A Robust System

for your Essential Science

Milli-Q® SQ 2Series
Water Purification Systems

The Life Science business of Merck operates

as MilliporeSigma in the U.S. and Canada. Lab Water Solutions
MILLI-Q® SQ 2SERIES

A new way
to think about
ultrapure water
Milli-Q® SQ 2Series

2
 Every lab bench in need can now easily access
freshly purified ultrapure water—even distant
benches without feed tap water. New Milli-Q®
SQ 2Series water purification systems are
simple, robust, innovative and completely
scalable so that you can focus on your science.

1. RAPIDLY FILL
the 3.5L Switch tank
with reverse osmosis
2. EASILY CARRY
(RO) water in as few the Switch tank to
as 6 minutes. your science.

Prefilter Pure Ultrapure

(optional)
2
18.2
Tap MΩ.cm

1 3

4 3. DISPENSE
freshly polished
18.2 MΩ.cm
ultrapure water
at any bench.

4. REPEAT
as needed.

3
MILLI-Q® SQ 2SERIES

Reliable
quality Pure RO Water
Production Station

ASSURED 18.2 MΩ∙CM

ULTRAPURE WATER
AT ANY BENCH
Proven Milli-Q® water purification
technologies mean you can trust your
system is always ready to dispense
consistent quality ultrapure water
(18.2 MΩ∙cm @25 °C).
For specifications on ultrapure water quality,
refer to page 14.

Pretreatment
unit (optional)
boosts system
• High-flow RO membrane (up
performance to 42 L/h) fills the Switch
• Prefiltration tank in as few as 6 min
cartridge removes ― faster than your coffee
chlorine, colloids break!
and particulates • Pure RO water quality is
from tap feed water
maintained by automatic
to protect the
production station’s rinsing of the RO membrane
RO membrane before tank filling and when
system is idle
• Booster pump
ensures constant high
flow of pure RO water

4
Ultrapure Water Final filters to
Dispensing Module match specific
application needs

SQPAK™
Final Filter
Removes particulates
and bacteria

SQPAK™
Bio Final Filter
Removes pyrogens,
nucleases, proteases
and bacteria

• SQPAK™ Quanta polishing

cartridge contains high-
efficiency IQnano™ resin for
removal of ions down to trace
levels
• SQPAK™ TOC Quanta
cartridge includes activated
carbon for organic-sensitive
applications
• Ultrapure water is
automatically recirculated
through photooxidation UV
lamp and polishing cartridges

5
MILLI-Q® SQ 2SERIES

ULTIMATE
Simplicity

EASY & INTUITIVE TO OPERATE FOR ANY USER

18.2
MΩ.cm 

ERGONOMIC MOBILE, UNIVERSAL

HANDSET TRANSPARENT INTERFACE
DISPENSER SWITCH TANK gives essential
smoothly adjusts is easy and safe information at a
from 1.6 L/min to to carry, and gives glance.
drop by drop. immediate water level
status, so there’s no
surprises when you
go to dispense.

6
 Remote Install
Support & Technical
Assistance will give
you self-installation
PROVEN, confidence.
DO-IT-YOURSELF
CONCEPT FOR
RAPID UPSTART 30-MIN SELF-
& EASY UPKEEP INSTALLATION
Guided setup with
printed, illustrative
manuals and online
how-to videos via
QR codes.

MINIMAL
MAINTENANCE
Twist & Lock design
means anyone can
change cartridges
and final filters,
and there’s no need
to replace the UV
lamp thanks its long
lifetime.

CLEAR COLOR-CODING
on packagings, manuals, cartridges and sytems supports intuitive
upstart and maintenance at each water purification step.

7
MILLI-Q® SQ 2SERIES

UNIQUELY SMALL SIZE

LEAVES SPACE FOR YOUR
SCIENCE AT ANY BENCH
Milli-Q® SQ 2Series systems have the same
footprint as a sheet of paper (22 x 27 cm/unit).
The dispensing module fits your busy bench

ULTRA
with no water inlet required. Only an electrical
outlet is needed to dispense ultrapure water
at your bench.

