Human Reproduction Notes

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ENDOCRINE CONTROL OF REPRODUCTIVE FUNCTION POSTERIOR PITUARY GLAND

ANTIDIURETIC HORMONE (ADH, OR VASOPRESSIN) - This


2 MAJOR GLANDS INVOLVED: hormone regulates the water balance and sodium levels in
your body.
1. Hypothalamus
2. Pituitary gland OXYTOCIN - Your hypothalamus makes oxytocin, and your
A. anterior pituitary gland pituitary gland stores and releases it. Oxytocin
b. posterior pituitary gland helps labor to progress during childbirth by sending signals
to their uterus to contract. It also causes breast milk to flow
and influences the bonding between parent and baby. In
male, oxytocin plays a role in moving sperm.

HYPOTHALAMUS - secretes hormones that stimulate or


suppress the release of hormones in the pituitary glands.

GONADS - are glands that produce hormones that are


involved in reproduction and other functions of the body.
female gonads are the ovaries, while male gonads are the
tes HYPOTHALAMIC-PITUITARY-GONAD AXIS

GONADOTROPIN - releasing hormone is a releasing The hypothalamic-pituitary-gonadal (HPG) axis is central


hormone responsible for the release of FSH and LH from for human reproduction. This axis includes neuroendocrine
the anterior pituitary gland. networks that integrate wide ranging internal and external
inputs to coordinate reproductive competence.
ANTERIOR PITUARY GLAND Gonadotrophin - releasing hormone (GnRH) is the principal
The anterior lobe of your pituitary gland makes and regulator of reproduction. GnRH controls gonadotrophin
releases the following hormones: secretion and subsequently, gonadal (testicular) function.
The HPG axis is activated during foetal life, neonatally and
ADRENOCORTICOTROPIC HORMONE (ACTH OR in puberty through adulthood. This developmental
CORTICOTROPHIN) - ACTH plays a role in how your body perspective is important as these periods contribute to the
responds to stress. It stimulates your adrenal glands to proper formation and development of sexual structures in
produce cortisol (the “stress hormone”), which has many utero as well as the development and function of the
functions, including regulating metabolism, system enabling reproductive capacity in adulthood. The
maintaining blood pressure, regulating blood glucose HPG axis remains silenced during childhood and
(blood sugar) levels and reducing inflammation, among neuroendocrine re-activation triggers pubertal onset.
others. Effective HPG axis function is needed for normal sexual
function and fertility and contributes to overall health and
FOLLICLE-STIMULATING HORMONE (FSH) - FSH stimulates well-being.
sperm production in male. FSH stimulates the ovaries to
produce estrogen and plays a role in egg development in MALE HORMONES
female. This is  Testosterone, the hormone responsible for the
known as a gonadotrophic hormone. secondary sexual characteristics that develop in the male
during adolescence, stimulates spermatogenesis. These
GROWTH HORMONE (GH) - In children, growth hormone secondary sex characteristics include a deepening of the
stimulates growth. In other words, it helps children grow voice, the growth of facial, axillary, and pubic hair, and the
taller. In adults, growth hormone helps maintain healthy beginnings of the sex drive.
muscles and bones and impacts fat distribution. GH also
impacts your metabolism (how your body turns the food FEMALE HORMONES
you eat into energy).  Estrogen is the reproductive hormone in females that
assists in endometrial regrowth, ovulation, and calcium
LUTEINIZING HORMONE (LH) - LH stimulates ovulation in absorption; it is also responsible for the secondary sexual
female and testosterone production in male. LH is also characteristics of females. These include breast
known as a gonadotrophic hormone because of the role it development, flaring of the hips, and a shorter period
plays in controlling the function of the ovaries and testes, necessary for bone maturation.
known as the gonads.
 Progesterone assists in endometrial re-growth and
PROLACTIN - Prolactin stimulates breast milk production inhibition of FSH and LH release.
(lactation) after giving birth. It can affect fertility and
sexual functions in adults.  Estradiol and progesterone are steroid hormones
that prepare the body for pregnancy. Estradiol produces
THYROID-STIMULATING HORMONE (TSH) - TSH stimulates secondary sex characteristics in females, while both
your thyroid to produce thyroid hormones that manage estradiol and progesterone regulate the menstrual cycle.
your metabolism, energy levels and your nervous system.
SEXUAL DIFFERENTIATION/PUBERTY

PUBERTY – is the stage of life at which secondary sex


changes begin.female begins puberty at the age of 9-12
years old. male begins puberty at the age of 12-14 years
old.

HORMONES RESPONSIBLE:

1.ANDROGEN HORMONES - are the hormones released by


the testes that responsible for muscular development,
physical growth, and the increase in sebacous glands
secretions that cause typical acne in both boys and girls
during adolescence.
2.ESTROGEN HORMONES – influences the development of
the uterus, fallopian tubes, and vagina; typical female fat
distribution; hair patterns; and breast development.

HORMONES RELEASED DURING PUBERTY

 Gonadotropin Releasing Hormone


 Follicle Stimulating Hormone
 Luteinizing Hormone

MALE HORMONE
TESTOSTERONE - the hormone responsible for the
secondary characteristics that develop in the male during
adolescence, stimulates spermatogenesis.

FEMALE HORMONE
ESTROGEN HORMONE - is the reproductive hormone in
females that assists in endometrial re-growth,
ovulation,and calcium absorption; it is also responsible for
the secondary sexual characteristics of females.
PROGESTERONE HORMONE – assists in endometrial
re-growth and inhibition of fsh and lh release.

MALE PUBESCENT DEVELOPMENTAL STAGES

1. Increase In Weight
2. Growth Of Testes
3. Growth Of Face, Axillary, And Pubic Hair
4. Voice Changes
5. Penile Growth
6. Increase In Height
7. Spermatogenesis

FEMALE PUBESCENT DEVELOPMENTAL STAGES

1. Growth Spurt
2. Increase In The Transverse Diameter Of The Pelvis
3. Breast Development
4. Growth Of Pubic Hair
5. Onset Of Menstruation
6. Growth Of Axillary Hair
7. Vaginal Secretions

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