    4. Piana, Ronald. "Nobel Laureate E. Donnall Thomas, MD, Dies at 92" (https://ascopost.com/i
    ssues/november-15-2012/nobel-laureate-e-donnall-thomas-md-dies-at-92/), The ASCO Post
    website, November 15, 2012. Retrieved May 22, 2022.
    5. "E. Donnall Thomas, Who Advanced Bone Marrow Transplants, Dies at 92" (https://www.nyti
    mes.com/2012/10/22/science/e-donnall-thomas-furthered-bone-marrow-transplants-dies.ht
    ml?amp&_r=1&). The New York Times. October 24, 2012.
    6. Storb, R. (2012). "Edward Donnall Thomas (1920–2012)" (https://doi.org/10.1038%2F49133
    4a). Nature. 491 (7424): 334. Bibcode:2012Natur.491..334S (https://ui.adsabs.harvard.edu/
    abs/2012Natur.491..334S). doi:10.1038/491334a (https://doi.org/10.1038%2F491334a).
    PMID 23151572 (https://pubmed.ncbi.nlm.nih.gov/23151572).
    7. "Notable Signers" (https://web.archive.org/web/20151021180556/http://americanhumanist.or
    g/Humanism/Humanist_Manifesto_III/Notable_Signers). Humanism and Its Aspirations.
    American Humanist Association. Archived from the original (http://www.americanhumanist.or
    g/Humanism/Humanist_Manifesto_III/Notable_Signers) on October 21, 2015. Retrieved
    October 4, 2012.
    8. "Golden Plate Awardees of the American Academy of Achievement" (https://achievement.or
    g/our-history/golden-plate-awards/#science-exploration). www.achievement.org. American
    Academy of Achievement.

    External links
    Fred Hutchinson Cancer Research Center. Nobel Prize: The Don and Dottie Story (http://ww
    w.fhcrc.org/research/nobel/thomas/dondottie.html)
    E. Donnall Thomas (https://www.nobelprize.org/laureate/443) on Nobelprize.org including
    the Nobel Lecture 8 December 1990 Bone Marrow Transplantation - Past, Present and
    Future

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