COMPACT

8
 Unlimited
SCALABILITY
ADAPT TO FIT Pure RO water production of
up to 42 L/h lets you rapidly
YOUR SET UP fill the Switch tank in as few
as 6 minutes. The dual tank
& EVOLVE AS production station supports
YOU NEED unlimited ultrapure water
dispensing modules.
Simply select the
configuration that best
fits your space and LAB 3
user requirements,
then easily expand
with more modules as
your lab evolves. LAB 1

LAB 2
Prefilter
(optional)

Pure

Ultrapure

Cartridges can be
individually replaced
when exhausted.

The above configuration consists of 1x Milli-Q® SR 240L production station; 1x Milli-Q® SP 240 prefilter module;
3x Milli-Q® SQ 200 dispensing modules; and 4x Milli-Q® SQ Switch tanks.

9
MILLI-Q® SQ 2SERIES

UNIQUE
innovations
Rapid pure RO water
production keeps your
workflow on the go
• Exceptionally high-flow RO membrane
(up to 42 L/h) rapidly refills your tank
in as few as 6 minutes.
• Membrane is housed in a compact,
single cartridge with Twist &
Lock design so you can easily
and individually replace it when
exhausted.

Intuitive dispensing with high-

quality ultrapure water thanks
to intelligent mechanical and
hydraulic design (patents pending)
• Ultrapure water quality is secured thanks
to two-way ‘multi-lumen’ tubing, which
recirculates water through the UV lamp,
polishing cartridge and to the handset
dispenser.

• Manually master your flow rate with just

the push or pull of your thumb; mechanical
dispensing lets you finetune the flow of
ultrapure water, so you always hit your mark.

8 technical & design IP (intellectual

property) filings for Milli-Q® SQ 2Series
systems.

10
 7 years
of tank
One-time peace of mind with usage
tested.
3-year extended warranty
options
As these systems are designed to
last, extended warranties simplify
system coverage.

Built and tested to last

From selection and development to
validation and production, Milli-Q® SQ
2Series components, subassemblies and
complete systems have been thoroughly
tested to ensure their long lifespan.

• Roboticized endurance testing simulated

7 years of usage of:
- Switch tank handling
- Repeated handset dispensing
• Manufacturing is assisted by camera
guidance and supported by AI (artificial
intelligence)

Confidence
in a Robust
system

11
MILLI-Q® SQ 2SERIES

Supports
sustainability

MILLI-Q® SQ Energy &

2SERIES SYSTEMS Emissions
ARE GREENER Less electricity consumed thanks to
simplified design, minimized electronics,
ALTERNATIVE and optimized stand-by mode (where
most energy is consumed).
PRODUCTS
As part of our Design for
Sustainability approach
to product development,
Milli-Q® SQ 2Series systems Water
were developed to deliver RO recovery loop consumes
high-quality ultrapure water 60% less tap water.1
at multiple locations with
a reduced environmental
footprint compared to previous
generation Direct-Q® systems.
As a result of these efforts, Materials
these new systems are Limited material requirements2
labeled Greener Alternative for multiple dispensing locations
Products thanks to thanks to a modular design that
improvements in the following only duplicates the ultrapure water
sustainability characteristics dispensing module.3
versus previous generation
systems. The following data
represents a comparison
versus Direct-Q® 3 systems: Circular
Economy
Designed to be easily maintained
and disassembled to maximize its
lifetime and facilitate end of life
We invite you to management.
review the Design for
Sustainability Scorecards
at SigmaAldrich.com/
Milli-Q-SQ-2Series Packaging
to support 100% recycled cardboard with
you in making sustainable forestry certification.
greener Protective inserts made of
purchasing polyethylene (PE) with
decisions. 50% recycled content.

12
Sustainability gains depend on the configuration selected. Below is a representative example of
the savings achieved by progressively scaling up the Milli-Q® SQ 2series system with increasing
numbers of dispensing modules4 (similar to the setup with multiple dispensing modules on
page 9) compared to increasing units of an older generation Direct-Q® 3 system.

