HVAC
HVAC
Systems (HVAC)
Course: 305 Pharmaceutical Engineering
Heating
Ventilation and
Air Conditioning
HAVC System
An HVAC system is Heating, Ventilation and Air
Conditioning system. This system is used in
conditioning air in a big area where a usual air
conditioner cannot be used. It contains a boiler, a
chiller, cooling tower and air handling unit.
This system is used to control the temperature of a
designated space with the control of moisture in
the air, supply the area with fresh air by controlling
the carbon dioxide and oxygen level. It also controls
the contamination of airborne particles by
regulating the movement of air.
HVAC system
Building and
construction Humidity Human comfort
Agriculture Aerospace
Fuel
Cont…
Food processing and preservation: The relative humidity
of the ambient air, influences various physical, chemical
and biological properties of a broad variety of food
products. Moisture in inappropriate amounts is very
damaging to the useful life of food. Because of this, much
effort is put into reducing the water content of dry foods
in order to prolong their shelf lives.
Pharmaceutical manufacturing: Humidity can affect the
quality and safety of pharmaceutical products. varying
humidity levels can have more serious consequences on
lifesaving drugs. While there are a lot of moving parts
that go into producing medications, maintaining safety
and potency through humidity control is a responsibility
that lies within the pharmaceutical industry.
Cont…
Medical and health monitoring: The most
important impact that humidity has in hospitals and
medical facilities is the protection of patients from
microbial attacks. Humidity affects the airborne
survival of viruses, bacteria and fungi. Humidity can
also affect other medical facilities like medical
machineries, storage of medicine or
pharmaceuticals and overall comfort of all people.
Thus humidity control and maintenance are
important for medical and health monitoring.
Cont…
Human comfort: Humidity plays an important
role for surface life. For animal life dependent
on perspiration to regulate internal body
temperature, high humidity impairs heat
exchange efficiency by reducing the rate of
moisture evaporation from skin surfaces.
Humans can be comfortable within a wide range
of humidity (depending on the temperature)
from 40–60%. In general, higher temperature
will require lower humidity to achieve thermal
comfort compared to lower temperature.
Cont…
Agriculture: Humidity directly influences the water
relations of plant and indirectly affects leaf growth,
photosynthesis, pollination, occurrence of diseases
and finally economic yield.
Most plants prefer a relative humidity range of 40 to
65%; High humidity in the air lowers the intensity and
the quality of solar radiation. Low intensity and poor
quality of solar radiation in turn reduces
photosynthesis in crop plants. Reduced photosynthesis
leads to low crop yields. High air humidity favors many
plant diseases and insect pests. It increases the growth
of shoots and leaves at the expense of yield of crops.
Refrigeration
Refrigeration
Refrigeration or cooling process, is the removal
of unwanted heat from a selected object,
substance or space and its transfer to another
object, substance or space. Removal of heat
lowers the temperature and may be
accomplished by use of ice, snow, chilled water
or mechanical refrigeration. Refrigeration is
used in manufacturing ice, for preserving
perishable food materials, for cooling water as
well as for preserving of blood, tissues and
medicines etc.
Refrigerants & Mechanical refrigeration
Refrigerants are chemical compounds that are
alternately compressed and condensed into a liquid
and then permitted to expand into a vapor or gas as
they are pumped through the mechanical
refrigeration system to cycle. Commonly used
refrigerants are fluorinated gases, chlorinated
gases, chlorofluorocarbons etc.
Whereas mechanical refrigeration, is the utilization
of mechanical components arranged in a
"refrigeration system" for the purpose of
transferring heat.
Substance BP ( °C)
Ammonia - 33.2 °C
Hydrogen chloride - 84.9 °C
Freon refrigerant R-12 - 29.8 °C
Cooling tower
Central air conditioning system AC unit
Chilled water AC unit
Human Comfort
Inevitably 'comfort' is a very subjective matter.
Most people (90%) are comfortable when the air
temperature is between 18-23 °C and the RH (%
saturation) is between 40-65%. This zone can be
shown on the psychrometric chart, and is known as
the comfort zone. Outside air is quite likely to be at
a different condition from the required comfort
zone condition. In order to bring its condition to
within the comfort zone we may need to do one or
more of the following : heat it; cool it; dehumidify
it; humidify it; or mix it.
Cont…
Importance of comfort zone:
• Comfort zone is necessary for personnel comfort which
is directly related to the efficiency of work or
production.
• For the preservation of pharmaceuticals strict control
of temperature and humidity is necessary. Too much
temperature or humidity may degrade the product
quality. Presence of excess moisture may also destroy
the packaging materials.
• The working area is highly sensitive to airborne
particles. Comfort zone strictly maintain the air quality
and protect from contamination.
• Over heating may destroy the equipment and
machineries during tablet manufacturing and
compression which can be protected by setting
comfort zone.
Application of air conditioning
o Promoting human comfort
o Maintenance of proper conditions for
manufacturing, processing and preservation of
material and equipment.
o Maintenance of environmental test chamber
o Maintenance of animal and equipment