Savings achieved with the Milli-Q® SQ 240 system configuration by increasing the number
of ultrapure water dispensing modules 4 vs. increasing units of Direct-Q® 3 systems

1
No. of ultrapure water
100 dispensing modules4 2
82 3
kWh
80 With Milli-Q SP 240
®

Prefilter module (optional)

60 48
kWh 54 m3

40 36 m3
25 kg
20 13 18m3
kWh 13 kg
1 kg
0

-20

Energy saved/year1 Water saved/year1 Weight of materials saved2

1 Assuming 14 L ultrapure water dispensed for 260 days per year, per distribution station.
2 Throughout product life cycle, considering mass of equipment and consumables for 7 years.
3 Total mass increases if only one dispensing module.
4 Each dispensing module consists of one Milli-Q® SQ 200 dispensing module and one Milli-Q® SQ Switch tank.

13
MILLI-Q® SQ 2SERIES

Water Specifications
The production station of the Milli-Q® SQ 2Series produces pure
RO water:
• Ionic content: >96% rejected typically
• Organics & particulates: >99% rejected typically
The dispensing module of Milli-Q® SQ 2Series systems produces
ultrapure water [18.2 MΩ·cm @ 25 °C] that fulfills the requirements
of the below organizations when equipped with a Prefilter module,
SQPAK™ TOC Quanta cartridge and SQPAK™ final filter.

Organization Water Quality / Grade

European Pharmacopoeia Purified water in bulk1
US Pharmacopeia Purified water in bulk1
Chinese Pharmacopoeia Purified water
Japanese Pharmacopoeia Purified water
ASTM® D1193-06 Type I water – Grade B
ISO 3696 Grade 1 water
Clinical and Laboratory Standards Institute Clinical Laboratory Reagent
(CLSI®) Water (CLRW)
Chinese National Standard GB/T 6682 Level I
Chinese National Standard GB/T 33087 Ultrapure water
JIS K0557 A4 water

Choice of polishers & final filters to fit

different user requirements1
With SQPAK™ TOC Quanta Cartridge
TOC ≤ 5 ppb(2)

With SQPAK™ Final Filter

Particulates None ≥ 0.22 μm
Bacteria ≤ 10 cfu/L (typically ≤ 1 cfu/L)

With SQPAK™ Bio Final Filter

Bacteria ≤ 10 cfu/L (typically ≤ 1 cfu/L)
Not detectable, under limit of
Pyrogens (endotoxins)
detection < 0.001 EU/mL
Not detectable, under limit of
RNases
detection < 1 pg/mL
Not detectable, under limit of
DNases
detection < 5 pg/mL
Not detectable, under limit of
Proteases
detection < 0.15 µg/mL

1. These values are typical and may vary depending on the nature and concentration of
contaminants in the feed water.
2. With SQPAK™ Final Filter and under controlled laboratory conditions.

14
 Dimensions & Operating Weights
Prefiltration RO Water Switch Tank Ultrapure Water
Module Production Station (3.5 L) Dispensing Module

50.3 cm
(19.8 in)

36.9 cm
(14.5 in)

21.2 cm 22.0 cm
14.1 cm 26.7 cm 12.4 cm (8.3 in) (8.7 in)
(5.6 in) (10.5 in)
26.7 cm
(4.9 in)
(10.5 in)

6 kg 10 kg 3.8 kg 12 kg
(13 lb) (22 lb) (6.6 lb) (26 lb)

Connections & Environment

1/2’’ Male 50/60 Hz ± 2 Hz 4-40 °C Relative humidity < 3000 m (9842 ft) < 60 dB @ 1 m
NPT/BSP/GAZ < 120 W (39-104 °F), < 80% @ 31 °C (88 °F), above sea level @ 20 kPa
100–240 Vac ± 10% air < 50% @ 40 °C (104 °F)

Feed Water Specifications

Prefilter Pressure
Production
Module Regulator
Station
Recommended Recommended

Pressure 2 – 3 bar 1 – 6 bar 3 – 6 bar

Free chlorine < 0.5 ppm < 2 ppm

Langlier Saturation Index (LSI) < 0.3

Silt Density Index (SDI) <5

Temperature 5 – 35 °C (41 – 95 °F)

Conductivity < 2000 μS/cm

TOC < 2 ppm

15
MILLI-Q® SQ 2SERIES

MILLI-Q® SQ 2SERIES CONFIGURATIONS

Select your purification cartridges, final filter(s), power cord(s), accessories and services in
the next section.

Milli-Q® SQ 240 Milli-Q® SQ 240L Milli-Q® SQ 240XL

ZSQ240R0TK*† ZSQ240RLTK*† ZSQ240RXTK*†

Standard Dual Tank 50 L Tank

Configuration Configuration Configuration

• Suitable for one small team • Suitable for multiple or larger • Suitable for direct feed of lab
• Install Dispensing Module next teams equipment from the 50 L tank
to ultrapure water need • Install Dispensing Module next • Install Dispensing Module next
• Expand capabilities with to ultrapure water need to ultrapure water need
additional autonomous • Expand capabilities with • Expand capabilities with
ultrapure water dispensing additional tanks and additional autonomous
modules autonomous ultrapure water ultrapure water dispensing
dispensing modules modules

Included: Included: Included:

x1 x1 x1
ZSR240R0T0 ZSR240RLT0 ZSR240RXT0
Milli-Q® SR 240 Pure RO Milli-Q® SR 240L Pure RO Milli-Q® SR 240XL Pure RO
Water Production Station Water Production Station Water Production Station

x1 x1 x1
ZSQ200U0T0 ZSQ200U0T0 ZSQ200U0T0
Milli-Q® SQ 200 Ultrapure Milli-Q® SQ 200 Ultrapure Milli-Q® SQ 200 Ultrapure
Water Dispensing Module Water Dispensing Module Water Dispensing Module

x2 x3 x2
TANKSQ003 TANKSQ003 TANKSQ003
Milli-Q® SQ Switch Milli-Q® SQ Switch Milli-Q® SQ Switch
3.5L Tank 3.5L Tank 3.5L Tank

x1
TANKSQ050
Milli-Q® SQ XL 50L Tank

Ordering
Information
16
 Milli-Q® SQ 240C Milli-Q® SQ 240CV Milli-Q® SQ 200P
ZSQ240UCTK*‡ ZSQ240UCVTK*‡ ZSQ200UPT0‡

Combined Combined, Preset Pressurized Loop

Configuration Volume Configuration Configuration

• Suitable for one small lab or • Suitable for routine lab • Suitable for labs with a
team activities pressurized purified water loop
• Install system next to a sink • Repeat serial ultrapure water • Connect system to a
• Expand capabilities with preset volume dispense from a pressurized pure water loop
additional autonomous fixed point • Expand capabilities by
ultrapure water dispensing • Install system next to a sink connecting additional systems
modules • Expand capabilities with to the pressurized pure water
additional autonomous ultrapure loop
water dispensing modules

Included: Included: Included:

x1 x1 x1
ZSQ240UCVT0 ZSQ200UPT0
ZSQ240UCT0 Milli-Q® SQ 240CV Milli-Q® SQ 200P Ultrapure
Milli-Q® SQ 240C RO Water RO Water Production & Water Dispensing from a
Production & Ultrapure Ultrapure Water Dispensing Pressurized Pure Water
Water Dispensing System System, with Preset Loop
Volume Dispensing

x1 x1
TANKSQ003 TANKSQ003
Milli-Q® SQ Switch Milli-Q® SQ Switch
3.5L Tank 3.5L Tank

Configure and order your solution at

SigmaAldrich.com/Milli-Q-SQ-2Series

*Gravity valve (ZSQ240GVT0) included in the shipping kit.

†Two power cords required; Refer to Table on page 19.
‡One power cord required; Refer to Table on page 19.

17
MILLI-Q® SQ 2SERIES

PURIFICATION CARTRIDGES AND FILTERS

SQPAKGARM1 SQPAKPR0M1 SQPAKQUAM1 SQPAKT0CM1

SQPAK™ SQPAK™ SQPAK™ SQPAK™ TOC
Gard Pack RO Cartridge Quanta Cartridge Quanta Cartridge

SQPAKFINM1 SQPAKBI0M1
SQPAK™ SQPAK™
Final Filter Bio Final Filter

ACCESSORIES

TANKSQ003 ZWATSENA1
Milli-Q® SQ Switch
ZSQ240GVT0 Water Sensor
Milli-Q® SQ
3.5 L Tank
Gravity Valve Stops system
To carry RO water in case water
To dispense
from the production is detected on
RO water from
station to the the bench or
Switch tank.
dispensing module. floor.

ZSR240PFT0
Milli-Q® SP 240
Prefilter Module ZFMQPR3BT0
Milli-Q® Pressure Regulator
Boosts performance of RO
Limits tap feed water
water production station.
pressure to 3 bars to
Includes a pressure
optimize RO membrane
regulator (see page 4).
performance.
Requires one power cord
(see page 19).

ZWCL01F50
ZSQ240CTT0 ROProtect C
Milli-Q® SQ Cleaning Tool

To sanitize the Switch 5874316024

EfferSan Effervescent Tablets (US only)
Tank and RO water
production station, along 5874316024C
with cleaning tablets. EfferSan Effervescent Tablets (CA only)

Cleaning tablets to sanitize the Switch Tank and RO

water production station, along with the Cleaning Tool.

18
 Milli-Q® Services Cat. No.

Milli-Q SQ 2Series Remote Installation Support & Technical Assistance

®
ZWSQ2INSUP
Milli-Q® SR 240 ZWSQ2S5EXW
Milli-Q® SR 240L ZWSQ2S6EXW
Milli-Q SR 240XL
®
ZWSQ2S7EXW
3-Year Extension of Service Warranty
Milli-Q® SQ 200 ZWSQ2S1EXW
(per configuration component)
Milli-Q® SQ 200P ZWSQ2S2EXW
Milli-Q® SQ 240C ZWSQ2S3EXW
Milli-Q® SQ 240CV ZWSQ2S4EXW

Power cords Cat. No.

For WEU, CEE, GR, IR, RU, TR, IL, PK, CL, ID, JP, KP, KR, PH, TH, VN FTPF01866
For US, CA, CO, GT, MX, PE, TW (115 V) FTPF02471
For GB, IE, HK, MY, SG SIMCABLE1
For Denmark SIMCABLE2
For South Africa SIMCABLE3
For Switzerland SIMCABLE4
For China SIMCABLE5
For India SIMCABLE6
For Japan, Thailand SIMCABLE7
For Argentina, Australia, New Zealand SIMCABLE8
For Brazil SIMCABLE11

INTERNATIONAL REGULATORY REQUIREMENTS

EU declaration of conformity – UL safety marking
Milli-Q® SQ 2Series systems have been Milli-Q® SQ 2Series systems are also subject
designed and manufactured in accordance to of the UL listing Marking Program and meets
the international standard and test method the following marking and registration
defined by the IECEE organization according requirements listed below:
CB Scheme process. CB Scheme process was • UL registration can be verified on the UL
applied for electromagnetic compatibility and website: iq.ulprospector.com (E216983)
safety compliance. • Access to CB certificate:
certificates.iecee.org (DK-137474-UL)

We also meet the regulatory requirements of the following organizations:

All our production sites are ISO 14001 certified, and all Milli-Q® systems comply with critical
environmental regulations and directives, such as RoHS, REACH and WEEE. Since April 2022,
our Molsheim site in France, where Milli-Q® systems are manufactured, is ISO 50001 certified on
energy management.

As a member of the Together for Sustainability initiative, we encourage

our suppliers to be assessed and ensure compliance with our standards
and values in the categories of Environment, Labor and Human Rights,
Ethics, and Sustainable Procurement. Today, 50% of the suppliers
for the Milli-Q® SQ 2Series participate in this initiative and have a valid
assessment.

19
Lab Water Solutions

Configure and order your solution at

SigmaAldrich.com/Milli-Q-SQ-2Series

© 2023 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved. Merck, the
vibrant M, Milli-Q, SQPAK and Direct-Q are trademarks of Merck KGaA, Darmstadt, Germany or its
affiliates. All other trademarks are the property of their respective owners. Detailed information on
trademarks is available via publicly accessible resources.

Lit. No. MK_BR12185EN